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Gene: Chst4 MGI:1349479

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

carbohydrate sulfotransferase 4

Synonyms:

high endothelial cell GlcNAC-6-sulphotransferase, GST-3, HEC-GlcNAc6ST

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chst4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Chst4 (0 diseases)
Human diseases predicted to be associated with Chst4 (236 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chst4 by phenotypic similarity.

Disease	Matching phenotypes	Source
Hepatic Venoocclusive Disease With Immunodeficiency	Decreased circulating IgG level, Absence of lymph node germinal center	OMIM:235550
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency	Lymphadenopathy	ORPHA:319600
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)	Abnormal lymph node morphology	OMIM:136580
Immunodeficiency With Hyper-Igm, Type 3	Decreased circulating IgG level, Impaired memory B cell generation, Absence of lymph node germina...	OMIM:606843
Immunodeficiency 38 With Basal Ganglia Calcification	Axillary lymphadenopathy, Inguinal lymphadenopathy, Lymphadenopathy	OMIM:616126
Immunodeficiency With Hyper-Igm, Type 5	Decreased circulating IgG level, Decreased circulating IgA level, Impaired Ig class switch recomb...	OMIM:608106
Immunodeficiency With Hyper-Igm, Type 2	Decreased circulating IgG level, Decreased circulating IgA level, Complete or near-complete absen...	OMIM:605258
Squamous Cell Carcinoma Of The Esophagus	Lymphadenopathy	ORPHA:99977
Kimura Disease	Increased circulating IgE level, Follicular hyperplasia, Lymphadenopathy	ORPHA:482
Reticuloendotheliosis, X-Linked	Hepatosplenomegaly, Lymphadenopathy	OMIM:312500
Pulmonary Nodular Lymphoid Hyperplasia	Mediastinal lymphadenopathy, Follicular hyperplasia	ORPHA:60026
Lymphoproliferative Syndrome 3	Hepatosplenomegaly, Partial absence of specific antibody response to tetanus vaccine, Decreased c...	OMIM:618261
Mantle Cell Lymphoma	Splenomegaly, Lymphadenopathy	ORPHA:52416
Caspase 8 Deficiency	Decreased circulating IgG level, Decreased circulating IgA level, Splenomegaly, Defective B cell ...	OMIM:607271
Immunodeficiency 75 With Lymphoproliferation	Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy	OMIM:619126
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia	Decreased circulating total IgM, Decreased circulating IgG level, Cervical lymphadenopathy	OMIM:618987
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant	Decreased specific pneumococcal antibody level, Decreased circulating IgG2 level, Splenomegaly, L...	OMIM:615513
Kerion Celsi	Lymphadenopathy	ORPHA:499
Mast Cell Sarcoma	Mastocytosis, Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy	ORPHA:66661
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias	Absent specific antibody response, Decreased circulating antibody level, Follicular hyperplasia, ...	OMIM:619846
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation	Increased circulating IgE level, Increased circulating IgG level, Hepatosplenomegaly, Lymphadenop...	OMIM:618982
Immunodeficiency 78 With Autoimmunity And Developmental Delay	Increased circulating IgG level, Increased circulating IgM level, Fluctuating splenomegaly, Lymph...	OMIM:619220
Adenocarcinoma Of The Esophagus	Lymphadenopathy	ORPHA:99976
Immunodeficiency, Common Variable, 2	Decreased circulating IgG level, Impaired T cell function, Decreased circulating IgA level, Folli...	OMIM:240500
Rosaï-Dorfman Disease	Dysgammaglobulinemia, Lymphadenopathy	ORPHA:158014
Immunodeficiency 64 With Lymphoproliferation	Decreased circulating IgG level, Cervical lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Defe...	OMIM:618534
Immunodeficiency With Hyper-Igm, Type 4	Impaired Ig class switch recombination, Absence of lymph node germinal center	OMIM:608184
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Decreased specific anti-polysaccharide antibody level, Splenomegaly, Decreased T cell activation,...	OMIM:300853
Immunodeficiency 109 With Lymphoproliferation	Decreased circulating IgG level, Decreased specific pneumococcal antibody level, Complete or near...	OMIM:620282
Alpha-Heavy Chain Disease	Dysgammaglobulinemia, Splenomegaly, Lymphadenopathy	ORPHA:100025
Mu-Heavy Chain Disease	Lymphadenopathy, Splenomegaly, Increased circulating antibody level	ORPHA:100024
Immunodeficiency 105	Decreased circulating IgG level, Absence of lymph node germinal center, Decreased circulating IgA...	OMIM:619924
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease	Hepatosplenomegaly, Splenomegaly, Abnormal natural killer cell physiology, Lymphadenopathy, Decre...	OMIM:613101
Immunodeficiency 32A	Lymphadenitis, Lymphadenopathy	OMIM:614893
Immunodeficiency 104	Splenomegaly, Lymphadenopathy	OMIM:608971
Deafness, Autosomal Dominant 34, With Or Without Inflammation	Lymphadenopathy	OMIM:617772
Autoinflammation With Episodic Fever And Lymphadenopathy	Recurrent tonsillitis, Splenomegaly, Lymphadenopathy	OMIM:618852
Immunodeficiency 52	Decreased circulating IgA level, Splenomegaly, Defective T cell proliferation, Lymphadenopathy, D...	OMIM:617514
Immunodeficiency, Common Variable, 1	Decreased circulating IgG level, Impaired T cell function, Decreased circulating IgA level, Splen...	OMIM:607594
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Increased circulating IgE level, Absent tonsils, Absence of lymph node germinal center, Lack of T...	ORPHA:277
Indolent Systemic Mastocytosis	Mastocytosis, Increased proportion of CD25+ mast cells, Splenomegaly, Lymphadenopathy, Abnormal m...	ORPHA:98848
Immunodeficiency 103, Susceptibility To Fungal Infections	Increased circulating IgE level, Lymphadenopathy	OMIM:212050
Immunodeficiency 27A	Enlarged mesenteric lymph node, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Increased circ...	OMIM:209950
Follicular Lymphoma	Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy	ORPHA:545
Autoimmune Lymphoproliferative Syndrome, Type Iii	Hepatosplenomegaly, Follicular hyperplasia, Splenomegaly, Increased circulating antibody level, G...	OMIM:615559
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:444463
Nodular Lymphocyte Predominant Hodgkin Lymphoma	Splenomegaly, Lymphadenopathy	ORPHA:86893
Activated Pi3K-Delta Syndrome	Recurrent tonsillitis, Decreased circulating antibody level, Splenomegaly, Lymphadenopathy, Incre...	ORPHA:397596
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia	Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology	ORPHA:97290
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	Increased circulating IgG level, Splenomegaly, Lymphadenopathy	OMIM:618495
Granulomatous Slack Skin	Abnormal lymph node morphology	ORPHA:33111
Familial Papillary Or Follicular Thyroid Carcinoma	Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology	ORPHA:319487
Schnitzler Syndrome	Splenomegaly, Increased circulating IgM level, Lymphadenopathy	ORPHA:37748
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency	Decreased circulating IgG level, Increased circulating IgE level, Decreased circulating IgA level...	ORPHA:98813
Immunodeficiency 27B	Generalized lymphadenopathy	OMIM:615978
Immunodeficiency With Hyper-Igm, Type 1	Decreased circulating IgG level, Impaired memory B cell generation, Absence of lymph node germina...	OMIM:308230
Autoimmune Lymphoproliferative Syndrome	Reduced delayed hypersensitivity, Chronic noninfectious lymphadenopathy, Follicular hyperplasia, ...	OMIM:601859
Immunodeficiency 76	Splenomegaly, Lymphadenopathy	OMIM:619164
Ras-Associated Autoimmune Leukoproliferative Disorder	Splenomegaly, Follicular hyperplasia, Increased circulating antibody level	OMIM:614470
Lymphoproliferative Syndrome, X-Linked, 1	Decreased circulating IgG level, Decreased circulating antibody level, Splenomegaly, Dysgammaglob...	OMIM:308240
Laryngeal Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100083
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation	Decreased circulating IgG level, Decreased circulating IgA level, Splenomegaly, Lymphadenopathy, ...	OMIM:616100
Papa Syndrome	Lymphadenopathy, Increased circulating antibody level	ORPHA:69126
Burkitt Lymphoma	Abnormality of the spleen, Abnormal lymph node morphology	ORPHA:543
Tularemia	Cervical lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Increased circulating antib...	ORPHA:3392
Autoimmune Lymphoproliferative Syndrome, Type Iia	Reduced delayed hypersensitivity, Chronic noninfectious lymphadenopathy, Follicular hyperplasia, ...	OMIM:603909
Fish-Eye Disease	Splenomegaly, Lymphadenopathy	ORPHA:79292
Immunodeficiency 10	Decreased circulating IgG level, Decreased circulating IgA level, Splenomegaly, Increased circula...	OMIM:612783
Pfapa Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:42642
Lymphoproliferative Syndrome 2	Splenomegaly, Hepatosplenomegaly, Decreased circulating antibody level, Lymphadenopathy	OMIM:615122
Classic Hodgkin Lymphoma	Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly	ORPHA:391
Boutonneuse Fever	Cervical lymphadenopathy, Increased circulating IgG level, Increased circulating IgM level, Lymph...	ORPHA:83313
Hemophagocytic Lymphohistiocytosis, Familial, 4	Splenomegaly, Lymphadenopathy	OMIM:603552
Mycosis Fungoides	Lymphadenopathy	OMIM:254400
Proteasome-Associated Autoinflammatory Syndrome 2	Abnormal circulating IgM level, Increased circulating IgG level, Increased circulating IgA level,...	OMIM:618048
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Panhypogammaglobulinemia, Increased circulating IgE level, Lymph node hypoplasia, Splenomegaly, A...	OMIM:602450
Sézary Syndrome	Abnormal immunoglobulin level, Lymphadenopathy, Splenomegaly	ORPHA:3162
Leishmaniasis	Splenomegaly, Lymphadenopathy, Increased circulating antibody level	ORPHA:507
Immune Dysregulation, Autoimmunity, And Autoinflammation	Cervical lymphadenopathy, Inguinal lymphadenopathy	OMIM:620514
Leukocyte Adhesion Deficiency, Type Iii	Hepatosplenomegaly, Splenomegaly, Abnormal lymph node morphology	OMIM:612840
Pleural Mesothelioma	Lymphadenopathy	ORPHA:50251
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies	Hepatosplenomegaly, Decreased circulating antibody level, Lymphadenopathy	OMIM:619750
Familial Cold Autoinflammatory Syndrome 2	Splenomegaly, Lymphadenopathy	OMIM:611762
Pseudomyxoma Peritonei	Lymphadenopathy	ORPHA:26790
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency	Increased circulating IgE level, Hepatosplenomegaly, Increased circulating antibody level, Increa...	ORPHA:169154
Classic Mycosis Fungoides	Splenomegaly, Lymphadenopathy	ORPHA:2584
Roifman Syndrome	Hepatosplenomegaly, Decreased circulating antibody level, Lymphadenopathy	ORPHA:353298
Immunodeficiency 97 With Autoinflammation	Decreased circulating IgG level, Decreased circulating IgA level, Hepatosplenomegaly, Splenomegal...	OMIM:619802
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Cutaneous anergy, Absent peripheral lymph nodes in presence of infection, Abnormality of B cell p...	OMIM:600802
Granulomatous Disease, Chronic, Autosomal Recessive, 5	Recurrent tonsillitis, Lymphadenitis, Hepatosplenomegaly, Impaired oxidative burst, Splenomegaly,...	OMIM:618935
Lymphoproliferative Syndrome 1	Decreased circulating IgG level, Decreased circulating antibody level, Lymphadenopathy, Splenomegaly	OMIM:613011
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency	Decreased circulating IgG level, Decreased circulating IgA level, Splenomegaly, Lymphadenopathy, ...	ORPHA:436159
Cold Agglutinin Disease	Splenomegaly, Lymphadenopathy	ORPHA:56425
Congenital Toxoplasmosis	Lymphadenopathy	ORPHA:858
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia	Decreased circulating IgG level, Lymphadenitis, Hepatosplenomegaly, Impaired neutrophil chemotaxi...	OMIM:618986
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome	Splenomegaly, Lymphadenopathy	OMIM:150550
Immunodeficiency 98 With Autoinflammation, X-Linked	Decreased circulating IgG level, Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly	OMIM:301078
Griscelli Syndrome	Bone marrow hypocellularity, Decreased circulating antibody level, Lymphadenopathy, Splenomegaly	ORPHA:381
Immunodeficiency 54	Splenomegaly, Lymphadenopathy	OMIM:609981
Middle Ear Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100084
Deafness-Lymphedema-Leukemia Syndrome	Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly	ORPHA:3226
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency	Splenomegaly, Lymphadenopathy	OMIM:619375
Immunodeficiency 7	Splenomegaly, Lymphadenopathy	OMIM:615387
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Increased circulating IgA level, Lymphadenopathy, Increased circulating IgM level	OMIM:617099
Corticosteroid-Sensitive Aseptic Abscess Syndrome	Abnormality of the lymphatic system, Abnormal lymph node morphology	ORPHA:54251
Heme Oxygenase 1 Deficiency	Cervical lymphadenopathy, Asplenia, Lymphadenopathy	OMIM:614034
Aggressive Systemic Mastocytosis	Hypersplenism, Increased proportion of CD25+ mast cells, Hepatosplenomegaly, Lymphadenopathy, Abn...	ORPHA:98850
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity	Decreased specific anti-polysaccharide antibody level, Increased circulating IgE level, Decreased...	OMIM:606367
Immunodeficiency, Common Variable, 8, With Autoimmunity	Decreased circulating IgG level, Decreased circulating IgA level, Decreased specific antibody res...	OMIM:614700
Griscelli Syndrome Type 2	Splenomegaly, Lymphadenopathy	ORPHA:79477
Cinca Syndrome	Hepatosplenomegaly, Lymphadenopathy	OMIM:607115
Nephroblastoma	Lymphadenopathy	ORPHA:654
Hyperimmunoglobulinemia D With Periodic Fever	Increased circulating IgA level, Lymphadenopathy	ORPHA:343
Thyroid Lymphoma	Lymphadenopathy	ORPHA:97285
Acquired Hypertrichosis Lanuginosa	Lymphadenopathy	ORPHA:2221
Systemic-Onset Juvenile Idiopathic Arthritis	Splenomegaly, Lymphadenopathy	ORPHA:85414
Combined Immunodeficiency Due To Zap70 Deficiency	Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy, Abnormal lymph node morphology	ORPHA:911
Roifman Syndrome	Splenomegaly, Lymphadenopathy	OMIM:616651
Rhabdoid Tumor	Lymphadenopathy	ORPHA:69077
Desmoplastic Small Round Cell Tumor	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:83469
Squamous Cell Carcinoma Of The Anal Canal	Lymphadenopathy	ORPHA:424019
Hyper-Igd Syndrome	Lymphadenitis, Hepatosplenomegaly, Splenomegaly, Increased circulating IgA level, Lymphadenopathy...	OMIM:260920
Pulmonary Non-Tuberculous Mycobacterial Infection	Lymphadenopathy	ORPHA:411703
Proteasome-Associated Autoinflammatory Syndrome 4	Splenomegaly, Lymphadenopathy	OMIM:619183
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	Increased circulating IgE level, Lymphadenopathy	OMIM:304790
Familial Hemophagocytic Lymphohistiocytosis	Reduced natural killer cell activity, Splenomegaly, Decreased circulating antibody level, Lymphad...	ORPHA:540
Proteasome-Associated Autoinflammatory Syndrome 3	Splenomegaly, Lymphadenopathy, Increased circulating antibody level	OMIM:617591
Pancreatoblastoma	Abnormal lymph node morphology	ORPHA:677
Klatskin Tumor	Lymphadenopathy	ORPHA:99978
Niemann-Pick Disease, Type A	Splenomegaly, Lymphadenopathy	OMIM:257200
Granulomatous Disease, Chronic, Autosomal Recessive, 1	Splenomegaly, Impaired oxidative burst, Lymphadenitis, Lymphadenopathy	OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2	Splenomegaly, Impaired oxidative burst, Lymphadenitis, Lymphadenopathy	OMIM:233710
Multiple Myeloma	Splenomegaly, Increased circulating IgA level, Lymphadenopathy, Increased circulating IgG level, ...	ORPHA:29073
Anaplastic Thyroid Carcinoma	Lymphadenopathy	ORPHA:142
Scrub Typhus	Splenomegaly, Lymphadenopathy	ORPHA:83317
Primary Myelofibrosis	Splenomegaly, Hepatosplenomegaly, Lymphadenopathy	ORPHA:824
Sting-Associated Vasculopathy, Infantile-Onset	Increased circulating IgG level, Increased circulating IgA level, Follicular hyperplasia, Paratra...	OMIM:615934
Immunodeficiency 91 And Hyperinflammation	Hepatosplenomegaly, Lymphadenopathy	OMIM:619644
American Trypanosomiasis	Splenomegaly, Lymphadenopathy	ORPHA:3386
Cyclic Neutropenia	Cervical lymphadenopathy, Recurrent tonsillitis, Lymphadenopathy	ORPHA:2686
Felty Syndrome	Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly	ORPHA:47612
Medullary Thyroid Carcinoma	Lymphadenopathy	ORPHA:1332
Granulomatous Disease, Chronic, Autosomal Recessive, 4	Splenomegaly, Impaired oxidative burst, Lymphadenitis, Lymphadenopathy	OMIM:233690
Melkersson-Rosenthal Syndrome	Lymphadenopathy	ORPHA:2483
Hemophagocytic Lymphohistiocytosis, Familial, 2	Reduced natural killer cell activity, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy	OMIM:603553
Mevalonic Aciduria	Fluctuating splenomegaly, Increased circulating IgD level, Hepatosplenomegaly, Lymphadenopathy	OMIM:610377
Thymic Neuroendocrine Tumor	Neoplasm of the thymus, Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy	ORPHA:97289
Adult-Onset Still Disease	Bone marrow hypocellularity, Generalized lymphadenopathy, Lymphadenopathy, Splenomegaly	ORPHA:829
Castleman Disease	Generalized lymphadenopathy, Mediastinal lymphadenopathy, Follicular hyperplasia, Lymphadenopathy	ORPHA:160
Diffuse Cutaneous Mastocytosis	Abnormality of the spleen, Lymphadenopathy	ORPHA:79456
Legionnaires Disease	Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly	ORPHA:549
Omenn Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:39041
Aregenerative Anemia	Bone marrow hypocellularity, Lymphadenopathy	ORPHA:101096
Common Variable Immunodeficiency	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy	ORPHA:1572
Gamma-Heavy Chain Disease	Splenomegaly, Lymphadenopathy	ORPHA:100026
Omenn Syndrome	Hypoplasia of the thymus, Splenomegaly, Lymphadenopathy	OMIM:603554
Cinca Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:1451
Hereditary Amyloidosis With Primary Renal Involvement	Hepatosplenomegaly, Lymphadenopathy, Abnormal lymph node morphology	ORPHA:85450
Combined Immunodeficiency Due To Crac Channel Dysfunction	Splenomegaly, Lymphadenopathy	ORPHA:169090
Tafro Syndrome	Hepatosplenomegaly, Splenomegaly, Lymphadenopathy	ORPHA:457077
Meige Disease	Lymph node hypoplasia, Absence of lymph node germinal center	ORPHA:90186
Igg4-Related Submandibular Gland Disease	Increased circulating IgE level, Increased circulating IgG4 level, Increased circulating antibody...	ORPHA:449432
Hypocomplementemic Urticarial Vasculitis	Splenomegaly, Lymphadenopathy	ORPHA:36412
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome	Hepatosplenomegaly, Absence of lymph node germinal center, Panhypogammaglobulinemia	ORPHA:79124
T-Cell Immunodeficiency With Thymic Aplasia	Aplasia of the thymus, Lymphadenopathy, Oligoclonal T cell expansion	ORPHA:83471
Joint Contractures, Osteochondromas, And B-Cell Lymphoma	Generalized lymphadenopathy	OMIM:620232
Autoimmune Lymphoproliferative Syndrome	Bone marrow hypocellularity, Decreased circulating IgG level, Decreased specific anti-polysacchar...	ORPHA:3261
Cutaneous Neuroendocrine Carcinoma	Chronic noninfectious lymphadenopathy	ORPHA:79140
Poems Syndrome	Splenomegaly, Lymphadenopathy, Increased circulating antibody level	ORPHA:2905
Waldenström Macroglobulinemia	Splenomegaly, Monoclonal immunoglobulin M proteinemia, Lymphadenopathy	ORPHA:33226
Macrophage Activation Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:158061
Mixed Connective Tissue Disease	Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:809
Granulomatous Disease, Chronic, X-Linked	Splenomegaly, Impaired oxidative burst, Lymphadenitis, Lymphadenopathy	OMIM:306400
Lig4 Syndrome	Lymphadenopathy	ORPHA:99812
Selective Igm Deficiency	Lymphadenitis, Paraproteinemia, Decreased specific antibody response to vaccination, Lymphadenopa...	ORPHA:331235
Chediak-Higashi Syndrome	Splenomegaly, Lymphadenopathy, Impaired neutrophil bactericidal activity	OMIM:214500
Pulmonary Capillary Hemangiomatosis	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:199241
Acute Interstitial Pneumonia	Lymphadenopathy	ORPHA:79126
Malt Lymphoma	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:52417
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency	Splenomegaly, Lymphadenitis, Lymphadenopathy	OMIM:615895
Q Fever	Splenomegaly, Hepatosplenomegaly, Lymphadenopathy, Increased circulating antibody level	ORPHA:781
Hennekam Syndrome	Decreased circulating antibody level, Splenomegaly, Lymphadenopathy, Pulmonary lymphangiectasia, ...	ORPHA:2136
Systemic Mastocytosis With Associated Hematologic Neoplasm	Splenomegaly, Lymphadenopathy, Abnormal mast cell morphology	ORPHA:98849
Hemophagocytic Lymphohistiocytosis, Familial, 1	Splenomegaly, Lymphadenopathy	OMIM:267700
Lymphatic Filariasis	Lymphadenitis, Lymphadenopathy, Lymphangiectasis, Abnormality of the lymphatic system	ORPHA:2035
Drug Reaction With Eosinophilia And Systemic Symptoms	Lymphadenopathy	ORPHA:139402
Acute Promyelocytic Leukemia	Lymphadenopathy	ORPHA:520
Pediatric Systemic Lupus Erythematosus	Lymphadenopathy	ORPHA:93552
Carney Triad	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:139411
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome	Bone marrow hypocellularity, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Decreased circula...	OMIM:615688
Graft Versus Host Disease	Hepatosplenomegaly, Lymphadenopathy	ORPHA:39812
Riddle Syndrome	Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level...	ORPHA:420741
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Increased circulating IgE level, Splenomegaly, Lymphadenopathy	ORPHA:37042
Farber Disease	Hepatosplenomegaly, Lymphadenopathy	ORPHA:333
Kikuchi-Fujimoto Disease	Abnormal lymph node morphology, Cervical lymphadenopathy, Splenomegaly, Generalized lymphadenopat...	ORPHA:50918
Chédiak-Higashi Syndrome	Abnormality of neutrophil physiology, Hepatosplenomegaly, Increased proportion of CD25+ mast cell...	ORPHA:167
Acute Generalized Exanthematous Pustulosis	Lymphadenopathy	ORPHA:293173
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia	Cervical lymphadenopathy, Lymphadenopathy	OMIM:617718
Immunodeficiency 55	Lymphadenopathy	OMIM:617827
Coccidioidomycosis	Abnormality of the spleen, Lymphadenopathy, Increased circulating IgG level, Increased circulatin...	ORPHA:228123
Neuroblastoma	Lymphadenopathy	ORPHA:635
Histiocytosis-Lymphadenopathy Plus Syndrome	Cervical lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy	OMIM:602782
Familial Pancreatic Carcinoma	Hepatosplenomegaly, Lymphadenopathy	ORPHA:1333
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2	Accessory spleen, Splenomegaly, Lymphadenopathy, Polysplenia	OMIM:619418
Igg4-Related Dacryoadenitis And Sialadenitis	Increased circulating IgG4 level, Increased circulating IgA level, Lymphadenopathy, Increased cir...	ORPHA:79078
H Syndrome	Hepatosplenomegaly, Lymphadenopathy	ORPHA:168569
Sarcoidosis, Susceptibility To, 1	Abnormality of T cell physiology, Splenomegaly, Increased circulating antibody level, Generalized...	OMIM:181000
Cherubism	Submandibular lymph node enlargement	OMIM:118400
Igg4-Related Kidney Disease	Lymphadenitis, Increased circulating IgE level, Increased circulating IgG4 level, Lymphadenopathy...	ORPHA:449395
Immunodeficiency 82 With Systemic Inflammation	Decreased circulating total IgG, Follicular hyperplasia, Splenomegaly, Lymphadenopathy, Decreased...	OMIM:619381
Congenital Syphilis	Hepatosplenomegaly, Lymphadenopathy	ORPHA:499009
Tangier Disease	Hepatosplenomegaly, Orange discolored tonsils, Chronic noninfectious lymphadenopathy	ORPHA:31150
Spondyloenchondrodysplasia With Immune Dysregulation	Lymphadenopathy	OMIM:607944
Lymphangioleiomyomatosis	Pulmonary lymphangiomyomatosis, Lymphadenopathy, Abnormality of the lymphatic system	ORPHA:538
Immunodeficiency 31C	Splenomegaly, Lymphadenopathy	OMIM:614162
Gallbladder Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100086
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Hepatosplenomegaly, Lymphadenopathy	ORPHA:85408
Brucellosis	Hypersplenism, Splenomegaly, Lymphadenopathy, Increased circulating IgG level, Increased circulat...	ORPHA:1304
Adenocarcinoma Of The Anal Canal	Lymphadenopathy	ORPHA:424016
Proteasome-Associated Autoinflammatory Syndrome 1	Splenomegaly, Increased circulating antibody level, Increased circulating IgA level, Lymphadenopa...	OMIM:256040
Igg4-Related Ophthalmic Disease	Increased circulating IgE level, Lymphadenopathy, Increased circulating IgG4 level	ORPHA:449563
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:32960
Primary Sjögren Syndrome	Decreased circulating antibody level, Lymphadenopathy, Increased circulating antibody level	ORPHA:289390
Ileal Neuroendocrine Tumor	Lymphadenopathy	ORPHA:100078
Familial Mediterranean Fever	Splenomegaly, Lymphadenopathy	ORPHA:342
Chikungunya	Cervical lymphadenopathy, Lymphadenopathy	ORPHA:324625
Crimean-Congo Hemorrhagic Fever	Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy, Splenomegaly	ORPHA:99827
Autosomal Recessive Malignant Osteopetrosis	Splenomegaly, Lymphadenopathy	ORPHA:667
Marburg Hemorrhagic Fever	Lymphadenopathy, Increased circulating antibody level	ORPHA:99826
Behçet Disease	Splenomegaly, Lymphadenopathy	ORPHA:117
Sarcoidosis	Lymphadenopathy, Abnormal lymph node morphology	ORPHA:797
Systemic Lupus Erythematosus	Lymphadenopathy	ORPHA:536
Blau Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:90340
Cushing Syndrome Due To Ectopic Acth Secretion	Neoplasm of the thymus, Abnormal lymph node morphology	ORPHA:99889
African Trypanosomiasis	Splenomegaly, Hepatosplenomegaly, Lymphadenopathy	ORPHA:3385
Leptospirosis	Lymphadenopathy	ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chst4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chst4.

No publications found that use IMPC mice or data for Chst4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Chst4^{tm96744(L1L2_Bact_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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