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Gene: Tpsg1 MGI:1349391

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tryptase gamma 1
Synonyms:
TMT,  Prss31

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tpsg1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tpsg1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cleft Larynx, Posterior
Aspiration OMIM:215800
Laryngotracheoesophageal Cleft
Aspiration, Impaired oropharyngeal swallow response ORPHA:2004
Developmental And Epileptic Encephalopathy 38
Aspiration, Gastroesophageal reflux OMIM:617020
Congenital Disorder Of Glycosylation, Type Im
Diarrhea, Aspiration, Inflammatory abnormality of the skin, Vomiting OMIM:610768
Tay-Sachs Disease
Aspiration OMIM:272800
Hyperekplexia 1
Aspiration OMIM:149400
Amyotrophic Lateral Sclerosis 21
Aspiration, Dysphagia OMIM:606070
Vocal Cord And Pharyngeal Distal Myopathy
Aspiration, Dysphagia ORPHA:600
Spinocerebellar Ataxia Type 8
Aspiration, Dysphagia ORPHA:98760
Pontine Tegmental Cap Dysplasia
Aspiration, Dysphagia OMIM:614688
Lissencephaly Type 1 Due To Doublecortin Gene Mutation
Aspiration, Dysphagia ORPHA:2148
Gm2-Gangliosidosis, Ab Variant
Aspiration OMIM:272750
Rett Syndrome, Congenital Variant
Constipation, Aspiration, Gastroesophageal reflux OMIM:613454
Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities
Aspiration, Dysphagia OMIM:618922
Halperin-Birk Syndrome
Aspiration, Gastroesophageal reflux, Pseudobulbar paralysis OMIM:618651
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Hypoventilation, Gastroesophageal reflux, Myositis, Aspiration, Dysphagia ORPHA:258
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Gastroesophageal reflux, Aspiration, Esophagitis, Vomiting, Constipation ORPHA:96182
Opitz Gbbb Syndrome
Aspiration, Dysphagia, Gastroesophageal reflux OMIM:300000
Alternating Hemiplegia Of Childhood
Oral-pharyngeal dysphagia, Diarrhea, Aspiration, Vomiting, Constipation, Dysphagia ORPHA:2131
Neuromuscular Oculoauditory Syndrome
Aspiration OMIM:618733
Neuropathy, Hereditary Sensory And Autonomic, Type Vi
Aspiration, Gastroesophageal reflux OMIM:614653
Developmental And Epileptic Encephalopathy 100
Gastroesophageal reflux, Aspiration, Dysphagia, Chronic constipation OMIM:619777
Esophageal Atresia
Gastroesophageal reflux, Aspiration, Esophagitis, Vomiting, Dysphagia ORPHA:1199
Adnp Syndrome
Gastroesophageal reflux, Oral-pharyngeal dysphagia, Aspiration, Vomiting, Chronic constipation ORPHA:404448
Bilateral Perisylvian Polymicrogyria
Aspiration, Dysphagia, Gastroesophageal reflux, Pseudobulbar paralysis ORPHA:98889
Oculopharyngodistal Myopathy 1
Aspiration, Dysphagia OMIM:164310
Ogden Syndrome
Recurrent otitis media, Diarrhea, Aspiration, Eczematoid dermatitis, Vomiting, Dysphagia OMIM:300855
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Chronic otitis media, Recurrent otitis media, Aspiration, Atopic dermatitis, Dysphagia, Chronic c... OMIM:619503
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Gastroesophageal reflux, Aspiration, Constipation, Otitis media, Pneumonia ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Gastroesophageal reflux, Aspiration, Constipation, Otitis media, Pneumonia ORPHA:353277
Acrofacial Dysostosis, Cincinnati Type
Aspiration, Recurrent otitis media, Dysphagia OMIM:616462

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tpsg1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tpsg1.

No publications found that use IMPC mice or data for Tpsg1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tpsg1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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