The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
|Prostate gland||Wholemount images||heterozygote||Not available|
|Testis||Wholemount images||heterozygote||50% (1 of 2)|
|Vas deferens||Wholemount images||heterozygote||Not available|
|Adrenal gland||N/A||heterozygote||0.0% (0 of 2)|
|Aorta||N/A||heterozygote||0.0% (0 of 2)|
|Bone||N/A||heterozygote||0.0% (0 of 2)|
|Brain||N/A||heterozygote||0.0% (0 of 2)|
|Brainstem||N/A||heterozygote||0.0% (0 of 2)|
|Brown adipose tissue||N/A||heterozygote||0.0% (0 of 2)|
|Cartilage tissue||N/A||heterozygote||0.0% (0 of 2)|
|Cecum||N/A||heterozygote||0.0% (0 of 2)|
|Cerebellum||N/A||heterozygote||0.0% (0 of 2)|
|Cerebral cortex||N/A||heterozygote||0.0% (0 of 2)|
|Esophagus||N/A||heterozygote||0.0% (0 of 2)|
|Gall bladder||N/A||heterozygote||0.0% (0 of 2)|
|Heart||N/A||heterozygote||0.0% (0 of 2)|
|Hippocampus||N/A||heterozygote||0.0% (0 of 2)|
|Hypothalamus||N/A||heterozygote||0.0% (0 of 2)|
|Kidney||N/A||heterozygote||0.0% (0 of 2)|
|Large intestine||N/A||heterozygote||0.0% (0 of 2)|
|Liver||N/A||heterozygote||0.0% (0 of 2)|
|Lower urinary tract||N/A||heterozygote||0.0% (0 of 2)|
|Lung||N/A||heterozygote||0.0% (0 of 2)|
|Lymph node||N/A||heterozygote||0.0% (0 of 2)|
|Mammary gland||N/A||heterozygote||0.0% (0 of 2)|
|Olfactory lobe||N/A||heterozygote||0.0% (0 of 2)|
|Oral epithelium||N/A||heterozygote||0.0% (0 of 2)|
|Ovary||N/A||heterozygote||0.0% (0 of 2)|
|Oviduct||N/A||heterozygote||0.0% (0 of 2)|
|Pancreas||N/A||heterozygote||0.0% (0 of 2)|
|Parathyroid gland||N/A||heterozygote||0.0% (0 of 2)|
|Peripheral nervous system||N/A||heterozygote||0.0% (0 of 2)|
|Peyer's patch||N/A||heterozygote||0.0% (0 of 2)|
|Pituitary gland||N/A||heterozygote||0.0% (0 of 2)|
|Skeletal muscle||N/A||heterozygote||0.0% (0 of 2)|
|Skin||N/A||heterozygote||0.0% (0 of 2)|
|Small intestine||N/A||heterozygote||0.0% (0 of 2)|
|Spinal cord||N/A||heterozygote||0.0% (0 of 2)|
|Spleen||N/A||heterozygote||0.0% (0 of 2)|
|Stomach||N/A||heterozygote||0.0% (0 of 2)|
|Striatum||N/A||heterozygote||0.0% (0 of 2)|
|Thymus||N/A||heterozygote||0.0% (0 of 2)|
|Thyroid gland||N/A||heterozygote||0.0% (0 of 2)|
|Trachea||N/A||heterozygote||0.0% (0 of 2)|
|Trigeminal V nerve||N/A||heterozygote||0.0% (0 of 2)|
|Uterus||N/A||heterozygote||0.0% (0 of 2)|
|Vascular system||N/A||heterozygote||0.0% (0 of 2)|
|White adipose tissue||N/A||heterozygote||0.0% (0 of 2)|
Background staining occurs in wild type mice and embryos at an incidental rate.
|Anatomy||Background staining in controls (WT)|
|brown adipose tissue||0.0%|
|lower urinary tract||0.0%|
|peripheral nervous system||0.0%|
|trigeminal v nerve||0.0%|
|white adipose tissue||0.0%|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Col14a1 by orthology or direct annotation.
|Punctate Palmoplantar Keratoderma Type 1||
The table below shows human diseases predicted to be associated to Col14a1 by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Col14a1
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|MGI Allele||Allele Type||Produced|
|Col14a1tm44841(L1L2_st1)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Col14a1tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Col14a1tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Col14a1tm1b(KOMP)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Mice|