Mthfd2 | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Physiological systems
21 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological Skeleton Mortality/aging Cardiovascular system Craniofacial
10 No significant impact
3 Not tested
Data collections
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
Human diseases caused by Mthfd2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
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