Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mediator complex subunit 24
Synonyms:
Gse2,  Pparb2,  R75526,  Trap100,  100kDa,  Thrap4,  D11Ertd307e,  DRIP100

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Med24 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Med24 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cardiomyopathy, Dilated, 1R
Congestive heart failure, Restrictive cardiomyopathy, Cardiomyocyte hypertrophy, Ventricular arrh... OMIM:613424
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Left Ventricular Noncompaction 1
Congestive heart failure, Patent ductus arteriosus, Palpitations, Atrial fibrillation, Noncompact... OMIM:604169
Hemoglobin D Disease
Anemia, HbS hemoglobin, Reduced alpha/beta synthesis ratio, Sickled erythrocytes, Decreased mean ... ORPHA:90039
Cardiomyopathy, Dilated, 1C, With Or Without Left Ventricular Noncompaction
Congestive heart failure, Endocardial fibrosis, Left bundle branch block, Ventricular arrhythmia,... OMIM:601493
Isobutyryl-Coa Dehydrogenase Deficiency
Dilated cardiomyopathy, Anemia OMIM:611283
Cardiomyopathy, Dilated, 1Aa, With Or Without Left Ventricular Noncompaction
Endocardial fibrosis, Atrial fibrillation, Supraventricular tachycardia, Cardiac arrest, Hypertro... OMIM:612158
Congenital Amegakaryocytic Thrombocytopenia
Thrombocytopenia, Anemia, Abnormal hemoglobin, Abnormal cardiac septum morphology ORPHA:3319
Diamond-Blackfan Anemia 16
Pulmonic stenosis, Atrial septal defect, Anemia OMIM:617408
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Camptodactyly, Spina bifida, Mitral valve prolapse, Small hypothenar eminence, Small thenar emine... OMIM:211960
Atrial Standstill
Bradycardia, Cardiomyopathy, Abnormal heart morphology, Mobitz I atrioventricular block, Ventricu... ORPHA:1344
Attrv122I Amyloidosis
Abnormal atrioventricular conduction, Congestive heart failure, Anemia, Reduced left ventricular ... ORPHA:85451
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ventricular septal defect, Anencephaly, Spina bifida, Hypoplastic left heart ORPHA:2476
Eosinophilia, Familial
Anemia, Myocardial eosinophilic infiltration, Leukocytosis, Thrombocytopenia, Eosinophilia OMIM:131400
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Fetal Parvovirus Syndrome
Thrombocytopenia, Anemia, Hypertrophic cardiomyopathy ORPHA:295
Peripartum Cardiomyopathy
Left atrial enlargement, Hypertension, Sinus tachycardia, Heart murmur, Left ventricular hypertro... ORPHA:563
Sick Sinus Syndrome 2
Paroxysmal atrial fibrillation, Sick sinus syndrome, Aortic regurgitation, Atrial fibrillation, P... OMIM:163800
Neonatal Lupus Erythematosus
Aplastic anemia, Heart block, Prolonged QT interval, Anemia, Pancytopenia, Hydrocephalus, Abnorma... ORPHA:398124
Mitochondrial Complex I Deficiency, Nuclear Type 39
Perimembranous ventricular septal defect, Anemia, Hypertrophic cardiomyopathy, Cardiomegaly, Atri... OMIM:620135
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Congenital diaphragmatic hernia, Atrioventricular canal defect, Abnormal aortic valve morphology,... ORPHA:1120
Thoraco-Abdominal Enteric Duplication
Camptodactyly of finger, Abnormal tricuspid valve morphology, Dextrocardia, Meningocele ORPHA:1759
Takayasu Arteritis
Abnormal endocardium morphology, Abnormal aortic valve morphology, Anemia, Abnormal heart valve m... ORPHA:3287
Transaldolase Deficiency
Anemia, Coarctation of aorta, Hepatosplenomegaly, Thrombocytopenia, Atrial septal defect, Biventr... ORPHA:101028
Aminopterin/Methotrexate Embryofetopathy
Situs inversus totalis, Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Pulmonary artery ... ORPHA:1908
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Hb Bart'S Hydrops Fetalis
Congestive heart failure, Anemia, Hydrocephalus, Pericarditis, Splenomegaly, Abnormal hemoglobin ORPHA:163596
Long Qt Syndrome 15
2:1 atrioventricular block, Polymorphic ventricular tachycardia, Ventricular bigeminy, Bradycardi... OMIM:616249
Cardiomyopathy, Dilated, 1D
Congestive heart failure, Prolonged QT interval, Reduced left ventricular ejection fraction, Inco... OMIM:601494
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Erythroid hyperplasia, Anemia, Increased mean corpuscular volume, Extramedullary hematopoiesis, H... OMIM:617021
Anemia, Congenital Dyserythropoietic, Type Iv
Reduced hematocrit, Anemia, Anemia of inadequate production, Hypertrophic cardiomyopathy, Reticul... OMIM:613673
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Meckel Syndrome, Type 4
Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Atrial septal defect, Ventricular septal ... OMIM:611134
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Chronic hemolytic anemia, Anemia, Reduced red cell pyruvate kinase level, Reticulocytosis, Poikil... ORPHA:766
Cardiomyopathy, Dilated, 1S
Congestive heart failure, Perimembranous ventricular septal defect, Reduced left ventricular ejec... OMIM:613426
Isolated Klippel-Feil Syndrome
Congenital muscular torticollis, Ventricular septal defect, Spina bifida ORPHA:2345
Cardiac Diverticulum
Premature ventricular contraction, Aortic valve stenosis, Abnormal heart morphology, Arrhythmia, ... ORPHA:1686
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Congenitally Corrected Transposition Of The Great Arteries
Mesocardia, Bradycardia, Pulmonic stenosis, Discordant atrioventricular connection, Abnormal hear... ORPHA:216694
Alpha-Thalassemia
Anisopoikilocytosis, Congestive heart failure, Hemoglobin Barts, Anemia, Reticulocytosis, Pericar... ORPHA:846
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Abnormal aortic morphology, Ventricular septal defect, Abnormal tricuspid valve morphology, Anemia ORPHA:3405
Pagod Syndrome
Congenital diaphragmatic hernia, Situs inversus totalis, Encephalocele, Meningocele, Abnormal aor... ORPHA:991
Dohle Bodies And Leukemia
Secundum atrial septal defect, Anemia, Acute myeloid leukemia, Leukocyte inclusion bodies OMIM:223350
Alg3-Cdg
Neural tube defect, Coarctation of the descending aortic arch, Cardiomyopathy, Arthrogryposis mul... ORPHA:79321
Schisis Association
Congenital diaphragmatic hernia, Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Subependymal Nodular Heterotopia
Occipital encephalocele, Nasofrontal encephalocele, Myelomeningocele, Meningocele ORPHA:101030
Neural Tube Defects, Susceptibility To
Hydrocephalus, Myelomeningocele, Anencephaly, Spina bifida occulta OMIM:182940
Chiari Malformation Type Ii
Cervical myelopathy, Hydrocephalus, Myelomeningocele, Limb muscle weakness, Spina bifida OMIM:207950
Fliedner-Zweier Syndrome
Bicuspid aortic valve, Ventricular septal defect, Hypoplastic aortic arch, Meningocele OMIM:620511
Diamond-Blackfan Anemia 20
Erythroid hypoplasia, Anemia, Total anomalous pulmonary venous return OMIM:618313
Czeizel-Losonci Syndrome
Dextrocardia, Spina bifida occulta, Hydrocephalus, Aplasia of the left hemidiaphragm, Myelomening... ORPHA:2437
Muscle-Eye-Brain Disease
Hydrocephalus, Holoprosencephaly, Myopathy, Meningocele ORPHA:588
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Joubert Syndrome 14
Encephalocele, Meningocele, Hydrocephalus, Hypertension, Intracranial hemorrhage, Ventricular sep... OMIM:614424
Wildervanck Syndrome
Facial palsy, Meningocele ORPHA:3456
Triploidy
Meningocele, Hydrocephalus, Holoprosencephaly, Macroglossia, Abnormal cardiac septum morphology ORPHA:3376
Heterotaxy, Visceral, 1, X-Linked
Myelomeningocele, Pulmonic stenosis, Cardiomegaly, Right atrial isomerism, Transposition of the g... OMIM:306955
Intellectual Developmental Disorder, Autosomal Dominant 72
Facial hypotonia, Spina bifida OMIM:620439
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Acropectorovertebral Dysplasia
Camptodactyly of finger, Spina bifida ORPHA:957
Lateral Meningocele Syndrome
Patent ductus arteriosus, Meningocele, Hydrocephalus, Aortic aneurysm, Decreased muscle mass, Umb... OMIM:130720
Camptodactyly Syndrome, Guadalajara Type 1
Camptodactyly of finger, Scapular winging, Spina bifida ORPHA:1327
Craniorachischisis
Congenital diaphragmatic hernia, Sirenomelia, Anencephaly, Myelomeningocele, Spinal dysraphism, C... ORPHA:63260
Autosomal Recessive Spondylocostal Dysostosis
Congenital diaphragmatic hernia, Spina bifida occulta, Meningocele, Camptodactyly of finger, Umbi... ORPHA:2311
Humero-Radial Synostosis
Meningocele ORPHA:3265
Mosaic Trisomy 9
Dextrocardia, Abnormal heart valve morphology, Spina bifida, Asplenia, Camptodactyly of finger, P... ORPHA:99776
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Cerebrocostomandibular Syndrome
Hydranencephaly, Meningocele, Myelomeningocele, Spina bifida, Ventricular septal defect ORPHA:1393
Meckel Syndrome, Type 2
Anencephaly, Encephalocele, Meningocele OMIM:603194
Limb Body Wall Complex
Congenital diaphragmatic hernia, Ectopia cordis, Short umbilical cord, Anencephaly, Encephalocele... ORPHA:2369
Lateral Meningocele Syndrome
Meningocele, Ventricular septal defect, Umbilical hernia ORPHA:2789
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Neurocutaneous Melanocytosis
Intracranial hemorrhage, Meningocele ORPHA:2481
Focal Dermal Hypoplasia
Congenital diaphragmatic hernia, Patent ductus arteriosus, Diastasis recti, Spina bifida, Camptod... ORPHA:2092
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Cutis Laxa, Autosomal Recessive, Type Ib
Congenital diaphragmatic hernia, Pulmonary insufficiency, Pulmonary artery aneurysm, Bradycardia,... OMIM:614437
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
Phakomatosis Pigmentokeratotica
Rhabdomyosarcoma, Arrhythmia, Raynaud phenomenon, Spina bifida ORPHA:2874
Amish Lethal Microcephaly
Limb hypertonia, Spina bifida ORPHA:99742
Thrombocytopenia-Absent Radius Syndrome
Atrioventricular canal defect, Anemia, Shoulder muscle hypoplasia, Leukocytosis, Spina bifida, Co... OMIM:274000
Marfan Syndrome
Congestive heart failure, Tricuspid valve prolapse, Abnormal left ventricular function, Aortic re... ORPHA:558
Fanconi Anemia
Abnormal aortic valve morphology, Anemia, Patent ductus arteriosus, Hydrocephalus, Abnormal aorti... ORPHA:84
Fibular Hemimelia
Abnormal heart morphology, Thrombocytopenia, Spina bifida ORPHA:93323
Iniencephaly
Congenital diaphragmatic hernia, Anencephaly, Encephalocele, Hydrocephalus, Myelomeningocele, Spi... ORPHA:63259
Pelvis-Shoulder Dysplasia
Hydrocephalus, Camptodactyly of finger, Spina bifida, Hydranencephaly ORPHA:2839
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Perimembranous ventricular septal defect, Atrioventricular canal defect, Aortic regurgitation, Tr... ORPHA:508498
Isolated Posterior Meningocele
Neural tube defect, Meningocele, Hydrocephalus, Lipomyelomeningocele, Occipital meningocele ORPHA:268810
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome
Anemia, Aortic aneurysm, Aortic dissection, Epistaxis, Hematochezia, Mitral valve prolapse, Pulmo... OMIM:175050
Trisomy 18
Congenital diaphragmatic hernia, Anencephaly, Spina bifida, Camptodactyly of finger, Holoprosence... ORPHA:3380
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Chromosome 17P13.1 Deletion Syndrome
Hydrocephalus, Elbow flexion contracture, Spina bifida, Umbilical hernia, Generalized amyotrophy,... OMIM:613776
Lathosterolosis
Anisopoikilocytosis, Thrombocytopenia, Abnormal platelet morphology, Meningocele ORPHA:46059
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
22Q11.2 Deletion Syndrome
Gastrointestinal hemorrhage, Tricuspid atresia, Abnormal aortic valve morphology, Corneal neovasc... ORPHA:567
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele ORPHA:1827
Neu-Laxova Syndrome 1
Short umbilical cord, Stillbirth, Transposition of the great arteries, Small placenta, Hydranence... OMIM:256520
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Congenital diaphragmatic hernia, Anencephaly, Hydrocephalus, Occipital meningocele, Atrial septal... OMIM:616546
Jacobsen Syndrome
Spina bifida, Aortic valve stenosis, Coarctation of aorta, Thrombocytopenia, Ventricular septal d... ORPHA:2308
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Unilateral facial palsy, Atrioventricular canal defect, Torticollis, Spina bifida, Coarctation of... OMIM:619480
Trisomy 20P
Camptodactyly of finger, Spina bifida, Umbilical hernia ORPHA:261318
Sacral Defect With Anterior Meningocele
Myeloschisis, Meningocele, Hydrocephalus, Dermal sinus tract, Myelomeningocele OMIM:600145
Basal Cell Nevus Syndrome 1
Cardiac fibroma, Cardiac rhabdomyoma, Hydrocephalus, Spina bifida OMIM:109400
Orofaciodigital Syndrome Vi
Coarctation of aorta, Occipital meningocele, Hypoplastic left heart OMIM:277170
Koolen-De Vries Syndrome Due To A Point Mutation
Aortic aneurysm, Hydrocephalus, Cardiomyopathy, Spina bifida, Pulmonic stenosis, Abnormal heart m... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Aortic aneurysm, Hydrocephalus, Cardiomyopathy, Spina bifida, Pulmonic stenosis, Abnormal heart m... ORPHA:363958
Nail-Patella Syndrome
Quadriceps aplasia, Biceps aplasia, Spina bifida, Absence of pectoralis minor muscle, Triceps apl... OMIM:161200
Neu-Laxova Syndrome
Muscular dystrophy, Aplasia/Hypoplasia involving the skeletal musculature, Spina bifida, Flexion ... ORPHA:2671
Vater/Vacterl Association
Occipital encephalocele, Transposition of the great arteries, Patent ductus arteriosus, Spina bif... OMIM:192350
Rubinstein-Taybi Syndrome 1
Perimembranous ventricular septal defect, Spina bifida occulta, Accessory spleen, Patent foramen ... OMIM:180849
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
Neurofibromatosis, Type I
Aqueductal stenosis, Rhabdomyosarcoma, Hydrocephalus, Hypertension, Renal artery stenosis, Spina ... OMIM:162200
Hallermann-Streiff Syndrome
Hypertension, Telangiectasia, Pulmonary arterial hypertension, Spina bifida OMIM:234100
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Femoral-Facial Syndrome
Encephalocele, Truncus arteriosus, Spina bifida, Pulmonic stenosis, Camptodactyly of finger, Coar... OMIM:134780
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Vacterl With Hydrocephalus
Hydrocephalus, Aqueductal stenosis, Spina bifida ORPHA:3412
Arima Syndrome
Occipital meningocele, Hypertension, Anemia OMIM:243910
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Campomelic Dysplasia
Hydrocephalus, Spina bifida, Abnormal heart morphology, Contracture of the distal interphalangeal... OMIM:114290
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Flexion contracture of finger, Meningocele ORPHA:1010
Otopalatodigital Syndrome, Type Ii
Stillbirth, Hydrocephalus, Spina bifida, Dilatation of the sinus of Valsalva, Umbilical hernia, A... OMIM:304120
Holoprosencephaly 7
Semilobar holoprosencephaly, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Oc... OMIM:610828
Phocomelia, Schinzel Type
Meningocele ORPHA:2879
Knobloch Syndrome 1
Occipital encephalocele, Occipital meningocele, Spina bifida occulta, Patent ductus arteriosus OMIM:267750
Aicardi Syndrome
Spina bifida OMIM:304050
Exstrophy-Epispadias Complex
Hydrocephalus, Abnormal heart morphology, Spina bifida ORPHA:322
Holoprosencephaly 9
Hydrocephalus, Occipital meningocele, Holoprosencephaly, Alobar holoprosencephaly OMIM:610829
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele, Elbow flexion contracture OMIM:276820

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Med24

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Med24.

No publications found that use IMPC mice or data for Med24.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Med24tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Med24tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Med24tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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