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Gene: Foxd4 MGI:1347467

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Gene Summary

Name:
forkhead box D4
Synonyms:
FREAC5,  Fkh2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
anophthalmia Foxd4em1(IMPC)Mbp HOM Early adult 0.00
preweaning lethality, incomplete penetrance Foxd4em1(IMPC)Mbp HOM Early adult 0.00
abnormal eye morphology Foxd4em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

30 Images

View images

Human diseases caused by Foxd4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxd4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Anophthalmia, Microphthalmia ORPHA:85275
Microphthalmia, Isolated 1
Anophthalmia, Microphthalmia OMIM:251600
Microphthalmia, Isolated, With Coloboma 10
Anophthalmia, Microphthalmia OMIM:616428
Microphthalmia, Isolated, With Coloboma 5
Anophthalmia, Bilateral microphthalmos, Microphthalmia OMIM:611638
Microphthalmia, Syndromic 16
Anophthalmia, Microphthalmia OMIM:611038
Microphthalmia, Syndromic 12
Anophthalmia, Microphthalmia, Neonatal death OMIM:615524
Fryns Microphthalmia Syndrome
Anophthalmia, Microphthalmia OMIM:600776
Microphthalmia, Isolated 8
True anophthalmia, Anophthalmia, Microphthalmia, Optic nerve hypoplasia OMIM:615113
Anencephaly 2
Anophthalmia OMIM:619452
Oculocerebrocutaneous Syndrome
Anophthalmia, Microphthalmia OMIM:164180
Meckel Syndrome, Type 8
Anophthalmia, Microphthalmia OMIM:613885
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Trisomy 13
Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia ORPHA:3378
Anophthalmia Plus Syndrome
Anophthalmia ORPHA:1104
Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia ORPHA:2717
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Hydrolethalus
Anophthalmia, Microphthalmia ORPHA:2189
Solitary Median Maxillary Central Incisor
Anophthalmia, Microphthalmia OMIM:147250
Microphthalmia With Brain And Digit Anomalies
Anophthalmia, Microphthalmia ORPHA:139471
Microphthalmia, Syndromic 5
Anophthalmia, Microphthalmia, Optic nerve hypoplasia OMIM:610125
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia, Microphthalmia ORPHA:77298
Microphthalmia With Limb Anomalies
Anophthalmia, Microphthalmia OMIM:206920
Matthew-Wood Syndrome
Anophthalmia, Microphthalmia ORPHA:2470
Manitoba Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia OMIM:248450
Cockayne Syndrome Type 2
Anophthalmia ORPHA:90322
Walker-Warburg Syndrome
Anophthalmia, Microphthalmia ORPHA:899
Trisomy 1Q
Anophthalmia ORPHA:261344
Microphthalmia, Syndromic 9
Anophthalmia, Bilateral microphthalmos, Neonatal death OMIM:601186
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Anophthalmia, Microphthalmia OMIM:615877
Cockayne Syndrome Type 1
Anophthalmia ORPHA:90321
Microphthalmia, Syndromic 3
Anophthalmia, Microphthalmia, Optic nerve aplasia, Optic nerve hypoplasia OMIM:206900
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Anophthalmia, Aniridia ORPHA:1101
Vacterl With Hydrocephalus
Anophthalmia, Microphthalmia ORPHA:3412
Fibular Hemimelia
Anophthalmia ORPHA:93323
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anophthalmia, Microphthalmia ORPHA:2250
Holoprosencephaly
Anophthalmia, Microphthalmia ORPHA:2162
Cerebrooculonasal Syndrome
Anophthalmia, Optic nerve hypoplasia OMIM:605627
14Q22Q23 Microdeletion Syndrome
Anophthalmia, Optic nerve aplasia ORPHA:264200
Microgastria-Limb Reduction Defect Syndrome
Anophthalmia, Microphthalmia ORPHA:2538
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Anophthalmia, Microphthalmia ORPHA:2526
Meckel Syndrome
Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia ORPHA:564
Holoprosencephaly 9
Anophthalmia, Microphthalmia, Optic nerve hypoplasia OMIM:610829
Joubert Syndrome 21
Anophthalmia OMIM:615636
Microphthalmia With Linear Skin Defects Syndrome
Anophthalmia, Microphthalmia ORPHA:2556
Proboscis Lateralis
Anophthalmia, Microphthalmia, Optic nerve hypoplasia ORPHA:141099
Charge Syndrome
Anophthalmia, Microphthalmia ORPHA:138
Fraser Syndrome 1
Anophthalmia, Bilateral microphthalmos OMIM:219000
Focal Dermal Hypoplasia
Anophthalmia, Aniridia, Microphthalmia OMIM:305600
Microphthalmia, Syndromic 2
Anophthalmia, Microphthalmia OMIM:300166
Microphthalmia With Limb Anomalies
True anophthalmia, Microphthalmia ORPHA:1106
Fraser Syndrome
Anophthalmia, Microphthalmia ORPHA:2052
Charge Syndrome
Unilateral microphthalmos, Anophthalmia, Microphthalmia OMIM:214800
Microphthalmia, Syndromic 6
Anophthalmia, Microphthalmia OMIM:607932
Branchiooculofacial Syndrome
Anophthalmia, Microphthalmia OMIM:113620
Craniofacial Microsomia
Anophthalmia, Microphthalmia OMIM:164210
Microphthalmia, Syndromic 1
Anophthalmia, Microphthalmia OMIM:309800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxd4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxd4.

No publications found that use IMPC mice or data for Foxd4.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Foxd4em1(IMPC)Mbp Whole-gene deletion Mice, Tissue
Foxd4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Foxd4tm400606(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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