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Gene: Celf2 MGI:1338822

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Gene Summary

Name:
CUGBP, Elav-like family member 2
Synonyms:
Napor-2,  Cugbp2,  ETR-3,  B230345P09Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Celf2tm1b(EUCOMM)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Celf2tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Celf2tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Celf2tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Celf2tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Celf2tm1a(EUCOMM)Wtsi
WT, Female, WTSI

View all 15 images

Celf2tm1b(EUCOMM)Wtsi
head, HET, Female, WTSI

Human diseases caused by Celf2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Celf2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Non-Specific Early-Onset Epileptic Encephalopathy
ORPHA:442835
Developmental And Epileptic Encephalopathy 97
OMIM:619561

The table below shows human diseases predicted to be associated to Celf2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death, Eosinophilia OMIM:257100
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Non-Specific Early-Onset Epileptic Encephalopathy
ORPHA:442835
Developmental And Epileptic Encephalopathy 97
OMIM:619561

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Celf2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Celf2.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Celf2tm1b(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Celf2tm1b(EUCOMM)Wtsi PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Celf2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Celf2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Celf2tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
Celf2tm33634(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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