Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tryptase gamma 1
Synonyms:
TMT,  Prss31

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tpsg1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tpsg1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Laryngotracheoesophageal Cleft
Dyspnea, Cough, Neonatal respiratory distress, Impaired oropharyngeal swallow response, Stridor, ... ORPHA:2004
Spermatogenic Failure 15
Aspiration OMIM:616950
Cleft Larynx, Posterior
Aspiration OMIM:215800
Obesity-Hypoventilation Syndrome
Hypoventilation OMIM:257500
Mitochondrial Complex I Deficiency, Nuclear Type 9
Hypoventilation, Breathing dysregulation OMIM:618232
Hyperekplexia 1
Apnea, Aspiration OMIM:149400
Amyotrophic Lateral Sclerosis 21
Dysphagia, Aspiration, Respiratory insufficiency due to muscle weakness OMIM:606070
Postpoliomyelitis Syndrome
Dysphagia, Hypoventilation, Respiratory insufficiency ORPHA:2942
Tay-Sachs Disease
Aspiration OMIM:272800
Vocal Cord And Pharyngeal Distal Myopathy
Dysphagia, Aspiration, Respiratory insufficiency due to muscle weakness ORPHA:600
Opitz Gbbb Syndrome, Type I
Dysphagia, Gastroesophageal reflux, Aspiration OMIM:300000
Spinocerebellar Ataxia Type 8
Dysphagia, Aspiration ORPHA:98760
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Hypoventilation, Dysphagia, Gastroesophageal reflux, Respiratory insufficiency, Atelectasis, Inte... ORPHA:258
Joubert Syndrome 17
Hyperventilation OMIM:614615
Gm2-Gangliosidosis, Ab Variant
Aspiration OMIM:272750
Lissencephaly Type 1 Due To Doublecortin Gene Mutation
Dysphagia, Aspiration ORPHA:2148
Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities
Dysphagia, Neonatal respiratory distress, Aspiration OMIM:618922
Pontine Tegmental Cap Dysplasia
Dysphagia, Aspiration OMIM:614688
Central Hypoventilation Syndrome, Congenital, 1
Apnea, Hypoventilation, Hypercapnia, Constipation, Central hypoventilation, Hypoxemia OMIM:209880
Oculopharyngodistal Myopathy 1
Restrictive ventilatory defect, Hypercapnia, Dysphagia, Respiratory insufficiency due to muscle w... OMIM:164310
Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies
Pseudobulbar paralysis, Gastroesophageal reflux, Aspiration OMIM:618651
Neuromuscular Oculoauditory Syndrome
Respiratory distress, Aspiration OMIM:618733
Rett Syndrome, Congenital Variant
Constipation, Gastroesophageal reflux, Aspiration OMIM:613454
Esophageal Atresia
Esophagitis, Restrictive ventilatory defect, Episodic respiratory distress, Chronic pulmonary obs... ORPHA:1199
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Esophagitis, Constipation, Gastroesophageal reflux, Vomiting, Obstructive sleep apnea, Aspiration ORPHA:96182
Alternating Hemiplegia Of Childhood
Apnea, Respiratory distress, Dysphagia, Constipation, Oral-pharyngeal dysphagia, Diarrhea, Vomiti... ORPHA:2131
Adnp Syndrome
Respiratory distress, Gastroesophageal reflux, Oral-pharyngeal dysphagia, Chronic constipation, V... ORPHA:404448
Bilateral Perisylvian Polymicrogyria
Pseudobulbar paralysis, Apnea, Dysphagia, Gastroesophageal reflux, Aspiration ORPHA:98889
Opitz Gbbb Syndrome, Type Ii
Pulmonary arterial hypertension, Dysphagia, Aspiration OMIM:145410
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Constipation, Gastroesophageal reflux, Pneumonia, Otitis media, Asthma, Obstructive sleep apnea, ... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Constipation, Gastroesophageal reflux, Pneumonia, Otitis media, Asthma, Obstructive sleep apnea, ... ORPHA:353277

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tpsg1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tpsg1.

No publications found that use IMPC mice or data for Tpsg1.

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MGI Allele Allele Type Produced
Tpsg1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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