Ap4e1 | adaptor-related protein complex AP-4, epsilon 1

GeneMGI:1336993Synonyms: 2310033A20Rik

Physiological systems

24 / 24 physiological systems tested

17 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological Skeleton Mortality/aging

7 No significant impact

Gene metrics:74Significant phenotypes
3Associated diseases
Expression examined in:158Adult tissues
59Embryo tissues

Phenotypes

decreased total body fat amount10 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adult7.88x10-14 
abnormal lens morphology4 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adult4.28x10-7 
increased red blood cell distribution width1 supporting datasetAp4e1tm1b(KOMP)WtsihomozygoteEarly adult7.1x10-5 
small testis2 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased anxiety-related response1 supporting datasetAp4e1tm1b(KOMP)WtsihomozygoteEarly adult3.48x10-7 
decreased mean corpuscular volume1 supporting datasetAp4e1tm1a(KOMP)WtsihomozygoteEarly adult1.4x10-21 
abnormal sleep behavior8 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adult5.81x10-9 
decreased grip strength3 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adult3.68x10-7 
hyperactivity28 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adult1.19x10-14 
abnormal testis morphology2 supporting datasetsAp4e1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ap4e1em1(IMPC)BayExon Deletionmouse
Ap4e1em1(IMPC)JIndelmouse
Ap4e1em2(IMPC)MbpIndelmouse
Ap4e1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ap4e1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Ap4e1tm1c(KOMP)WtsiWild type floxed exon (post-Flp)mouse
Ap4e1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Ap4e1tm35132(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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