Gene Summary

sodium channel, voltage-gated, type XI, alpha
NSS2,  NaN,  SNS2,  NaT

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Scn11aem1(IMPC)H HOM Early adult 1.87×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Lateral Orientation

4 Images

MicroCT E18.5

Embryo reconstruction

4 Images


XRay Images Whole Body Dorso Ventral

4 Images

Human diseases caused by Scn11a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Scn11a by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Primary Erythromelalgia
Erythema ORPHA:90026
Episodic Pain Syndrome, Familial, 3
Neuropathy, Hereditary Sensory And Autonomic, Type Vii
Paroxysmal Extreme Pain Disorder

The table below shows human diseases predicted to be associated to Scn11a by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Electroencephalographic Peculiarity: 14 And 6 Per Sec. Positive Spike Phenomenon
EEG abnormality OMIM:130200
Photoparoxysmal Response 1
EEG with photoparoxysmal response OMIM:132100
Electroencephalographic Peculiarity: Fronto-Precentral Beta Wave Groups
EEG abnormality OMIM:130300
Epilepsy, Benign Occipital
EEG abnormality OMIM:132090
Epilepsy, Reading
EEG abnormality OMIM:132300
EEG abnormality OMIM:181500
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Skin ulcer, Decreased motor nerve conduction velocity, Acral ulceration ORPHA:139578
Non-Epidermolytic Palmoplantar Keratoderma
Skin ulcer, Erythema ORPHA:2337
Proliferating Trichilemmal Cyst
Skin ulcer ORPHA:492
Dermatofibrosarcoma Protuberans
Skin ulcer, Erythema ORPHA:31112
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Chilblain Lupus 1
Skin ulcer OMIM:610448
Flynn-Aird Syndrome
Skin ulcer, EEG abnormality ORPHA:2047
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer, Decreased motor nerve conduction velocity OMIM:613640
Hereditary Sensory And Autonomic Neuropathy Type 1
Skin ulcer, Decreased amplitude of sensory action potentials, Penetrating foot ulcers ORPHA:36386
Complex Regional Pain Syndrome
Allodynia ORPHA:83452
Buerger Disease
Skin ulcer ORPHA:36258
Classic Mycosis Fungoides
Skin ulcer, Erythema, Dry skin ORPHA:2584
Aplasia Cutis Congenita
Skin ulcer ORPHA:1114
Skin ulcer ORPHA:231
Hyperkeratosis Lenticularis Perstans
Skin ulcer ORPHA:409
Excessive wrinkled skin, Skin ulcer ORPHA:2500
Juvenile Hyaline Fibromatosis
Skin ulcer ORPHA:2028
Dermatoosteolysis, Kirghizian Type
Skin ulcer OMIM:221810
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Skin ulcer, Purpura ORPHA:743
Aplasia Cutis-Myopia Syndrome
Skin ulcer ORPHA:1117
Chilblain Lupus
Skin ulcer ORPHA:90280
Necrobiosis Lipoidica
Skin ulcer, Erythema ORPHA:542592
Trigeminal Neuralgia
Allodynia ORPHA:221091
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Limited Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220402
Ollier Disease
Skin ulcer ORPHA:296
Anterior Cutaneous Nerve Entrapment Syndrome
Allodynia ORPHA:51890
Charcot-Marie-Tooth Disease With Ptosis And Parkinsonism
Penetrating foot ulcers, Decreased nerve conduction velocity OMIM:118301
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Skin ulcer, Pallor ORPHA:848
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Neurotrophic Keratopathy
Allodynia ORPHA:137596
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Skin ulcer, Pallor ORPHA:507
Polyarteritis Nodosa
Skin ulcer, Erythema ORPHA:767
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Takayasu Arteritis
Skin ulcer ORPHA:3287
Pyoderma Gangrenosum
Skin ulcer, Skin vesicle ORPHA:48104
Brooke-Spiegler Syndrome
Skin ulcer ORPHA:79493
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Skin ulcer ORPHA:69126
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Cryoglobulinemic Vasculitis
Skin ulcer, Purpura, Petechiae ORPHA:91138
Lichen Planopilaris
Skin ulcer ORPHA:525
Dermatoosteolysis, Kirghizian Type
Skin ulcer ORPHA:1657
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Familial Multiple Nevi Flammei
Skin ulcer ORPHA:624
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Skin ulcer ORPHA:280062
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Benign Schwannoma
Allodynia ORPHA:252164
X-Linked Agammaglobulinemia
Skin ulcer ORPHA:47
Prolidase Deficiency
Skin ulcer, Petechiae OMIM:170100
Infantile Myofibromatosis
Skin ulcer ORPHA:2591
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Skin ulcer, Erythema ORPHA:659
Prolidase Deficiency
Skin ulcer, Erythema, Dry skin ORPHA:742
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Acquired Purpura Fulminans
Macular purpura, Pyoderma gangrenosum ORPHA:49566
Familial Keratoacanthoma
Skin ulcer ORPHA:493
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Skin ulcer ORPHA:86884
Autosomal Dominant Hyper-Ige Syndrome
Skin ulcer, Skin vesicle ORPHA:2314
Werner Syndrome
Skin ulcer, Lack of skin elasticity ORPHA:902
Reynolds Syndrome
Skin ulcer ORPHA:779
Neutrophilic Dermatosis, Acute Febrile
Erythema, Pyoderma gangrenosum OMIM:608068
Acrodermatitis Enteropathica
Skin ulcer, Erythema, Dry skin ORPHA:37
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Livedoid Vasculopathy
Skin ulcer, Macular purpura, Ecchymosis ORPHA:542643
Charcot-Marie-Tooth Disease Type 4B2
Decreased distal sensory nerve action potential, Penetrating foot ulcers ORPHA:99956
Microscopic Polyangiitis
Skin ulcer, Erythema ORPHA:727
Hereditary Spherocytosis
Skin ulcer, Pallor ORPHA:822
Chronic Mucocutaneous Candidiasis
Skin ulcer, Erythema ORPHA:1334
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Beta-Thalassemia Intermedia
Skin ulcer, Pallor ORPHA:231222
Infantile Systemic Hyalinosis
Skin ulcer ORPHA:2176
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Meige Disease
Skin ulcer ORPHA:90186
Dominant Beta-Thalassemia
Skin ulcer, Pallor ORPHA:231226
Giant Cell Arteritis
Skin ulcer ORPHA:397
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Adult Syndrome
Skin ulcer, Dry skin ORPHA:978
Chronic Granulomatous Disease
Skin ulcer ORPHA:379
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Juvenile Dermatomyositis
Skin ulcer, Erythema, Dry skin ORPHA:93672
Beta-Thalassemia Major
Skin ulcer, Pallor ORPHA:231214
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Allodynia OMIM:603041
Incontinentia Pigmenti
Skin ulcer, Erythema ORPHA:464
Skin ulcer ORPHA:443811
Immunoglobulin A Vasculitis
Skin ulcer, Purpura, Erythema ORPHA:761
Cushing Disease
Purpura, Striae distensae, Ecchymosis, Skin ulcer, Fatiguable weakness of proximal limb muscles ORPHA:96253
Hereditary Acrokeratotic Poikiloderma
Skin ulcer, Erythema ORPHA:2907
Toxic Epidermal Necrolysis
Skin ulcer, Erythema ORPHA:537
Hajdu-Cheney Syndrome
Skin ulcer, Dry skin ORPHA:955
Dyskeratosis Congenita
Skin ulcer, Skin vesicle ORPHA:1775
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Oculocerebrorenal Syndrome Of Lowe
Skin ulcer, EEG abnormality ORPHA:534
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Skin ulcer, Purpura OMIM:615688
Skin ulcer ORPHA:228119
Wiskott-Aldrich Syndrome
Skin ulcer, Purpura, Petechiae ORPHA:906
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Skin ulcer, Scaling skin, Dry skin ORPHA:2526
Sweet Syndrome
Skin vesicle, Pyoderma gangrenosum ORPHA:3243
Systemic Sclerosis
Acral ulceration, Digital ulcer ORPHA:90291
Chime Syndrome
Skin ulcer, Erythema ORPHA:3474
Parkes Weber Syndrome
Skin ulcer, Scaling skin ORPHA:90307
Amoebiasis Due To Free-Living Amoebae
Skin ulcer ORPHA:68
Skin ulcer ORPHA:556
Skin ulcer, Erythema, Dry skin ORPHA:221
Granulomatosis With Polyangiitis
Skin ulcer, Purpura ORPHA:900
Primary Sjögren Syndrome
Skin ulcer, Purpura, Dry skin ORPHA:289390
Blau Syndrome
Skin ulcer OMIM:186580
Angioosteohypertrophic Syndrome
Skin ulcer ORPHA:2346
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Atypical Werner Syndrome
Skin ulcer, Lack of skin elasticity ORPHA:79474
Cushing Syndrome Due To Ectopic Acth Secretion
Purpura, Striae distensae, Ecchymosis, Skin ulcer, Fatiguable weakness of proximal limb muscles ORPHA:99889
Blau Syndrome
Skin ulcer, Erythema, Dry skin ORPHA:90340
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Chronic Graft Versus Host Disease
Skin ulcer, Skin vesicle, Erythema ORPHA:99921
Penetrating foot ulcers, Acral ulceration ORPHA:548
Skin ulcer, Dry skin ORPHA:707
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Skin ulcer ORPHA:95455
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Split Cord Malformation
Penetrating foot ulcers ORPHA:573278
Primary Erythromelalgia
Erythema ORPHA:90026
Neuropathy, Hereditary Sensory And Autonomic, Type Vii
Episodic Pain Syndrome, Familial, 3
Paroxysmal Extreme Pain Disorder


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Scn11a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Scn11a.

No publications found that use IMPC mice or data for Scn11a.

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MGI Allele Allele Type Produced
Scn11aem1(IMPC)H Exon Deletion Mice
Scn11aem2(IMPC)H Exon Deletion Mice
Scn11atm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Scn11atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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