Aldh1l1 | aldehyde dehydrogenase 1 family, member L1

GeneMGI:1340024Synonyms: Fthfd, 1810048F20Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Skeleton Cardiovascular system

16 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

abnormal retina blood vessel morphology1 supporting datasetAldh1l1tm1b(KOMP)WtsihomozygoteEarly adult1.85x10-5 
abnormal retina vasculature morphology1 supporting datasetAldh1l1tm1b(KOMP)WtsihomozygoteEarly adult4.13x10-6 
abnormal lens morphology1 supporting datasetAldh1l1tm1b(KOMP)WtsihomozygoteEarly adult6.19x10-11 
cataract1 supporting datasetAldh1l1tm1b(KOMP)WtsihomozygoteEarly adult4.6x10-9 
decreased bone mineral density1 supporting datasetAldh1l1em1(IMPC)KmpchomozygoteEarly adult6.33x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aldh1l1em1(IMPC)KmpcDeletionmouse
Aldh1l1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Aldh1l1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Aldh1l1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Aldh1l1tm44466(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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