Itsn1 | intersectin 1 (SH3 domain protein 1A)

GeneMGI:1338069Synonyms: Sh3p17, EHSH1, +3 more

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Nervous system Behavior/neurological

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:10Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating amylase level1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult2.81x10-8 
increased circulating iron level1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult2.67x10-11 
increased circulating total protein level1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult2.31x10-5 
abnormal gait1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult1.26x10-5 
decreased exploration in new environment1 supporting datasetItsn1em1(IMPC)HheterozygoteEarly adult6.08x10-7 
abnormal skin coloration2 supporting datasetsItsn1em1(IMPC)HhomozygoteEarly adult2.76x10-11 
increased circulating alkaline phosphatase level1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult2x10-17 
limb grasping1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult1.04x10-8 
decreased prepulse inhibition1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult2.57x10-5 
increased circulating serum albumin level1 supporting datasetItsn1em1(IMPC)HhomozygoteEarly adult6.26x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

Associated images

Loading...

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Itsn1em1(IMPC)HExon Deletionmouse
Itsn1tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter