IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|decreased total body fat amount||Dlg2tm1Dsb||HOM||Early adult||2.36×10-06|
|decreased circulating LDL cholesterol level||Dlg2tm1Dsb||HOM||Early adult||5.36×10-05|
|decreased body weight||Dlg2tm1Dsb||HOM||Early adult||6.88×10-08|
|decreased circulating HDL cholesterol level||Dlg2tm1Dsb||HOM||Early adult||1.24×10-05|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Dlg2 by phenotypic similarity.
|Familial Apolipoprotein Gene Cluster Deletion Syndrome||
||Hypocholesterolemia, Decreased circulating apolipoprotein A-I concentration, Decreased HDL choles...||OMIM:620058|
|Chylomicron Retention Disease||
||Decreased LDL cholesterol concentration, Steatorrhea, Failure to thrive, Hypotriglyceridemia, Hyp...||OMIM:246700|
||Hypertriglyceridemia, Decreased HDL cholesterol concentration, Hypercholesterolemia||OMIM:619324|
|Microcephaly, Congenital Cataract, And Psoriasiform Dermatitis||
||Hypocholesterolemia, Failure to thrive, Decreased LDL cholesterol concentration, Decreased HDL ch...||OMIM:616834|
|Hypobetalipoproteinemia, Familial, 1||
||Decreased LDL cholesterol concentration, Steatorrhea, Decreased HDL cholesterol concentration, Hy...||OMIM:615558|
|Gaucher Disease, Atypical, Due To Saposin C Deficiency||
|Peroxisome Biogenesis Disorder 3B||
||Hypocholesterolemia, Failure to thrive, Steatorrhea, Elevated circulating phytanic acid concentra...||OMIM:266510|
|Squalene Synthase Deficiency||
||Knee flexion contracture, Decreased LDL cholesterol concentration, Elbow flexion contracture, Ele...||OMIM:618156|
|Bile Acid Synthesis Defect, Congenital, 1||
||Hypocholesterolemia, Failure to thrive, Conjugated hyperbilirubinemia, Steatorrhea||OMIM:607765|
||Hypocholesterolemia, Failure to thrive, Small for gestational age||OMIM:610883|
|Chylomicron Retention Disease||
||Hypocholesterolemia, Failure to thrive, Hypertriglyceridemia, Steatorrhea||ORPHA:71|
|Maternal Uniparental Disomy Of Chromosome 4||
||Decreased LDL cholesterol concentration, Decreased body weight, Elevated circulating creatine kin...||ORPHA:96180|
|Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal||
|Congenital Disorder Of Glycosylation, Type Ia||
||Flexion contracture, Abnormal subcutaneous fat tissue distribution, Steatorrhea, Failure to thriv...||OMIM:212065|
||Camptodactyly, Failure to thrive, Hyponatremia, Hypocholesterolemia, Abnormal adipose tissue morp...||ORPHA:79324|
||Decreased LDL cholesterol concentration, Hyperbilirubinemia, Abnormal circulating apolipoprotein ...||ORPHA:14|
|Kaufman Oculocerebrofacial Syndrome||
||Hypocholesterolemia, Failure to thrive||OMIM:244450|
|Complex Regional Pain Syndrome||
|Secondary Intestinal Lymphangiectasia||
||Decreased prealbumin level, Secondary hyperaldosteronism, Reduced circulating transferrin concent...||ORPHA:90363|
||Hypocholesterolemia, Inguinal hernia||OMIM:223370|
|Anterior Cutaneous Nerve Entrapment Syndrome||
||Hypocholesterolemia, Failure to thrive, Elevated 7-dehydrocholesterol, Hypoalbuminemia||OMIM:270400|
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Dlg2
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dlg2.
There are 7 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2.||Genes, brain, and behavior (February 2022)||Dlg2tm1a(EUCOMM)Wtsi||PMC9393930|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Dlg2tm1a(EUCOMM)Wtsi||PMC7263671|
|A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum.||Molecular Autism (March 2020)||Dlg2tm1a(EUCOMM)Wtsi||PMC7069029|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Dlg2tm1a(EUCOMM)Wtsi Dlg2tm1Dsb||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Dlg2tm1Dsb Dlg2tm1a(EUCOMM)Wtsi||PMC6459510|
|Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma.||Oncogene (August 2018)||Dlg2tm1a(EUCOMM)Wtsi||30093633|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Dlg2tm1a(EUCOMM)Wtsi||PMC5827107|
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|MGI Allele||Allele Type||Produced|
|Dlg2tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
|Dlg2tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Dlg2tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|
|Dlg2tm1Dsb||Reporter-tagged deletion allele (with selection cassette)||ES Cells|
|Dlg2tm42053(L1L2_gt1)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
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