Gene Summary

opsin 3
ERO,  Ecpn,  panopsin,  encephalopsin

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral content Opn3em1(IMPC)Mbp HOM Early adult 5.63×10-07
abnormal eye morphology Opn3em1(IMPC)Mbp HOM Early adult 0.00
increased basophil cell number Opn3em1(IMPC)Mbp HOM Early adult 8.01×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

57 Images


XRay Images Whole Body Lateral Orientation

19 Images

Human diseases caused by Opn3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Opn3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Fever, Familial Lifelong Persistent
Fever OMIM:228400
Ragweed Sensitivity
Fever OMIM:179450
Chronic Myeloid Leukemia
Thrombocytosis, Abnormal basophil morphology, Leukocytosis, Abnormal granulocyte morphology, Thro... ORPHA:521
Primary Erythromelalgia
Hypothermia ORPHA:90026
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Decreased resting energy expenditure OMIM:601665
Systemic Mastocytosis With Associated Hematologic Neoplasm
Myeloid leukemia, Osteoporosis, Leukocytosis, Chronic lymphatic leukemia, Normocytic anemia, Thro... ORPHA:98849
Immunodeficiency 60
Pancytopenia, Decreased basophil count, Decreased proportion of memory B cells, Splenomegaly OMIM:618394
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Hereditary Central Diabetes Insipidus
Polydipsia, Fever ORPHA:30925
Idiopathic Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:95717
Menkes Disease
Hypothermia OMIM:309400
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
Permanent Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:226292
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia, Umbilical hernia ORPHA:226313
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Familial Cold Urticaria
Polydipsia, Fever ORPHA:47045
Familial Thyroid Dyshormonogenesis
Hypothermia, Umbilical hernia ORPHA:95716
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Central Diabetes Insipidus
Polydipsia, Fever ORPHA:178029
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Meningococcal Meningitis
Hypothermia, Fever ORPHA:33475
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Abnormality of temperature regulation, Hypothermia, Hip contracture, Elbow flexion contracture, F... OMIM:618493
Yellow Fever
Malignant hyperthermia, Hypothermia, Fever ORPHA:99829
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Congenital Enterovirus Infection
Hypothermia, Fever ORPHA:292
Carnitine-Acylcarnitine Translocase Deficiency
Cyanosis, Hypothermia ORPHA:159
Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:442
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Dysphagia, Flexion contracture, Hypothermia ORPHA:99027
Genetic Transient Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:226316
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia, Unexplained fevers OMIM:125800
Diabetes Insipidus, Nephrogenic, X-Linked
Polydipsia, Unexplained fevers OMIM:304800
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Diabetes Insipidus, Neurohypophyseal Type
Polydipsia OMIM:304900
Hypothyroidism Due To Tsh Receptor Mutations
Hypothermia, Umbilical hernia ORPHA:90673
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polyphagia, Hypothermia, Cyanosis, Polydipsia, Fever ORPHA:293987
Mitochondrial Dna-Associated Leigh Syndrome
Dysphagia, Hypothermia, Fever ORPHA:255210
3-Hydroxy-3-Methylglutaric Aciduria
Hypothermia, Fever ORPHA:20
Ethylene Glycol Poisoning
Cyanosis, Hypothermia ORPHA:31826
Occipital Horn Syndrome
Hiatus hernia, Scarring, Atypical scarring of skin, Dysphagia, Keloids, Inguinal hernia, Femoral ... ORPHA:198
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia ORPHA:26793
Polydipsia, Fever ORPHA:213
Menkes Disease
Chondrocalcinosis, Atypical scarring of skin, Umbilical hernia, Inguinal hernia, Hernia, Hypothermia ORPHA:565
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Alexander Disease
Dysphagia, Hypothermia ORPHA:58
Neuroleptic Malignant Syndrome
Dysphagia, Hypothermia, Fever ORPHA:94093
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Isolated Thyroid-Stimulating Hormone Deficiency
Hypothermia, Umbilical hernia ORPHA:90674
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Hereditary Sensory And Autonomic Neuropathy Type 4
Atypical scarring of skin, Dysphagia, Corneal scarring, Recurrent fever, Fasciitis, Unexplained f... ORPHA:642
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Aromatic L-Amino Acid Decarboxylase Deficiency
Temperature instability, Intermittent hypothermia OMIM:608643
Teratoma, Pineal
Polydipsia OMIM:273120
Ochoa Syndrome
Polydipsia ORPHA:2704
Gitelman Syndrome
Polydipsia, Salt craving, Recurrent fever, Chondrocalcinosis OMIM:263800
Nephrogenic Diabetes Insipidus
Polydipsia, Fever ORPHA:223
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Pediatric-Onset Graves Disease
Polydipsia, Polyphagia ORPHA:525731
Whipple Disease
Polydipsia, Fever ORPHA:3452
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Flexion contracture, Hypothermia ORPHA:17
Brain-Lung-Thyroid Syndrome
Abnormal drinking behavior, Abnormal eating behavior, Unexplained fevers ORPHA:209905
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia ORPHA:79282
Helix Syndrome
Heat intolerance, Polydipsia OMIM:617671
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothermia, Umbilical hernia OMIM:218700
Nephronophthisis 4
Polydipsia OMIM:606966
Primary Parathyroid Hyperplasia
Dysphagia, Polydipsia, Chondrocalcinosis ORPHA:99878
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Umbilical hernia ORPHA:226307
Rabson-Mendenhall Syndrome
Reduced subcutaneous adipose tissue, Polydipsia ORPHA:769
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Hyperparathyroidism-Jaw Tumor Syndrome
Dysphagia, Polydipsia, Lipoma, Chondrocalcinosis ORPHA:99880
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Parathyroid Carcinoma
Dysphagia, Polydipsia, Lipoma, Chondrocalcinosis ORPHA:143
Nephronophthisis 3
Polydipsia OMIM:604387
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Nephronophthisis 1
Polydipsia OMIM:256100
Renal Hypoplasia
Polydipsia ORPHA:93101
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Dysphagia, Uterine prolapse, Hypothermia ORPHA:438213
Polydipsia, Congenital diaphragmatic hernia ORPHA:2260
Nephronophthisis 11
Polydipsia OMIM:613550
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Polydipsia ORPHA:95513
Erdheim-Chester Disease
Polydipsia, Fever ORPHA:35687
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Decreased resting energy expenditure, Achilles tendon contracture, Corneal scarring, Impaired oro... ORPHA:404454
Scarring, Hypothermia, Fever ORPHA:797
Toxic Epidermal Necrolysis
Dysphagia, Polydipsia ORPHA:537
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Gitelman Syndrome
Polydipsia, Salt craving, Chondrocalcinosis ORPHA:358
Bartter Syndrome, Type 2, Antenatal
Polydipsia, Fever, Chondrocalcinosis OMIM:241200
Wolfram Syndrome
Polydipsia ORPHA:3463
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Cystinosis, Nephropathic
Dysphagia, Polydipsia, Oral-pharyngeal dysphagia OMIM:219800
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Proximal Renal Tubular Acidosis
Polydipsia, Enamel hypomineralization ORPHA:47159
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Opn3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Opn3.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proceedings of the National Academy of Sciences of the United States of America (September 2015) Opn3tm2a(EUCOMM)Wtsi Opn3tm2b(EUCOMM)Wtsi PMC4620855

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MGI Allele Allele Type Produced
Opn3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Opn3em1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Opn3tm40432(L1L2_gt1) Targeting vectors
Opn3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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