Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger E-box binding homeobox 2
Synonyms:
9130203F04Rik,  SIP1,  Zfx1b,  Zfhx1b,  D130016B08Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zeb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Zeb2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

The table below shows human diseases predicted to be associated to Zeb2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Acalvaria
Abnormality of neuronal migration, Holoprosencephaly, Hydrocephalus, Spina bifida ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Subependymal Nodular Heterotopia
Occipital encephalocele, Polymicrogyria, Myelomeningocele, Abnormality of neuronal migration, Nas... ORPHA:101030
Lambert Syndrome
Branchial anomaly ORPHA:1296
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Wildervanck Syndrome
Low posterior hairline, Webbed neck, Meningocele, Short neck ORPHA:3456
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida, Gray matter heterotopia OMIM:207950
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Branchiogenic-Deafness Syndrome
Branchial fistula, Branchial cyst OMIM:609166
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Schisis Association
Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Isolated Klippel-Feil Syndrome
Webbed neck, Congenital muscular torticollis, Low posterior hairline, Short neck, Spina bifida ORPHA:2345
Diaphanospondylodysostosis
Myelomeningocele, Short neck ORPHA:66637
Humero-Radial Synostosis
Meningocele ORPHA:3265
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Meckel Syndrome, Type 2
Cystic hygroma, Meningocele, Anencephaly, Encephalocele OMIM:603194
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
Meckel Syndrome, Type 4
Hydrocephalus, Meningocele, Anencephaly, Encephalocele OMIM:611134
X-Linked Mandibulofacial Dysostosis
Webbed neck, Branchial anomaly ORPHA:1131
Intellectual Developmental Disorder, Autosomal Dominant 72
Short neck, Spina bifida OMIM:620439
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Encephalocele, Hydrocephalus, Meningocele, Holoprosencephaly, Anencephaly ORPHA:1908
Branchiogenic Deafness Syndrome
Branchial fistula, Branchial cyst ORPHA:50815
Isolated Posterior Meningocele
Limitation of neck motion, Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocel... ORPHA:268810
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Verheij Syndrome
Short neck, Branchial cyst OMIM:615583
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Neurocutaneous Melanocytosis
Abnormality of neuronal migration, Meningocele ORPHA:2481
Enlarged Parietal Foramina
Myelomeningocele, Occipital encephalocele ORPHA:60015
Camptodactyly Syndrome, Guadalajara Type 1
Abnormality of dental eruption, Spina bifida ORPHA:1327
Czeizel-Losonci Syndrome
Myelomeningocele, Hydrocephalus, Spina bifida, Thickened nuchal skin fold, Spina bifida occulta ORPHA:2437
Amish Lethal Microcephaly
Spina bifida, Lissencephaly ORPHA:99742
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Iniencephaly
Spinal dysraphism, Myelomeningocele, Encephalocele, Hydrocephalus, Spina bifida, Cystic hygroma, ... ORPHA:63259
Triploidy
Meningocele, Holoprosencephaly, Hydrocephalus, Short neck ORPHA:3376
Bor Syndrome
Branchial cyst ORPHA:107
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Autosomal Recessive Spondylocostal Dysostosis
Spina bifida occulta, Meningocele, Short neck, Umbilical hernia ORPHA:2311
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Branchiootorenal Syndrome 1
Branchial fistula, Branchial cyst OMIM:113650
Neu-Laxova Syndrome 2
Short neck, Spina bifida, Lissencephaly OMIM:616038
Cerebrocostomandibular Syndrome
Webbed neck, Hydranencephaly, Myelomeningocele, Spina bifida, Meningocele ORPHA:1393
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Gray matter heterotopia, Cystic hygroma, Increased nuchal translucency, Branchial anomaly ORPHA:453499
Joubert Syndrome 14
Hydrocephalus, Meningocele, Encephalocele OMIM:614424
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Fliedner-Zweier Syndrome
Meningocele OMIM:620511
Holoprosencephaly
Spinal dysraphism, Branchial anomaly, Encephalocele, Abnormality of neuronal migration, Short nec... ORPHA:2162
Acromelic Frontonasal Dysplasia
Meningocele, Encephalocele ORPHA:1827
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Lateral Meningocele Syndrome
Low posterior hairline, Short neck, Meningocele, Umbilical hernia ORPHA:2789
Chromosome 17P13.1 Deletion Syndrome
Webbed neck, Broad neck, Umbilical hernia, Short neck, Hydrocephalus, Spina bifida OMIM:613776
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Oligomeganephronia
Branchial cyst ORPHA:2260
Neu-Laxova Syndrome
Abnormal cortical gyration, Polymicrogyria, Abnormality of neuronal migration, Spina bifida, Pach... ORPHA:2671
Lateral Meningocele Syndrome
Short neck, Meningocele, Hydrocephalus, Umbilical hernia OMIM:130720
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele, Polymicrogyria OMIM:601707
Trisomy 20P
Low posterior hairline, Short neck, Spina bifida, Umbilical hernia ORPHA:261318
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Gray matter heterotopia, Cystic hygroma, Increased nuchal translucency, Branchial anomaly ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Gray matter heterotopia, Cystic hygroma, Increased nuchal translucency, Branchial anomaly ORPHA:352665
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polymicrogyria, Occipital meningocele, Short neck, Hydrocephalus, Anencephaly OMIM:616546
Pagod Syndrome
Abnormality of neuronal migration, Meningocele, Encephalocele, Spina bifida ORPHA:991
Mosaic Trisomy 9
Cystic hygroma, Webbed neck, Short neck, Spina bifida ORPHA:99776
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Distal 22Q11.2 Microdeletion Syndrome
Branchial fistula ORPHA:261330
Vacterl With Hydrocephalus
Aqueductal stenosis, Hydrocephalus, Spina bifida ORPHA:3412
Distal 22Q11.2 Microduplication Syndrome
Low posterior hairline, Webbed neck, Branchial fistula, Hydrocephalus ORPHA:261337
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Meningocele, Occipital encephalocele, Redundant neck skin ORPHA:397715
Treacher-Collins Syndrome
Branchial fistula, Encephalocele ORPHA:861
Limb Body Wall Complex
Myelomeningocele, Encephalocele, Short umbilical cord, Hydrocephalus, Spina bifida, Spina bifida ... ORPHA:2369
Trisomy 18
Webbed neck, Holoprosencephaly, Anencephaly, Spina bifida ORPHA:3380
Nail-Patella Syndrome
Spina bifida OMIM:161200
Lathosterolosis
Meningocele ORPHA:46059
Fibular Hemimelia
Spina bifida ORPHA:93323
Orofaciodigital Syndrome Vi
Periventricular nodular heterotopia, Occipital meningocele, Polymicrogyria OMIM:277170
Aicardi Syndrome
Pachygyria, Gray matter heterotopia, Spina bifida, Polymicrogyria OMIM:304050
Phocomelia, Schinzel Type
Meningocele, Short neck ORPHA:2879
Hallermann-Streiff Syndrome
Natal tooth, Spina bifida OMIM:234100
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Neu-Laxova Syndrome 1
Broad neck, Hydranencephaly, Small placenta, Short umbilical cord, Neonatal death, Short neck, Sp... OMIM:256520
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Natal tooth, Branchial cyst OMIM:620186
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Jacobsen Syndrome
Pachygyria, Webbed neck, Short neck, Spina bifida ORPHA:2308
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Knobloch Syndrome 1
Spina bifida occulta, Occipital encephalocele, Occipital meningocele, Polymicrogyria OMIM:267750
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Short neck, Spina bifida ORPHA:508498
8Q24.3 Microdeletion Syndrome
Spina bifida occulta, Short neck, Branchial cyst ORPHA:508488
Arima Syndrome
Gray matter heterotopia, Occipital meningocele OMIM:243910
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida, Torticollis OMIM:619480
Campomelic Dysplasia
Hydrocephalus, Spinal dysraphism, Spina bifida OMIM:114290
Holoprosencephaly 9
Abnormal cortical gyration, Alobar holoprosencephaly, Short neck, Hydrocephalus, Holoprosencephal... OMIM:610829
22Q11.2 Deletion Syndrome
Umbilical hernia, Short neck, Hydrocephalus, Spina bifida, Meningocele ORPHA:567
Fanconi Anemia
Hydrocephalus, Spina bifida, Umbilical hernia ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Branchiooculofacial Syndrome
Low posterior hairline, Short neck, Branchial anomaly OMIM:113620
Vater/Vacterl Association
Patent urachus, Occipital encephalocele, Spina bifida OMIM:192350
Witteveen-Kolk Syndrome
Bilateral polymicrogyria, Branchial fistula OMIM:613406
Cutis Laxa, Autosomal Recessive, Type Ib
Spina bifida, Neonatal death OMIM:614437
Rubinstein-Taybi Syndrome 1
Low posterior hairline, Spina bifida occulta, Spina bifida OMIM:180849
Otopalatodigital Syndrome, Type Ii
Umbilical hernia, Short neck, Hydrocephalus, Spina bifida, Stillbirth OMIM:304120
Marfan Syndrome
Meningocele ORPHA:558
Femoral-Facial Syndrome
Encephalocele, Spina bifida OMIM:134780
Craniofacial Microsomia 1
Branchial anomaly, Occipital encephalocele, Hydrocephalus OMIM:164210
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Broad neck, Short neck, Occipital meningocele OMIM:276820
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zeb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zeb2.

No publications found that use IMPC mice or data for Zeb2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Zeb2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zeb2tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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