Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | Section images | heterozygote | 100% (2 of 2) |
Heart | Section images | heterozygote | 100% (2 of 2) |
Kidney | Section images | heterozygote | 100% (2 of 2) |
Midbrain | Section images | heterozygote | 100% (2 of 2) |
Ovary | Section images | heterozygote | Not available |
Spleen | Section images | heterozygote | 100% (2 of 2) |
Submandibular gland | Section images | heterozygote | 50% (1 of 2) |
Testis | Section images | heterozygote | 0.0% (0 of 2) |
Thyroid gland | Section images | heterozygote | 0.0% (0 of 2) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
Epididymis | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
Large intestine | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
Oviduct | N/A | heterozygote | 0.0% (0 of 2) |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | Not available |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Small intestine | N/A | heterozygote | 0.0% (0 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Stomach | N/A | heterozygote | 0.0% (0 of 2) |
Striatum | N/A | heterozygote | 0.0% (0 of 2) |
Thalamus | N/A | heterozygote | 0.0% (0 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Trachea | N/A | heterozygote | 0.0% (0 of 2) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 2) |
Uterus | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | homozygote | 0.0% (0 of 1) |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 2) |
Dorsal root ganglion | N/A | homozygote | 0.0% (0 of 1) |
Ear | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | homozygote | 0.0% (0 of 1) |
Embryo | N/A | heterozygote | 0.0% (0 of 2) |
Embryo | N/A | homozygote | 0.0% (0 of 1) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | homozygote | 0.0% (0 of 1) |
Footplate | N/A | heterozygote | 0.0% (0 of 2) |
Footplate | N/A | homozygote | 0.0% (0 of 1) |
Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
Forebrain | N/A | homozygote | 0.0% (0 of 1) |
Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
Forelimb | N/A | homozygote | 0.0% (0 of 1) |
Fronto-nasal process | N/A | heterozygote | 0.0% (0 of 2) |
Fronto-nasal process | N/A | homozygote | 0.0% (0 of 1) |
Handplate | N/A | heterozygote | 0.0% (0 of 2) |
Handplate | N/A | homozygote | 0.0% (0 of 1) |
Head | N/A | heterozygote | 0.0% (0 of 2) |
Head | N/A | homozygote | 0.0% (0 of 1) |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | homozygote | 0.0% (0 of 1) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
Hindbrain | N/A | homozygote | 0.0% (0 of 1) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Hindlimb | N/A | homozygote | 0.0% (0 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | homozygote | 0.0% (0 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | homozygote | 0.0% (0 of 1) |
Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
Mandibular process | N/A | homozygote | 0.0% (0 of 1) |
Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
Maxillary process | N/A | homozygote | 0.0% (0 of 1) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | homozygote | 0.0% (0 of 1) |
Nose | N/A | heterozygote | 0.0% (0 of 2) |
Nose | N/A | homozygote | 0.0% (0 of 1) |
Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | homozygote | 0.0% (0 of 1) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | homozygote | 0.0% (0 of 1) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Spinal cord | N/A | homozygote | 0.0% (0 of 1) |
Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | homozygote | 0.0% (0 of 1) |
Tail | N/A | heterozygote | 0.0% (0 of 2) |
Tail | N/A | homozygote | 0.0% (0 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.7% (4 of 573) |
aorta | 0.18% (1 of 571) |
brain | 0.53% (3 of 570) |
brainstem | 0.35% (2 of 564) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.18% (1 of 569) |
cerebellum | 0.53% (3 of 565) |
cerebral cortex | 0.35% (2 of 565) |
epididymis | 13.08% (17 of 130) |
esophagus | 1.8% (7 of 389) |
eye | 0.0% |
heart | 0.35% (2 of 566) |
hippocampus | 0.53% (3 of 571) |
hypothalamus | 0.36% (2 of 560) |
kidney | 3.72% (21 of 565) |
large intestine | 1.78% (10 of 561) |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.35% (2 of 577) |
lymph node | 0.18% (1 of 566) |
mammary gland | 0.0% |
midbrain | 0.0% |
olfactory lobe | 0.18% (1 of 553) |
ovary | 0.18% (1 of 566) |
oviduct | 0.0% |
pancreas | 0.89% (5 of 559) |
peripheral nervous system | 0.35% (2 of 574) |
peyers patch | 0.0% |
pituitary gland | 0.18% (1 of 570) |
prostate gland | 1.77% (10 of 564) |
skeletal muscle | 0.0% |
skin | 0.18% (1 of 563) |
small intestine | 1.59% (9 of 565) |
spinal cord | 0.53% (3 of 566) |
spleen | 0.53% (3 of 566) |
stomach | 2.12% (12 of 565) |
striatum | 0.53% (3 of 567) |
submandibular gland | 1.56% (2 of 128) |
testis | 1.05% (6 of 572) |
thalamus | 0.0% |
thymus | 0.18% (1 of 567) |
thyroid gland | 2.84% (16 of 563) |
trachea | 0.53% (3 of 562) |
urinary bladder | 0.0% |
uterus | 0.0% |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 1.18% (6 of 508) |
dorsal root ganglion | 1.67% (1 of 60) |
ear | 0.2% (1 of 508) |
embryo | 0.2% (1 of 509) |
eye | 0.2% (1 of 508) |
footplate | 0.2% (1 of 508) |
forebrain | 0.2% (1 of 508) |
forelimb | 0.2% (1 of 508) |
fronto-nasal process | 1.64% (1 of 61) |
handplate | 0.2% (1 of 508) |
head | 0.98% (5 of 508) |
heart | 0.2% (1 of 508) |
hindbrain | 1.18% (6 of 508) |
hindlimb | 0.2% (1 of 508) |
liver | 0.2% (1 of 503) |
lung | 0.2% (1 of 503) |
mandibular process | 0.2% (1 of 508) |
maxillary process | 0.2% (1 of 508) |
midbrain | 0.2% (1 of 508) |
nose | 1.28% (1 of 78) |
oral cavity | 0.2% (1 of 503) |
skin | 0.2% (1 of 508) |
spinal cord | 1.39% (1 of 72) |
tail | 0.2% (1 of 508) |
tail somite group | 0.2% (1 of 508) |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Golga5 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Hyperekplexia 3 | Exaggerated startle response | OMIM:614618 | |
Developmental And Epileptic Encephalopathy 8 | Exaggerated startle response | OMIM:300607 | |
Hyperekplexia 2 | Exaggerated startle response | OMIM:614619 | |
Hyperekplexia-Epilepsy Syndrome | Exaggerated startle response | ORPHA:163985 | |
Developmental And Epileptic Encephalopathy 68 | Exaggerated startle response | OMIM:618201 | |
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination | Exaggerated startle response | OMIM:618367 | |
Spastic Paraplegia, Optic Atrophy, And Neuropathy | Exaggerated startle response | OMIM:609541 | |
Spastic Tetraplegia And Axial Hypotonia, Progressive | Exaggerated startle response | OMIM:618598 | |
Hyperekplexia 1 | Exaggerated startle response | OMIM:149400 | |
Stiff Person Spectrum Disorder | Exaggerated startle response | ORPHA:3198 | |
Tay-Sachs Disease | Exaggerated startle response | OMIM:272800 | |
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome | Exaggerated startle response | ORPHA:320406 | |
Stiff-Person Syndrome | Opisthotonus, Exaggerated startle response | OMIM:184850 | |
Gm2 Gangliosidosis, Ab Variant | Exaggerated startle response | ORPHA:309246 | |
Gm2-Gangliosidosis, Ab Variant | Exaggerated startle response | OMIM:272750 | |
Asparagine Synthetase Deficiency | Exaggerated startle response | OMIM:615574 | |
Aromatic L-Amino Acid Decarboxylase Deficiency | Limb tremor, Exaggerated startle response | OMIM:608643 | |
Glycine Encephalopathy With Normal Serum Glycine | Exaggerated startle response | OMIM:617301 | |
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation | Exaggerated startle response | ORPHA:438216 | |
Sandhoff Disease | Exaggerated startle response | OMIM:268800 | |
Tay-Sachs Disease | Tremor, Exaggerated startle response | ORPHA:845 | |
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4 | Exaggerated startle response | OMIM:253800 | |
Gm1 Gangliosidosis Type 1 | Exaggerated startle response | ORPHA:79255 | |
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies | Exaggerated startle response | OMIM:617527 | |
Plaa-Associated Neurodevelopmental Disorder | Exaggerated startle response | ORPHA:521426 | |
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities | Exaggerated startle response | OMIM:619522 | |
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome | Exaggerated startle response | ORPHA:438213 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
MGI Allele | Allele Type | Produced |
---|---|---|
Golga5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Golga5tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Golga5tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter