Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Pkdrej by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Spermatogenic Failure 67 | Male infertility, Globozoospermia | OMIM:619803 | |
Spermatogenic Failure 69 | Male infertility, Globozoospermia | OMIM:619826 | |
Spermatogenic Failure 68 | Male infertility, Globozoospermia | OMIM:619805 | |
Spermatogenic Failure 66 | Male infertility, Globozoospermia | OMIM:619799 | |
Spermatogenic Failure 9 | Male infertility, Globozoospermia | OMIM:613958 | |
Spermatogenic Failure 6 | Male infertility, Decreased acrosin in sperm head, Globozoospermia | OMIM:102530 | |
Spermatogenic Failure, X-Linked, 7 | Male infertility, Multiflagellar spermatozoa, Globozoospermia, Excess residual spermatozoal cytop... | OMIM:301106 | |
Male Infertility With Teratozoospermia Due To Single Gene Mutation | Non-obstructive azoospermia, Abnormal sperm tail morphology, Abnormal spermatogenesis, Globozoosp... | ORPHA:399808 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Pkdrejtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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