Gene: Pak1

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Name
p21 (RAC1) activated kinase 1
MGI ID
MGI:1339975
Synonyms
PAK-1 Paka
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Pak1tm1b(EUCOMM)Hmgu HOM   Early adult 4.14×10-07
increased total body fat amount Pak1tm1b(EUCOMM)Hmgu HOM Early adult 4.71×10-06
decreased bone mineral content Pak1tm1b(EUCOMM)Hmgu HOM Early adult 6.95×10-05
increased circulating triglyceride level Pak1tm1b(EUCOMM)Hmgu HOM Early adult 2.38×10-10
increased blood urea nitrogen level Pak1tm1b(EUCOMM)Hmgu HOM Early adult 4.56×10-08

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584) N/A
Aorta 2 No  (1/584) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (4/584)  (2/2)  Wholemount images
Brainstem 2 No  (2/584)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584) N/A
Cerebellum 2 No  (3/584) N/A
Cerebral cortex 2 No  (2/584)  (2/2)  Wholemount images
Esophagus 2 No  (7/408) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/584) N/A
Hippocampus 2 No  (3/584)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/584) N/A
Kidney 2 No  (21/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/584) N/A
Lung 2 No  (2/584) N/A
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/562) N/A
Peripheral nervous system 2 No  (2/584) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (3/584) N/A
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (3/584) N/A
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584) N/A
Thyroid gland 2 No  (16/584) N/A
Trachea 2 No  (3/584) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/507) N/A
Ear 1  (1/507) N/A
Embryo 1  (1/508)  (2/2) N/A
Eye 1  (1/507) N/A
Footplate 1  (1/507) Image Only N/A
Forebrain 1  (1/507) N/A
Forelimb 1  (1/507) N/A
Handplate 1  (1/507) Image Only N/A
Head 1  (5/507) N/A
Heart 1  (1/507) Image Only N/A
Hindbrain 1  (6/507) N/A
Hindlimb 1  (1/507) N/A
Liver 1  (1/502) N/A
Lung 1  (1/502) N/A
Mandibular process 1  (1/507) N/A
Maxillary process 1  (1/507) N/A
Midbrain 1  (1/507) N/A
Oral cavity 1  (1/502) N/A
Skin 1  (1/507) N/A
Tail 1  (1/507) N/A
Tail somite group 1  (1/507) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Adult LacZ: LacZ Images Wholemount
7 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pak1tm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp) Mice
Pak1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Pak1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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