Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
bone morphogenetic protein receptor, type 1A
Synonyms:
ALK3,  BMPR-IA,  Bmpr,  1110037I22Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bmpr1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bmpr1a by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Juvenile Polyposis Of Infancy
Patent ductus arteriosus ORPHA:79076
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
ORPHA:329971
Polyposis Syndrome, Hereditary Mixed, 2
OMIM:610069
Familial Colorectal Cancer Type X
ORPHA:440437
Juvenile Polyposis Syndrome
OMIM:174900
Hereditary Mixed Polyposis Syndrome
ORPHA:157794

The table below shows human diseases predicted to be associated to Bmpr1a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Juvenile Polyposis Of Infancy
Patent ductus arteriosus ORPHA:79076
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
ORPHA:329971
Polyposis Syndrome, Hereditary Mixed, 2
OMIM:610069
Familial Colorectal Cancer Type X
ORPHA:440437
Juvenile Polyposis Syndrome
OMIM:174900
Hereditary Mixed Polyposis Syndrome
ORPHA:157794

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmpr1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmpr1a.

No publications found that use IMPC mice or data for Bmpr1a.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Bmpr1atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bmpr1atm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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