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Gene: Mmp24 MGI:1341867

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
matrix metallopeptidase 24
Synonyms:
Membrane type 5-MMP,  MT5-MMP

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mmp24 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mmp24 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pseudoxanthomatous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280794
Pandas
Depression, Abnormal fear-induced behavior, Chorea, Oppositional defiant disorder, Emotional labi... ORPHA:66624
Intellectual Developmental Disorder, Autosomal Recessive 54
Attention deficit hyperactivity disorder, Emotional lability, Exaggerated startle response OMIM:617028
Neutrophil Immunodeficiency Syndrome
Abnormality of neutrophil physiology, Leukocytosis ORPHA:183707
Indolent Systemic Mastocytosis
Mastocytosis, Increased proportion of CD25+ mast cells, Splenomegaly, Abnormal mast cell morphology ORPHA:98848
Immunodeficiency 86
Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level OMIM:619549
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2A2
Impaired vibratory sensation, Somatic sensory dysfunction, Impaired pain sensation, Hand tremor, ... ORPHA:99947
Trigeminal Neuralgia
Depression, Paresthesia, Somatic sensory dysfunction, Allodynia ORPHA:221091
Spinocerebellar Ataxia Type 2
Spinal cord posterior columns myelin loss, Abnormality of the spinocerebellar tracts, Chorea, Pos... ORPHA:98756
Mastocytosis, Cutaneous
Cutaneous mastocytosis OMIM:154800
Specific Granule Deficiency 1
Increased neutrophil mitochondria, Increased neutrophil ribosomes, Absent neutrophil lactoferrin,... OMIM:245480
Complex Regional Pain Syndrome
Dysesthesia, Trophic changes related to pain, Somatic sensory dysfunction, Allodynia ORPHA:83452
Focal Facial Dermal Dysplasia Type Iv
Hydrocephalus, Abnormal mast cell morphology ORPHA:398189
Mast Cell Sarcoma
Mastocytosis, Splenomegaly ORPHA:66661
Gm2 Gangliosidosis, Ab Variant
Abnormal fear-induced behavior, Inappropriate behavior, Chorea, Exaggerated startle response, Dys... ORPHA:309246
Spinal Cord Injury
Somatic sensory dysfunction, Syringomyelia, Spinal cord lesion, Dysesthesia, Allodynia ORPHA:90058
Anterior Cutaneous Nerve Entrapment Syndrome
Hyperesthesia, Somatic sensory dysfunction, Impaired tactile sensation, Anorexia, Allodynia ORPHA:51890
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear-induced behavior, Resting tremor, Tremor, Irritability, Aggressive behavior, Hypera... ORPHA:3077
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Aggressive behavior, Abnormal fear-induced behavior, Pseudobulbar paralysis ORPHA:208441
Immunodeficiency 81
Abnormally low T cell receptor excision circle level, Autoimmune hemolytic anemia, Abscess, Decre... OMIM:619374
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Pancytopenia, Hypersplenism, Leukocytosis, Increased proportion of CD25+ mast... ORPHA:98850
Bullous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280785
Cutaneous Mastocytosis, Conductive Hearing Loss And Microtia
Cutaneous mastocytosis OMIM:248910
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Chronic myelomonocytic leukemia, Leukocytosis, Splenomegaly, Chronic lymphatic... ORPHA:98849
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Abnormally low T cell receptor excision circle level, Reduction of neutrophil motility, Rectal ab... OMIM:608203
Pudendal Neuralgia
Paresthesia, Allodynia ORPHA:60039
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Truncal titubation, Impaired vibration sensation in the lower limbs, Positive Romberg sign, Gait ... ORPHA:88628
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Impaired pain sensation, Abnormal spinal cord morphology ORPHA:139578
Immunodeficiency 108 With Autoinflammation
Impaired neutrophil chemotaxis, Hyposegmentation of neutrophil nuclei OMIM:260570
Keratoderma Hereditarium Mutilans
Self-injurious behavior, Abnormal spinal cord morphology ORPHA:494
Neurotrophic Keratopathy
Hyperesthesia, Allodynia ORPHA:137596
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Abnormally low T cell receptor excision circle level, Decreased circulating IgG level, Lymphopeni... OMIM:618986
Chédiak-Higashi Syndrome
Abnormality of neutrophil physiology, Hemophagocytosis, Abnormal natural killer cell morphology, ... ORPHA:167
Hennekam-Beemer Syndrome
Mastocytosis ORPHA:2135
Porphyria Due To Ala Dehydratase Deficiency
Depression, Restlessness, Abnormal fear-induced behavior, Agitation ORPHA:100924
Acute Disseminated Encephalomyelitis
Myelitis, Somatic sensory dysfunction, Irritability, Aggressive behavior, Abnormal spinal cord mo... ORPHA:83597
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Hypoesthesia, Dysphagia, Distal sensory impairment, Allodynia OMIM:603041
Spinal Arteriovenous Metameric Syndrome
Spinal arteriovenous malformation, Abnormal spinal cord morphology ORPHA:53721
X-Linked Cerebral Adrenoleukodystrophy
Myelopathy, Dysmetria, Abnormal spinal cord morphology, Hyperactivity, Ataxia, Dysphagia ORPHA:139396
Superficial Siderosis
Impaired pain sensation, Impaired temperature sensation, Paresthesia, Limb ataxia, Dysmetria, Pro... ORPHA:247245
Benign Schwannoma
Allodynia ORPHA:252164
Solitary Bone Cyst
Abnormal spinal cord morphology ORPHA:83468
Adrenomyeloneuropathy
Distal sensory impairment, Dorsal column degeneration, Atrophy of the spinal cord, Abnormal spina... ORPHA:139399
Pituitary Adenoma 4, Acth-Secreting
Abnormal fear-induced behavior, Emotional lability OMIM:219090
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Self-injurious behavior, Abnormal fear-induced behavior, Emotional lability, Cervical cord compre... ORPHA:353281
Amoebiasis Due To Free-Living Amoebae
Restlessness, Irritability, Abnormal spinal cord morphology, Ataxia ORPHA:68
Primary Sjögren Syndrome
Chorea, Depression, Abnormal spinal cord morphology, Somatic sensory dysfunction ORPHA:289390
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Self-injurious behavior, Abnormal fear-induced behavior, Emotional lability, Cervical cord compre... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Self-injurious behavior, Abnormal fear-induced behavior, Emotional lability, Cervical cord compre... ORPHA:353277
Mosaic Trisomy 20
Abnormal spinal cord morphology ORPHA:1724
Tetrasomy 9P
Inappropriate behavior, Abnormal spinal cord morphology, Hyperactivity ORPHA:3310
Limb Body Wall Complex
Spina bifida occulta, Abnormal spinal cord morphology, Spina bifida ORPHA:2369

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mmp24

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mmp24.

No publications found that use IMPC mice or data for Mmp24.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mmp24tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Mmp24em1(IMPC)H Exon Deletion Mice
Mmp24em2(IMPC)H Exon Deletion Mice
Mmp24em3(IMPC)H Exon Deletion Mice
Mmp24tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Mmp24tm29164(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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