Gene Summary

Name:
myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms:
Myhs-f,  MHC2A,  Myhsf1,  Myhs-f1,  MyHC-IIa

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral content Myh2em1(IMPC)Bay HOM Early adult 9.23×10-05
abnormal retina outer nuclear layer morphology Myh2em1(IMPC)Bay HOM   Early adult 3.49×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left fundus

15 Images

Eye Morphology

VIP of right eye

15 Images

Eye Morphology

VIP of right fundus

15 Images

Eye Morphology

VIP of left eye

15 Images

Human diseases caused by Myh2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Myh2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Congenital Myopathy 6 With Ophthalmoplegia
OMIM:605637

The table below shows human diseases predicted to be associated to Myh2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
Stargardt Disease 1
Retinitis pigmentosa inversa, Macular degeneration, Bull's eye maculopathy OMIM:248200
Night Blindness, Congenital Stationary, Type 1D
Pigmentary retinopathy, Attenuation of retinal blood vessels, Congenital stationary night blindne... OMIM:613830
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Congenital Myopathy 6 With Ophthalmoplegia
OMIM:605637

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myh2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myh2.

No publications found that use IMPC mice or data for Myh2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Myh2tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Myh2tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Myh2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Myh2tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Myh2em1(IMPC)Bay Exon Deletion Mice

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