Ap4m1 | adaptor-related protein complex AP-4, mu 1

GeneMGI:1337063Synonyms: 4930443L05Rik

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system

15 No significant impact

6 Not tested

Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased leukocyte cell number1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult4.1x10-5 
increased circulating alanine transaminase level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult1.94x10-11 
increased hematocrit1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult9.48x10-5 
increased circulating alkaline phosphatase level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult1.71x10-7 
increased circulating iron level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult1.79x10-5 
increased circulating cholesterol level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult4.82x10-5 
increased circulating aspartate transaminase level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult1.85x10-33 
decreased circulating serum albumin level1 supporting datasetAp4m1tm1b(EUCOMM)WtsihomozygoteEarly adult5.1x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ap4m1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Ap4m1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ap4m1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Ap4m1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Ap4m1tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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