Gene Summary

Name:
chromodomain helicase DNA binding protein 4
Synonyms:
Mi-2beta,  D6Ertd380e,  9530019N15Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Chd4tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
embryonic lethality prior to organogenesis Chd4tm1b(EUCOMM)Wtsi HOM   E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Wholemount images heterozygote 100% (4 of 4)
Aorta  Wholemount images heterozygote 100% (4 of 4)
Bone  Wholemount images heterozygote 100% (4 of 4)
Brain  Wholemount images heterozygote 100% (4 of 4)
Brainstem  Wholemount images heterozygote 100% (4 of 4)
Brown adipose tissue  Wholemount images heterozygote 100% (4 of 4)
Cartilage tissue  Wholemount images heterozygote 100% (4 of 4)
Cerebellum  Wholemount images heterozygote 100% (4 of 4)
Cerebral cortex  Wholemount images heterozygote 100% (4 of 4)
Esophagus  Wholemount images heterozygote 100% (4 of 4)
Gall bladder  Wholemount images heterozygote 100% (4 of 4)
Heart  Wholemount images heterozygote 100% (4 of 4)
Hippocampus  Wholemount images heterozygote 100% (4 of 4)
Hypothalamus  Wholemount images heterozygote 100% (4 of 4)
Kidney  Wholemount images heterozygote 100% (4 of 4)
Large intestine  Wholemount images heterozygote 100% (4 of 4)
Liver  Wholemount images heterozygote 100% (4 of 4)
Lower urinary tract  Wholemount images heterozygote 100% (4 of 4)
Mammary gland  Wholemount images heterozygote 50% (2 of 4)
Olfactory lobe  Wholemount images heterozygote 100% (4 of 4)
Oral epithelium  Wholemount images heterozygote 50% (2 of 4)
Ovary  Wholemount images heterozygote 50% (2 of 4)
Oviduct  Wholemount images heterozygote 50% (2 of 4)
Pancreas  Wholemount images heterozygote 100% (4 of 4)
Parathyroid gland  Wholemount images heterozygote 100% (4 of 4)
Peripheral nervous system  Wholemount images heterozygote 100% (4 of 4)
Peyer's patch  Wholemount images heterozygote 100% (4 of 4)
Pituitary gland  Wholemount images heterozygote 50% (2 of 4)
Prostate gland  Wholemount images heterozygote 50% (2 of 4)
Skeletal muscle  Wholemount images heterozygote 100% (4 of 4)
Skin  Wholemount images heterozygote 100% (4 of 4)
Small intestine  Wholemount images heterozygote 100% (4 of 4)
Spinal cord  Wholemount images heterozygote 100% (4 of 4)
Spleen  Wholemount images heterozygote 75% (3 of 4)
Stomach  Wholemount images heterozygote 100% (4 of 4)
Striatum  Wholemount images heterozygote 100% (4 of 4)
Testis  Wholemount images heterozygote 50% (2 of 4)
Thymus  Wholemount images heterozygote 100% (4 of 4)
Thyroid gland  Wholemount images heterozygote 100% (4 of 4)
Trachea  Wholemount images heterozygote 100% (4 of 4)
Trigeminal V nerve  Wholemount images heterozygote 75% (3 of 4)
Uterus  Wholemount images heterozygote 50% (2 of 4)
Vas deferens  Wholemount images heterozygote 50% (2 of 4)
Vascular system  Wholemount images heterozygote 100% (4 of 4)
White adipose tissue  Wholemount images heterozygote 100% (4 of 4)
Cecum N/A heterozygote 0.0% (0 of 4)
Eye N/A heterozygote Not available
Lung N/A heterozygote 100% (4 of 4)
Lymph node N/A heterozygote 100% (4 of 4)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Heart atrium N/A heterozygote 100% (3 of 3)
Axial skeleton N/A heterozygote 100% (3 of 3)
Brain N/A heterozygote 100% (3 of 3)
Central nervous system ganglion N/A heterozygote 100% (3 of 3)
Cranium N/A heterozygote 100% (3 of 3)
Dorsal root ganglion N/A heterozygote 100% (3 of 3)
Ear N/A heterozygote 100% (3 of 3)
Embryo N/A heterozygote 100% (3 of 3)
Outer ear N/A heterozygote 100% (3 of 3)
Eye N/A heterozygote 100% (3 of 3)
Femur pre-cartilage condensation N/A heterozygote 100% (3 of 3)
Footplate N/A heterozygote 100% (3 of 3)
Forearm N/A heterozygote 100% (3 of 3)
Forebrain N/A heterozygote 100% (3 of 3)
Forelimb N/A heterozygote 100% (3 of 3)
Fronto-nasal process N/A heterozygote 100% (3 of 3)
Gut N/A heterozygote 100% (3 of 3)
Handplate N/A heterozygote 100% (3 of 3)
Head mesenchyme N/A heterozygote 100% (3 of 3)
Head N/A heterozygote 100% (3 of 3)
Heart ventricle N/A heterozygote 100% (3 of 3)
Heart N/A heterozygote 100% (3 of 3)
Hindbrain N/A heterozygote 100% (3 of 3)
Hindlimb N/A heterozygote 100% (3 of 3)
Humerus pre-cartilage condensation N/A heterozygote 100% (3 of 3)
Inner ear N/A heterozygote 100% (3 of 3)
Intestine N/A heterozygote 100% (3 of 3)
Liver N/A heterozygote 100% (3 of 3)
Lower leg N/A heterozygote 100% (3 of 3)
Lung N/A heterozygote 100% (3 of 3)
Mandibular process N/A heterozygote 100% (3 of 3)
Maxillary process N/A heterozygote 100% (3 of 3)
Mesonephros of female N/A heterozygote 100% (3 of 3)
Mesonephros of male N/A heterozygote 66.67% (2 of 3)
Metanephros N/A heterozygote 100% (3 of 3)
Midbrain N/A heterozygote 100% (3 of 3)
Nasal septum N/A heterozygote 100% (3 of 3)
Nose N/A heterozygote 100% (3 of 3)
Notochord N/A heterozygote 100% (3 of 3)
Oral cavity N/A heterozygote 100% (3 of 3)
Outflow tract N/A heterozygote 100% (3 of 3)
Pancreas N/A heterozygote 100% (3 of 3)
N/A heterozygote 100% (3 of 3)
Pharynx N/A heterozygote 100% (3 of 3)
Radius-ulna pre-cartilage condensation N/A heterozygote 100% (3 of 3)
Rib pre-cartilage condensation N/A heterozygote 100% (3 of 3)
Skeleton N/A heterozygote 100% (3 of 3)
Skin N/A heterozygote 100% (3 of 3)
Spinal cord N/A heterozygote 100% (3 of 3)
Stomach N/A heterozygote 100% (3 of 3)
Tail somite N/A heterozygote 100% (3 of 3)
Tail N/A heterozygote 100% (3 of 3)
Thoracic vertebral cartilage condensation N/A heterozygote 100% (3 of 3)
Tongue N/A heterozygote 100% (3 of 3)
Trachea N/A heterozygote 100% (3 of 3)
Trunk mesenchyme N/A heterozygote 100% (3 of 3)
Umbilical artery embryonic part N/A heterozygote 100% (3 of 3)
Umbilical vein embryonic part N/A heterozygote 100% (3 of 3)
Upper arm N/A heterozygote 100% (3 of 3)
Upper leg N/A heterozygote 100% (3 of 3)
Urinary system N/A heterozygote 100% (3 of 3)
Vibrissa N/A heterozygote 100% (3 of 3)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.67% (4 of 598)
aorta 0.17% (1 of 598)
bone 0.0%
brain 0.84% (5 of 598)
brainstem 0.33% (2 of 598)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 598)
cecum 5.73% (22 of 384)
cerebellum 0.5% (3 of 598)
cerebral cortex 0.33% (2 of 598)
esophagus 1.66% (7 of 422)
eye 0.0%
gall bladder 0.0%
heart 0.33% (2 of 598)
hippocampus 0.5% (3 of 598)
hypothalamus 0.33% (2 of 598)
kidney 4.52% (27 of 598)
large intestine 5.35% (32 of 598)
liver 0.0%
lower urinary tract 0.17% (1 of 598)
lung 0.33% (2 of 598)
lymph node 0.17% (1 of 598)
mammary gland 0.0%
olfactory lobe 0.33% (2 of 598)
oral epithelium 0.0%
ovary 0.17% (1 of 598)
oviduct 0.0%
pancreas 0.84% (5 of 598)
parathyroid gland 0.17% (1 of 576)
peripheral nervous system 0.33% (2 of 598)
peyers patch 0.0%
pituitary gland 0.17% (1 of 598)
prostate gland 2.17% (13 of 598)
skeletal muscle 0.0%
skin 0.17% (1 of 598)
small intestine 5.35% (32 of 598)
spinal cord 0.5% (3 of 598)
spleen 0.5% (3 of 598)
stomach 3.68% (22 of 598)
striatum 0.5% (3 of 598)
testis 1% (6 of 598)
thymus 0.17% (1 of 598)
thyroid gland 3.01% (18 of 598)
trachea 0.5% (3 of 598)
trigeminal v nerve 0.0%
uterus 0.33% (2 of 598)
vas deferens 4.56% (18 of 395)
vascular system 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
atrium 1.75% (1 of 57)
axial skeleton 0.0%
brain 1.36% (6 of 440)
central nervous system ganglion 0.0%
cranium 1.72% (1 of 58)
dorsal root ganglion 1.75% (1 of 57)
ear 0.0%
embryo 0.22% (1 of 458)
external ear 1.45% (1 of 69)
eye 0.22% (1 of 457)
femur pre-cartilage condensation 2.04% (1 of 49)
footplate 0.21% (1 of 466)
forearm 0.37% (1 of 268)
forebrain 0.22% (1 of 455)
forelimb 0.22% (1 of 452)
fronto-nasal process 1.82% (1 of 55)
gut 1.85% (1 of 54)
handplate 0.22% (1 of 460)
head 0.87% (4 of 461)
head mesenchyme 1.85% (1 of 54)
heart 0.22% (1 of 455)
heart ventricle 1.85% (1 of 54)
hindbrain 1.08% (5 of 463)
hindlimb 0.0%
humerus pre-cartilage condensation 1.79% (1 of 56)
inner ear 1.67% (1 of 60)
intestine 0.0%
liver 0.22% (1 of 454)
lower leg 0.37% (1 of 270)
lung 0.22% (1 of 453)
mandibular process 0.0%
maxillary process 0.22% (1 of 445)
mesonephros of female 0.0%
mesonephros of male 1.92% (1 of 52)
metanephros 1.96% (1 of 51)
midbrain 0.22% (1 of 458)
nasal septum 1.92% (1 of 52)
nose 1.45% (1 of 69)
notochord 1.85% (1 of 54)
oral cavity 0.22% (1 of 451)
outflow tract 1.85% (1 of 54)
pancreas 2.13% (1 of 47)
pericardium 2.08% (1 of 48)
pharynx 1.89% (1 of 53)
radius-ulna pre cartilage condensation 1.92% (1 of 52)
rib pre-cartilage condensation 2.17% (1 of 46)
skeleton 1.43% (1 of 70)
skin 0.22% (1 of 458)
spinal cord 1.59% (1 of 63)
stomach 2% (1 of 50)
tail 0.22% (1 of 465)
tail somite group 0.22% (1 of 455)
thoracic vertebral cartilage condensation 2.08% (1 of 48)
tongue 2.04% (1 of 49)
trachea 0.0%
trunk mesenchyme 1.89% (1 of 53)
umbilical artery embryonic part 1.92% (1 of 52)
umbilical vein embryonic part 1.92% (1 of 52)
upper arm 0.37% (1 of 273)
upper leg 0.0%
urinary system 1.96% (1 of 51)
vibrissa 1.52% (1 of 66)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Wholemount

55 Images

Eye Morphology

VIP of right fundus

14 Images

Eye Morphology

VIP of left eye

14 Images

X-ray

XRay Images Whole Body Lateral Orientation

7 Images

X-ray

XRay Images Whole Body Dorso Ventral

7 Images

X-ray

XRay Images Skull Lateral Orientation

7 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

7 Images

Embryo LacZ

LacZ images wholemount

4 Images

Eye Morphology

VIP of left fundus

14 Images

X-ray

XRay Images Forepaw

7 Images

Eye Morphology

VIP of right eye

14 Images

Immunophenotyping

Panel B FCS file(s)

6 Images

Human diseases caused by Chd4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Chd4 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Sifrim-Hitz-Weiss Syndrome
Patent ductus arteriosus OMIM:617159

The table below shows human diseases predicted to be associated to Chd4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Sifrim-Hitz-Weiss Syndrome
Patent ductus arteriosus OMIM:617159

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chd4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chd4.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Chd4tm1b(EUCOMM)Wtsi PMC7263671

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Chd4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Chd4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Chd4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Chd4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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