Gene Summary

opsin 3
Ecpn,  ERO,  encephalopsin,  panopsin

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Opn3em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Lateral Orientation

19 Images


XRay Images Whole Body Dorso Ventral

57 Images

Human diseases caused by Opn3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Opn3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Fever, Familial Lifelong Persistent
Fever OMIM:228400
Primary Erythromelalgia
Hypothermia ORPHA:90026
Riboflavin Deficiency
Hypothermia OMIM:615026
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Decreased resting energy expenditure OMIM:601665
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Hereditary Central Diabetes Insipidus
Fever, Polydipsia ORPHA:30925
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Coenzyme Q10 Deficiency, Primary, 5
Hypothermia OMIM:614654
Idiopathic Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:95717
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Nephronophthisis-Like Nephropathy 2
Recurrent fever, Polydipsia OMIM:619468
Permanent Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:226292
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Inguinal hernia, Hypothermia, Joint contracture OMIM:614498
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Obesity Due To Sim1 Deficiency
Attention deficit hyperactivity disorder, Polyphagia, Increased resting energy expenditure ORPHA:369873
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Central Diabetes Insipidus
Fever, Polydipsia ORPHA:178029
Familial Cold Urticaria
Fever, Polydipsia ORPHA:47045
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia, Umbilical hernia ORPHA:226313
Familial Thyroid Dyshormonogenesis
Hypothermia, Umbilical hernia ORPHA:95716
Menkes Disease
Hypothermia OMIM:309400
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Meningococcal Meningitis
Hypothermia, Fever ORPHA:33475
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Abnormality of temperature regulation, Hip contracture, Hypothermia, Elbow flexion contracture, F... OMIM:618493
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Carnitine-Acylcarnitine Translocase Deficiency
Cyanosis, Hypothermia ORPHA:159
Bardet-Biedl Syndrome 9
Polyphagia, Polydipsia OMIM:615986
Congenital Enterovirus Infection
Hypothermia, Fever ORPHA:292
Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:442
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Unexplained fevers, Polydipsia OMIM:125800
Ethylene Glycol Poisoning
Cyanosis, Hypothermia, Alcoholism ORPHA:31826
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Unexplained fevers, Polydipsia OMIM:304800
Adult-Onset Autosomal Dominant Leukodystrophy
Hypothermia, Flexion contracture, Temperature instability, Dysphagia ORPHA:99027
Isolated Thyroid-Stimulating Hormone Deficiency
Hypothermia, Attention deficit hyperactivity disorder, Umbilical hernia ORPHA:90674
Genetic Transient Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:226316
Fever, Polydipsia ORPHA:213
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia ORPHA:26793
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Neuroleptic Malignant Syndrome
Hypothermia, Fever, Agitation, Dysphagia ORPHA:94093
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
3-Hydroxy-3-Methylglutaric Aciduria
Hypothermia, Fever ORPHA:20
Hypothyroidism Due To Tsh Receptor Mutations
Hypothermia, Umbilical hernia ORPHA:90673
Pediatric-Onset Graves Disease
Hyperactivity, Polyphagia, Polydipsia ORPHA:525731
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
Ochoa Syndrome
Polydipsia ORPHA:2704
Teratoma, Pineal
Polydipsia OMIM:273120
Alexander Disease
Hypothermia, Dysphagia ORPHA:58
Occipital Horn Syndrome
Keloids, Hypothermia, Scarring, Inguinal hernia, Hiatus hernia, Dysphagia, Atypical scarring of s... ORPHA:198
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Cyanosis, Hypothermia, Polyphagia, Fever, Polydipsia ORPHA:293987
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Mitochondrial Dna-Associated Leigh Syndrome
Hypothermia, Fever, Dysphagia ORPHA:255210
Nephrogenic Diabetes Insipidus
Fever, Polydipsia ORPHA:223
Aromatic L-Amino Acid Decarboxylase Deficiency
Intermittent hypothermia, Temperature instability OMIM:608643
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Hereditary Sensory And Autonomic Neuropathy Type 4
Hyperactivity, Corneal scarring, Fasciitis, Hypothermia, Impulsivity, Unexplained fevers, Dysphag... ORPHA:642
East Syndrome
Salt craving, Polydipsia ORPHA:199343
Gitelman Syndrome
Salt craving, Chondrocalcinosis, Recurrent fever, Polydipsia OMIM:263800
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Menkes Disease
Hernia, Hypothermia, Inguinal hernia, Atypical scarring of skin, Chondrocalcinosis, Umbilical hernia ORPHA:565
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Brain-Lung-Thyroid Syndrome
Abnormal drinking behavior, Hyperactivity, Unexplained fevers, Abnormal eating behavior ORPHA:209905
Whipple Disease
Fever, Polydipsia ORPHA:3452
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia, Flexion contracture ORPHA:17
Helix Syndrome
Heat intolerance, Polydipsia OMIM:617671
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia ORPHA:79282
Nephronophthisis 4
Polydipsia OMIM:606966
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Hyperparathyroidism-Jaw Tumor Syndrome
Chondrocalcinosis, Lipoma, Polydipsia, Dysphagia ORPHA:99880
Congenital diaphragmatic hernia, Polydipsia ORPHA:2260
Nephronophthisis 1
Polydipsia OMIM:256100
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Rabson-Mendenhall Syndrome
Reduced subcutaneous adipose tissue, Polydipsia ORPHA:769
Parathyroid Carcinoma
Chondrocalcinosis, Lipoma, Polydipsia, Dysphagia ORPHA:143
Nephronophthisis 3
Polydipsia OMIM:604387
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothermia, Umbilical hernia OMIM:218700
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Salt craving, Polydipsia OMIM:612780
Nephronophthisis 11
Polydipsia OMIM:613550
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Umbilical hernia ORPHA:226307
Renal Hypoplasia
Polydipsia ORPHA:93101
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Erdheim-Chester Disease
Fever, Polydipsia ORPHA:35687
Polydipsia ORPHA:95513
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Dysphagia, Hypothermia, Uterine prolapse ORPHA:438213
Marburg Hemorrhagic Fever
Hypothermia, Fever ORPHA:99826
Senior-Boichis Syndrome
Agitation, Attention deficit hyperactivity disorder, Polydipsia ORPHA:84081
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Impaired oropharyngeal swallow response, Achilles tendon contracture, Corneal scarring, Decreased... ORPHA:404454
Hypothermia, Scarring, Fever ORPHA:797
Bartter Syndrome, Type 2, Antenatal
Chondrocalcinosis, Fever, Polydipsia OMIM:241200
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Gitelman Syndrome
Salt craving, Chondrocalcinosis, Polydipsia ORPHA:358
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Wolfram Syndrome
Polydipsia ORPHA:3463
Arima Syndrome
Polydipsia OMIM:243910
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Cystinosis, Nephropathic
Oral-pharyngeal dysphagia, Polydipsia, Dysphagia OMIM:219800
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Proximal Renal Tubular Acidosis
Enamel hypomineralization, Polydipsia ORPHA:47159
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Opn3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Opn3.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2. American journal of respiratory cell and molecular biology (January 2021) Opn3tm2b(EUCOMM)Wtsi PMC7780995
Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model. eNeuro (September 2020) Opn3tm2b(EUCOMM)Wtsi PMC7477952
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proceedings of the National Academy of Sciences of the United States of America (September 2015) Opn3tm2a(EUCOMM)Wtsi Opn3tm2b(EUCOMM)Wtsi PMC4620855

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MGI Allele Allele Type Produced
Opn3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Opn3em1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Opn3tm40432(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Opn3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Opn3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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