Gene Summary

Name:
forkhead box D4
Synonyms:
FREAC5,  Fkh2

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Foxd4em1(IMPC)Mbp HOM Early adult 0.00
preweaning lethality, incomplete penetrance Foxd4em1(IMPC)Mbp HOM Early adult 0.00
anophthalmia Foxd4em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Foxd4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxd4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Anophthalmia, Microphthalmia ORPHA:85275
Microphthalmia, Isolated 1
Anophthalmia, Microphthalmia OMIM:251600
Microphthalmia, Isolated, With Coloboma 10
Anophthalmia, Microphthalmia OMIM:616428
Microphthalmia, Isolated, With Coloboma 5
Anophthalmia, Bilateral microphthalmos, Microphthalmia OMIM:611638
Microphthalmia, Isolated 3
Anophthalmia, Microphthalmia OMIM:611038
Fryns Microphthalmia Syndrome
Anophthalmia, Microphthalmia OMIM:600776
Dextrocardia With Unusual Facies And Microphthalmia
Anophthalmia, Microphthalmia OMIM:221950
Microphthalmia, Isolated 8
Optic nerve hypoplasia, Anophthalmia, True anophthalmia, Microphthalmia OMIM:615113
Microphthalmia, Syndromic 12
Anophthalmia, Microphthalmia OMIM:615524
Anencephaly 2
Anophthalmia OMIM:619452
Meckel Syndrome, Type 8
Anophthalmia, Microphthalmia OMIM:613885
Oculocerebrocutaneous Syndrome
Anophthalmia, Microphthalmia OMIM:164180
Manitoba Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia OMIM:248450
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Trisomy 13
Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia ORPHA:3378
Anophthalmia Plus Syndrome
Anophthalmia ORPHA:1104
Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia ORPHA:2717
Microphthalmia With Limb Anomalies
Anophthalmia, Microphthalmia OMIM:206920
Solitary Median Maxillary Central Incisor
Anophthalmia, Microphthalmia OMIM:147250
Hydrolethalus
Anophthalmia, Microphthalmia ORPHA:2189
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Microphthalmia, Syndromic 5
Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:610125
Microphthalmia With Brain And Digit Anomalies
Anophthalmia, Microphthalmia ORPHA:139471
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia, Microphthalmia ORPHA:77298
Matthew-Wood Syndrome
Anophthalmia, Microphthalmia ORPHA:2470
Cockayne Syndrome Type 2
Anophthalmia ORPHA:90322
Walker-Warburg Syndrome
Anophthalmia, Microphthalmia ORPHA:899
Trisomy 1Q
Anophthalmia ORPHA:261344
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Anophthalmia, Microphthalmia OMIM:615877
Microphthalmia, Syndromic 9
Anophthalmia, Bilateral microphthalmos OMIM:601186
Cockayne Syndrome Type 1
Anophthalmia ORPHA:90321
Microphthalmia, Syndromic 3
Optic nerve hypoplasia, Optic nerve aplasia, Anophthalmia, Microphthalmia OMIM:206900
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Anophthalmia, Aniridia ORPHA:1101
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anophthalmia, Microphthalmia ORPHA:2250
Fibular Hemimelia
Anophthalmia ORPHA:93323
Vacterl With Hydrocephalus
Anophthalmia, Microphthalmia ORPHA:3412
Holoprosencephaly
Anophthalmia, Microphthalmia ORPHA:2162
Joubert Syndrome 21
Anophthalmia OMIM:615636
Cerebrooculonasal Syndrome
Optic nerve hypoplasia, Anophthalmia OMIM:605627
Microgastria-Limb Reduction Defects Association
Anophthalmia OMIM:156810
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia ORPHA:264200
Microgastria-Limb Reduction Defect Syndrome
Anophthalmia, Microphthalmia ORPHA:2538
Meckel Syndrome
Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia ORPHA:564
Holoprosencephaly 9
Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:610829
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Anophthalmia, Microphthalmia ORPHA:2526
Microphthalmia With Linear Skin Defects Syndrome
Anophthalmia, Microphthalmia ORPHA:2556
Proboscis Lateralis
Optic nerve hypoplasia, Anophthalmia, Microphthalmia ORPHA:141099
Charge Syndrome
Anophthalmia, Microphthalmia ORPHA:138
Focal Dermal Hypoplasia
Aniridia, Anophthalmia, Microphthalmia OMIM:305600
Fraser Syndrome 1
Anophthalmia, Bilateral microphthalmos OMIM:219000
Microphthalmia, Syndromic 2
Anophthalmia, Microphthalmia OMIM:300166
Fraser Syndrome
Anophthalmia, Microphthalmia ORPHA:2052
Microphthalmia With Limb Anomalies
True anophthalmia, Microphthalmia ORPHA:1106
Charge Syndrome
Anophthalmia, Unilateral microphthalmos, Microphthalmia OMIM:214800
Microphthalmia, Syndromic 6
Anophthalmia, Microphthalmia OMIM:607932
Branchiooculofacial Syndrome
Anophthalmia, Microphthalmia OMIM:113620
Craniofacial Microsomia
Anophthalmia, Microphthalmia OMIM:164210
Microphthalmia, Syndromic 1
Anophthalmia, Microphthalmia OMIM:309800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxd4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxd4.

No publications found that use IMPC mice or data for Foxd4.

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MGI Allele Allele Type Produced
Foxd4em1(IMPC)Mbp Whole-gene deletion Mice, Tissue
Foxd4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Foxd4tm400606(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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