Pla2g10 | phospholipase A2, group X

GeneMGI:1347522Synonyms: mGXsPLA2, PLA2GX, +1 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

16 No significant impact

2 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

abnormal lens morphology1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult9.03x10-9 
cataract1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult3.76x10-8 
decreased heart rate1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult4.93x10-6 
increased heart rate variability1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult2.83x10-9 
cardiovascular system phenotype1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult7.66x10-22 
preweaning lethality, incomplete penetrance1 supporting datasetPla2g10tm1a(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased mature B cell number1 supporting datasetPla2g10tm1a(EUCOMM)HmguheterozygoteEarly adult6.98x10-5 
prolonged QT interval1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult2.2x10-14 
abnormal QT variability1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult8.99x10-18 
prolonged RR interval1 supporting datasetPla2g10tm1b(EUCOMM)HmguhomozygoteEarly adult6.17x10-26 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pla2g10tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Pla2g10tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pla2g10tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Pla2g10tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Pla2g10tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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