Gene Summary

opsin 3
Ecpn,  ERO,  encephalopsin,  panopsin

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Opn3em1(IMPC)Mbp HOM Early adult 0.00
increased basophil cell number Opn3em1(IMPC)Mbp HOM Early adult 2.12×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

57 Images


XRay Images Whole Body Lateral Orientation

19 Images

Human diseases caused by Opn3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Opn3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Chronic Myeloid Leukemia
Myeloproliferative disorder, Leukocytosis, Abnormal granulocyte morphology, Thrombocytopenia, Spl... ORPHA:521
Primary Erythromelalgia
Hypothermia ORPHA:90026
Riboflavin Deficiency
Hypothermia OMIM:615026
Neutropenia, Lethal Congenital, With Eosinophilia
Eosinophilia, Neutropenia OMIM:257100
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Kleine-Levin Syndrome
Polydipsia, Agitation, Abnormal eating behavior, Polyphagia, Fever, Repetitive compulsive behavio... ORPHA:33543
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Decreased resting energy expenditure OMIM:601665
Immunodeficiency 60 And Autoimmunity
Decreased proportion of memory B cells, Decreased basophil count, Splenomegaly, Pancytopenia OMIM:618394
Hereditary Central Diabetes Insipidus
Fever, Polydipsia ORPHA:30925
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Acute myeloid leukemia, Normochromic anemia, Chronic lymphatic leukemia, Chron... ORPHA:98849
Idiopathic Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:95717
Coenzyme Q10 Deficiency, Primary, 5
Hypothermia OMIM:614654
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Central Diabetes Insipidus
Fever, Polydipsia, Anorexia ORPHA:178029
Nephronophthisis-Like Nephropathy 2
Polydipsia, Recurrent fever OMIM:619468
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Joint contracture, Hypothermia, Inguinal hernia OMIM:614498
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
N-Acetylglutamate Synthase Deficiency
Anorexia, Hypothermia, Aggressive behavior OMIM:237310
Meningococcal Meningitis
Fever, Hypothermia, Anorexia ORPHA:33475
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Familial Cold Urticaria
Fever, Polydipsia ORPHA:47045
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia, Umbilical hernia ORPHA:226313
Familial Thyroid Dyshormonogenesis
Hypothermia, Umbilical hernia ORPHA:95716
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Menkes Disease
Hypothermia OMIM:309400
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Abnormality of temperature regulation, Hypothermia, Elbow flexion contracture, Fever, Hip contrac... OMIM:618493
Timothy Syndrome
Hypothermia OMIM:601005
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Carnitine-Acylcarnitine Translocase Deficiency
Cyanosis, Hypothermia ORPHA:159
Sepsis In Premature Infants
Fever, Cyanosis, Hypothermia, Temperature instability ORPHA:90051
Congenital Enterovirus Infection
Fever, Hypothermia ORPHA:292
Nephronophthisis 9
Polydipsia OMIM:613824
Fever, Polydipsia, Motor stereotypy ORPHA:213
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Unexplained fevers, Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Unexplained fevers, Polydipsia OMIM:304800
3-Hydroxy-3-Methylglutaric Aciduria
Fever, Hypothermia, Anorexia ORPHA:20
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Hypothermia, Compulsive behaviors, Polyphagia, Fever, Self-injurious behavior, Cyanos... ORPHA:293987
Ethylene Glycol Poisoning
Cyanosis, Addictive alcohol use, Hypothermia ORPHA:31826
Genetic Transient Congenital Hypothyroidism
Hypothermia, Umbilical hernia ORPHA:226316
Isolated Thyroid-Stimulating Hormone Deficiency
Attention deficit hyperactivity disorder, Hypothermia, Umbilical hernia ORPHA:90674
Adult-Onset Autosomal Dominant Leukodystrophy
Flexion contracture, Hypothermia, Temperature instability, Dysphagia ORPHA:99027
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Nephrogenic Diabetes Insipidus
Fever, Polydipsia, Anorexia ORPHA:223
Alexander Disease
Self-injurious behavior, Hypothermia, Dysphagia ORPHA:58
Aromatic L-Amino Acid Decarboxylase Deficiency
Intermittent hypothermia, Temperature instability, Tongue thrusting OMIM:608643
Hypothyroidism Due To Tsh Receptor Mutations
Hypothermia, Umbilical hernia ORPHA:90673
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia ORPHA:26793
Neuroleptic Malignant Syndrome
Fever, Agitation, Hypothermia, Dysphagia ORPHA:94093
Hereditary Sensory And Autonomic Neuropathy Type 4
Hypothermia, Nail-biting, Hyperactivity, Corneal scarring, Impulsivity, Unexplained fevers, Recur... ORPHA:642
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Ochoa Syndrome
Polydipsia ORPHA:2704
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia, Flexion contracture, Aggressive behavior ORPHA:17
Mitochondrial Dna-Associated Leigh Syndrome
Fever, Hypothermia, Dysphagia ORPHA:255210
Occipital Horn Syndrome
Scarring, Hypothermia, Inguinal hernia, Femoral hernia, Dysphagia, Atypical scarring of skin, Kel... ORPHA:198
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Pediatric-Onset Graves Disease
Polydipsia, Polyphagia, Hyperactivity ORPHA:525731
Teratoma, Pineal
Polydipsia OMIM:273120
Whipple Disease
Fever, Polydipsia, Anorexia ORPHA:3452
Brain-Lung-Thyroid Syndrome
Hyperactivity, Compulsive behaviors, Unexplained fevers, Abnormal drinking behavior, Abnormal eat... ORPHA:209905
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Menkes Disease
Hypothermia, Inguinal hernia, Umbilical hernia, Atypical scarring of skin, Hernia, Chondrocalcinosis ORPHA:565
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Gitelman Syndrome
Polydipsia, Recurrent fever, Salt craving, Chondrocalcinosis OMIM:263800
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Helix Syndrome
Polydipsia, Heat intolerance OMIM:617671
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia ORPHA:79282
Nephronophthisis 4
Polydipsia OMIM:606966
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Marburg Hemorrhagic Fever
Fever, Hypothermia, Anorexia, Aggressive behavior ORPHA:99826
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Hyperparathyroidism-Jaw Tumor Syndrome
Polydipsia, Dysphagia, Chondrocalcinosis, Lipoma ORPHA:99880
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Umbilical hernia ORPHA:226307
Congenital diaphragmatic hernia, Polydipsia ORPHA:2260
Parathyroid Carcinoma
Polydipsia, Dysphagia, Chondrocalcinosis, Lipoma ORPHA:143
Nephronophthisis 1
Polydipsia OMIM:256100
Rabson-Mendenhall Syndrome
Polydipsia, Reduced subcutaneous adipose tissue ORPHA:769
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothermia, Umbilical hernia OMIM:218700
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Nephronophthisis 11
Polydipsia OMIM:613550
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Uterine prolapse, Hypothermia, Dysphagia, Stereotypical hand wringing ORPHA:438213
Renal Hypoplasia
Polydipsia ORPHA:93101
Erdheim-Chester Disease
Fever, Polydipsia ORPHA:35687
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Polydipsia ORPHA:95513
Nephronophthisis 3
Polydipsia OMIM:604387
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia OMIM:617994
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Corneal scarring, Impaired oral bolus formation, Impaired oropharyngeal swallow response, Achille... ORPHA:404454
Fever, Scarring, Hypothermia ORPHA:797
Bartter Syndrome, Type 2, Antenatal
Fever, Polydipsia, Chondrocalcinosis OMIM:241200
Gitelman Syndrome
Polydipsia, Salt craving, Chondrocalcinosis ORPHA:358
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Wolfram Syndrome
Polydipsia ORPHA:3463
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Cystinosis, Nephropathic
Polydipsia, Dysphagia OMIM:219800
Proximal Renal Tubular Acidosis
Polydipsia, Enamel hypomineralization ORPHA:47159
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Hypomagnesemia 3, Renal
Amelogenesis imperfecta, Enamel hypoplasia, Hypomature enamel, Polydipsia OMIM:248250
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Opn3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Opn3.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2. American journal of respiratory cell and molecular biology (January 2021) Opn3tm2b(EUCOMM)Wtsi PMC7780995
Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model. eNeuro (September 2020) Opn3tm2b(EUCOMM)Wtsi PMC7477952
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea. Investigative ophthalmology & visual science (June 2020) Opn3tm2b(EUCOMM)Wtsi PMC7415322
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell reports (January 2020) Opn3tm2a(EUCOMM)Wtsi PMC7341981
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proceedings of the National Academy of Sciences of the United States of America (September 2015) Opn3tm2a(EUCOMM)Wtsi Opn3tm2b(EUCOMM)Wtsi PMC4620855

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MGI Allele Allele Type Produced
Opn3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Opn3em1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Opn3tm40432(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Opn3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Opn3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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