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Gene: Lynx1 MGI:1345180

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Ly6/neurotoxin 1
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lynx1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lynx1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Chudley-Mccullough Syndrome
Polymicrogyria, Cerebellar dysplasia, Hypoplasia of the corpus callosum, Cerebellar hypoplasia, D... OMIM:604213
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Mental deterioration, Cerebellar atrophy, Chorea, Limb ataxia, Gait ataxia, Decreased number of l... OMIM:208920
Neurodegeneration, Childhood-Onset, With Cerebellar Atrophy
Global brain atrophy, Cerebellar atrophy, Hypoplasia of the pons, Motor axonal neuropathy, Dyspla... OMIM:618276
Charcot-Marie-Tooth Disease, Dominant Intermediate B
Distal sensory impairment, Decreased number of peripheral myelinated nerve fibers, Axonal degener... OMIM:606482
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1
Cerebellar atrophy, Dysmetria, Decreased number of peripheral myelinated nerve fibers, Distal sen... OMIM:302800
Charcot-Marie-Tooth Disease, Axonal, Type 2P
Axonal degeneration/regeneration, Distal sensory impairment, Axonal degeneration, Peripheral axon... OMIM:614436
Polymicrogyria Due To Tubb2B Mutation
Abnormal corpus callosum morphology, Cerebellar atrophy, Hypoplasia of the pons, Lateral ventricl... ORPHA:300573
Charcot-Marie-Tooth Disease, Type 4A
Hypertrophic nerve changes, Basal lamina onion bulb formation, Distal sensory impairment, Decreas... OMIM:214400
Spinocerebellar Ataxia 23
Cerebellar atrophy, Impaired vibration sensation in the lower limbs, Limb ataxia, Gait ataxia, Dy... OMIM:610245
Cortical Dysplasia, Complex, With Other Brain Malformations 7
Cerebellar vermis hypoplasia, Polymicrogyria, Hypoplasia of the corpus callosum, Agenesis of corp... OMIM:610031
Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Cerebral atrophy, Chorea, Peripheral demyelination, Axonal degeneration, Peripheral hypomyelinati... OMIM:604168
Lissencephaly 3
Cerebellar vermis hypoplasia, Polymicrogyria, Periventricular laminar heterotopia, Hypoplasia of ... OMIM:611603
Ceroid Lipofuscinosis, Neuronal, 7
Mental deterioration, Optic atrophy, Cerebellar atrophy, Cerebral atrophy, Neurodegeneration, Ataxia OMIM:610951
Charcot-Marie-Tooth Disease, Type 4C
Basal lamina onion bulb formation, Abnormal cranial nerve morphology, Distal sensory impairment, ... OMIM:601596
Sin3A-Related Intellectual Disability Syndrome Due To A Point Mutation
Dysplastic corpus callosum, Short attention span, Mild malformation of cortical development, Abno... ORPHA:500166
Microcephaly 5, Primary, Autosomal Recessive
Small cerebral cortex, Hypoplasia of the corpus callosum, Agenesis of corpus callosum, Cerebellar... OMIM:608716
Charcot-Marie-Tooth Disease Type 2B1
Sensory axonal neuropathy, Decreased number of small peripheral myelinated nerve fibers, Motor ax... ORPHA:98856
Leukoencephalopathy, Progressive, With Ovarian Failure
Leukoencephalopathy, Cerebellar atrophy, Lateral ventricle dilatation, Neurodegeneration, Periven... OMIM:615889
Cortical Dysplasia, Complex, With Other Brain Malformations 6
Cerebellar vermis hypoplasia, Dysgenesis of the basal ganglia, Focal polymicrogyria, Dilated four... OMIM:615771
Schizencephaly
Cerebral cortical atrophy, Schizencephaly, Agenesis of corpus callosum OMIM:269160
Lissencephaly 4
Agenesis of corpus callosum, Cerebellar hypoplasia, Colpocephaly, Primary microcephaly, Lissencep... OMIM:614019
Neurodevelopmental Disorder With Microcephaly And Speech Delay, With Or Without Brain Abnormalities
Leukoencephalopathy, Reduced cerebral white matter volume, Secondary microcephaly, Dysplastic cor... OMIM:620317
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Decreased number of peripheral myelinated nerve fibers, Distal sensory impairment, Degeneration o... OMIM:604484
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Cerebellar hypoplasia, Polymicrogyria, Primary microcephaly, Agenesis of corpus callosum ORPHA:171703
Charcot-Marie-Tooth Disease, Axonal, Type 2S
Distal sensory impairment, Axonal degeneration OMIM:616155
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Cerebellar dysplasia OMIM:615041
Lissencephaly Due To Tuba1A Mutation
Cerebellar vermis hypoplasia, Dysgenesis of the basal ganglia, Polymicrogyria, Dilated fourth ven... ORPHA:171680
Neurodegeneration, Childhood-Onset, With Brain Atrophy
Cerebral cortical atrophy, Mental deterioration, Cerebellar atrophy, Cerebral atrophy, Neurodegen... OMIM:617672
Spastic Paraplegia 45, Autosomal Recessive
Dysplastic corpus callosum, Optic atrophy, Hypoplasia of the corpus callosum OMIM:613162
Mucolipidosis Iv
Optic atrophy, Cerebellar atrophy, Dysplastic corpus callosum, Microcephaly, Progressive neurolog... OMIM:252650
Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic lateral sclerosis, Axonal degeneration, Abnormal lower motor neuron morphology, Perip... OMIM:602433
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23
Abnormal cerebral white matter morphology, Axonal degeneration OMIM:618138
Spastic Paraplegia 35, Autosomal Recessive, With Or Without Neurodegeneration
Mental deterioration, Optic atrophy, Cerebellar atrophy, Neurodegeneration, Abnormal periventricu... OMIM:612319
Stxbp1-Related Encephalopathy
Dysplastic corpus callosum, Cerebral white matter atrophy, Ataxia ORPHA:599373
Combined Oxidative Phosphorylation Deficiency 29
Optic atrophy, Global brain atrophy, Cerebellar atrophy, Axonal degeneration, Microcephaly, Optic... OMIM:616811
Combined Oxidative Phosphorylation Defect Type 29
Diffuse cerebellar atrophy, Global brain atrophy, Neurodegeneration, Axonal degeneration, Primary... ORPHA:478029
Polymicrogyria With Optic Nerve Hypoplasia
Polymicrogyria, Agenesis of corpus callosum, Dysplastic corpus callosum, Colpocephaly, Optic nerv... ORPHA:250972
Pyruvate Dehydrogenase E3-Binding Protein Deficiency
Abnormal corpus callosum morphology, Cerebral atrophy, Periventricular cysts, Abnormal basal gang... ORPHA:255182
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Impaired vibration sensation in the lower limbs, Positive Romberg sign, Gait ataxia, Axonal degen... ORPHA:88628
Amyotrophy, Hereditary Neuralgic
Peripheral axonal degeneration, Axonal degeneration OMIM:162100
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 6
Peripheral axonal neuropathy, Axonal degeneration OMIM:620011
De Sanctis-Cacchione Syndrome
Mental deterioration, Optic atrophy, Global brain atrophy, Cerebral atrophy, Basal ganglia calcif... OMIM:278800
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Memory impairment, Global brain atrophy, Neurofibrillary tangles, Amyotrophic lateral sclerosis, ... OMIM:619132
Charcot-Marie-Tooth Disease, Axonal, Type 2R
Decreased number of peripheral myelinated nerve fibers, Peripheral axonal neuropathy, Axonal dege... OMIM:615490
Microcephaly, Short Stature, And Polymicrogyria With Or Without Seizures
Cerebellar atrophy, Polymicrogyria, Agenesis of corpus callosum, Dysplastic corpus callosum, Micr... OMIM:614833
Pontocerebellar Hypoplasia Type 2
Cerebellar vermis hypoplasia, Abnormal cortical gyration, Hypoplasia of the corpus callosum, Cere... ORPHA:2524
Combined Oxidative Phosphorylation Deficiency 54
Impaired vibratory sensation, Memory impairment, Secondary microcephaly, Periventricular nodular ... OMIM:619737
Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies 3
Cerebellar vermis hypoplasia, Cerebral atrophy, Small basal ganglia, Abnormal periventricular whi... OMIM:616900
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 5
Lissencephaly, Hypoplasia of the pons, Type II lissencephaly, Cerebellar dysplasia, Cerebellar cy... OMIM:613153
Mitochondrial Dna Depletion Syndrome 18
Axonal degeneration OMIM:618811
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 1
Peripheral axonal degeneration, Degeneration of anterior horn cells, Axonal degeneration OMIM:604320
Microcephaly 10, Primary, Autosomal Recessive
Reduced cerebral white matter volume, Cerebellar atrophy, Cerebral atrophy, Agenesis of corpus ca... OMIM:615095
Alzheimer Disease 4
Memory impairment, Neurofibrillary tangles, Cognitive impairment, Dementia, Senile plaques, Cereb... OMIM:606889
Cerebrotendinous Xanthomatosis
Optic atrophy, Global brain atrophy, Cerebellar atrophy, Somatic sensory dysfunction, Progressive... ORPHA:909
Adrenomyeloneuropathy
Memory impairment, Distal sensory impairment, Axonal degeneration, Peripheral axonal degeneration... ORPHA:139399
Joubert Syndrome 23
Dysplastic corpus callosum, Cerebellar dysplasia OMIM:616490
Alzheimer Disease 9, Susceptibility To
Cerebral cortical atrophy, Memory impairment, Neurofibrillary tangles, Hippocampal atrophy, Senil... OMIM:608907
Neurodegeneration With Brain Iron Accumulation 2B
Mental deterioration, Optic atrophy, Cerebellar atrophy, Neurofibrillary tangles, Cerebral atroph... OMIM:610217
Craniotelencephalic Dysplasia
Optic atrophy, Agenesis of corpus callosum, Cerebellar hypoplasia, Microcephaly, Septo-optic dysp... ORPHA:1528
Craniotelencephalic Dysplasia
Absent septum pellucidum, Agenesis of corpus callosum, Cerebellar hypoplasia, Lissencephaly, Opti... OMIM:218670
Weiss-Kruszka Syndrome
Dysplastic corpus callosum ORPHA:502430
Autosomal Recessive Cutis Laxa Type 2A
Cerebellar vermis hypoplasia, Secondary microcephaly, Cerebellar malformation, Dilated fourth ven... ORPHA:357058
Joubert Syndrome 30
Cerebellar atrophy, Polymicrogyria, Agenesis of corpus callosum, Gray matter heterotopia, Superio... OMIM:617622
Early-onset Alzheimer disease with cerebral amyloid angiopathy
Dementia, Senile plaques, Neurofibrillary tangles DECIPHER:48
Pyruvate Dehydrogenase E1-Beta Deficiency
Corticospinal tract hypoplasia, Periventricular cysts, Periventricular leukomalacia, Periventricu... ORPHA:255138
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Cerebral cortical atrophy, Memory impairment, Neurofibrillary tangles, Lateral ventricle dilatati... OMIM:607485
Bilateral Frontoparietal Polymicrogyria
Cerebellar vermis hypoplasia, Hypoplasia of the pons, Cerebellar dysplasia, Abnormal cerebellum m... ORPHA:101070
Kanzaki Disease
Cerebral atrophy, Distal sensory impairment, Axonal degeneration, Peripheral axonal neuropathy, W... OMIM:609242
Gerstmann-Straussler Disease
Memory impairment, Cerebellar atrophy, Neurofibrillary tangles, Limb ataxia, Gait ataxia, Dementi... OMIM:137440
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cerebral cortical atrophy, Cerebellar atrophy, Cerebral atrophy, Neurodegeneration, Limb ataxia, ... OMIM:615157
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 11
Leukoencephalopathy, Hypoplasia of the pons, Polymicrogyria, Type II lissencephaly, Cerebellar dy... OMIM:615181
Dworschak-Punetha Neurodevelopmental Syndrome
Agenesis of corpus callosum, Dysplastic corpus callosum, Peripheral axonal neuropathy, Colpocepha... OMIM:619955
Early-Onset Autosomal Dominant Alzheimer Disease
Cerebral cortical atrophy, Memory impairment, Neurofibrillary tangles, Confusion, Ataxia, Dementi... ORPHA:1020
Angioedema, Hereditary, 1
Hypoesthesia, Peripheral axonal neuropathy, Axonal degeneration OMIM:106100
Alzheimer Disease 3
Cerebral cortical atrophy, Memory impairment, Neurofibrillary tangles, Optic ataxia, Dementia OMIM:607822
Poretti-Boltshauser Syndrome
Cerebellar vermis hypoplasia, Cerebellar dysplasia, Dilated fourth ventricle, Abnormal periventri... OMIM:615960
Neurodevelopmental Disorder With Spasticity, Seizures, And Brain Abnormalities
Dysplastic corpus callosum, Cerebellar vermis hypoplasia, Microcephaly, Simplified gyral pattern OMIM:620001
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Mental deterioration, Optic atrophy, Neurodegeneration, Cerebral calcification, Periventricular h... OMIM:618476
Ataxia-Intellectual Disability-Oculomotor Apraxia-Cerebellar Cysts Syndrome
Inferior cerebellar vermis hypoplasia, Cerebellar dysplasia, Dilated fourth ventricle, Elongated ... ORPHA:370022
Neurodegeneration With Brain Iron Accumulation 5
Mental deterioration, Cerebellar atrophy, Cerebral atrophy, Eye of the tiger anomaly of globus pa... OMIM:300894
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion Pathology
Cerebral cortex with spongiform changes, Senile plaques, Neurofibrillary tangles OMIM:605055
Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities
Cerebellar atrophy, Focal polymicrogyria, Dysplastic corpus callosum, Microcephaly, Attention def... OMIM:619103
Microcephaly 20, Primary, Autosomal Recessive
Small cerebral cortex, Simplified gyral pattern, Hypoplasia of the corpus callosum, Agenesis of c... OMIM:617914
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Cerebellar hypoplasia, Peripheral axonal neuropathy, Dysplastic corpus callosum OMIM:618810
Even-Plus Syndrome
Dysplastic corpus callosum, Agenesis of corpus callosum OMIM:616854
Neurodegeneration With Brain Iron Accumulation 4
Mental deterioration, Optic atrophy, Cerebellar atrophy, Eye of the tiger anomaly of globus palli... OMIM:614298
Severe Growth Deficiency-Strabismus-Extensive Dermal Melanocytosis-Intellectual Disability Syndrome
Cerebral cortical atrophy, Lateral ventricle dilatation, Hypoplasia of the corpus callosum, Dyspl... ORPHA:488627
Parkinson Disease 23, Autosomal Recessive Early-Onset
Cerebral cortical atrophy, Mental deterioration, Neurofibrillary tangles, Lewy bodies, Dementia OMIM:616840
Mitochondrial Complex I Deficiency, Nuclear Type 39
Dysplastic corpus callosum OMIM:620135
Spongiform Encephalopathy With Neuropsychiatric Features
Dementia, Memory impairment, Neurofibrillary tangles, Cerebral cortex with spongiform changes OMIM:606688
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Dementia, Cerebral amyloid angiopathy, Neurofibrillary tangles, Ataxia OMIM:117300
Developmental And Epileptic Encephalopathy 49
Cerebellar vermis hypoplasia, Optic atrophy, Basal ganglia calcification, Cerebral calcification,... OMIM:617281
Cerebrofacioarticular Syndrome
Cerebellar vermis hypoplasia, Hypoplasia of the corpus callosum, Agenesis of corpus callosum, Dys... ORPHA:314679
Global Developmental Delay-Alopecia-Macrocephaly-Facial Dysmorphism-Structural Brain Anomalies Syndrome
Lateral ventricle dilatation, Periventricular cysts, Dysplastic corpus callosum, Hyperintensity o... ORPHA:544488
Niemann-Pick Disease, Type C1
Neurofibrillary tangles, Gait ataxia, Neuronal loss in central nervous system, Ataxia, Dementia OMIM:257220
Alzheimer Disease 2
Dementia, Neurofibrillary tangles OMIM:104310
Alzheimer Disease, Familial, 1
Dementia, Neurofibrillary tangles OMIM:104300
Glycosylphosphatidylinositol Biosynthesis Defect 17
Dysplastic corpus callosum, Microcephaly OMIM:618010
Microcephaly 26, Primary, Autosomal Dominant
Hypoplasia of the corpus callosum, Dysplastic corpus callosum, Microcephaly, Pachygyria, Simplifi... OMIM:619179
Kapur-Toriello Syndrome
Dysplastic corpus callosum, Patent ductus arteriosus, Pachygyria, Polymicrogyria ORPHA:2328
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 1
Dysplastic corpus callosum, Microcephaly OMIM:604273
Oculoskeletodental Syndrome
Dysplastic corpus callosum, Focal white matter lesions ORPHA:557003
Supranuclear Palsy, Progressive, 1
Neuronal loss in basal ganglia, Memory impairment, Neurofibrillary tangles, Cerebral atrophy, Fro... OMIM:601104
Genitourinary And/Or Brain Malformation Syndrome
Chiari malformation, Polymicrogyria, Secondary microcephaly, Absent septum pellucidum, Agenesis o... OMIM:618820
Combined Oxidative Phosphorylation Deficiency 53
Dysplastic corpus callosum, Secondary microcephaly OMIM:619423
Supranuclear Palsy, Progressive, 2
Neuronal loss in basal ganglia, Memory impairment, Neurofibrillary tangles, Frontolimbic dementia... OMIM:609454
Combined Oxidative Phosphorylation Deficiency 12
Dysplastic corpus callosum, Leukoencephalopathy, Hypoplasia of the corpus callosum, Agenesis of c... OMIM:614924
Thoc6-Related Developmental Delay-Microcephaly-Facial Dysmorphism Syndrome
Dysplastic corpus callosum, Patent ductus arteriosus ORPHA:363444
Neurodevelopmental Disorder With Ataxia, Hypotonia, And Microcephaly
Dysplastic corpus callosum, Microcephaly, Hypoplasia of the corpus callosum OMIM:618569
Niemann-Pick Disease, Type C2
Dementia, Neurofibrillary tangles, Ataxia OMIM:607625
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Optic atrophy, Abnormal cerebral cortex morphology, Global brain atrophy, Chiari malformation, La... ORPHA:500150
Adult-Onset Dystonia-Parkinsonism
Generalized cerebral atrophy/hypoplasia, Frontotemporal cerebral atrophy, Neurofibrillary tangles... ORPHA:199351
Zttk Syndrome
Optic atrophy, Periventricular leukomalacia, Hypoplasia of the corpus callosum, Cerebellar hypopl... OMIM:617140
Intellectual Developmental Disorder, X-Linked, Syndromic 34
Ataxia, Cerebellar hypoplasia, Dysplastic corpus callosum, Thick corpus callosum, Patent ductus a... OMIM:300967
Lenz-Majewski Hyperostotic Dwarfism
Dysplastic corpus callosum, Cerebral cortical atrophy, Microcephaly, Agenesis of corpus callosum OMIM:151050
Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome
Hypoplasia of the corpus callosum, Cerebellar hypoplasia, Chiari type I malformation, Dysplastic ... ORPHA:466791
White-Kernohan Syndrome
Dysplastic corpus callosum, Attention deficit hyperactivity disorder OMIM:619426
Witteveen-Kolk Syndrome
Hypoplasia of the corpus callosum, Dysplastic corpus callosum, Microcephaly, Attention deficit hy... OMIM:613406

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lynx1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lynx1.

No publications found that use IMPC mice or data for Lynx1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lynx1tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Lynx1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lynx1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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