The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Polr2f by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Polr2f.
There are 2 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Polr2ftm1e(EUCOMM)Wtsi||PMC7263671|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Polr2ftm1e(EUCOMM)Wtsi||PMC6671969|
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|MGI Allele||Allele Type||Produced|
|Polr2ftm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Polr2ftm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Polr2ftm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||Mice|