Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

LanC (bacterial lantibiotic synthetase component C)-like 1
p40,  LanC-like protein 1,  Gpr69a

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lancl1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lancl1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Complement Component 8 Deficiency, Type Ii
Meningitis, Recurrent Neisserial infections OMIM:613789
Encephalopathy, Acute, Infection-Induced (Herpes-Specific), Susceptibility To, 7
Encephalitis OMIM:616532
Neurodegeneration Due To Cerebral Folate Transport Deficiency
Neurodegeneration OMIM:613068
Subacute Sclerosing Panencephalitis
Encephalitis OMIM:260470
Immunodeficiency 37
Recurrent infections, Encephalitis, Colitis OMIM:616098
Complement Component 8 Deficiency, Type I
Meningitis OMIM:613790
Agammaglobulinemia 2, Autosomal Recessive
Meningitis, Recurrent respiratory infections, Recurrent bacterial infections, Recurrent pneumonia OMIM:613500
Bare Lymphocyte Syndrome, Type Ii
Recurrent fungal infections, Recurrent upper respiratory tract infections, Viral hepatitis, Recur... OMIM:209920
Complement Component 4B Deficiency
Meningitis, Chronic active hepatitis OMIM:614379
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Prostatitis, Epididymitis, Recurrent otitis media, Recurrent urinary tract infections, Pneumonia,... OMIM:307200
L-2-Hydroxyglutaric Aciduria
Encephalitis ORPHA:79314
Agammaglobulinemia, X-Linked
Prostatitis, Epididymitis, Recurrent urinary tract infections, Pneumonia, Septic arthritis, Pyode... OMIM:300755
Pfapa Syndrome
Recurrent pharyngitis, Encephalitis, Arthritis ORPHA:42642
Lymphoproliferative Syndrome, X-Linked, 1
Severe Epstein Barr virus infection, Meningitis, Fulminant hepatitis, Encephalitis, Recurrent pha... OMIM:308240
Cerebral Visual Impairment
Unusual CNS infection, Neurodegeneration, Meningitis, Encephalitis, Central nervous system degene... ORPHA:447788
Crigler-Najjar Syndrome
Encephalitis ORPHA:205
Nipah Virus Disease
Recurrent pharyngitis, Encephalitis ORPHA:99825
Lyme Disease
Meningitis, Uveitis, Encephalitis, Arthritis ORPHA:91546
Invasive pulmonary aspergillosis, Bronchiectasis, Unusual CNS infection, Pneumonia, Meningitis, H... ORPHA:1163
Scrub Typhus
Skin rash, Meningitis, Encephalitis, Anterior uveitis, Myocarditis ORPHA:83317
Bacterial Toxic-Shock Syndrome
Peritonitis, Skin rash, Severe viral infection, Recurrent urinary tract infections, Pneumonia, Se... ORPHA:36234
Leukoencephalopathy, Progressive, With Ovarian Failure
Cerebellar atrophy, Neurodegeneration OMIM:615889
Ceroid Lipofuscinosis, Neuronal, 7
Cerebellar atrophy, Cerebral atrophy, Neurodegeneration OMIM:610951
Neurodegeneration OMIM:222350
Neurocutaneous Melanocytosis
Encephalitis, Abnormality of neuronal migration ORPHA:2481
Tmem70-Related Mitochondrial Encephalo-Cardio-Myopathy
Cerebral cortical atrophy, Encephalitis ORPHA:1194
New-Onset Refractory Status Epilepticus
Encephalitis, Global brain atrophy ORPHA:363558
Zika Virus Disease
Skin rash, Myelitis, Maculopapular exanthema, Conjunctivitis, Meningitis, Encephalitis, Arthritis ORPHA:448237
Rift Valley Fever
Meningitis, Encephalitis ORPHA:319251
Drug Rash With Eosinophilia And Systemic Symptoms
Skin rash, Pustule, Interstitial pneumonitis, Thyroiditis, Erythroderma, Hepatitis, Tubulointerst... ORPHA:139402
Skin rash, Encephalitis ORPHA:99745
Candidiasis, Familial, 2
Chronic tinea infection, Chronic oral candidiasis, Onychomycosis, Meningitis, Deep dermatophytosis OMIM:212050
Encephalopathy, Acute, Infection-Induced (Herpes-Specific), Susceptibility To, 8
Meningitis, Herpes simplex encephalitis OMIM:617900
American Trypanosomiasis
Skin rash, Encephalitis, Myocarditis ORPHA:3386
Congenital Enterovirus Infection
Skin rash, Meningitis, Hepatitis, Encephalitis, Myocarditis ORPHA:292
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive
Recurrent opportunistic infections, Failure to thrive secondary to recurrent infections, Purulent... OMIM:601457
Legionnaires Disease
Endocarditis, Pericarditis, Hepatitis, Encephalitis, Pancreatitis, Myocarditis, Recurrent pharyng... ORPHA:549
Reynolds Syndrome
Skin rash, Keratoconjunctivitis sicca, Encephalitis, Arthritis ORPHA:779
Immunodeficiency 83, Susceptibility To Viral Infections
Meningitis, Herpes simplex encephalitis OMIM:613002
Immunodeficiency 59 And Hypoglycemia
Arteritis, Stomatitis, Herpes encephalitis, Encephalitis, Acne inversa, Recurrent skin infections OMIM:233600
Avian Influenza
Myelitis, Pneumonia, Meningitis, Conjunctivitis, Hepatitis, Encephalitis ORPHA:454836
Peritonitis, Prostatitis, Nephritis, Endocarditis, Bronchiolitis, Lymphadenitis, Thyroiditis, Pne... ORPHA:2552
Complement Factor B Deficiency
Peritonitis, Pneumonia, Meningitis, Recurrent meningococcal disease, Recurrent bacterial infections OMIM:615561
Whipple Disease
Pericarditis, Uveitis, Encephalitis, Myocarditis, Myositis, Arthritis ORPHA:3452
Gm1 Gangliosidosis
Aspiration pneumonia, Recurrent respiratory infections, Patent ductus arteriosus, Encephalitis ORPHA:354
Hartnup Disease
Skin rash, Encephalitis ORPHA:2116
Peritonitis, Pustule, Endocarditis, Pericarditis, Pyelonephritis, Arteritis, Unusual skin infecti... ORPHA:533
Peritonitis, Cutaneous abscess, Endocarditis, Pericarditis, Scleritis, Lymphadenitis, Thyroiditis... ORPHA:31204
Meningococcal Meningitis
Skin rash, Encephalitis ORPHA:33475
Immunoglobulin M, Level Of
Meningitis OMIM:308250
Immunodeficiency 66
Meningitis, Pustule, Recurrent skin infections OMIM:618847
Familial Hemophagocytic Lymphohistiocytosis
Skin rash, Erythroderma, Maculopapular exanthema, Colitis, Encephalitis ORPHA:540
Q Fever
Endocarditis, Pericarditis, Cholecystitis, Maculopapular exanthema, Pneumonia, Meningitis, Hepati... ORPHA:781
Yellow Fever
Meningitis, Encephalitis ORPHA:99829
Neurodegeneration With Brain Iron Accumulation 5
Cerebellar atrophy, Cerebral atrophy, Neurodegeneration OMIM:300894
Arthralgia/arthritis, Pericarditis, Endocarditis, Fungal meningitis, Unusual skin infection, Unus... ORPHA:449280
Meningitis, Myelitis, Encephalitis ORPHA:2912
Neurodegeneration, Childhood-Onset, With Brain Atrophy
Cerebral cortical atrophy, Cerebellar atrophy, Cerebral atrophy, Neurodegeneration OMIM:617672
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Cerebral cortical atrophy, Recurrent urinary tract infections, Encephalitis ORPHA:847
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Recurrent herpes, Recurrent Aspergillus infections, Bronchiectasis, Recurrent upper respiratory t... ORPHA:391487
Peritonitis, Pustule, Nephritis, Endocarditis, Pericarditis, Enterocolitis, Unusual skin infectio... ORPHA:73263
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Cerebellar atrophy, Neurodegeneration ORPHA:438134
Hemophagocytic Lymphohistiocytosis, Familial, 1
Meningitis, Encephalitis OMIM:267700
Hemophagocytic Lymphohistiocytosis, Familial, 2
Meningitis, Skin rash, Encephalitis OMIM:603553
Amoebiasis Due To Free-Living Amoebae
Pustule, Unusual skin infection, Pneumonia, Encephalitis, Sinusitis, Myocardial necrosis ORPHA:68
Selective Igm Deficiency
Cutaneous abscess, Bronchiectasis, Recurrent urinary tract infections, Onychomycosis, Pulmonary t... ORPHA:331235
Behçet Disease
Endocarditis, Pericarditis, Increased inflammatory response, Retrobulbar optic neuritis, Orchitis... ORPHA:117
Immunodeficiency, Common Variable, 2
Recurrent bronchitis, Bronchiectasis, Recurrent otitis media, Recurrent sinusitis, Meningitis, Co... OMIM:240500
Incontinentia Pigmenti
Skin rash, Uveitis, Cerebral cortical atrophy, Keratitis, Encephalitis ORPHA:464
Japanese Encephalitis
Meningitis, Encephalitis ORPHA:79139
Isolated Agammaglobulinemia
Skin rash, Pneumonia, Recurrent respiratory infections, Meningitis, Inflammatory abnormality of t... ORPHA:229717
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cerebellar atrophy, Cerebral atrophy, Axonal degeneration, Neurodegeneration OMIM:615157
Complement Factor I Deficiency
Recurrent Haemophilus influenzae infections, Pyelonephritis, Recurrent otitis media, Recurrent si... OMIM:610984
Autosomal Agammaglobulinemia
Skin rash, Bronchiectasis, Chronic otitis media, Recurrent respiratory infections, Conjunctivitis... ORPHA:33110
Spastic Paraplegia 35, Autosomal Recessive
Atrophy/Degeneration affecting the brainstem, Cerebellar atrophy, Neurodegeneration OMIM:612319
Immunodeficiency Due To Selective Anti-Polysaccharide Antibody Deficiency
Atopic dermatitis, Recurrent upper and lower respiratory tract infections, Rhinitis, Sinusitis, R... ORPHA:70593
Immunodeficiency 46
Meningitis, Conjunctivitis, Chronic oral candidiasis, Recurrent sinopulmonary infections OMIM:616740
Epididymitis, Endocarditis, Pericarditis, Arteritis, Hip osteoarthritis, Orchitis, Pneumonia, Sep... ORPHA:1304
Immunoglobulin A Vasculitis
Skin rash, Pustule, Orchitis, Episcleritis, Encephalitis, Arthritis ORPHA:761
Neurodegeneration With Brain Iron Accumulation 6
Neurodegeneration OMIM:615643
Skin rash, Maculopapular exanthema, Synovitis, Crusting erythematous dermatitis, Encephalitis, Er... ORPHA:324625
Alexander Disease
Encephalitis ORPHA:58
Skin rash, Cutaneous abscess, Pneumonia, Conjunctivitis, Meningitis, Inflammatory abnormality of ... ORPHA:3392
Severe Combined Immunodeficiency, X-Linked
Skin rash, Recurrent fungal infections, Chronic oral candidiasis, Pneumonia, Recurrent pneumonia,... OMIM:300400
Iridocyclitis, Encephalitis ORPHA:1560
Neurodegeneration With Brain Iron Accumulation 2A
Cerebellar atrophy, Cerebral atrophy, Neuronal loss in central nervous system, Neurodegeneration OMIM:256600
Krabbe Disease
Diffuse cerebral atrophy, Neurodegeneration OMIM:245200
Central Precocious Puberty
Meningitis, Acne ORPHA:759
Spastic Paraplegia 79, Autosomal Recessive
Cerebellar atrophy, Cerebral atrophy, Neurodegeneration OMIM:615491
X-Linked Agammaglobulinemia
Skin rash, Chronic otitis media, Sinusitis, Conjunctivitis, Meningitis, Hepatitis, Recurrent cuta... ORPHA:47
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Neurodegeneration, Periventricular heterotopia OMIM:618476
Combined Oxidative Phosphorylation Deficiency 24
Cerebellar atrophy, Neurodegeneration, Neuronal loss in central nervous system OMIM:616239
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Recurrent lower respiratory tract infections, Encephalitis, Recurrent upper respiratory tract inf... ORPHA:293987
Peritonitis, Bronchiectasis, Unusual CNS infection, Panniculitis, Maculopapular exanthema, Onycho... ORPHA:228119
Immunodeficiency 68
Lymphadenitis, Recurrent meningitis, Recurrent skin infections, Septic arthritis OMIM:612260
Hsd10 Disease, Infantile Type
Neurodegeneration, Diffuse cerebral atrophy, Cerebral atrophy, Frontotemporal cerebral atrophy ORPHA:391428
Amyotrophic Lateral Sclerosis
Neurodegeneration, Motor neuron atrophy, Amyotrophic lateral sclerosis ORPHA:803
Neonatal Alloimmune Neutropenia
Severe infection, Meningitis, Pneumonia ORPHA:464370
Cinca Syndrome
Meningitis, Skin rash, Uveitis, Arthritis OMIM:607115
Follicular Lymphoma
Meningitis ORPHA:545
Aplasia Cutis-Myopia Syndrome
Meningitis ORPHA:1117
Combined Immunodeficiency Due To Crac Channel Dysfunction
Recurrent fungal infections, Chronic otitis media, Recurrent viral infections, Pneumonia, Meningi... ORPHA:169090
Rat-Bite Fever
Skin rash, Parotitis, Pustule, Endocarditis, Pericarditis, Lymphadenitis, Maculopapular exanthema... ORPHA:31205
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Skin rash, Cerebral atrophy, Neurodegeneration OMIM:618321
Combined Oxidative Phosphorylation Defect Type 29
Neurodegeneration, Axonal degeneration, Diffuse cerebellar atrophy, Global brain atrophy ORPHA:478029
Adult-Onset Still Disease
Skin rash, Pericarditis, Meningitis, Hepatitis, Myocarditis, Recurrent pharyngitis, Arthritis ORPHA:829
Hypocomplementemic Urticarial Vasculitis
Skin rash, Uveitis, Meningitis, Conjunctivitis, Episcleritis, Recurrent bacterial infections, Inf... ORPHA:36412
Autoinflammation With Infantile Enterocolitis
Meningitis, Skin rash, Enterocolitis OMIM:616050
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Recurrent gastroenteritis, Interstitial pneumonitis, Eczematoid dermatitis, Thyroiditis, Pneumoni... ORPHA:37042
Prostatitis, Cutaneous abscess, Unusual skin infection, Acute infectious pneumonia, Pneumonia, Se... ORPHA:31202
Gm2 Gangliosidosis, Ab Variant
Cerebral atrophy, Neurodegeneration ORPHA:309246
Chronic Granulomatous Disease
Recurrent respiratory infections, Otitis media, Meningitis, Sinusitis, Eczema, Inflammatory abnor... ORPHA:379
Immunodeficiency With Hyper-Igm, Type 1
Sclerosing cholangitis, Stomatitis, Meningitis, Chronic hepatitis, Hepatitis, Recurrent bacterial... OMIM:308230
Nijmegen Breakage Syndrome
Recurrent pneumonia, Recurrent bronchitis, Bronchiectasis, Neurodegeneration, Recurrent urinary t... OMIM:251260
Cinca Syndrome
Meningitis, Retrobulbar optic neuritis, Uveitis, Inflammatory abnormality of the eye ORPHA:1451
Mixed Connective Tissue Disease
Skin rash, Pericarditis, Meningitis, Keratoconjunctivitis sicca, Gastritis, Myocarditis, Myositis... ORPHA:809
Leukocyte Adhesion Deficiency
Peritonitis, Bronchiectasis, Recurrent urinary tract infections, Pneumonia, Lymphocytic interstit... ORPHA:2968
Meningitis ORPHA:137817
Gm2-Gangliosidosis, Ab Variant
Cerebral atrophy, Neurodegeneration OMIM:272750
Chediak-Higashi Syndrome
Recurrent systemic pyogenic infections, Recurrent bacterial skin infections, Neurodegeneration, P... OMIM:214500
Gorham-Stout Disease
Meningitis, Osteomyelitis ORPHA:73
Ataxia-Telangiectasia-Like Disorder 2
Cerebellar atrophy, Neurodegeneration OMIM:615919
Neurodegeneration OMIM:300100
Whim Syndrome
Severe periodontitis, Recurrent pneumonia, Recurrent bacterial infections, Bronchiectasis, Recurr... ORPHA:51636
Mucopolysaccharidosis, Type Ii
Recurrent otitis media, Neurodegeneration OMIM:309900
Hurler Syndrome
Recurrent ear infections, Neurodegeneration, Recurrent respiratory infections OMIM:607014
Mucopolysaccharidosis, Type Vii
Neurodegeneration, Recurrent upper respiratory tract infections OMIM:253220
Peritonitis, Skin rash, Coccidioidal meningitis, Folliculitis, Pericarditis, Unusual CNS infectio... ORPHA:228123
Neurodegeneration With Brain Iron Accumulation 3
Neurodegeneration OMIM:606159
Meningitis, Unusual CNS infection ORPHA:74
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism ORPHA:31
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Recurrent upper respiratory tract infections, Recurrent otitis media, Pneumonia, Meningitis, Recu... OMIM:600802
Neurodegeneration With Brain Iron Accumulation 2B
Cerebellar atrophy, Cerebral atrophy, Neurodegeneration OMIM:610217
Pyruvate Dehydrogenase E2 Deficiency
Neurodegeneration ORPHA:79244
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Cerebral atrophy, Neurodegeneration OMIM:616878
Progressive Multifocal Leukoencephalopathy
Meningitis ORPHA:217260
Wiskott-Aldrich Syndrome, Autosomal Dominant
Inflammation of the large intestine, Recurrent upper respiratory tract infections, Pneumonia, Men... OMIM:600903
Neurodegeneration With Brain Iron Accumulation 4
Cerebellar atrophy, Neurodegeneration OMIM:614298
Giant Cell Arteritis
Meningitis, Recurrent pharyngitis, Pericarditis, Arthritis ORPHA:397
Peritonitis, Prostatitis, Pneumonia, Cerebral cortical atrophy, Meningitis, Osteomyelitis ORPHA:1546
Leukocyte Adhesion Deficiency Type Ii
Severe periodontitis, Recurrent gastroenteritis, Recurrent otitis media, Cerebral atrophy, Recurr... ORPHA:99843
Igg4-Related Kidney Disease
Prostatitis, Arteritis, Pericarditis, Interstitial pneumonitis, Lymphadenitis, Urinary bladder in... ORPHA:449395
Sepsis In Premature Infants
Severe infection, Meningitis, Enterocolitis, Disseminated viral infection ORPHA:90051
Familial Mediterranean Fever
Peritonitis, Pericarditis, Orchitis, Meningitis, Erysipelas, Crohn's disease, Arthritis OMIM:249100
Familial Mediterranean Fever
Peritonitis, Skin rash, Pericarditis, Orchitis, Meningitis, Erysipelas, Pancreatitis, Osteoarthri... ORPHA:342
Tick-Borne Encephalitis
Meningitis, Unusual CNS infection, Myelitis ORPHA:297
Granulomatosis With Polyangiitis
Prostatitis, Skin rash, Pericarditis, Increased inflammatory response, Chronic otitis media, Recu... ORPHA:900
Infection-Related Hemolytic Uremic Syndrome
Acute colitis, Severe viral infection, Pneumonia, Septic arthritis, Severe infection, Meningitis,... ORPHA:544482
Wiskott-Aldrich Syndrome
Recurrent herpes, Inflammation of the large intestine, Recurrent upper respiratory tract infectio... OMIM:301000
Primary Sjögren Syndrome
Parotitis, Arteritis, Chronic active hepatitis, Thyroiditis, Optic neuritis, Chronic hepatitis, M... ORPHA:289390
Kawasaki Disease
Skin rash, Pericarditis, Cheilitis, Conjunctivitis, Meningitis, Hepatitis, Cholecystitis, Recurre... ORPHA:2331
Wiskott-Aldrich Syndrome
Inflammation of the large intestine, Chronic otitis media, Recurrent respiratory infections, Conj... ORPHA:906
Multiple System Atrophy 1, Susceptibility To
Neurodegeneration OMIM:146500
Pituitary Dermoid And Epidermoid Cysts
Meningitis ORPHA:91351
Primary Intestinal Lymphangiectasia
Meningitis ORPHA:90362
Sacral Defect With Anterior Meningocele
Meningitis OMIM:600145
Meningitis, Cerebral cortical atrophy ORPHA:2177
Meningitis, Skin rash, Conjunctivitis ORPHA:863
Inflammation of the large intestine, Skin rash, Chapped lip, Endocarditis, Lymphadenitis, Acute i... ORPHA:707
Neurodegeneration With Brain Iron Accumulation 1
Neurodegeneration, Cerebral degeneration, Global brain atrophy OMIM:234200
Mitochondrial Dna-Associated Leigh Syndrome
Abnormality of Krebs cycle metabolism ORPHA:255210
Skin rash, Pericarditis, Uveitis, Optic neuritis, Meningitis, Hepatitis ORPHA:509
Kikuchi-Fujimoto Disease
Skin rash, Pustule, Meningitis, Malar rash, Myocarditis ORPHA:50918
Primrose Syndrome
Neurodegeneration OMIM:259050


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lancl1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lancl1.

No publications found that use IMPC mice or data for Lancl1.

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MGI Allele Allele Type Produced
Lancl1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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