Adamts6 | ADAM metallopeptidase with thrombospondin type 1 motif 6
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Mortality/aging Craniofacial Cardiovascular system Renal/urinary system
12 No significant impact
2 Not tested
Data collections
Gene metrics:15Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
cleft palate | 1 supporting dataset | Adamts6em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
abnormal limb morphology | 1 supporting dataset | Adamts6em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
abnormal vitreous body morphology | 1 supporting dataset | Adamts6em1(IMPC)Mbp | heterozygote | Early adult | 5.99x10-5 | ||
abnormal blood vessel morphology | 1 supporting dataset | Adamts6em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
abnormal craniofacial morphology | 1 supporting dataset | Adamts6em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
microphthalmia | 1 supporting dataset | Adamts6em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
preweaning lethality, complete penetrance | 3 supporting datasets | Adamts6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
cataract | 1 supporting dataset | Adamts6em1(IMPC)Mbp | heterozygote | Early adult | 6.35x10-5 | ||
abnormal kidney morphology | 1 supporting dataset | Adamts6em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
abnormal head shape | 1 supporting dataset | Adamts6em1(IMPC)Mbp | homozygote | E15.5 | N/A * |
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This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Adamts6.
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Adamts6em1(IMPC)Mbp | Exon Deletion | | mouse |
Adamts6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |