Gene: Acvr1b

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Name
activin A receptor, type 1B
MGI ID
MGI:1338944
Synonyms
SKR2 Acvrlk4 ActR-IB ActRIB Alk4
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Acvr1btm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
abnormal midbrain development Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
abnormal embryo size Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
preweaning lethality, complete penetrance Acvr1btm1.1(KOMP)Vlcg HOM n/a 0.00
increased prepulse inhibition Acvr1btm1.1(KOMP)Vlcg HET postnatal 7.06×10-09
abnormal neural tube closure Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.00
abnormal coat/ hair morphology Acvr1btm1.1(KOMP)Vlcg HET postnatal 3.31×10-05
embryonic lethality prior to organogenesis Acvr1btm1.1(KOMP)Vlcg HOM embryonic day 9.5 0.00
abnormal bone structure Acvr1btm1.1(KOMP)Vlcg HET postnatal 8.08×10-05
small testis Acvr1btm1.1(KOMP)Vlcg HET postnatal 0.00
abnormal uterus morphology Acvr1btm1.1(KOMP)Vlcg HET postnatal 0.00
small adrenal glands Acvr1btm1.1(KOMP)Vlcg HET postnatal 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (1/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2)  Section images
Trachea 2 No  (1/2)  Section images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Dorso Ventral
16 Images
X-ray: XRay Images Lateral Orientation
32 Images
X-ray: XRay Images Hind Leg and Hip
16 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
Adult LacZ: LacZ Images Section
4 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
Eye Morphology: Images Slit Lamp
5 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Acvr1btm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Acvr1btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Acvr1btm442836(L1L2_Bact_P) Targeting vectors
Acvr1btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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