Pla2g2e | phospholipase A2, group IIE

GeneMGI:1349660Synonyms: mGIIEsPLA2s

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system Cardiovascular system

15 No significant impact

6 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetPla2g2etm1b(EUCOMM)WtsihomozygoteEarly adult1.49x10-5 
increased red blood cell distribution width1 supporting datasetPla2g2etm1b(EUCOMM)WtsihomozygoteEarly adult2.33x10-8 
increased cardiac stroke volume1 supporting datasetPla2g2etm1b(EUCOMM)WtsihomozygoteEarly adult2.37x10-6 
dilated heart left ventricle1 supporting datasetPla2g2etm1b(EUCOMM)WtsihomozygoteEarly adult9.97x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/1)0.7% (4/570)
aortaheterozygoten/a0% (0/1)0.19% (1/533)
bloodheterozygoten/a0% (0/1)0% (0/17)
boneheterozygoten/a0% (0/1)0% (0/394)
bone marrowheterozygoten/a0% (0/1)0% (0/22)
brainheterozygoten/a0% (0/1)0.86% (5/579)
brainstemheterozygoten/a0% (0/1)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/1)0% (0/588)
cartilage tissueheterozygoten/a0% (0/1)0.22% (1/454)
cecumheterozygoten/a0% (0/1)7.75% (22/284)
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Histopathology

IMPC related publications

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Pla2g2etm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Pla2g2etm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pla2g2etm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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