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Gene: Mapk10 MGI:1346863

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Gene Summary

Name:
mitogen-activated protein kinase 10
Synonyms:
JNK3,  p493F12,  C230008H04Rik,  Serk2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Forepaw

13 Images

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X-ray

XRay Images Whole Body Lateral Orientation

13 Images

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X-ray

XRay Images Skull Lateral Orientation

13 Images

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Legacy Phenotype Associated Images
Mapk10tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mapk10tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mapk10tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mapk10tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Mapk10tm1a(EUCOMM)Wtsi
HOM, Male, WTSI

View all 67 images

Mapk10tm1a(EUCOMM)Wtsi
cornea/lens fusion, HOM, Female, WTSI
Mapk10tm1a(EUCOMM)Wtsi
right eye, abnormal retinal pigmentation, HOM, Male, WTSI
Mapk10tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Mapk10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Mapk10 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lennox-Gastaut Syndrome
Myoclonus, Focal-onset seizure, Generalized tonic seizure, Bilateral tonic-clonic seizure, Atonic... ORPHA:2382

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mapk10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mapk10.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Mapk10tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Mapk10tm1a(EUCOMM)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mapk10tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Mapk10tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Mapk10tm44146(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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