Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms:
Lmp-7,  Lmp7

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Psmb8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Psmb8 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Proteasome-Associated Autoinflammatory Syndrome 1
Increased circulating antibody level, Increased circulating IgG level, Increased circulating IgA ... OMIM:256040

The table below shows human diseases predicted to be associated to Psmb8 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nasopharyngeal Carcinoma, Susceptibility To, 2
Neoplasm OMIM:161550
Drug Metabolism, Poor, Cyp2D6-Related
Neoplasm OMIM:608902
Multiple Self-Healing Squamous Epithelioma, Susceptibility To
Neoplasm OMIM:132800
Cancer, Familial, With In Vitro Radioresistance
Neoplasm OMIM:114450
Adamantinoma Of Long Bones
Neoplasm OMIM:102660
Prostate Cancer, Hereditary, 1
Neoplasm, Prostate cancer OMIM:601518
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Cerebral Sarcoma
Neoplasm, Fibrosarcoma OMIM:117600
Keratosis, Familial Actinic
Neoplasm, Uterine neoplasm, Carcinoma OMIM:148390
Proteasome-Associated Autoinflammatory Syndrome 1
Increased circulating antibody level, Increased circulating IgG level, Increased circulating IgA ... OMIM:256040

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Psmb8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Psmb8.

No publications found that use IMPC mice or data for Psmb8.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Psmb8tm213117(L1L2_Bact_P) Targeting vectors
Psmb8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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