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Gene: Med24 MGI:1344385

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mediator complex subunit 24
Synonyms:
Gse2,  Pparb2,  R75526,  Trap100,  100kDa,  Thrap4,  D11Ertd307e,  DRIP100

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Med24 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Med24 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cardiomyopathy, Dilated, 1R
Restrictive cardiomyopathy, Dilated cardiomyopathy, Cardiomyocyte hypertrophy, Left ventricular n... OMIM:613424
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Left Ventricular Noncompaction 1
Hypoplastic left heart, Congestive heart failure, Left ventricular noncompaction, Left ventricula... OMIM:604169
Hemoglobin D Disease
Reduced beta/alpha synthesis ratio, Reduced hemoglobin A, Imbalanced hemoglobin synthesis, Spleno... ORPHA:90039
Cardiomyopathy, Dilated, 1C, With Or Without Left Ventricular Noncompaction
Dilated cardiomyopathy, Endocardial fibrosis, Congestive heart failure, Left ventricular noncompa... OMIM:601493
Isobutyryl-Coa Dehydrogenase Deficiency
Anemia, Dilated cardiomyopathy OMIM:611283
Cardiomyopathy, Dilated, 1Aa, With Or Without Left Ventricular Noncompaction
Atrioventricular block, Dilated cardiomyopathy, Endocardial fibrosis, Cardiomyocyte hypertrophy, ... OMIM:612158
Congenital Amegakaryocytic Thrombocytopenia
Anemia, Abnormal cardiac septum morphology, Abnormal hemoglobin, Thrombocytopenia ORPHA:3319
Diamond-Blackfan Anemia 16
Anemia, Atrial septal defect, Pulmonic stenosis OMIM:617408
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Joint contracture of the hand, Small hypothenar eminence, Mitral valve prolapse, Spina bifida, Sm... OMIM:211960
Atrial Standstill
Left ventricular noncompaction, Arrhythmia, Atrial standstill, Muscular dystrophy, Abnormal heart... ORPHA:1344
Attrv122I Amyloidosis
Aortic valve stenosis, Abnormal atrioventricular conduction, Restrictive cardiomyopathy, Congesti... ORPHA:85451
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Hypoplastic left heart, Anencephaly, Spina bifida, Ventricular septal defect ORPHA:2476
Eosinophilia, Familial
Leukocytosis, Eosinophilia, Thrombocytopenia, Myocardial eosinophilic infiltration, Anemia OMIM:131400
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Fetal Parvovirus Syndrome
Anemia, Hypertrophic cardiomyopathy, Thrombocytopenia ORPHA:295
Sick Sinus Syndrome 2
Aortic regurgitation, Left ventricular noncompaction, Torsade de pointes, Paroxysmal atrial fibri... OMIM:163800
Peripartum Cardiomyopathy
Abnormal cardiac atrium morphology, Mitral regurgitation, Elevated jugular venous pressure, Left ... ORPHA:563
Neonatal Lupus Erythematosus
Atrioventricular block, Dilated cardiomyopathy, Aplastic anemia, Abnormal heart morphology, Pancy... ORPHA:398124
Mitochondrial Complex I Deficiency, Nuclear Type 39
Hypertrophic cardiomyopathy, Cardiomegaly, Perimembranous ventricular septal defect, Atrial septa... OMIM:620135
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Atrioventricular canal defect, Tricuspid regurgitation, Congenital diaphragmatic hernia, Abnormal... ORPHA:1120
Thoraco-Abdominal Enteric Duplication
Meningocele, Abnormal tricuspid valve morphology, Dextrocardia, Camptodactyly of finger ORPHA:1759
Takayasu Arteritis
Vasculitis, Hypertensive crisis, Hypertrophic cardiomyopathy, Abnormal heart valve morphology, Ar... ORPHA:3287
Transaldolase Deficiency
Biventricular hypertrophy, Hepatosplenomegaly, Telangiectasia, Coarctation of aorta, Atrial septa... ORPHA:101028
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Tetralogy of Fallot, Situs inversus totalis, Encephalocele, Ventricular septal... ORPHA:1908
Long Qt Syndrome 15
Ventricular bigeminy, Left ventricular noncompaction, 2:1 atrioventricular block, Sinus bradycard... OMIM:616249
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Cardiomyopathy, Dilated, 1D
Dilated cardiomyopathy, Incomplete right bundle branch block, Congestive heart failure, Left vent... OMIM:601494
Hb Bart'S Hydrops Fetalis
Congestive heart failure, Splenomegaly, Abnormal hemoglobin, Hydrocephalus, Anemia, Pericarditis ORPHA:163596
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Increased mean corpuscular volume, Second degree atrioventricular block, Extramedullary hematopoi... OMIM:617021
Anemia, Congenital Dyserythropoietic, Type Iv
Increased RBC distribution width, Persistence of hemoglobin F, Hypertrophic cardiomyopathy, Hepat... OMIM:613673
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Meckel Syndrome, Type 4
Encephalocele, Ventricular septal defect, Atrial septal defect, Hydrocephalus, Meningocele, Anenc... OMIM:611134
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Reduced red cell pyruvate kinase level, Congenital hemolytic anemia, Abnormal erythrocyte morphol... ORPHA:766
Cardiomyopathy, Dilated, 1S
Pulmonary artery hypoplasia, Dilated cardiomyopathy, Congestive heart failure, Left ventricular n... OMIM:613426
Isolated Klippel-Feil Syndrome
Congenital muscular torticollis, Spina bifida, Ventricular septal defect ORPHA:2345
Cardiac Diverticulum
Aortic valve stenosis, Mitral valve prolapse, Ventricular septal defect, Bicuspid aortic valve, P... ORPHA:1686
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Congenitally Corrected Transposition Of The Great Arteries
Atrial situs ambiguous, Ventricular septal defect, Discordant atrioventricular connection, Arrhyt... ORPHA:216694
Alpha-Thalassemia
Extramedullary hematopoiesis, Congestive heart failure, Microcytic anemia, Hemoglobin Barts, Hepa... ORPHA:846
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Anemia, Abnormal tricuspid valve morphology, Abnormal aortic morphology, Ventricular septal defect ORPHA:3405
Pagod Syndrome
Hypoplastic left heart, Pulmonary artery hypoplasia, Abnormality of the spleen, Situs inversus to... ORPHA:991
Dohle Bodies And Leukemia
Anemia, Acute myeloid leukemia, Secundum atrial septal defect, Leukocyte inclusion bodies OMIM:223350
Alg3-Cdg
Cardiomyopathy, Coarctation of the descending aortic arch, Macroglossia, Arthrogryposis multiplex... ORPHA:79321
Schisis Association
Congenital diaphragmatic hernia, Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Subependymal Nodular Heterotopia
Myelomeningocele, Meningocele, Occipital encephalocele, Nasofrontal encephalocele ORPHA:101030
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Limb muscle weakness, Hydrocephalus, Spina bifida OMIM:207950
Fliedner-Zweier Syndrome
Bicuspid aortic valve, Meningocele, Hypoplastic aortic arch, Ventricular septal defect OMIM:620511
Diamond-Blackfan Anemia 20
Erythroid hypoplasia, Anemia, Total anomalous pulmonary venous return OMIM:618313
Czeizel-Losonci Syndrome
Myelomeningocele, Hydrocephalus, Spina bifida, Dextrocardia, Spina bifida occulta, Posterolateral... ORPHA:2437
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus, Myopathy ORPHA:588
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Joubert Syndrome 14
Encephalocele, Ventricular septal defect, Hydrocephalus, Meningocele, Intracranial hemorrhage, Hy... OMIM:614424
Wildervanck Syndrome
Meningocele, Facial palsy ORPHA:3456
Triploidy
Hydrocephalus, Abnormal cardiac septum morphology, Macroglossia, Meningocele, Holoprosencephaly ORPHA:3376
Heterotaxy, Visceral, 1, X-Linked
Ventricular septal defect, Atrial septal defect, Dextrocardia, Single ventricle, Aqueductal steno... OMIM:306955
Intellectual Developmental Disorder, Autosomal Dominant 72
Facial hypotonia, Spina bifida OMIM:620439
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Acropectorovertebral Dysplasia
Spina bifida, Camptodactyly of finger ORPHA:957
Lateral Meningocele Syndrome
Decreased muscle mass, Umbilical hernia, Ventricular septal defect, Bicuspid aortic valve, Aortic... OMIM:130720
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida, Scapular winging, Camptodactyly of finger ORPHA:1327
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Congenital diaphragmatic... ORPHA:63260
Autosomal Recessive Spondylocostal Dysostosis
Umbilical hernia, Camptodactyly of finger, Congenital diaphragmatic hernia, Spina bifida occulta,... ORPHA:2311
Humero-Radial Synostosis
Meningocele ORPHA:3265
Mosaic Trisomy 9
Camptodactyly of finger, Abnormal heart valve morphology, Endocardial fibroelastosis, Ventricular... ORPHA:99776
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Ventricular septal defect, Spina bifida, Meningocele ORPHA:1393
Meckel Syndrome, Type 2
Meningocele, Anencephaly, Encephalocele OMIM:603194
Limb Body Wall Complex
Myelomeningocele, Abnormal heart morphology, Diastasis recti, Encephalocele, Short umbilical cord... ORPHA:2369
Lateral Meningocele Syndrome
Meningocele, Ventricular septal defect, Umbilical hernia ORPHA:2789
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Neurocutaneous Melanocytosis
Meningocele, Intracranial hemorrhage ORPHA:2481
Focal Dermal Hypoplasia
Umbilical hernia, Camptodactyly of finger, Diastasis recti, Congenital diaphragmatic hernia, Vent... ORPHA:2092
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Cutis Laxa, Autosomal Recessive, Type Ib
Pulmonary artery aneurysm, Aortic root aneurysm, Pulmonary artery dilatation, Tricuspid regurgita... OMIM:614437
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Phakomatosis Pigmentokeratotica
Raynaud phenomenon, Arrhythmia, Rhabdomyosarcoma, Spina bifida ORPHA:2874
Amish Lethal Microcephaly
Limb hypertonia, Spina bifida ORPHA:99742
Thrombocytopenia-Absent Radius Syndrome
Tetralogy of Fallot, Atrioventricular canal defect, Hepatosplenomegaly, Leukocytosis, Ventricular... OMIM:274000
Marfan Syndrome
Aortic regurgitation, Aortic root aneurysm, Aortic dissection, Pulmonary artery dilatation, Skele... ORPHA:558
Fanconi Anemia
Umbilical hernia, Hypertrophic cardiomyopathy, Tetralogy of Fallot, Leukopenia, Abnormal aortic m... ORPHA:84
Fibular Hemimelia
Abnormal heart morphology, Spina bifida, Thrombocytopenia ORPHA:93323
Iniencephaly
Spinal dysraphism, Arthrogryposis multiplex congenita, Myelomeningocele, Encephalocele, Congenita... ORPHA:63259
Pelvis-Shoulder Dysplasia
Hydrocephalus, Hydranencephaly, Spina bifida, Camptodactyly of finger ORPHA:2839
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Aortic regurgitation, Tetralogy of Fallot, Atrioventricular canal defect, Truncus arteriosus, Ven... ORPHA:508498
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube defect ORPHA:268810
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome
Epistaxis, Hematochezia, Aortic dissection, Mitral regurgitation, Mitral valve prolapse, Pulmonar... OMIM:175050
Trisomy 18
Camptodactyly of finger, Congenital diaphragmatic hernia, Ventricular septal defect, Atrial septa... ORPHA:3380
Chromosome 17P13.1 Deletion Syndrome
Umbilical hernia, Elbow flexion contracture, Knee flexion contracture, Hydrocephalus, Spina bifid... OMIM:613776
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
Lathosterolosis
Meningocele, Abnormal platelet morphology, Thrombocytopenia, Anisopoikilocytosis ORPHA:46059
22Q11.2 Deletion Syndrome
Abnormal aortic arch morphology, Gastrointestinal hemorrhage, Hypertensive crisis, Umbilical hern... ORPHA:567
Acromelic Frontonasal Dysplasia
Meningocele, Encephalocele ORPHA:1827
Neu-Laxova Syndrome 1
Hydranencephaly, Joint contracture of the hand, Small placenta, Short umbilical cord, Patent fora... OMIM:256520
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Occipital meningocele, Congenital diaphragmatic hernia, Hydrocephalus, Atrial septal defect, Anen... OMIM:616546
Jacobsen Syndrome
Aortic valve stenosis, Hypoplastic left heart, Ventricular septal defect, Coarctation of aorta, S... ORPHA:2308
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Atrioventricular canal defect, Coarctation of aorta, Spina bifida, Torticollis, Unilateral facial... OMIM:619480
Trisomy 20P
Spina bifida, Camptodactyly of finger, Umbilical hernia ORPHA:261318
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Basal Cell Nevus Syndrome 1
Hydrocephalus, Cardiac rhabdomyoma, Spina bifida, Cardiac fibroma OMIM:109400
Orofaciodigital Syndrome Vi
Hypoplastic left heart, Coarctation of aorta, Occipital meningocele OMIM:277170
Koolen-De Vries Syndrome Due To A Point Mutation
Cardiomyopathy, Abnormal heart morphology, Hand muscle atrophy, Ventricular septal defect, Bicusp... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Cardiomyopathy, Abnormal heart morphology, Hand muscle atrophy, Ventricular septal defect, Bicusp... ORPHA:363958
Nail-Patella Syndrome
Triceps aplasia, Quadriceps aplasia, Biceps aplasia, Absence of pectoralis minor muscle, Spina bi... OMIM:161200
Neu-Laxova Syndrome
Aplasia/Hypoplasia involving the skeletal musculature, Muscular dystrophy, Skeletal muscle atroph... ORPHA:2671
Vater/Vacterl Association
Occipital encephalocele, Tetralogy of Fallot, Ventricular septal defect, Transposition of the gre... OMIM:192350
Rubinstein-Taybi Syndrome 1
Accessory spleen, Hypoplastic left heart, Aortic isthmus hypoplasia, Mitral valve prolapse, Ventr... OMIM:180849
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
Neurofibromatosis, Type I
Renal artery stenosis, Hydrocephalus, Spina bifida, Aqueductal stenosis, Rhabdomyosarcoma, Hypert... OMIM:162200
Hallermann-Streiff Syndrome
Telangiectasia, Pulmonary arterial hypertension, Hypertension, Spina bifida OMIM:234100
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Meningocele, Occipital encephalocele ORPHA:397715
Femoral-Facial Syndrome
Camptodactyly of finger, Encephalocele, Truncus arteriosus, Ventricular septal defect, Coarctatio... OMIM:134780
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Vacterl With Hydrocephalus
Hydrocephalus, Aqueductal stenosis, Spina bifida ORPHA:3412
Arima Syndrome
Anemia, Occipital meningocele, Hypertension OMIM:243910
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Campomelic Dysplasia
Spinal dysraphism, Abnormal heart morphology, Contracture of the distal interphalangeal joint of ... OMIM:114290
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele, Flexion contracture of finger ORPHA:1010
Otopalatodigital Syndrome, Type Ii
Stillbirth, Umbilical hernia, Elbow contracture, Hydrocephalus, Atrial septal defect, Spina bifid... OMIM:304120
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Phocomelia, Schinzel Type
Meningocele ORPHA:2879
Knobloch Syndrome 1
Spina bifida occulta, Occipital encephalocele, Patent ductus arteriosus, Occipital meningocele OMIM:267750
Aicardi Syndrome
Spina bifida OMIM:304050
Exstrophy-Epispadias Complex
Abnormal heart morphology, Hydrocephalus, Spina bifida ORPHA:322
Holoprosencephaly 9
Holoprosencephaly, Alobar holoprosencephaly, Occipital meningocele, Hydrocephalus OMIM:610829
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Elbow flexion contracture, Occipital meningocele OMIM:276820

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Med24

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Med24.

No publications found that use IMPC mice or data for Med24.

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MGI Allele Allele Type Produced
Med24tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Med24tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Med24tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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