Gene: Myh8 MGI:1339712
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased hematocrit | Myh8em1(IMPC)Tcp | HET | Early adult | 2.35×10-07 | ||
abnormal embryo size | Myh8em1(IMPC)Tcp | HOM | E15.5 | 0.00 | ||
preweaning lethality, complete penetrance | Myh8em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
enlarged urinary bladder | Myh8em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
edema | Myh8em1(IMPC)Tcp | HOM | E15.5 | 0.00 | ||
abnormal sternum morphology | Myh8em1(IMPC)Tcp | HET | Early adult | 0.00 |
Human diseases caused by Myh8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Myh8 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Trismus-Pseudocamptodactyly Syndrome | Hip dislocation, Symphalangism affecting the phalanges of the hand | ORPHA:3377 | |
Arthrogryposis, Distal, Type 7 | Metatarsus adductus, Cutaneous syndactyly of toes, Hammertoe, Hip dislocation | OMIM:158300 | |
Carney Complex Variant | OMIM:608837 |
The table below shows human diseases predicted to be associated to Myh8 by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Myh8tm2e(KOMP)Mbp | Targeted, non-conditional allele | ES Cells |
Myh8tm1e(KOMP)Mbp | Targeted, non-conditional allele | ES Cells |
Myh8tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Myh8em1(IMPC)Tcp | Exon Deletion | Mice |
Myh8tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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