Sufu | SUFU negative regulator of hedgehog signaling
Physiological systems
20 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Immune system Integument Adipose tissue Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Digestive/alimentary Behavior/neurological Mortality/aging Cardiovascular system
7 No significant impact
4 Not tested
Gene metrics:20Significant phenotypes
11Associated diseases
Expression examined in:41Adult tissues
30Embryo tissues
| abnormal neural tube closure | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Sufutm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| cardiovascular system phenotype | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | heterozygote | Early adult | 4.9x10-5 | ||
| pale liver | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal midbrain development | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal hindbrain development | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal limb bud morphology | 1 supporting dataset | Sufutm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 50% (1/2) | 1.67% (7/419) |
| eye | heterozygote | Section images | 100% (2/2) | 0% (0/335) |
| heart | heterozygote | Section images | 100% (2/2) | 0.36% (2/550) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Sufu.
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| Sufutm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sufutm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sufutm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |