Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
solute carrier family 30 (zinc transporter), member 3
Synonyms:
Znt3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc30a3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Slc30a3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Iron Overload In Africa
Elevated transferrin saturation OMIM:601195
Zinc Deficiency, Transient Neonatal
Decreased serum zinc OMIM:608118
Hyperzincemia With Functional Zinc Depletion
Increased serum zinc OMIM:601979
Gracile Syndrome
Increased circulating ferritin concentration, Increased serum pyruvate, Increased serum iron OMIM:603358
Cog2-Cdg
Small pituitary gland, Hypoplasia of the corpus callosum, Decreased circulating ceruloplasmin con... ORPHA:435934
Slc39A8-Cdg
Hypomanganesemia, Abnormal blood zinc concentration, Cerebral cortical atrophy ORPHA:468699
Neonatal Hemochromatosis
Increased circulating ferritin concentration, Increased serum iron ORPHA:446
Growth Delay-Intellectual Disability-Hepatopathy Syndrome
Microcephaly, Decreased serum zinc ORPHA:541423
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Decreased serum zinc OMIM:201100
Hemochromatosis Type 2
Increased circulating ferritin concentration, Elevated transferrin saturation, Abnormality of iro... ORPHA:79230
Hemochromatosis, Neonatal
Increased circulating ferritin concentration, Increased serum iron, Abnormality of iron homeostasis OMIM:231100
X-Linked Sideroblastic Anemia
Abnormality of iron homeostasis ORPHA:75563
Copper Deficiency, Familial Benign
Decreased circulating copper concentration, Abnormal circulating copper concentration OMIM:121270
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Decreased serum zinc, Decreased serum iron, Decreased plasma carnitine, Hypoalbuminemia, Abnormal... ORPHA:89842
Idiopathic Copper-Associated Cirrhosis
Increased circulating copper concentration ORPHA:209919
Mednik Syndrome
Decreased circulating ceruloplasmin concentration, Decreased circulating copper concentration ORPHA:171851
Hemochromatosis, Type 2B
Increased circulating ferritin concentration, Increased serum iron, Elevated transferrin saturation OMIM:613313
Lysinuric Protein Intolerance
Increased circulating ferritin concentration, Abnormal circulating serine concentration, Hypercho... ORPHA:470
Immunodeficiency 103, Susceptibility To Fungal Infections
Decreased serum iron OMIM:212050
Hemochromatosis, Type 3
Increased circulating ferritin concentration, Increased serum iron, Elevated transferrin saturation OMIM:604250
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Increased circulating ferritin concentration, Unconjugated hyperbilirubinemia, Increased serum ir... ORPHA:766
Irida Syndrome
Decreased circulating copper concentration ORPHA:209981
Gracile Syndrome
Increased circulating ferritin concentration, Elevated hepatic iron concentration, Decreased tran... ORPHA:53693
Hemochromatosis, Type 2A
Increased circulating ferritin concentration, Increased serum iron OMIM:602390
Bile Acid Synthesis Defect, Congenital, 5
Hyperbilirubinemia, Increased serum bile acid concentration, Increased total iron binding capacity OMIM:616278
Hemochromatosis, Type 4
Increased circulating ferritin concentration, Elevated transferrin saturation OMIM:606069
Familial Benign Copper Deficiency
Decreased circulating copper concentration ORPHA:1551
Aceruloplasminemia
Decreased serum iron, Increased circulating ferritin concentration, Aceruloplasminemia OMIM:604290
Beta-Thalassemia
Abnormality of iron homeostasis ORPHA:848
Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Due To Copper Metabolism Defect
Abnormal circulating copper concentration ORPHA:521411
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Abnormal circulating selenium concentration, Decreased serum zinc, Decreased plasma total carnitine ORPHA:79408
Aceruloplasminemia
Increased circulating ferritin concentration, Decreased serum iron, Decreased circulating cerulop... ORPHA:48818
Hypermanganesemia With Dystonia 1
Unconjugated hyperbilirubinemia, Increased total iron binding capacity, Hypermanganesemia OMIM:613280
Congenital Dyserythropoietic Anemia Type Iii
Increased serum iron, Hyperbilirubinemia, Increased total iron binding capacity ORPHA:98870
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Increased circulating ferritin concentration, Elevated hepatic iron concentration, Decreased tran... ORPHA:300298
Symptomatic Form Of Hemochromatosis Type 1
Increased circulating ferritin concentration, Elevated transferrin saturation, Abnormality of iro... ORPHA:465508
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Decreased circulating ferritin concentration, Abnormal globus pallidus morphology, Microcephaly, ... ORPHA:309854
Trichohepatoenteric Syndrome 2
Decreased serum iron OMIM:614602
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome
Decreased serum iron ORPHA:391372
Hemochromatosis, Type 1
Increased circulating ferritin concentration, Increased serum iron OMIM:235200
Microcephaly-Intellectual Disability-Sensorineural Hearing Loss-Epilepsy-Abnormal Muscle Tone Syndrome
Primary microcephaly, Microcephaly, Cerebral cortical atrophy, Hypoplasia of the corpus callosum,... ORPHA:457351
Beta-Thalassemia Intermedia
Elevated hepatic iron concentration, Abnormality of iron homeostasis ORPHA:231222
African Iron Overload
Increased circulating ferritin concentration, Elevated hepatic iron concentration, Elevated trans... ORPHA:139507
Dominant Beta-Thalassemia
Hypopituitarism, Abnormality of iron homeostasis ORPHA:231226
Trichohepatoenteric Syndrome 1
Hypermethioninemia, Increased serum iron, Hypoalbuminemia, Abnormality of iron homeostasis OMIM:222470
Porphyria Cutanea Tarda
Increased circulating ferritin concentration, Decreased hepcidin level, Elevated hepatic iron con... ORPHA:101330
Beta-Thalassemia Major
Hypopituitarism, Abnormality of iron homeostasis ORPHA:231214
Wilson Disease
High nonceruloplasmin-bound serum copper OMIM:277900
Retinitis Pigmentosa And Erythrocytic Microcytosis
Decreased serum iron OMIM:616959
Syndromic Diarrhea
Abnormality of iron homeostasis ORPHA:84064
Immunodeficiency 47
Decreased circulating copper concentration, Hypercholesterolemia OMIM:300972
Acute Transverse Myelitis
Decreased circulating copper concentration ORPHA:139417
Wrinkly Skin Syndrome
Thick cerebral cortex, Progressive microcephaly, High nonceruloplasmin-bound serum copper ORPHA:2834
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Abnormality of the anterior pituitary, Hyperintensity of cerebral white matter on MRI, Decreased ... ORPHA:438213
Paroxysmal Nocturnal Hemoglobinuria
Reduced haptoglobin level, Decreased serum iron, Unconjugated hyperbilirubinemia, Increased blood... ORPHA:447

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc30a3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc30a3.

No publications found that use IMPC mice or data for Slc30a3.

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MGI Allele Allele Type Produced
Slc30a3tm463645(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Slc30a3em1(IMPC)H Indel Mice

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