Gene: Sufu

Name
SUFU negative regulator of hedgehog signaling
MGI ID
MGI:1345643
Synonyms
b2b273Clo 2810026F04Rik Su(Fu)
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Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged lymph nodes Sufutm1b(KOMP)Wtsi HET postnatal 0.00
abnormal forebrain development Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
abnormal limb bud morphology Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
decreased eosinophil cell number Sufutm1b(KOMP)Wtsi HET postnatal 6.22×10-05
abnormal liver size Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal midbrain development Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
pale liver Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal hindbrain development Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
abnormal placenta size Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
pale yolk sac Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal stomach morphology Sufutm1b(KOMP)Wtsi HET postnatal 0.00
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
abnormal neural tube closure Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
embryonic growth retardation Sufutm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Sufutm1b(KOMP)Wtsi HOM n/a 0.00
abnormal eye morphology Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
embryonic lethality prior to tooth bud stage Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
pallor Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
decreased mean corpuscular volume Sufutm1b(KOMP)Wtsi HET postnatal 2.14×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No N/A
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2)  Section images
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415)  (1/2) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (1/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2)  Section images
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2)  Section images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 6  (6/485)  (2/6) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Ear 6  (1/485)  (2/6) N/A
Embryo 6  (1/485)  (2/6) N/A
Eye 6  (1/485)  (2/6) N/A
Foot 6  (1/485)  (2/6) N/A
Forebrain 6  (1/485)  (2/6) N/A
Forelimb 6  (1/485)  (2/6) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 6  (1/485)  (2/6) N/A
Head 6  (5/485)  (2/6) N/A
Heart 6  (1/485)  (2/6) N/A
Hindbrain 6  (6/485)  (2/6) N/A
Hindlimb 6  (1/485)  (2/6) N/A
Liver 6  (1/485)  (2/6) N/A
Lung 6  (1/485)  (2/6) N/A
Mandibular process 6  (1/485)  (2/6) N/A
Maxillary process 6  (1/485)  (2/6) N/A
Midbrain 6  (1/485)  (2/6) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 6  (1/485)  (2/6) N/A
2  (7/25) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 6  (1/485)  (2/6) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 6  (1/485)  (2/6) N/A
Tail somite 6  (1/485)  (2/6) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Lateral Orientation
10 Images
Eye Morphology: Images Ophthalmoscopy
2 Images
Embryo LacZ: LacZ images wholemount
16 Images
Adult LacZ: LacZ Images Section
21 Images
Gross Pathology and Tissue Collection
9 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sufutm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sufutm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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