Gene: Abcb11

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Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11
MGI ID
MGI:1351619
Synonyms
PGY4 ABC16 PFIC2 Lith1 sister of P-glycoprotein Bsep
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
hypoactivity Abcb11tm1b(EUCOMM)Hmgu HET Early adult 4.78×10-06
increased grip strength Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 8.29×10-05
increased circulating potassium level Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 4.20×10-10
abnormal behavior Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 5.53×10-05
increased circulating fructosamine level Abcb11tm1b(EUCOMM)Hmgu HET Early adult 4.17×10-05
preweaning lethality, incomplete penetrance Abcb11tm1b(EUCOMM)Hmgu HOM Early adult 0.0455
decreased bone mineral density Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 3.22×10-15
abnormal lung morphology Abcb11tm1b(EUCOMM)Hmgu HET Early adult 0.00
decreased circulating triglyceride level Abcb11tm1b(EUCOMM)Hmgu HET Early adult 1.13×10-07
abnormal retina morphology Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 1.26×10-07
increased circulating alkaline phosphatase level Abcb11tm1a(EUCOMM)Hmgu HOM Early adult 2.10×10-05

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 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
13 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Abcb11tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Abcb11tm27268(L1L2_gt1) Targeting vectors
Abcb11tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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