Gene Summary

Name:
purinergic receptor P2X, ligand-gated ion channel 4
Synonyms:
D5Ertd444e,  P2X4

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased mean corpuscular volume P2rx4tm1b(EUCOMM)Wtsi HOM Early adult 2.05×10-05
abnormal clavicle morphology P2rx4tm1b(EUCOMM)Wtsi HOM Early adult 1.08×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Wholemount images heterozygote 100% (2 of 2)
Aorta  Wholemount images heterozygote 100% (2 of 2)
Bone  Wholemount images heterozygote 100% (2 of 2)
Cartilage tissue  Wholemount images heterozygote 100% (2 of 2)
Esophagus  Wholemount images heterozygote 100% (2 of 2)
Gall bladder  Wholemount images heterozygote 100% (2 of 2)
Heart  Wholemount images heterozygote 100% (2 of 2)
Kidney  Wholemount images heterozygote 100% (2 of 2)
Large intestine  Wholemount images heterozygote 100% (2 of 2)
Lung  Wholemount images heterozygote 100% (2 of 2)
Lymph node  Wholemount images heterozygote 100% (2 of 2)
Ovary  Wholemount images heterozygote 0.0% (0 of 2)
Oviduct  Wholemount images heterozygote 50% (1 of 2)
Pancreas  Wholemount images heterozygote 100% (2 of 2)
Parathyroid gland  Wholemount images heterozygote 100% (2 of 2)
Peripheral nervous system  Wholemount images heterozygote 100% (2 of 2)
Pituitary gland  Wholemount images heterozygote 100% (2 of 2)
Skin  Wholemount images heterozygote 100% (2 of 2)
Small intestine  Wholemount images heterozygote 100% (2 of 2)
Spinal cord  Wholemount images heterozygote 100% (2 of 2)
Stomach  Wholemount images heterozygote 100% (2 of 2)
Thymus  Wholemount images heterozygote 100% (2 of 2)
Thyroid gland  Wholemount images heterozygote 100% (2 of 2)
Trachea  Wholemount images heterozygote 100% (2 of 2)
Vascular system  Wholemount images heterozygote 100% (2 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote 100% (2 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (2 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 100% (2 of 2)
Hypothalamus N/A heterozygote 100% (2 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 100% (2 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 100% (2 of 2)
Testis N/A heterozygote 50% (1 of 2)
Uterus N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.7% (4 of 573)
aorta 0.18% (1 of 571)
bone 0.0%
brain 0.53% (3 of 570)
brainstem 0.35% (2 of 564)
brown adipose tissue 0.0%
cartilage tissue 0.18% (1 of 569)
cerebellum 0.53% (3 of 565)
cerebral cortex 0.35% (2 of 565)
esophagus 1.8% (7 of 389)
eye 0.0%
gall bladder 0.0%
heart 0.35% (2 of 566)
hippocampus 0.53% (3 of 571)
hypothalamus 0.36% (2 of 560)
kidney 3.72% (21 of 565)
large intestine 1.78% (10 of 561)
liver 0.0%
lower urinary tract 0.0%
lung 0.35% (2 of 577)
lymph node 0.18% (1 of 566)
mammary gland 0.0%
olfactory lobe 0.18% (1 of 553)
oral epithelium 0.0%
ovary 0.18% (1 of 566)
oviduct 0.0%
pancreas 0.89% (5 of 559)
parathyroid gland 0.18% (1 of 546)
peripheral nervous system 0.35% (2 of 574)
peyers patch 0.0%
pituitary gland 0.18% (1 of 570)
prostate gland 1.77% (10 of 564)
skeletal muscle 0.0%
skin 0.18% (1 of 563)
small intestine 1.59% (9 of 565)
spinal cord 0.53% (3 of 566)
spleen 0.53% (3 of 566)
stomach 2.12% (12 of 565)
striatum 0.53% (3 of 567)
testis 1.05% (6 of 572)
thymus 0.18% (1 of 567)
thyroid gland 2.84% (16 of 563)
trachea 0.53% (3 of 562)
uterus 0.0%
vascular system 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Echo

M-Mode Images

32 Images

Adult LacZ

LacZ Images Wholemount

18 Images

X-ray

XRay Images Whole Body Dorso Ventral

13 Images

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

13 Images

Human diseases caused by P2rx4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to P2rx4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Atr-16 syndrome
Abnormal erythrocyte morphology DECIPHER:65
Methemoglobin Reductase Deficiency
Abnormal erythrocyte morphology OMIM:250700
Diamond-Blackfan Anemia 19
Anemia, Steroid-responsive anemia, Erythroid hypoplasia OMIM:618312
Monosomy 7 Myelodysplasia And Leukemia Syndrome 1
Acute myeloid leukemia, Increased mean corpuscular volume, Thrombocytopenia OMIM:252270
Heinz Body Anemias
Heinz bodies, Heinz body anemia, Nonspherocytic hemolytic anemia OMIM:140700
Hemoglobin D Disease
Reduced alpha/beta synthesis ratio, Imbalanced hemoglobin synthesis, Sickled erythrocytes, Anemia... ORPHA:90039
Diamond-Blackfan Anemia 3
Macrocytic anemia, Reticulocytopenia, Increased mean corpuscular volume, Persistence of hemoglobin F OMIM:610629
Dehydrated Hereditary Stomatocytosis 2
Anisopoikilocytosis, Increased mean corpuscular volume, Acanthocytosis, Splenomegaly, Increased m... OMIM:616689
Glomerulopathy With Fibronectin Deposits 1
Hypertension, Nephrotic syndrome, Stage 5 chronic kidney disease, Microscopic hematuria, Proteinu... OMIM:137950
Monosomy 7 Myelodysplasia And Leukemia Syndrome 2
Neutropenia, Increased mean corpuscular volume, Anemia, Acute myeloid leukemia, Pancytopenia, Thr... OMIM:619041
Iga Nephropathy, Susceptibility To, 3
Hypertension, IgA deposition in the glomerulus, Hematuria, Stage 5 chronic kidney disease, Mesang... OMIM:616818
Nail-Patella-Like Renal Disease
Hypertension, Microscopic hematuria, Glomerulopathy, Proteinuria, Renal insufficiency ORPHA:2613
Iga Nephropathy, Susceptibility To, 2
Hypertension, IgA deposition in the glomerulus, Hematuria, Nephritis, Stage 5 chronic kidney dise... OMIM:613944
Focal Segmental Glomerulosclerosis 2
Hypertension, Focal segmental glomerulosclerosis, Nephrotic syndrome, Stage 5 chronic kidney dise... OMIM:603965
Intrinsic Factor Deficiency
Megaloblastic anemia, Megaloblastic erythroid hyperplasia, Increased mean corpuscular volume OMIM:261000
Glomerulopathy With Fibronectin Deposits 2
Hypertension, Nephrotic syndrome, Renal cell carcinoma, Stage 5 chronic kidney disease, Microscop... OMIM:601894
Renal Failure, Progressive, With Hypertension
Hypertension, Nephritis, Stage 5 chronic kidney disease, Microscopic hematuria, Proteinuria, Rena... OMIM:161900
Focal Segmental Glomerulosclerosis 5
Hypertension, Focal segmental glomerulosclerosis, Stage 5 chronic kidney disease, Microscopic hem... OMIM:613237
Oslam Syndrome
Clinodactyly of the 5th finger, Abnormality of neutrophils, Increased mean corpuscular volume, Ra... ORPHA:2760
Focal Segmental Glomerulosclerosis 3, Susceptibility To
Hypertension, Focal segmental glomerulosclerosis, Hematuria, Proteinuria, Renal insufficiency OMIM:607832
Delta-Beta-Thalassemia
Microcytic anemia, Anemia, Abnormal hemoglobin ORPHA:231237
Familial Pseudohyperkalemia
Stomatocytosis, Episodic hemolytic anemia, Reticulocytosis, Increased mean corpuscular volume ORPHA:90044
Beta-Thalassemia, Dominant Inclusion Body Type
Splenomegaly, Persistence of hemoglobin F, Microcytic anemia, Erythrocyte inclusion bodies, Decre... OMIM:603902
Moyamoya Disease 1
Telangiectasia, Inflammatory arteriopathy OMIM:252350
Dyserythropoiesis, Congenital, With Ultrastructurally Normal Erythroblast Heterochromatin
Anisocytosis, Poikilocytosis, Oval macrocytosis, Anemia of inadequate production OMIM:603529
Hemoglobin C-Beta-Thalassemia Syndrome
Microcytic anemia, Anemia, Abnormal hemoglobin, Splenomegaly ORPHA:231242
Iga Nephropathy, Susceptibility To, 1
Hypertension, IgA deposition in the glomerulus, Hematuria, Nephritis, Stage 5 chronic kidney dise... OMIM:161950
Long Qt Syndrome 13
Syncope, Hypertension, Prolonged QT interval, Atrial fibrillation, Atrioventricular block, Tachyc... OMIM:613485
Arterial Calcification, Generalized, Of Infancy, 2
Hypertension, Nephrocalcinosis, Coronary artery calcification, Myocardial infarction, Congestive ... OMIM:614473
Sickle Cell Anemia
Leukocytosis, Abnormality of the spleen, Thrombocytosis, Increased mean corpuscular volume, Iron ... ORPHA:232
Diamond-Blackfan Anemia 8
Macrocytic anemia, Neutropenia, Increased mean corpuscular volume OMIM:612563
Capillary Malformation-Arteriovenous Malformation 2
Telangiectasia OMIM:618196
Dehydrated Hereditary Stomatocytosis
Congenital hemolytic anemia, Macrocytic anemia, Schistocytosis, Increased mean corpuscular volume... ORPHA:3202
Adenosine Triphosphate, Elevated, Of Erythrocytes
Polycythemia, Reduced erythrocyte 2,3-diphosphoglycerate concentration OMIM:102900
Bone Marrow Failure Syndrome 6
Neutropenia, Increased mean corpuscular volume, Anemia, Persistence of hemoglobin F, Lymphopenia OMIM:618849
Hemolytic Poikilocytic Anemia Due To Reduced Ankyrin Binding Sites
Poikilocytosis, Heinz body anemia, Nonspherocytic hemolytic anemia, Elliptocytosis OMIM:141700
Pulmonary Hypertension, Primary, 1
Right ventricular failure, Telangiectasia, Hypertension, Pulmonary artery vasoconstriction, Pulmo... OMIM:178600
Adenine Phosphoribosyltransferase Deficiency
Macroscopic hematuria, Hypertension, Atrial fibrillation, Urinary retention, Urinary hesitancy, D... ORPHA:976
Congenital Dyserythropoietic Anemia Type Iii
Increased mean corpuscular volume, Anemia, Anisocytosis, Poikilocytosis, Abnormal erythrocyte mor... ORPHA:98870
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
Macrocytic anemia, Neutropenia, Abnormal reticulocyte morphology, Abnormal platelet morphology, A... OMIM:300835
Brachydactyly, Type E1
Short clavicles, Short metatarsal, Short metacarpal, Brachydactyly, Type E brachydactyly OMIM:113300
Diamond-Blackfan Anemia 6
Macrocytic anemia, Triphalangeal thumb, Increased mean corpuscular volume, Persistence of hemoglo... OMIM:612561
Pyropoikilocytosis, Hereditary
Hemolytic anemia, Pyropoikilocytosis, Microspherocytosis, Elliptocytosis OMIM:266140
Ovalocytosis, Hereditary Hemolytic, With Defective Erythropoiesis
Hemolytic anemia, Elliptocytosis, Anemia of inadequate production OMIM:166910
Telangiectasia, Hereditary Hemorrhagic, Type 5
Telangiectasia, Portal hypertension, Spontaneous, recurrent epistaxis OMIM:615506
Humerofemoral Hypoplasia With Radiotibial Ray Deficiency
Short clavicles, Hypoplastic scapulae, Absent thumb, Bowed humerus, Hypoplastic pelvis OMIM:618022
Pelvis-Shoulder Dysplasia
Short clavicles, Hypoplastic scapulae, Hypoplastic acetabulae, Congenital hip dislocation, Clinod... OMIM:169550
Ivic Syndrome
Leukocytosis, Triphalangeal thumb, Thrombocytopenia, Aplastic clavicle, Synostosis of carpal bone... ORPHA:2307
Methylcobalamin Deficiency Type Cble
Macrocytic anemia, Neutropenia, Increased mean corpuscular volume, Syndactyly, Pancytopenia, Clin... ORPHA:2169
Spondyloepimetaphyseal Dysplasia, X-Linked
Metaphyseal irregularity, Long fibula, Short phalanx of finger, Short long bone, Flat acetabular ... OMIM:300106
Holt-Oram Syndrome
Short clavicles, Triphalangeal thumb, Phocomelia, Aplasia of the ulna, Hypoplasia of the radius, ... OMIM:142900
Ivic Syndrome
Leukocytosis, Upper limb undergrowth, Short clavicles, Triphalangeal thumb, Thrombocytopenia, Hyp... OMIM:147750
Parietal Foramina With Cleidocranial Dysplasia
Short clavicles OMIM:168550
Shwachman-Diamond Syndrome
Chronic neutropenia, Macrocytic anemia, Neutropenia, Proximal femoral epiphysiolysis, Normocytic ... ORPHA:811
Diamond-Blackfan Anemia 7
Macrocytic anemia, Triphalangeal thumb, Increased mean corpuscular volume, Neutropenia, Short thumb OMIM:612562
Fgfr2-Related Bent Bone Dysplasia
Steep acetabular roof, Short clavicles, Bowing of the legs, Hepatosplenomegaly, Hypoplastic ischi... ORPHA:313855
Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism
Down-sloping shoulders, Short clavicles OMIM:212112
Blackfan-Diamond Anemia
Thrombocytosis, Elevated red cell adenosine deaminase level, Neutropenia, Triphalangeal thumb, In... ORPHA:124
Desbuquois Dysplasia 2
Monkey wrench femoral neck, Genu varum, Short clavicles, Metaphyseal widening, Epiphyseal dysplas... OMIM:615777
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Megaloblastic anemia, Increased mean corpuscular volume OMIM:277410
Bent Bone Dysplasia Syndrome
Hepatosplenomegaly, Short clavicles, Brachydactyly OMIM:614592
16Q24.3 Microdeletion Syndrome
Increased mean corpuscular volume, Hip dysplasia, Proximal placement of thumb, Thrombocytopenia ORPHA:261250
Intellectual Developmental Disorder With Short Stature, Facial Anomalies, And Speech Defects
Short clavicles, Short 4th metacarpal OMIM:606220
Xylt1-Cdg
Short clavicles, Short femoral neck, Coxa valga, Broad thumb, Flared metaphysis, Short long bone,... ORPHA:370930
Melnick-Needles Syndrome
Short clavicles, Bowing of the long bones, Abnormality of the metaphysis, Hip dislocation, Short ... ORPHA:2484
Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia
Absent tibia, Short metatarsal, Proximal placement of thumb, Hypoplasia of the radius, Shallow ac... OMIM:609945
Rhizomelic Dysplasia, Scoliosis, And Retinitis Pigmentosa
Short femoral neck, Short clavicles, Prominent deltoid tuberosities, Short humerus OMIM:610319
Cleidocranial Dysplasia
Short clavicles, Hypoplastic scapulae, Tapered finger, Abnormality of epiphysis morphology, Hypop... ORPHA:1452
Crane-Heise Syndrome
Toe syndactyly, Hypoplastic scapulae, Aplastic clavicle, Finger syndactyly, Short distal phalanx ... ORPHA:1512
Achondrogenesis, Type Ia
Short clavicles, Hypoplastic scapulae, Hypoplasia of the radius, Abnormality of the femoral metap... OMIM:200600
Enlarged Parietal Foramina
Broad thumb, Short clavicles ORPHA:60015
9Q31.1Q31.3 Microdeletion Syndrome
Short clavicles, Small hand, Tapered finger ORPHA:401923
Cleidocranial Dysplasia
Short clavicles, Long second metacarpal, Hypoplastic scapulae, Hypoplastic iliac wing, Wide pubic... OMIM:119600
Sweeney-Cox Syndrome
Long fingers, Cutaneous syndactyly, Short clavicles, Asplenia OMIM:617746
Hurler Syndrome
Short clavicles, Diaphyseal thickening, Hypoplasia of the femoral head, Splenomegaly, Hepatosplen... OMIM:607014
Sifrim-Hitz-Weiss Syndrome
Short femoral neck, Short clavicles, Flat acetabular roof, Tapered finger OMIM:617159
Occipital Horn Syndrome
Aplasia/hypoplasia of the humerus, Absent tibia, Humerus varus, Avascular necrosis of the capital... ORPHA:198
Microgastria-Limb Reduction Defect Syndrome
Abnormality of the spleen, Phocomelia, Aplastic clavicle, Abnormality of the radius, Abnormality ... ORPHA:2538
Blomstrand Lethal Chondrodysplasia
Abnormality of epiphysis morphology, Bowing of the long bones, Aplastic clavicle, Short metacarpa... ORPHA:50945
Melnick-Needles Syndrome
Tibial bowing, Short clavicles, Hypoplastic scapulae, Genu valgum, Hip dislocation, Short distal ... OMIM:309350
Mandibuloacral Dysplasia With Type B Lipodystrophy
Short phalanx of finger, Osteolytic defects of the distal phalanges of the hand, Acroosteolysis o... OMIM:608612
Chime Syndrome
Aplasia/Hypoplasia of the phalanges of the toes, Acute leukemia, Abnormality of epiphysis morphol... ORPHA:3474
Spondylodysplastic Ehlers-Danlos Syndrome
Hallux valgus, Short clavicles, Flat capital femoral epiphysis, Abnormal femoral head morphology,... ORPHA:536471
Ulnar-Mammary Syndrome
Short 5th toe, Short clavicles, Hypoplastic scapulae, Short 4th toe, Aplasia of the ulna, Hypopla... OMIM:181450
Focal Dermal Hypoplasia
Toe syndactyly, Short clavicles, Abnormality of epiphysis morphology, Finger syndactyly, Split ha... ORPHA:2092
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Short clavicles, Hypoplastic scapulae, Epiphyseal stippling, Congenital hip dislocation, Hypoplas... OMIM:308050
Van Maldergem Syndrome 2
Cutaneous finger syndactyly, Short clavicles, Short fourth metatarsal, Short 4th metacarpal, Clin... OMIM:615546
Mandibuloacral Dysplasia
Short clavicles, Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal... ORPHA:2457
Van Maldergem Syndrome 1
Cutaneous finger syndactyly, Short clavicles, Short fourth metatarsal, Short 4th metacarpal, Clin... OMIM:601390
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 1
Short clavicles, Bowing of the long bones, Dislocated radial head, Arachnodactyly, Long toe, Coxa... OMIM:130070
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Preaxial polydactyly, Aplastic clavicle, Postaxial polydactyly OMIM:616546
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
Bifid femur, Aplastic clavicle, Abnormality of the metaphysis, Broad distal phalanx of finger, Ab... ORPHA:2636
Marbach-Rustad Progeroid Syndrome
Femur fracture, Short clavicles OMIM:619322
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Short clavicles, Splenomegaly, Postaxial hand polydactyly, Short long bone, Brachydactyly OMIM:617088
Familial Osteodysplasia, Anderson Type
Aplasia/hypoplasia of the femur, Clinodactyly of the 5th finger, Aplastic clavicle, Bifid femur ORPHA:2769
Lenz-Majewski Hyperostotic Dwarfism
Symphalangism affecting the phalanges of the hand, Aplastic clavicle, Abnormality of the metaphys... ORPHA:2658
Ear-Patella-Short Stature Syndrome
Patellar aplasia, Abnormality of epiphysis morphology, Aplastic clavicle, Slender long bone, Camp... ORPHA:2554
Cdags Syndrome
Short clavicles OMIM:603116
Mandibuloacral Dysplasia With Type A Lipodystrophy
Short clavicles, Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal... OMIM:248370
Occipital Horn Syndrome
Short clavicles, Capitate-hamate fusion, Genu valgum, Pelvic bone exostoses, Short humerus, Coxa ... OMIM:304150
Eisenmenger Syndrome
Iron deficiency anemia, Increased mean corpuscular volume, Hypochromic microcytic anemia, Clubbing ORPHA:97214
Yunis-Varon Syndrome
Short metatarsal, Absent hallux, Aplastic clavicle, Aplasia/Hypoplasia of the distal phalanges of... OMIM:216340
Craniosynostosis-Anal Anomalies-Porokeratosis Syndrome
Tarsal synostosis, Aplastic clavicle ORPHA:85199
Floating-Harbor Syndrome
Short clavicles, Humeral pseudarthrosis, Avascular necrosis of the capital femoral epiphysis, Dis... ORPHA:2044
Hutchinson-Gilford Progeria Syndrome
Coxa valga, Hip dislocation, Short clavicles, Osteolytic defects of the distal phalanges of the hand ORPHA:740
Microphthalmia, Syndromic 1
Short clavicles, Radial deviation of finger, Down-sloping shoulders, Syndactyly, Camptodactyly, C... OMIM:309800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for P2rx4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to P2rx4.

No publications found that use IMPC mice or data for P2rx4.

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MGI Allele Allele Type Produced
P2rx4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele Mice
P2rx4tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
P2rx4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
P2rx4tm40299(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
P2rx4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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