Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Cdc45 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Meier-Gorlin Syndrome 7 | Thin eyebrow | OMIM:617063 | |
Ear-Patella-Short Stature Syndrome | ORPHA:2554 |
The table below shows human diseases predicted to be associated to Cdc45 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
22q11 duplication syndrome | Telecanthus | DECIPHER:32 | |
Oculomotor-Levator Synkinesis | Ptosis, Eyelid retraction, Abnormal eyelid morphology | OMIM:151610 | |
Ptosis, Hereditary Congenital 1 | Congenital ptosis | OMIM:178300 | |
Marcus Gunn Phenomenon | Unilateral ptosis, Congenital ptosis | OMIM:154600 | |
Orbital Margin, Hypoplasia Of | Lacrimal duct atresia, Lower eyelid coloboma, Congenital extraocular muscle anomaly | OMIM:165600 | |
Short Tarsus With Absence Of Lower Eyelashes | Absent lower eyelashes, Hypoplasia of the lower eyelids | OMIM:600269 | |
Meier-Gorlin Syndrome 7 | Thin eyebrow | OMIM:617063 | |
Ear-Patella-Short Stature Syndrome | ORPHA:2554 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Cdc45tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Cdc45tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Cdc45em1(IMPC)Bay | Exon Deletion | Mice |
Cdc45tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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