Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
carbohydrate sulfotransferase 4
Synonyms:
high endothelial cell GlcNAC-6-sulphotransferase,  HEC-GlcNAc6ST,  GST-3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chst4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chst4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center, Decreased circulating IgG level OMIM:235550
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency With Hyper-Igm, Type 3
Impaired memory B cell generation, Increased circulating IgM level, Decreased circulating IgE, De... OMIM:606843
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Immunodeficiency With Hyper-Igm, Type 5
Increased circulating IgM level, Decreased circulating IgA level, Impaired Ig class switch recomb... OMIM:608106
Immunodeficiency With Hyper-Igm, Type 2
Impaired Ig class switch recombination, Decreased circulating IgG level, Decreased circulating Ig... OMIM:605258
Kimura Disease
Increased circulating IgE level, Follicular hyperplasia, Lymphadenopathy ORPHA:482
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Lymphoproliferative Syndrome 3
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating antibody ... OMIM:618261
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Decreased circulating total IgM, Decreased circulating IgG level, Cervical lymphadenopathy OMIM:618987
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Increased circulating antibody level, Lymphadenopathy, Splenomegaly OMIM:618495
Mast Cell Sarcoma
Mediastinal lymphadenopathy, Mastocytosis, Lymphadenopathy, Splenomegaly ORPHA:66661
Kerion Celsi
Lymphadenopathy ORPHA:499
Immunodeficiency 75
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Apolipoprotein A-I Deficiency
Lymphadenopathy, Splenomegaly ORPHA:425
Immunodeficiency 14A, Autosomal Dominant
Increased circulating IgM level, Decreased circulating IgG2 level, Splenomegaly, Lymphadenopathy,... OMIM:615513
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Candidiasis, Familial, 2
Increased circulating IgE level, Lymphadenopathy OMIM:212050
Immunodeficiency 72 With Autoinflammation
Increased circulating IgG level, Hepatosplenomegaly, Increased circulating IgE level, Lymphadenop... OMIM:618982
Rosaï-Dorfman Disease
Dysgammaglobulinemia, Lymphadenopathy ORPHA:158014
Immunodeficiency 64
Increased circulating IgM level, Defective T cell proliferation, Increased circulating IgA level,... OMIM:618534
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
T-Cell Receptor-Alpha/Beta Deficiency
Lymphadenopathy OMIM:615387
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Increased circulating IgM level, Increased circulating IgG level, Fluctuating splenomegaly, Lymph... OMIM:619220
Immunodeficiency, Common Variable, 2
Partial absence of specific antibody response to unconjugated pneumococcus vaccine, Follicular hy... OMIM:240500
Immunodeficiency With Hyper-Igm, Type 4
Impaired Ig class switch recombination, Absence of lymph node germinal center OMIM:608184
Mu-Heavy Chain Disease
Increased circulating antibody level, Lymphadenopathy, Splenomegaly ORPHA:100024
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Splenomegaly OMIM:608971
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Abnormal natural killer cell physiology, Decreased circulating antibody level, Splenomegaly, Hepa... OMIM:613101
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased CD69 upregulation upon TCR activation, Decreased specific anti-polysaccharide antibody ... OMIM:300853
Proteasome-Associated Autoinflammatory Syndrome 2
Increased circulating antibody level, Lymphadenopathy OMIM:618048
Immunodeficiency, Common Variable, 1
Impaired T cell function, Decreased circulating IgA level, Splenomegaly, Decreased circulating to... OMIM:607594
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Alpha-Heavy Chain Disease
Dysgammaglobulinemia, Lymphadenopathy, Splenomegaly ORPHA:100025
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Lack of T cell function, Absence of lymph node germinal center, Increased circula... ORPHA:277
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Autoinflammation With Episodic Fever And Lymphadenopathy
Recurrent tonsillitis, Lymphadenopathy, Splenomegaly OMIM:618852
Indolent Systemic Mastocytosis
Increased proportion of CD25+ mast cells, Splenomegaly, Abnormal mast cell morphology, Mastocytos... ORPHA:98848
Immunodeficiency 52
Decreased circulating antibody level, Lymphadenopathy, Splenomegaly OMIM:617514
Autoimmune Lymphoproliferative Syndrome, Type Iii
Increased circulating antibody level, Generalized lymphadenopathy, Follicular hyperplasia, Spleno... OMIM:615559
Immunodeficiency 27A
Increased circulating IgM level, Increased circulating IgG level, Splenomegaly, Enlarged mesenter... OMIM:209950
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Follicular Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:545
Lymphoproliferative Syndrome, X-Linked, 1
Increased circulating IgM level, Decreased circulating antibody level, Dysgammaglobulinemia, Sple... OMIM:308240
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Immunodeficiency With Hyper-Igm, Type 1
Impaired memory B cell generation, Increased circulating IgM level, Decreased circulating IgE, En... OMIM:308230
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy OMIM:615895
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus, Panhypogammaglobulinemia OMIM:602450
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Schnitzler Syndrome
Increased circulating IgM level, Lymphadenopathy, Splenomegaly ORPHA:37748
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgM level, Increased circulating IgA level, Chronic noninfectious lymphaden... OMIM:601859
Ras-Associated Autoimmune Leukoproliferative Disorder
Increased circulating antibody level, Follicular hyperplasia, Splenomegaly OMIM:614470
Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:98293
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Autoimmune Lymphoproliferative Syndrome, Type V
Decreased circulating antibody level, Decreased circulating IgA level, Splenomegaly, Decreased ci... OMIM:616100
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the lymph nodes ORPHA:543
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Increased circulating antibody level, Lymphadenopathy ORPHA:69126
Lymphoproliferative Syndrome 2
Decreased circulating antibody level, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:615122
Tularemia
Abnormal nasopharyngeal adenoid morphology, Increased circulating antibody level, Mediastinal lym... ORPHA:3392
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Autoimmune Lymphoproliferative Syndrome, Type Iia
Increased circulating IgM level, Increased circulating IgA level, Chronic noninfectious lymphaden... OMIM:603909
Lcat Deficiency
Lymphadenopathy, Splenomegaly ORPHA:650
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Boutonneuse Fever
Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy, Cervical lymph... ORPHA:83313
Classic Hodgkin Lymphoma
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:391
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Sézary Syndrome
Abnormal immunoglobulin level, Lymphadenopathy, Splenomegaly ORPHA:3162
Leishmaniasis
Increased circulating antibody level, Lymphadenopathy, Splenomegaly ORPHA:507
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection, Abnormality of B cell physiology, Panhypo... OMIM:600802
Roifman Syndrome
Decreased circulating antibody level, Hepatosplenomegaly, Lymphadenopathy ORPHA:353298
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Increased circulating IgE level, Increased circulating antibody level, Increased circulating IgG ... ORPHA:169154
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Lymphadenitis, Impaired oxidative burst, Splenomegaly, Hepatosplenomegaly,... OMIM:618935
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Lymphoproliferative Syndrome 1
Decreased circulating antibody level, Decreased circulating IgG level, Lymphadenopathy, Splenomegaly OMIM:613011
Griscelli Syndrome
Decreased circulating antibody level, Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:381
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine, Lym... OMIM:618986
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:3226
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormality of the lymph nodes ORPHA:54251
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Increased circulating IgM level, Lymphadenopathy, Increased circulating IgA level OMIM:617099
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Increased circulating IgE level, Decreased specific anti-polysaccharide antibody level, Enlarged ... OMIM:606367
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Rhabdoid Tumor
Lymphadenopathy ORPHA:69077
Nephroblastoma
Lymphadenopathy ORPHA:654
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Hepatosplenomegaly, Abnormality of the lymph nodes, Lymphadenopathy ORPHA:911
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy, Increased circulating IgA level ORPHA:343
Omenn Syndrome
Hypoplasia of the thymus, Lymphadenopathy, Splenomegaly OMIM:603554
Aggressive Systemic Mastocytosis
Increased proportion of CD25+ mast cells, Hypersplenism, Abnormal mast cell morphology, Hepatospl... ORPHA:98850
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy ORPHA:2221
Immunodeficiency, Common Variable, 8, With Autoimmunity
Decreased specific antibody response to vaccination, Generalized lymphadenopathy, Decreased circu... OMIM:614700
Roifman Syndrome
Lymphadenopathy, Splenomegaly OMIM:616651
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Hyper-Igd Syndrome
Lymphadenitis, Splenomegaly, Increased circulating IgA level, Hepatosplenomegaly, Increased circu... OMIM:260920
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Desmoplastic Small Round Cell Tumor
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:83469
Thymoma
Decreased circulating antibody level, Neoplasm of the thymus, Lymphadenopathy ORPHA:99867
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Increased circulating IgE level, Lymphadenopathy OMIM:304790
Proteasome-Associated Autoinflammatory Syndrome 3
Increased circulating antibody level, Lymphadenopathy, Splenomegaly OMIM:617591
Familial Hemophagocytic Lymphohistiocytosis
Reduced natural killer cell activity, Decreased circulating antibody level, Lymphadenopathy, Sple... ORPHA:540
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
X-Linked Lymphoproliferative Disease
Increased proportion of CD25+ mast cells, Increased circulating IgM level, Increased circulating ... ORPHA:2442
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Impaired oxidative burst, Lymphadenopathy, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Impaired oxidative burst, Lymphadenopathy, Splenomegaly OMIM:233710
Kaposi Sarcoma
Abnormality of the spleen, Generalized lymphadenopathy ORPHA:33276
Sting-Associated Vasculopathy, Infantile-Onset
Paratracheal lymphadenopathy, Increased circulating IgG level, Follicular hyperplasia, Increased ... OMIM:615934
Felty Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:47612
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Cyclic Neutropenia
Recurrent tonsillitis, Lymphadenopathy, Cervical lymphadenopathy ORPHA:2686
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Impaired oxidative burst, Lymphadenopathy, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Impaired oxidative burst, Lymphadenopathy, Splenomegaly OMIM:306400
Adult-Onset Still Disease
Bone marrow hypocellularity, Generalized lymphadenopathy, Splenomegaly ORPHA:829
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Multiple Myeloma
Decreased circulating antibody level, Increased circulating IgG level, Splenomegaly, Increased ci... ORPHA:29073
Primary Myelofibrosis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:824
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Mevalonic Aciduria
Hepatosplenomegaly, Fluctuating splenomegaly, Lymphadenopathy, Increased circulating IgD level OMIM:610377
Aregenerative Anemia
Bone marrow hypocellularity, Lymphadenopathy ORPHA:101096
Legionnaires Disease
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:549
Thymic Neuroendocrine Tumor
Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy, Neoplasm of the thymus ORPHA:97289
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Common Variable Immunodeficiency
Decreased circulating antibody level, Lymphadenopathy, Splenomegaly ORPHA:1572
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Cinca Syndrome
Lymphadenopathy, Splenomegaly ORPHA:1451
Omenn Syndrome
Lymphadenopathy, Splenomegaly ORPHA:39041
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Niemann-Pick Disease, Type A
Lymphadenopathy, Splenomegaly OMIM:257200
Hemophagocytic Lymphohistiocytosis, Familial, 2
Reduced natural killer cell activity, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:603553
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgE level, Decreased specific anti-polysaccharide antibody level, Increased... ORPHA:3261
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Absence of lymph node germinal center, Panhypogammaglobulinemia, Hepatosplenomegaly ORPHA:79124
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly ORPHA:36412
Igg4-Related Submandibular Gland Disease
Increased circulating IgE level, Increased circulating antibody level, Increased circulating IgG4... ORPHA:449432
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
Castleman Disease
Mediastinal lymphadenopathy, Generalized lymphadenopathy, Follicular hyperplasia, Lymphadenopathy ORPHA:160
Chediak-Higashi Syndrome
Impaired neutrophil bactericidal activity, Lymphadenopathy, Splenomegaly OMIM:214500
Mixed Connective Tissue Disease
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:809
Lassa Fever
Lymphadenopathy ORPHA:99824
Poems Syndrome
Increased circulating antibody level, Lymphadenopathy ORPHA:2905
Lig4 Syndrome
Lymphadenopathy ORPHA:99812
Waldenström Macroglobulinemia
Monoclonal immunoglobulin M proteinemia, Lymphadenopathy, Splenomegaly ORPHA:33226
Selective Igm Deficiency
Lymphadenitis, Decreased specific antibody response to vaccination, Paraproteinemia, Decreased ci... ORPHA:331235
Periodic Fever, Familial, Autosomal Dominant
Cervical lymphadenopathy OMIM:142680
Systemic Mastocytosis With Associated Hematologic Neoplasm
Abnormal mast cell morphology, Lymphadenopathy, Splenomegaly ORPHA:98849
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Acute Monoblastic/Monocytic Leukemia
Cervical lymphadenopathy ORPHA:514
Hennekam Syndrome
Pachygyria, Decreased circulating antibody level, Pulmonary lymphangiectasia, Splenomegaly, Lymph... ORPHA:2136
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Q Fever
Increased circulating antibody level, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:781
Carney Triad
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Decreased circulating antibody level, Splenomegaly, Hepatosplenomegaly, Bone marrow hypocellulari... OMIM:615688
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Carcinoid Syndrome
Chronic noninfectious lymphadenopathy ORPHA:100093
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Drug Rash With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Chédiak-Higashi Syndrome
Increased proportion of CD25+ mast cells, Abnormal platelet function, Splenomegaly, Abnormality o... ORPHA:167
Familial Pancreatic Carcinoma
Hepatosplenomegaly, Lymphadenopathy ORPHA:1333
Graft Versus Host Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:39812
Riddle Syndrome
Decreased circulating total IgM, Decreased circulating IgG level, Generalized lymphadenopathy, De... ORPHA:420741
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Splenomegaly OMIM:267700
Lymphatic Filariasis
Lymphadenitis, Abnormality of the lymphatic system, Lymphangiectasis, Lymphadenopathy ORPHA:2035
Farber Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:333
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Increased circulating IgE level, Lymphadenopathy, Splenomegaly ORPHA:37042
Kikuchi-Fujimoto Disease
Generalized lymphadenopathy, Splenomegaly, Abnormality of the lymph nodes, Lymphadenopathy, Cervi... ORPHA:50918
Histiocytosis-Lymphadenopathy Plus Syndrome
Splenomegaly, Hepatosplenomegaly, Lymphadenopathy, Cervical lymphadenopathy OMIM:602782
Coccidioidomycosis
Increased circulating IgM level, Increased circulating IgG level, Mediastinal lymphadenopathy, Ab... ORPHA:228123
H Syndrome
Hepatosplenomegaly, Lymphadenopathy ORPHA:168569
Neuroendocrine Tumor Of The Colon
Chronic noninfectious lymphadenopathy ORPHA:100080
Igg4-Related Kidney Disease
Increased circulating IgG1 level, Increased circulating IgE level, Lymphadenitis, Increased circu... ORPHA:449395
Cherubism
Submandibular lymph node enlargement OMIM:118400
Tangier Disease
Chronic noninfectious lymphadenopathy, Orange discolored tonsils, Hepatosplenomegaly ORPHA:31150
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Hepatosplenomegaly, Lymphadenopathy ORPHA:85408
Sarcoidosis, Susceptibility To, 1
Abnormality of T cell physiology, Increased circulating antibody level, Generalized lymphadenopat... OMIM:181000
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100086
Neuroendocrine Tumor Of The Rectum
Chronic noninfectious lymphadenopathy ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Chronic noninfectious lymphadenopathy ORPHA:100082
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy OMIM:607944
Lymphangioleiomyomatosis
Pulmonary lymphangiomyomatosis, Abnormality of the lymphatic system, Lymphadenopathy ORPHA:538
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Igg4-Related Ophthalmic Disease
Increased circulating IgG4 level, Increased circulating IgE level, Lymphadenopathy ORPHA:449563
Proteasome-Associated Autoinflammatory Syndrome 1
Increased circulating antibody level, Increased circulating IgG level, Splenomegaly, Increased ci... OMIM:256040
Brucellosis
Increased circulating IgM level, Increased circulating IgG level, Hypersplenism, Splenomegaly, Ly... ORPHA:1304
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
Primary Sjögren Syndrome
Decreased circulating antibody level, Increased circulating antibody level, Lymphadenopathy ORPHA:289390
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Splenomegaly ORPHA:32960
Chikungunya
Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
Familial Mediterranean Fever
Lymphadenopathy, Splenomegaly ORPHA:342
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Malakoplakia
Follicular hyperplasia ORPHA:556
Autosomal Recessive Malignant Osteopetrosis
Lymphadenopathy, Splenomegaly ORPHA:667
Behçet Disease
Lymphadenopathy, Splenomegaly ORPHA:117
Sarcoidosis
Abnormality of the lymph nodes, Lymphadenopathy ORPHA:797
African Trypanosomiasis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:3385
Blau Syndrome
Lymphadenopathy, Splenomegaly ORPHA:90340
Leptospirosis
Lymphadenopathy ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chst4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chst4.

No publications found that use IMPC mice or data for Chst4.

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MGI Allele Allele Type Produced
Chst4tm96744(L1L2_Bact_P) Targeting vectors

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