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Gene: Zeb2 MGI:1344407

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger E-box binding homeobox 2
Synonyms:
9130203F04Rik,  SIP1,  Zfx1b,  Zfhx1b,  D130016B08Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zeb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Zeb2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

The table below shows human diseases predicted to be associated to Zeb2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Frontal Encephalocele
Hydrocephalus, Spina bifida, Encephalocele ORPHA:1931
Acalvaria
Abnormality of neuronal migration, Hydrocephalus, Spina bifida, Holoprosencephaly ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Lambert Syndrome
Branchial anomaly ORPHA:1296
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Chiari Malformation Type Ii
Myelomeningocele, Hydrocephalus, Gray matter heterotopia, Spina bifida, Cervical myelopathy OMIM:207950
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Nevus Comedonicus Syndrome
Spina bifida, Spina bifida occulta ORPHA:64754
Schisis Association
Encephalocele, Spina bifida, Anencephaly ORPHA:63862
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Isolated Klippel-Feil Syndrome
Short neck, Congenital muscular torticollis, Webbed neck, Spina bifida, Low posterior hairline ORPHA:2345
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Short neck, Cervical spina bifida, Low posterior hairline OMIM:600122
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Amish Lethal Microcephaly
Spina bifida, Lissencephaly ORPHA:99742
X-Linked Mandibulofacial Dysostosis
Webbed neck, Branchial anomaly ORPHA:1131
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula ORPHA:50815
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Camptodactyly Syndrome, Guadalajara Type 1
Abnormality of dental eruption, Spina bifida ORPHA:1327
Czeizel-Losonci Syndrome
Myelomeningocele, Hydrocephalus, Thickened nuchal skin fold, Spina bifida occulta, Spina bifida ORPHA:2437
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Iniencephaly
Myelomeningocele, Hydrocephalus, Holoprosencephaly, Anencephaly, Spinal dysraphism, Lissencephaly... ORPHA:63259
Bor Syndrome
Branchial cyst ORPHA:107
Posterior Meningocele
Occipital meningocele, Hydrocephalus, Neural tube defect, Limitation of neck motion, Meningocele,... ORPHA:268810
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
Fountain Syndrome
Spina bifida, Spina bifida occulta ORPHA:3219
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Neu-Laxova Syndrome 2
Short neck, Spina bifida, Lissencephaly OMIM:616038
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Cerebrocostomandibular Syndrome
Myelomeningocele, Hydranencephaly, Meningocele, Webbed neck, Spina bifida ORPHA:1393
Holoprosencephaly
Hydrocephalus, Holoprosencephaly, Short neck, Spinal dysraphism, Branchial anomaly, Abnormality o... ORPHA:2162
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Cystic hygroma, Gray matter heterotopia, Increased nuchal translucency, Branchial anomaly ORPHA:453499
Pelvis-Shoulder Dysplasia
Hydrocephalus, Spina bifida, Hydranencephaly ORPHA:2839
Neu-Laxova Syndrome
Abnormal cortical gyration, Polymicrogyria, Lissencephaly, Abnormality of neuronal migration, Pac... ORPHA:2671
Oligomeganephronia
Branchial cyst ORPHA:2260
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Trisomy 20P
Short neck, Spina bifida, Low posterior hairline, Umbilical hernia ORPHA:261318
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Cystic hygroma, Gray matter heterotopia, Increased nuchal translucency, Branchial anomaly ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Cystic hygroma, Gray matter heterotopia, Increased nuchal translucency, Branchial anomaly ORPHA:352665
Vacterl With Hydrocephalus
Hydrocephalus, Spina bifida, Aqueductal stenosis, Arrhinencephaly ORPHA:3412
Pagod Syndrome
Abnormality of neuronal migration, Encephalocele, Spina bifida, Meningocele ORPHA:991
Mosaic Trisomy 9
Short neck, Cystic hygroma, Spina bifida, Webbed neck ORPHA:99776
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Distal 22Q11.2 Microduplication Syndrome
Hydrocephalus, Webbed neck, Low posterior hairline, Branchial fistula ORPHA:261337
Distal 22Q11.2 Microdeletion Syndrome
Branchial fistula ORPHA:261330
Trisomy 18
Webbed neck, Spina bifida, Anencephaly, Holoprosencephaly ORPHA:3380
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Treacher-Collins Syndrome
Branchial fistula, Encephalocele ORPHA:861
Nail-Patella Syndrome
Spina bifida OMIM:161200
Limb Body Wall Complex
Myelomeningocele, Hydrocephalus, Short umbilical cord, Anencephaly, Spina bifida occulta, Encepha... ORPHA:2369
Fibular Hemimelia
Spina bifida ORPHA:93323
Aicardi Syndrome
Gray matter heterotopia, Pachygyria, Spina bifida, Polymicrogyria OMIM:304050
Neu-Laxova Syndrome 1
Short umbilical cord, Short neck, Hydranencephaly, Small placenta, Lissencephaly, Spina bifida, S... OMIM:256520
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Basal Cell Nevus Syndrome
Hydrocephalus, Spina bifida OMIM:109400
Hallermann-Streiff Syndrome
Spina bifida, Natal tooth OMIM:234100
Neurofibromatosis, Type I
Hydrocephalus, Spina bifida, Aqueductal stenosis OMIM:162200
Jacobsen Syndrome
Short neck, Pachygyria, Spina bifida, Webbed neck ORPHA:2308
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Short neck, Spina bifida ORPHA:508498
22Q11.2 Deletion Syndrome
Hydrocephalus, Short neck, Arrhinencephaly, Umbilical hernia, Meningocele, Spina bifida, Occipita... ORPHA:567
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Torticollis, Spina bifida OMIM:619480
Campomelic Dysplasia
Spinal dysraphism, Hydrocephalus, Spina bifida OMIM:114290
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Branchiooculofacial Syndrome
Short neck, Low posterior hairline, Branchial anomaly OMIM:113620
Fanconi Anemia
Hydrocephalus, Spina bifida, Umbilical hernia ORPHA:84
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Witteveen-Kolk Syndrome
Branchial fistula, Bilateral polymicrogyria OMIM:613406
Rubinstein-Taybi Syndrome 1
Spina bifida, Low posterior hairline, Spina bifida occulta OMIM:180849
Split Cord Malformation
Myelomeningocele, Hydrocephalus, Cervical spina bifida, Meningocele, Lipomyelomeningocele ORPHA:573278
Vater/Vacterl Association
Spina bifida, Occipital encephalocele, Patent urachus OMIM:192350
Craniofacial Microsomia
Hydrocephalus, Occipital encephalocele, Branchial anomaly OMIM:164210
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
8Q24.3 Microdeletion Syndrome
Branchial cyst, Short neck, Spina bifida occulta ORPHA:508488
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Periventricular heterotopia, Delayed eruption of teeth, Polymicrogyria ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zeb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zeb2.

No publications found that use IMPC mice or data for Zeb2.

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MGI Allele Allele Type Produced
Zeb2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zeb2tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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