Gene: Wif1 MGI:1344332

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Gene Summary

Name:
Wnt inhibitory factor 1
Synonyms:
WIF-1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Wif1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Wif1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Chondrosarcoma, Extraskeletal Myxoid
Chondrosarcoma OMIM:612237
Chondrosarcoma
Chondrosarcoma OMIM:215300
Li-Fraumeni Syndrome 2
Glioma, Meningioma, Stomach cancer, Sarcoma, Breast carcinoma OMIM:609265
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Cerebral Sarcoma
Neoplasm, Fibrosarcoma OMIM:117600
Li-Fraumeni Syndrome
Prostate cancer, Prostate neoplasm, Soft tissue sarcoma, Lung adenocarcinoma, Nephroblastoma, Ost... OMIM:151623
Multiple Fibroadenomas Of The Breast
Fibroadenoma of the breast OMIM:615554
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Melanoma-Pancreatic Cancer Syndrome
Pancreatic squamous cell carcinoma, Sarcoma, Oropharyngeal squamous cell carcinoma, Squamous cell... OMIM:606719
Li-Fraumeni Syndrome
Non-Hodgkin lymphoma, Ovarian neoplasm, Neoplasm, Colorectal polyposis, Hodgkin lymphoma, Breast ... ORPHA:524
Oslam Syndrome
Neoplasm, Osteosarcoma OMIM:165660
Enchondromatosis, Multiple, Ollier Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:166000
Desmoid Disease, Hereditary
Desmoid tumors, Colon cancer OMIM:135290
Multiple Enchondromatosis, Maffucci Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:614569
Osteogenic Sarcoma
Retinoblastoma, Osteosarcoma OMIM:259500
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Neoplasm, Oropharyngeal squamous cell carcinom... ORPHA:443167
Oslam Syndrome
Osteosarcoma ORPHA:2760
Paget Disease Of Bone 3
Osteosarcoma OMIM:167250
Premature Aging Syndrome, Okamoto Type
Neoplasm, Osteosarcoma OMIM:601811
Exostoses, Multiple, Type Ii
Scapular exostoses, Rib exostoses, Chondrosarcoma, Pelvic bone exostoses OMIM:133701
Undifferentiated Pleomorphic Sarcoma
Soft tissue sarcoma ORPHA:2023
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Exostoses, Multiple, Type I
Scapular exostoses, Rib exostoses, Chondrosarcoma, Pelvic bone exostoses OMIM:133700
Maffucci Syndrome
Neoplasm of the parathyroid gland, Chondrosarcoma, Ovarian neoplasm, Hemangiomatosis, Multiple en... ORPHA:163634
Dermatofibrosarcoma Protuberans
Fibrosarcoma, Neoplasm of the skin ORPHA:31112
Paraneoplastic Pemphigus
Thymoma, Sarcoma, B-cell lymphoma ORPHA:63455
Retinoblastoma
Retinoblastoma, Lymphoma, Osteosarcoma, Pinealoma, Leukemia, Ewing sarcoma OMIM:180200
Acquired Ichthyosis
Neoplasm, Multiple myeloma, Sarcoma, Lymphoma ORPHA:454
Oncogenic Osteomalacia
Neoplasm of head and neck, Neurofibromas, Carcinoma, Giant cell tumor of bone, Neoplasm of the sk... ORPHA:352540
Ollier Disease
Hemangioma, Chondrosarcoma, Multiple enchondromatosis, Neoplasm, Sarcoma, Visceral angiomatosis, ... ORPHA:296
Keratosis, Familial Actinic
Neoplasm, Uterine neoplasm, Carcinoma OMIM:148390
Werner Syndrome
Meningioma, Osteosarcoma OMIM:277700
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Fibrosarcoma, Osteosarcoma, Histiocytoma OMIM:112250
Retinoblastoma
Retinoblastoma, Glioma, Lymphoma, Leiomyosarcoma, Osteosarcoma, Rhabdomyosarcoma, Leukemia, Pineo... ORPHA:790
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Large Congenital Melanocytic Nevus
Cutaneous melanoma, Neoplasm, Sarcoma, Rhabdomyosarcoma, Neoplasm of the skin ORPHA:626
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical adenoma, Fibrosarcoma, Adenomatous colonic polyposis, Breast carcinoma, Adrenocort... ORPHA:247806
Liposarcoma
Sarcoma ORPHA:69078
Infantile Myofibromatosis
Gingival fibromatosis, Benign neoplasm of the central nervous system, Fibroma, Sarcoma, Neoplasm ... ORPHA:2591
Dysplasia Epiphysealis Hemimelica With Chondromas And Osteochondromas
Osteochondroma OMIM:127820
Colorectal Cancer, Susceptibility To, 10
Colorectal polyposis, Endometrial carcinoma, Carcinoma OMIM:612591
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Unilateral vestibular Schwannoma, Carcinoma OMIM:603641
Muir-Torre Syndrome
Laryngeal carcinoma, Basal cell carcinoma, Carcinoma, Sebaceous gland carcinoma, Adenoma sebaceum... OMIM:158320
Rhabdoid Tumor
Neoplasm of the central nervous system, Renal neoplasm, Sarcoma, Neoplasm of the liver ORPHA:69077
Gardner Syndrome
Adrenocortical adenoma, Ampulla of Vater carcinoma, Fibrosarcoma, Adenomatous colonic polyposis, ... ORPHA:79665
Attenuated Familial Adenomatous Polyposis
Rectal polyposis, Adenocarcinoma of the colon, Fibroma, Uterine leiomyoma, Colorectal polyposis, ... ORPHA:220460
Desmoplastic Small Round Cell Tumor
Neoplasm of the central nervous system, Ovarian neoplasm, Sarcoma, Neoplasm of the lung, Testicul... ORPHA:83469
Familial Adenomatous Polyposis 1
Multiple gastric polyps, Medulloblastoma, Adrenocortical adenoma, Carcinoma, Fibroma, Osteoma, Sm... OMIM:175100
Rothmund-Thomson Syndrome Type 1
Basal cell carcinoma, Myelodysplasia, Squamous cell carcinoma, Osteosarcoma, Leukemia, Neoplasm o... ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Basal cell carcinoma, Myelodysplasia, Squamous cell carcinoma, Lymphoma, Osteosarcoma, Leukemia, ... ORPHA:221016
Baller-Gerold Syndrome
Osteosarcoma, Lymphoma ORPHA:1225
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Fibrous Dysplasia Of Bone
Neoplasm of the breast, Cutaneous myxoma, Thyroid carcinoma, Osteosarcoma, Testicular neoplasm ORPHA:249
Pleuropulmonary Blastoma
Medulloblastoma, Rhabdomyosarcoma, Pleuropulmonary blastoma OMIM:601200
Rothmund-Thomson Syndrome, Type 2
Basal cell carcinoma, Osteosarcoma, Squamous cell carcinoma OMIM:268400
Gastrointestinal Stromal Tumor
Neoplasm of the gastrointestinal tract, Gastrointestinal stroma tumor, Neoplasm of the rectum, Es... ORPHA:44890
Yellow Nail Syndrome
Biliary tract neoplasm, Renal neoplasm, Neoplasm, Sarcoma, Neoplasm of the lung ORPHA:662
Acromesomelic Dysplasia, Grebe Type
Sarcoma ORPHA:2098
Desmoid Tumor
Fibroma, Intestinal polyposis, Neoplasm of the skin, Desmoid tumors ORPHA:873
Familial Adenomatous Polyposis
Colorectal polyposis, Adenomatous colonic polyposis, Neoplasm of the adrenal gland, Fibroma, Neop... ORPHA:733
Rhabdomyosarcoma, Embryonal, 1
Embryonal rhabdomyosarcoma OMIM:268210
Blackfan-Diamond Anemia
Myelodysplasia, Adenocarcinoma of the colon, Malignant genitourinary tract tumor, Acute myeloid l... ORPHA:124
Werner Syndrome
Renal neoplasm, Ovarian neoplasm, Neoplasm of the oral cavity, Cutaneous melanoma, Meningioma, Ga... ORPHA:902
Diamond-Blackfan Anemia 1
Myelodysplasia, Osteosarcoma, Colon cancer OMIM:105650
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Rhabdomyosarcoma 2
Alveolar rhabdomyosarcoma OMIM:268220
Tuberous Sclerosis 2
Chordoma, Cardiac rhabdomyoma, Gingival fibromatosis, Subungual fibromas, Pulmonary lymphangiomyo... OMIM:613254
Ovarian Fibrothecoma
Diffuse leiomyomatosis, Ovarian fibroma, Fibrosarcoma ORPHA:314478
Carney Complex
Osteochondroma, Cardiac myxoma, Adrenocortical carcinoma, Parathyroid adenoma, Neoplasm of the pa... ORPHA:1359
Atypical Werner Syndrome
Renal neoplasm, Ovarian neoplasm, Neoplasm of the oral cavity, Neoplasm of the thyroid gland, Men... ORPHA:79474
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Neoplasm of the thyroid gland, Neoplasm of the breast, Sarcoma, Testicular neoplasm ORPHA:457059
Terminal Osseous Dysplasia
Fibroma OMIM:300244
Multiple Osteochondromas
Chondrosarcoma, Multiple exostoses, Neoplasm, Pelvic bone exostoses, Exostoses ORPHA:321
Milroy Disease
Angiosarcoma, Neoplasm of the skin ORPHA:79452
Mastocytosis
Acute leukemia, Chronic leukemia, Sarcoma ORPHA:98292
Camptodactyly, Tall Stature, And Hearing Loss Syndrome
Osteochondroma OMIM:610474
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Renal angiomyolipoma, Carcinoid tumor, Parathyroid adenoma... OMIM:610755
Neurofibromatosis Type 1
Lisch nodules, Neoplasm of the gastrointestinal tract, Urinary tract neoplasm, Plexiform neurofib... ORPHA:636
Monosomy 22
Schwannoma, Gonadal neoplasm, Meningioma, Sarcoma ORPHA:96123
Cowden Syndrome
Neoplasm of the central nervous system, Fibroma, Endometrial carcinoma, Neoplasm of the thyroid g... ORPHA:201
Multiple Endocrine Neoplasia Type 4
Pituitary growth hormone cell adenoma, Parathyroid carcinoma, Subcutaneous lipoma, Adrenocortical... ORPHA:276152
Meige Disease
Angiosarcoma ORPHA:90186
Lymphedema-Distichiasis Syndrome
Fibrosarcoma ORPHA:33001
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Vulvar neoplasm, Tracheobronchial leiomyomatosis, Fibroma, Esophageal neoplasm, Uterine neoplasm,... ORPHA:1018
Hyperparathyroidism-Jaw Tumor Syndrome
Fibroma, Uterine leiomyoma, Renal hamartoma, Nephroblastoma, Thyroid carcinoma, Testicular neopla... ORPHA:99880
Tolchin-Le Caignec Syndrome
Osteochondroma, Cardiac rhabdomyoma OMIM:618971
Parathyroid Carcinoma
Parathyroid carcinoma, Fibroma, Uterine leiomyoma, Nephroblastoma, Renal hamartoma, Thyroid carci... ORPHA:143
Tuberous Sclerosis Complex
Pancreatic endocrine tumor, Retinal astrocytic hamartoma, Cardiac rhabdomyoma, Pulmonary lymphang... ORPHA:805
Multiple Endocrine Neoplasia Type 1
Pancreatic endocrine tumor, Insulinoma, Pituitary thyrotropic cell adenoma, Carcinoid tumor, Adre... ORPHA:652
Aicardi Syndrome
Hemangioma, Carcinoma, Teratoma, Lipoma, Metastatic angiosarcoma, Hepatoblastoma OMIM:304050
Pallister-Hall Syndrome
Osteochondroma, Hypothalamic hamartoma, Midline facial capillary hemangioma ORPHA:672
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion
Hemangioma, Lisch nodules, Optic nerve glioma, Ossifying fibroma, Neurofibrosarcoma, Schwannoma, ... ORPHA:363700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Wif1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Wif1.

No publications found that use IMPC mice or data for Wif1.

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MGI Allele Allele Type Produced
Wif1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Wif1em1(IMPC)H Exon Deletion Mice
Wif1em2(IMPC)H Exon Deletion Mice

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