Gene: Sufu

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Name
SUFU negative regulator of hedgehog signaling
MGI ID
MGI:1345643
Synonyms
2810026F04Rik b2b273Clo Su(Fu)
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal placenta size Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal stomach morphology Sufutm1b(KOMP)Wtsi HET Early adult 0.00
abnormal eye morphology Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal forebrain development Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal neural tube closure Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal hindbrain development Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
enlarged lymph nodes Sufutm1b(KOMP)Wtsi HET Early adult 0.00
abnormal midbrain development Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal limb bud morphology Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
embryonic growth retardation Sufutm1b(KOMP)Wtsi HOM E9.5 0.00
preweaning lethality, complete penetrance Sufutm1b(KOMP)Wtsi HOM Early adult 0.00
decreased mean corpuscular volume Sufutm1b(KOMP)Wtsi HET Early adult 2.14×10-05
pale liver Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
pale yolk sac Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
decreased eosinophil cell number Sufutm1b(KOMP)Wtsi HET Early adult 6.22×10-05
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal liver size Sufutm1b(KOMP)Wtsi HOM E12.5 0.00
pallor Sufutm1b(KOMP)Wtsi HOM E12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No N/A
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2)  Section images
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415)  (1/2) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (1/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2)  Section images
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2)  Section images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/61)  (2/2) N/A
Brain 6  (6/504)  (2/6) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Ear 6  (1/504)  (2/6) N/A
Embryo 6  (1/505)  (2/6) N/A
Eye 6  (1/504)  (2/6) N/A
Foot 6  (1/504)  (2/6) N/A
Forebrain 6  (1/504)  (2/6) N/A
Forelimb 6  (1/504)  (2/6) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 6  (1/503)  (2/6) N/A
Head 6  (5/504)  (2/6) N/A
Heart 6  (1/504)  (2/6) N/A
Hindbrain 6  (6/504)  (2/6) N/A
Hindlimb 6  (1/503)  (2/6) N/A
Liver 6  (1/504)  (2/6) N/A
Lung 6  (1/500)  (2/6) N/A
Mandibular process 6  (1/504)  (2/6) N/A
Maxillary process 6  (1/504)  (2/6) N/A
Midbrain 6  (1/504)  (2/6) N/A
Nose 2  (1/70)  (2/2) N/A
Oral cavity 6  (1/504)  (2/6) N/A
2  (7/37) N/A
Skeleton 2  (1/70)  (2/2) N/A
Skin 6  (1/504)  (2/6) N/A
Spinal cord 2  (1/69)  (2/2) N/A
Tail 6  (1/504)  (2/6) N/A
Tail somite 6  (1/504)  (2/6) N/A
Trachea 2  (1/56)  (2/2) N/A
Urinary system 2  (1/56)  (2/2) N/A

 Associated Images

Adult LacZ: LacZ Images Section
21 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Gross Pathology and Tissue Collection
9 Images
Embryo LacZ: LacZ images wholemount
24 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Sufutm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sufutm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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