Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
regulator of G protein signaling 7
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rgs7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rgs7 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ataxia With Vitamin E Deficiency
Ataxia, Dysmetria, Mental deterioration, Abnormality of visual evoked potentials, Dysdiadochokine... ORPHA:96
Obesity Due To Sim1 Deficiency
Glucose intolerance, Hyperinsulinemia, Memory impairment, Cognitive impairment ORPHA:369873
Cortical Blindness-Intellectual Disability-Polydactyly Syndrome
Cachexia, Abnormality of visual evoked potentials, Short stature ORPHA:1389
Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Downslanted palpebral fissures, Abnormality of visual evoked potentials, Long eyelashes, Ptosis OMIM:617523
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria
Cachexia, Short stature, Abnormality of visual evoked potentials, Ptosis ORPHA:1933
Cln5 Disease
Ataxia, Inability to walk, Dysmetria, Mental deterioration, Abnormality of visual evoked potentia... ORPHA:228360
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1
Abnormality of visual evoked potentials, Memory impairment, Subcortical dementia, Gait disturbanc... OMIM:125310
Peroxisomal Acyl-Coa Oxidase Deficiency
Epicanthus, Abnormality of visual evoked potentials, Failure to thrive ORPHA:2971
Late Infantile Neuronal Ceroid Lipofuscinosis
Ataxia, Inability to walk, Abnormal amplitude of flash visual evoked potentials, Mental deteriora... ORPHA:168491
Oculocutaneous Albinism Type 1
White eyebrow, White eyelashes, Abnormality of visual evoked potentials ORPHA:352731
Ruvalcaba Syndrome
Abnormality of visual evoked potentials, Downslanted palpebral fissures, Delayed puberty, Intraut... ORPHA:3121
Developmental And Epileptic Encephalopathy 3
Abnormality of visual evoked potentials OMIM:609304
Autosomal Dominant Optic Atrophy Plus Syndrome
Bilateral ptosis, Abnormality of visual evoked potentials ORPHA:1215
Xq12-Q13.3 Duplication Syndrome
Epicanthus, Abnormality of visual evoked potentials, Short stature ORPHA:314389
Friedreich Ataxia
Ataxia, Limb ataxia, Abnormality of visual evoked potentials, Gait ataxia, Diabetes mellitus OMIM:229300
Pelizaeus-Merzbacher Disease
Cachexia, Abnormality of visual evoked potentials, Failure to thrive in infancy, Short stature ORPHA:702
Ichthyosis, Spastic Quadriplegia, And Mental Retardation
Growth delay, Abnormality of visual evoked potentials OMIM:614457
Charcot-Marie-Tooth Disease, Type 4D
Abnormality of visual evoked potentials OMIM:601455
Autosomal Recessive Spastic Paraplegia Type 44
Abnormality of visual evoked potentials ORPHA:320401
Canavan Disease
Abnormality of visual evoked potentials ORPHA:141
Stargardt Disease
Abnormality of visual evoked potentials ORPHA:827
White-Sutton Syndrome
Failure to thrive, Short stature, Upslanted palpebral fissure, Abnormality of visual evoked poten... OMIM:616364
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Abnormality of visual evoked potentials OMIM:601152
Micro Syndrome
Abnormality of visual evoked potentials, Intrauterine growth retardation, Delayed puberty, Short ... ORPHA:2510
Neurodegeneration With Brain Iron Accumulation 2A
Abnormality of visual evoked potentials OMIM:256600
Cerebellar Atrophy, Visual Impairment, And Psychomotor Retardation
Abnormality of visual evoked potentials OMIM:616875
Infantile Krabbe Disease
Failure to thrive, Abnormality of visual evoked potentials, Cachexia ORPHA:206436
Mohr-Tranebjaerg Syndrome
Abnormality of visual evoked potentials ORPHA:52368
Late-Infantile/Juvenile Krabbe Disease
Abnormality of visual evoked potentials ORPHA:206443
Infantile Neuroaxonal Dystrophy
Abnormality of visual evoked potentials ORPHA:35069
Achalasia-Addisonianism-Alacrima Syndrome
Abnormality of visual evoked potentials, Short stature OMIM:231550
Mff-Related Encephalopathy Due To Mitochondrial And Peroxisomal Fission Defect
Growth delay, Abnormality of visual evoked potentials ORPHA:485421
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Failure to thrive, Abnormality of visual evoked potentials OMIM:203700
Mogs-Cdg
Abnormality of visual evoked potentials, Long eyelashes, Short palpebral fissure ORPHA:79330
Global Developmental Delay-Visual Anomalies-Progressive Cerebellar Atrophy-Truncal Hypotonia Syndrome
Abnormality of visual evoked potentials ORPHA:480898
Hermansky-Pudlak Syndrome
Weight loss, Long eyelashes, Abnormality of visual evoked potentials ORPHA:79430
Oculocutaneous Albinism Type 1A
Abnormality of visual evoked potentials ORPHA:79431
Cockayne Syndrome B
Failure to thrive, Severe short stature, Severe failure to thrive, Small for gestational age, Abn... OMIM:133540
Metachromatic Leukodystrophy, Late Infantile Form
Abnormality of visual evoked potentials ORPHA:309256
Metachromatic Leukodystrophy, Juvenile Form
Abnormality of visual evoked potentials ORPHA:309263
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Abnormality of visual evoked potentials, Decreased body weight ORPHA:258
Cockayne Syndrome A
Failure to thrive, Short stature, Severe postnatal growth retardation, Abnormality of visual evok... OMIM:216400
Metachromatic Leukodystrophy, Adult Form
Abnormality of visual evoked potentials ORPHA:309271
Cerebrotendinous Xanthomatosis
Abnormality of visual evoked potentials, Abnormal eyelid morphology ORPHA:909
Metachromatic Leukodystrophy
Abnormality of visual evoked potentials ORPHA:512
Autosomal Recessive Malignant Osteopetrosis
Growth delay, Abnormality of visual evoked potentials ORPHA:667

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rgs7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rgs7.

No publications found that use IMPC mice or data for Rgs7.

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MGI Allele Allele Type Produced
Rgs7tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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