Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Psmb8 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Proteasome-Associated Autoinflammatory Syndrome 1 | Increased circulating IgG level, Increased circulating antibody level, Increased circulating IgA ... | OMIM:256040 |
The table below shows human diseases predicted to be associated to Psmb8 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Nasopharyngeal Carcinoma, Susceptibility To, 2 | Neoplasm | OMIM:161550 | |
Drug Metabolism, Poor, Cyp2D6-Related | Neoplasm | OMIM:608902 | |
Multiple Self-Healing Squamous Epithelioma, Susceptibility To | Neoplasm | OMIM:132800 | |
Cancer, Familial, With In Vitro Radioresistance | Neoplasm | OMIM:114450 | |
Adamantinoma Of Long Bones | Neoplasm | OMIM:102660 | |
Cervical Cancer | Cervix cancer, Neoplasm | OMIM:603956 | |
Reticulum Cell Sarcoma | Neoplasm, Sarcoma | OMIM:267730 | |
Proteasome-Associated Autoinflammatory Syndrome 1 | Increased circulating IgG level, Increased circulating antibody level, Increased circulating IgA ... | OMIM:256040 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Psmb8tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Psmb8tm213117(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Psmb8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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