Gene: Arpc1b

Name
actin related protein 2/3 complex, subunit 1B
MGI ID
MGI:1343142
Synonyms
L72 SOP2Hs p41-ARC
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased immature NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased marginal zone precursor B cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased circulating calcium level Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 1.89×10-07
decreased CD8-positive, alpha-beta T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 2.26×10-05
increased memory-marker NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased macrophage cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1-positive T-helper cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased transitional stage T2 B cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased red blood cell distribution width Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 2.77×10-05
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased circulating total protein level Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 7.08×10-05
increased memory-marker CD4-negative NK T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased circulating insulin level Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 1.01×10-05
increased CD103-positive CD11b-low dendritic cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased plasma cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
fusion of vertebral arches Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 4.96×10-05
decreased body length Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 2.99×10-06
decreased mature NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased eosinophil cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 2.26×10-05
increased effector memory T-helper cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased effector memory CD4-positive, alpha-beta T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased mean platelet volume Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 4.76×10-05
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased KLRG1-positive NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased mean corpuscular volume Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 4.74×10-09
increased effector memory CD8-positive, alpha-beta T cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 2.12×10-05
decreased circulating serum albumin level Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 3.43×10-05
decreased Ly6C-positive mature NK cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00
vertebral fusion Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 1.44×10-05
decreased mature B cell number Arpc1btm1a(EUCOMM)Wtsi HOM postnatal 0.00

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 Expression

Expression data not available

 Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
24 Images
X-ray: XRay Images Dorso Ventral
49 Images
X-ray: XRay Images Lateral Orientation
34 Images
X-ray: XRay Images Skull Lateral Orientation
17 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
X-ray: XRay Images Forepaw
16 Images
Spleen Immunophenotyping: Images associated with FACS analysis
46 Images
Eye Morphology: Images Slit Lamp
1 Images
Anti-nuclear antibody assay
3 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Kidney - process of degenerative change Arpc1btm1a(EUCOMM)Wtsi HOM postnatal
Kidney - MPATH diagnostic term glomerulonephritis Arpc1btm1a(EUCOMM)Wtsi HOM postnatal
Testes - atrophy Arpc1btm1a(EUCOMM)Wtsi HOM postnatal
Pancreas - inflammation Arpc1btm1a(EUCOMM)Wtsi HOM postnatal
Pancreas - MPATH diagnostic term vasculitis Arpc1btm1a(EUCOMM)Wtsi HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Arpc1btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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