Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
forkhead box L2
Synonyms:
Pfrk

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Foxl2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Foxl2 by orthology or direct annotation.

The table below shows human diseases predicted to be associated to Foxl2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Premature Ovarian Failure 5
Hypoplasia of the ovary, Streak ovary, Reduced antral follicle count, Primary amenorrhea, Seconda... OMIM:611548
Female Infertility Due To Oocyte Meiotic Arrest
Oocyte arrest at metaphase I, Female infertility, Abnormal meiosis ORPHA:488191
Ovarian Dysgenesis 2
Hypoplasia of the uterus, Streak ovary, Hypergonadotropic hypogonadism, Primary amenorrhea, Secon... OMIM:300510
Oocyte Maturation Defect 9
Oocyte arrest at metaphase I, Female infertility OMIM:619011
Oocyte Maturation Defect 4
Oocyte arrest at metaphase I, Female infertility OMIM:617743
Oocyte Maturation Defect 2
Oocyte arrest at metaphase I, Female infertility OMIM:616780
Premature Ovarian Failure 6
Female infertility, Hypoplasia of the uterus, Streak ovary, Elevated circulating luteinizing horm... OMIM:612310
Perrault Syndrome 6
Hypoplasia of the uterus, Streak ovary, Irregular menstruation, Primary amenorrhea, Secondary ame... OMIM:617565
Ovarian Dysgenesis 10
Hypoplasia of the ovary, Streak ovary, Elevated circulating luteinizing hormone level, Primary am... OMIM:619834
Premature Ovarian Failure 19
Irregular menstruation, Secondary amenorrhea, Female infertility, Premature ovarian insufficiency OMIM:619245
Ring Chromosome Y Syndrome
Urogenital sinus anomaly, Ambiguous genitalia, female, Female infertility, Ambiguous genitalia, m... ORPHA:261529
Oocyte Maturation Defect 8
Female infertility OMIM:619009
Premature Ovarian Failure 2A
Secondary amenorrhea, Premature ovarian insufficiency OMIM:300511
Hypergonadotropic Hypogonadism And Partial Alopecia
Hypergonadotropic hypogonadism, Streak ovary OMIM:241090
Perrault Syndrome 2
Amenorrhea, Streak ovary OMIM:614926
Oocyte Maturation Defect 12
Female infertility OMIM:619697
Ovarian Dysgenesis 9
Hypoplasia of the uterus, Hypoplasia of the ovary, Elevated circulating luteinizing hormone level... OMIM:619665
46,Xx Testicular Disorder Of Sex Development
Polycystic ovaries, Ambiguous genitalia, Male hypogonadism, Decreased testicular size ORPHA:393
Premature Ovarian Failure 13
Amenorrhea, Hypoplasia of the uterus, Female infertility, Oligomenorrhea, Elevated circulating fo... OMIM:617442
Premature Ovarian Failure 18
Hypoplasia of the uterus, Hypoplasia of the ovary, Elevated circulating luteinizing hormone level... OMIM:619203
Osteosclerosis With Ichthyosis And Premature Ovarian Failure
Hypoplasia of the ovary, Premature ovarian insufficiency OMIM:609993
Premature Ovarian Failure 10
Hypoplasia of the ovary, Elevated circulating luteinizing hormone level, Primary amenorrhea, Hypo... OMIM:612885
Premature Ovarian Failure 8
Ovarian neoplasm, Streak ovary, Elevated circulating luteinizing hormone level, Primary amenorrhe... OMIM:615723
Hydatidiform Mole, Recurrent, 4
Female infertility OMIM:618432
Ovarian Dysgenesis 3
Female infertility, Elevated circulating follicle stimulating hormone level, Elevated circulating... OMIM:614324
Orbital Margin, Hypoplasia Of
Congenital extraocular muscle anomaly, Lacrimal duct atresia, Lower eyelid coloboma OMIM:165600
Premature Ovarian Failure 15
Oligomenorrhea OMIM:618096
Oocyte Maturation Defect 10
Female infertility OMIM:619176
Familial Hyperprolactinemia
Amenorrhea, Infertility, Hemorrhagic ovarian cyst, Oligomenorrhea, Menorrhagia, Female hypogonadism ORPHA:397685
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypoplasia of the uterus, Hypoplasia of the ovary, Decreased serum testosterone concentration, Mi... OMIM:614841
Oocyte Maturation Defect 6
Female infertility OMIM:618353
Oocyte Maturation Defect 1
Female infertility OMIM:615774
Oocyte Maturation Defect 11
Female infertility OMIM:619643
Oocyte Maturation Defect 7
Female infertility OMIM:618550
Preimplantation Embryonic Lethality 1
Female infertility OMIM:616814
Progesterone Resistance
Female infertility OMIM:264080
Hypogonadotropic Hypogonadism 25 With Anosmia
Hypoplasia of the ovary, Decreased serum testosterone concentration, Micropenis, Primary amenorrh... OMIM:618841
Congenital Muscular Dystrophy-Infantile Cataract-Hypogonadism Syndrome
Abnormality of the ovary, Decreased testicular size, Hypogonadism ORPHA:1875
Short Tarsus With Absence Of Lower Eyelashes
Absent lower eyelashes, Hypoplasia of the lower eyelids OMIM:600269
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Abnormal vagina morphology, Infertility, Hypoplasia of the uterus, Decreased serum testosterone c... ORPHA:168563
Hepatic Adenomas, Familial
Polycystic ovaries, Maturity-onset diabetes of the young OMIM:142330
Gonadoblastoma
Ovarian gonadoblastoma, Increased serum testosterone level, Gonadal dysgenesis with female appear... ORPHA:206484
46,Xy Complete Gonadal Dysgenesis
Polycystic ovaries, Male pseudohermaphroditism, Testicular dysgenesis, Hypogonadotropic hypogonadism ORPHA:242
46,Xy Sex Reversal 7
Sex reversal, Gonadal dysgenesis, male, Hypoplasia of the uterus, Streak ovary, Primary amenorrhe... OMIM:233420
Perrault Syndrome 4
Hypoplasia of the uterus, Hypoplasia of the ovary, Bicornuate uterus, Primary amenorrhea, Oligome... OMIM:615300
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
Abnormal vagina morphology, Streak ovary, Hypospadias, Abnormality of the uterus, Gonadoblastoma,... OMIM:194072
Asherman Syndrome
Infertility, Dysmenorrhea, Metrorrhagia, Oligomenorrhea, Abnormality of the menstrual cycle, Decr... ORPHA:137686
Polycystic Ovary Syndrome 1
Amenorrhea, Oligomenorrhea, Enlarged polycystic ovaries OMIM:184700
Faundes-Banka Syndrome
Failure to thrive, Premature thelarche, Long palpebral fissure, Broad eyebrow, Hypoplasia of the ... OMIM:619376
46,Xx Gonadal Dysgenesis
Streak ovary, Primary amenorrhea, Aplasia/hypoplasia of the uterus, Gonadal dysgenesis, Secondary... ORPHA:243
Mandibulofacial Dysostosis With Mental Retardation
Downslanted palpebral fissures, Lower eyelid coloboma OMIM:248400
Frasier Syndrome
Ambiguous genitalia, male, Gonadal dysgenesis with female appearance, male, Streak ovary, Hypergo... ORPHA:347
Nasopalpebral Lipoma-Coloboma Syndrome
Sparse eyebrow, Upper eyelid coloboma, Absent lacrimal punctum, Lipomas of eyelids, Ectopic lacri... OMIM:167730
Satoyoshi Syndrome
Amenorrhea, Nephrogenic diabetes insipidus, Hypoplasia of the uterus, Hypoplasia of the ovary, Ab... ORPHA:3130
Obesity Due To Congenital Leptin Deficiency
Hypoplasia of the ovary, Hyperinsulinemia, Decreased serum testosterone concentration, Hypergonad... ORPHA:66628
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies
Abdominal obesity, Hypoplasia of the ovary, Micropenis, Decreased testicular size, Hypoplasia of ... OMIM:619321
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
Abnormal lacrimal duct morphology, Female infertility, Streak ovary, Hypergonadotropic hypogonadi... ORPHA:572333
Premature Ovarian Failure 20
Female infertility, Elevated circulating luteinizing hormone level, Elevated circulating follicle... OMIM:619938
Treacher Collins Syndrome 3
Downslanted palpebral fissures, Lower eyelid coloboma OMIM:248390
Obesity Due To Leptin Receptor Gene Deficiency
Hypoplasia of the ovary, Hyperinsulinemia, Decreased serum testosterone concentration, Hypergonad... ORPHA:179494
Ablepharon-Macrostomia Syndrome
Ablepharon, Cryptophthalmos, Absent eyebrow, Micropenis, Hypoplastic nipples, Ambiguous genitalia... OMIM:200110
Oculocerebrocutaneous Syndrome
Orbital cyst, Cryptorchidism, Eyelid coloboma OMIM:164180
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Hypoplasia of the ovary, Reduced circulating prolactin concentration, Hypogonadotropic hypogonadi... ORPHA:2235
Treacher Collins Syndrome 4
Downslanted palpebral fissures, Lower eyelid coloboma OMIM:618939
Xp22.3 Microdeletion Syndrome
Polycystic ovaries, Hypogonadotropic hypogonadism, Secondary amenorrhea, Decreased fertility ORPHA:1643
Aromatase Deficiency
Ovarian cyst, Hypergonadotropic hypogonadism, Primary amenorrhea, Female pseudohermaphroditism OMIM:613546
Fowler Urethral Sphincter Dysfunction Syndrome
Amenorrhea, Abnormality of the urethra, Menorrhagia, Oligomenorrhea, Polycystic ovaries, Abnormal... ORPHA:2795
Normosmic Congenital Hypogonadotropic Hypogonadism
Increased female libido, Hypoplasia of the uterus, Hypoplasia of the ovary, Cryptorchidism, Impot... ORPHA:432
46,Xy Partial Gonadal Dysgenesis
Streak ovary, Hypergonadotropic hypogonadism, Primary amenorrhea, Ambiguous genitalia, Clitoral h... ORPHA:251510
Dilated Cardiomyopathy-Hypergonadotropic Hypogonadism Syndrome
Hypergonadotropic hypogonadism, Polycystic ovaries, Precocious puberty ORPHA:2229
Testicular Regression Syndrome
Abnormal male internal genitalia morphology, Absent testis, Hypoplasia of penis, Male pseudoherma... ORPHA:983
Blepharophimosis, Ptosis, And Epicanthus Inversus
Amenorrhea, Female infertility, Hypoplasia of the uterus, Irregular menstruation, Highly arched e... OMIM:110100
Bartsocas-Papas Syndrome
Ankyloblepharon, Aplasia/Hypoplasia of the eyebrow, Sparse or absent eyelashes, Popliteal pterygi... ORPHA:1234
46,Xx Ovotesticular Disorder Of Sex Development
Urogenital sinus anomaly, Abnormal male internal genitalia morphology, Hypoplasia of penis, Bifid... ORPHA:2138
Ovarian Fibrothecoma
Increased serum testosterone level, Abnormal endometrium morphology, Metrorrhagia, Abnormal circu... ORPHA:314478
Teebi Hypertelorism Syndrome 2
Hypospadias, Upper eyelid coloboma, Thick eyebrow, Ptosis OMIM:619736
Barber-Say Syndrome
Failure to thrive, Ablepharon, Ectropion, Aplasia/Hypoplasia of the eyebrow, Sparse or absent eye... ORPHA:1231
Acrofrontofacionasal Dysostosis
Bifid scrotum, Aplasia/Hypoplasia of the eyebrow, Hypospadias, Downslanted palpebral fissures, Ey... ORPHA:1784
Toriello-Lacassie-Droste Syndrome
Failure to thrive, Short palpebral fissure, Abnormal penis morphology, Hypospadias, Limbal dermoi... ORPHA:3339
Postaxial Acrofacial Dysostosis
Downslanted palpebral fissures, Ectropion of lower eyelids, Supernumerary nipple, Eyelid coloboma ORPHA:246
Frontonasal Dysplasia 3
Upper eyelid coloboma, Absent eyebrow, Sparse eyelashes OMIM:613456
Müllerian Aplasia And Hyperandrogenism
Abnormal vagina morphology, Increased serum testosterone level, Hypoplasia of the uterus, Thick e... ORPHA:247768
Helsmoortel-Van Der Aa Syndrome
Decreased response to growth hormone stimulation test, Downslanted palpebral fissures, Narrow pal... OMIM:615873
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Cryptorchidism, Micropenis, Hypospadias, Decreased fertility in females... ORPHA:1916
Frontofacionasal Dysplasia
Absent inner eyelashes, Aplasia/Hypoplasia of the eyebrow, Upper eyelid coloboma, Limbal dermoid,... ORPHA:1791
Tetragametic Chimerism
Gonadal dysgenesis with female appearance, male, Micropenis, Bifid scrotum, Perineal hypospadias,... ORPHA:199310
Ovarian Fibroma
Ovarian fibroma, Gonadal calcification, Abnormality of the ovary ORPHA:314473
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Decreased serum testosterone concentration, Testicular microlithiasis, Micropenis, Ovarian cyst, ... OMIM:228300
Aromatase Deficiency
Ambiguous genitalia, female, Female infertility, Type II diabetes mellitus, Hypergonadotropic hyp... ORPHA:91
Bardet-Biedl Syndrome
Cryptorchidism, Hypoplasia of the ovary, Hypoplasia of penis, Hypogonadism ORPHA:110
Oculoauriculofrontonasal Syndrome
Upper eyelid coloboma, Limbal dermoid ORPHA:398156
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Infertility, Impotence, Decreased serum testosterone concentration, Cryptorchidism, Small pituita... ORPHA:2232
Cryptophthalmos, Unilateral Or Bilateral, Isolated
Cryptophthalmos, Ankyloblepharon OMIM:123570
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Blind vagina, Ovarian cyst, Decreased circulating cortisol level, Primary amenorrhea, Abnormal re... ORPHA:90793
Richieri-Costa/Guion-Almeida Syndrome
Downslanted palpebral fissures, Eyelid coloboma, Ptosis OMIM:268850
Acrofacial Dysostosis, Cincinnati Type
Ablepharon, Decreased body weight, Upper eyelid coloboma, Downslanted palpebral fissures, Lower e... OMIM:616462
Burn-Mckeown Syndrome
Blepharophimosis, Short palpebral fissure, Lower eyelid coloboma OMIM:608572
Anophthalmia Plus Syndrome
Blepharophimosis, Eyelid coloboma ORPHA:1104
Manitoba Oculotrichoanal Syndrome
Nasolacrimal duct obstruction, Eyelid coloboma OMIM:248450
Jacobsen Syndrome
Annular pancreas, Failure to thrive, Labial hypoplasia, Hypospadias, Clitoral hypoplasia, Telecan... OMIM:147791
Microphthalmia With Cyst, Bilateral Facial Clefts, And Limb Anomalies
Telecanthus, Eyelid coloboma OMIM:607597
Premature Ovarian Failure 3
Secondary amenorrhea, Hypoplasia of the uterus, Premature ovarian insufficiency OMIM:608996
Bartsocas-Papas Syndrome 1
Ablepharon, Ectropion, Absent external genitalia, Bicornuate uterus, Micropenis, Ankyloblepharon,... OMIM:263650
Momo Syndrome
Downslanted palpebral fissures, Epicanthus, Obesity, Eyelid coloboma OMIM:157980
Hypospadias, hypertelorism, upper LID coloboma, and mixed-type hearingloss
Hypospadias, Upper eyelid coloboma OMIM:603463
Plin1-Related Familial Partial Lipodystrophy
Infertility, Hyperinsulinemia, Oligomenorrhea, Insulin-resistant diabetes mellitus at puberty, Ab... ORPHA:280356
Oculocerebrocutaneous Syndrome
Cryptorchidism, Eyelid coloboma, Ptosis ORPHA:1647
Burkitt Lymphoma
Abnormality of the ovary ORPHA:543
Nager Syndrome
Aplasia/Hypoplasia of the eyebrow, Downslanted palpebral fissures, Sparse lower eyelashes, Lower ... ORPHA:245
Momo Syndrome
Downslanted palpebral fissures, Epicanthus, Large for gestational age, Eyelid coloboma, Obesity ORPHA:2563
46,Xy Disorder Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Decreased fertility in males, Decreased circulating androgen concentration, Hypergonadotropic hyp... ORPHA:90796
Fraser-Like Syndrome
Ovarian cyst OMIM:229230
Postaxial Acrofacial Dysostosis
Ectropion, Supernumerary nipple, Micropenis, Downslanted palpebral fissures, Eyelid coloboma, Cry... OMIM:263750
Functioning Gonadotropic Adenoma
Impotence, Ovarian cyst, Central diabetes insipidus, Enlarged polycystic ovaries, Pituitary gonad... ORPHA:91348
Oculotrichoanal Syndrome
Cryptophthalmos, Nasolacrimal duct obstruction, Upper eyelid coloboma ORPHA:2717
Mandibulofacial Dysostosis With Alopecia
Lower eyelid coloboma, Sparse eyelashes OMIM:616367
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Bifid scrotum, Abnormal penis morphology, Hypospadias, Downslanted palpebral fissures, Shawl scro... ORPHA:2211
Partial Androgen Insensitivity Syndrome
Abnormal circulating estrogen level, Blind vagina, Primary amenorrhea, Ambiguous genitalia, Clito... ORPHA:90797
45,X/46,Xy Mixed Gonadal Dysgenesis
Ambiguous genitalia, female, Streak ovary, Ambiguous genitalia, Abnormal internal genitalia, Bila... ORPHA:1772
Encephalocraniocutaneous Lipomatosis
Cryptorchidism, Limbal dermoid, Eyelid coloboma OMIM:613001
Woodhouse-Sakati Syndrome
Hypoplasia of the uterus, Hyperinsulinemia, Decreased response to growth hormone stimulation test... ORPHA:3464
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Polycystic ovaries, Elevated circulating growth hormone concentration, Enlarged polycystic ovarie... ORPHA:90301
Fraser Syndrome 2
Ambiguous genitalia, Cryptophthalmos OMIM:617666
Treacher-Collins Syndrome
Failure to thrive, Blepharospasm, Hypoplasia of penis, Hypoplasia of the thymus, Abnormality of t... ORPHA:861
Treacher Collins Syndrome 1
Upper eyelid coloboma, Lacrimal duct stenosis, Downslanted palpebral fissures, Sparse lower eyela... OMIM:154500
Sweeney-Cox Syndrome
Bilateral cryptorchidism, Upper eyelid coloboma OMIM:617746
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Precocious puberty, Cryptophthalmos, Hypospadias, Epicanthus, Long eyelashes OMIM:615877
Fraser Syndrome 3
Cryptophthalmos, Small scrotum OMIM:617667
Hymen, Imperforate
Amenorrhea, Hematocolpos, Imperforate hymen, Hydrocolpos OMIM:237100
Frontofacionasal Dysplasia
Ankyloblepharon, Absent inner eyelashes, S-shaped palpebral fissures, Telecanthus, Eyelid colobom... OMIM:229400
Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Labial hypoplasia, Bicornuate uterus, Telecanthus, Clitoral hypertrophy, Eyelid coloboma ORPHA:140952
Proboscis Lateralis
Abnormal eyebrow morphology, Unilateral narrow palpebral fissure, Abnormal morphology of bony orb... ORPHA:141099
Ablepharon Macrostomia Syndrome
Ablepharon, Cryptophthalmos, Hypoplasia of penis, Absent eyebrow, Ambiguous genitalia, Abnormalit... ORPHA:920
Gorlin-Chaudhry-Moss Syndrome
Upper eyelid coloboma, Abnormal eyelid morphology ORPHA:2095
Non-Functioning Pituitary Adenoma
Impotence, Decreased fertility in males, Central adrenal insufficiency, Erectile dysfunction, Hyp... ORPHA:91349
Hypoplasminogenemia
Abnormal fallopian tube morphology, Abnormality of the ovary, Cervicitis ORPHA:722
Scalp-Ear-Nipple Syndrome
Palpebral edema, Telecanthus, Breast aplasia, Type I diabetes mellitus, Eyelid coloboma ORPHA:2036
Congenital Adrenal Hyperplasia Due To 11-Beta-Hydroxylase Deficiency
Increased serum testosterone level, Ambiguous genitalia, female, Precocious puberty, Decreased ci... ORPHA:90795
Muscular Dystrophy, Congenital Hearing Loss, And Ovarian Insufficiency Syndrome
Failure to thrive, Female infertility, Premature ovarian insufficiency OMIM:619518
Branchioskeletogenital Syndrome
Absent nipple, Absent external genitalia, Micropenis, Downslanted palpebral fissures, Telecanthus... ORPHA:1299
Jacobsen Syndrome
Annular pancreas, Ectropion, Aplasia/Hypoplasia of the eyebrow, Downslanted palpebral fissures, E... ORPHA:2308
Oculoectodermal Syndrome
Epicanthus, Limbal dermoid, Supernumerary nipple, Eyelid coloboma OMIM:600268
Prolactinoma
Impotence, Dyspareunia, Decreased fertility in males, Central adrenal insufficiency, Erectile dys... ORPHA:2965
Leopard Syndrome 1
Hypoplasia of the ovary, Micropenis, Delayed menarche, Hypospadias, Delayed puberty, Cryptorchidi... OMIM:151100
Fraser Syndrome 1
Cryptophthalmos, Bicornuate uterus, Absent eyebrow, Micropenis, Hypospadias, Lacrimal duct aplasi... OMIM:219000
Acrofacial Dysostosis 1, Nager Type
Downslanted palpebral fissures, Sparse lower eyelashes, Bicornuate uterus, Lower eyelid coloboma OMIM:154400
Charge Syndrome
Labial hypoplasia, Micropenis, Bifid scrotum, Hypogonadotropic hypogonadism, Abnormality of the a... ORPHA:138
Neu-Laxova Syndrome 2
Ablepharon OMIM:616038
Akt2-Related Familial Partial Lipodystrophy
Oligomenorrhea, Decreased serum leptin, Insulin-resistant diabetes mellitus, Polycystic ovaries, ... ORPHA:79085
Congenital Factor Vii Deficiency
Ovarian cyst, Menorrhagia ORPHA:327
Fraser Syndrome
Abnormal vagina morphology, Cryptophthalmos, Urethral atresia, Hypoplasia of penis, Bicornuate ut... ORPHA:2052
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Sparse eyebrow, Sparse eyelashes, Epicanthus, Eyelid coloboma, Ptosis ORPHA:306542
Neu-Laxova Syndrome 1
Ablepharon, Bifid uterus, Absent eyelashes, Pterygium, Cryptorchidism, Stillbirth OMIM:256520
Pigmented Nodular Adrenocortical Disease, Primary, 2
Paradoxical increased cortisol secretion on dexamethasone suppression test, Pigmented micronodula... OMIM:610475
Aicardi-Goutières Syndrome
Micropenis, Hypothyroidism, Diabetes mellitus, Eyelid coloboma, Ptosis ORPHA:51
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Decreased circulating androgen concentration, Abnormal external genitalia, Decreased circulating ... ORPHA:95699
Genitourinary And/Or Brain Malformation Syndrome
Urogenital sinus anomaly, Chordee, Streak ovary, Micropenis, Uterus didelphys, Hypospadias, Gonad... OMIM:618820
Isolated Arrhinia
Eyelid coloboma ORPHA:1134
Mycophenolate Mofetil Embryopathy
Eyelid coloboma ORPHA:268249
Roberts-Sc Phocomelia Syndrome
Bicornuate uterus, Hypospadias, Shallow orbits, Long penis, Downslanted palpebral fissures, Enlar... OMIM:268300
Constricting Bands, Congenital
Eyelid coloboma OMIM:217100
Primary Ciliary Dyskinesia
Female infertility, Abnormal sperm motility, Male infertility ORPHA:244
Bardet-Biedl Syndrome 1
Abdominal obesity, Nephrogenic diabetes insipidus, Micropenis, Truncal obesity, Decreased testicu... OMIM:209900
Alg9-Cdg
Hypoplasia of the ovary, Bicornuate uterus, Hypoplastic nipples ORPHA:79328
Turner Syndrome Due To Structural X Chromosome Anomalies
Thyroiditis, Female infertility, Type II diabetes mellitus, Hyperinsulinemia, Primary amenorrhea,... ORPHA:99413
Turner Syndrome
Thyroiditis, Female infertility, Type II diabetes mellitus, Hyperinsulinemia, Primary amenorrhea,... ORPHA:881
Mosaic Monosomy X
Thyroiditis, Female infertility, Type II diabetes mellitus, Hyperinsulinemia, Primary amenorrhea,... ORPHA:99228
Monosomy X
Thyroiditis, Female infertility, Type II diabetes mellitus, Hyperinsulinemia, Primary amenorrhea,... ORPHA:99226
Carney Complex
Increased circulating insulin-like growth factor 1 concentration, Pituitary growth hormone cell a... ORPHA:1359
Ovarian Hyperstimulation Syndrome
Increased serum testosterone level, Ovarian cyst, Hemorrhagic ovarian cyst, Increased circulating... ORPHA:64739
Schinzel-Giedion Syndrome
Annular pancreas, Micropenis, Streak ovary, Hypospadias, Central hypothyroidism ORPHA:798
Craniofacial Microsomia
Limbal dermoid, Upper eyelid coloboma, Blepharophimosis, Ptosis OMIM:164210

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxl2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxl2.

No publications found that use IMPC mice or data for Foxl2.

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MGI Allele Allele Type Produced
Foxl2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Foxl2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Foxl2tm394442(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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