Gene Summary

glutamate receptor, metabotropic 5
Glu5R,  mGluR5,  6430542K11Rik,  Gprc1e

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Grm5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Grm5 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Photoparoxysmal Response 1
EEG with photoparoxysmal response OMIM:132100
Electroencephalographic Peculiarity: 14 And 6 Per Sec. Positive Spike Phenomenon
EEG abnormality OMIM:130200
Electroencephalographic Peculiarity: Fronto-Precentral Beta Wave Groups
EEG abnormality OMIM:130300
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
7q11.23 duplication syndrome
Short attention span DECIPHER:43
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant
Dementia, Cognitive impairment OMIM:618564
Alzheimer Disease 10
Dementia, Memory impairment OMIM:609636
Schizophrenia 19
Cognitive impairment OMIM:617629
Deafness, Autosomal Recessive 70, With Or Without Adult-Onset Neurodegeneration
Cognitive impairment OMIM:614934
Bulimia Nervosa, Susceptibility To
Bulimia OMIM:607499
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Short stepped shuffling gait, Falls, Akinesia, Gait imbalance, Freezing of gait, Loss of ambulati... ORPHA:240094
Spinocerebellar Ataxia Type 27
Difficulty walking, Akinesia, Limb ataxia, Gait ataxia, Gait disturbance, Truncal ataxia ORPHA:98764
Parkinson Disease 17
Akinesia OMIM:614203
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia ORPHA:98773
Atypical Juvenile Parkinsonism
Short stepped shuffling gait, Shuffling gait, Inability to walk, Akinesia, Gait ataxia ORPHA:391411
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Congenital Myopathy 9A
Akinesia OMIM:618822
Spinocerebellar Ataxia 21
Akinesia, Limb ataxia, Gait ataxia, Ataxia, Progressive cerebellar ataxia OMIM:607454
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Kleine-Levin Syndrome
Polydipsia, Abnormal eating behavior, Sweet craving, Polyphagia, Repetitive compulsive behavior, ... ORPHA:33543
Corticobasal Syndrome
Akinesia, Gait disturbance ORPHA:454887
Anterior Cutaneous Nerve Entrapment Syndrome
Hyperesthesia, Somatic sensory dysfunction, Inguinal hernia, Decreased body weight, Impaired tact... ORPHA:51890
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Hereditary Central Diabetes Insipidus
Polydipsia ORPHA:30925
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Shuffling gait, Akinesia, Gait ataxia, Ataxia, Dysdiadochokinesis ORPHA:247234
Mitochondrial Complex I Deficiency, Nuclear Type 28
Truncal ataxia, Akinesia, Choreoathetosis OMIM:618249
Perry Syndrome
Short stepped shuffling gait, Akinesia OMIM:168605
Neurodegeneration With Brain Iron Accumulation 5
Akinesia OMIM:300894
Manganese Poisoning
Akinesia, Gait disturbance ORPHA:306682
Kufor-Rakeb Syndrome
Akinesia, Gait disturbance, Ataxia OMIM:606693
Central Diabetes Insipidus
Polydipsia, Anorexia ORPHA:178029
Nephronophthisis 9
Polydipsia OMIM:613824
Classic Progressive Supranuclear Palsy Syndrome
Akinesia, Gait imbalance, Falls ORPHA:240071
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Congenital Myopathy 12
Akinesia OMIM:612540
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Akinesia, Limb ataxia, Gait ataxia, Ataxia ORPHA:48818
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Teratoma, Pineal
Polydipsia OMIM:273120
Postencephalitic Parkinsonism
Akinesia ORPHA:97349
Familial Cold Urticaria
Polydipsia ORPHA:47045
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Bardet-Biedl Syndrome 9
Polyphagia, Polydipsia OMIM:615986
Ochoa Syndrome
Polydipsia ORPHA:2704
Gaucher Disease, Perinatal Lethal
Akinesia OMIM:608013
Hereditary Late-Onset Parkinson Disease
Shuffling gait, Akinesia ORPHA:411602
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Nephronophthisis 4
Polydipsia OMIM:606966
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Supranuclear Palsy, Progressive, 2
Akinesia, Gait imbalance, Falls OMIM:609454
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Polydipsia, Motor stereotypy ORPHA:213
Supranuclear Palsy, Progressive, 1
Akinesia, Gait imbalance, Falls OMIM:601104
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia OMIM:304800
East Syndrome
Salt craving, Polydipsia ORPHA:199343
Pediatric-Onset Graves Disease
Polyphagia, Polydipsia, Hyperactivity ORPHA:525731
Neurodegeneration With Brain Iron Accumulation 1
Akinesia, Gait disturbance, Choreoathetosis, Ataxia OMIM:234200
Inability to walk, Akinesia, Ataxia ORPHA:86309
Nephrogenic Diabetes Insipidus
Polydipsia, Anorexia ORPHA:223
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Nephronophthisis 1
Polydipsia OMIM:256100
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Whipple Disease
Polydipsia, Anorexia ORPHA:3452
Nephronophthisis 11
Polydipsia OMIM:613550
Brain-Lung-Thyroid Syndrome
Compulsive behaviors, Abnormal drinking behavior, Abnormal eating behavior, Hyperactivity ORPHA:209905
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Nephronophthisis 3
Polydipsia OMIM:604387
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia OMIM:617994
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Salt craving, Polydipsia OMIM:612780
Renal Hypoplasia
Polydipsia ORPHA:93101
Senior-Boichis Syndrome
Aggressive behavior, Attention deficit hyperactivity disorder, Polydipsia, Agitation ORPHA:84081
Helix Syndrome
Polydipsia OMIM:617671
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
African Trypanosomiasis
Difficulty walking, Akinesia, Gait disturbance, Choreoathetosis ORPHA:3385
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Polydipsia ORPHA:95513
Gitelman Syndrome
Salt craving, Polydipsia OMIM:263800
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Rabson-Mendenhall Syndrome
Polydipsia ORPHA:769
Erdheim-Chester Disease
Polydipsia ORPHA:35687
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Polydipsia, Polyphagia, Aggressive behavior, Compulsive behaviors ORPHA:293987
Hyperparathyroidism-Jaw Tumor Syndrome
Polydipsia, Dysphagia ORPHA:99880
Wolfram Syndrome
Polydipsia ORPHA:3463
Parathyroid Carcinoma
Polydipsia, Dysphagia ORPHA:143
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Gitelman Syndrome
Salt craving, Polydipsia ORPHA:358
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Cystinosis, Nephropathic
Polydipsia, Dysphagia OMIM:219800
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731
Bartter Syndrome, Type 2, Antenatal
Polydipsia OMIM:241200
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Grm5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Grm5.

No publications found that use IMPC mice or data for Grm5.

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MGI Allele Allele Type Produced
Grm5em1(IMPC)H Exon Deletion Mice
Grm5tm42681(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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