Gene: Ap4e1

Log in to follow

Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 5.29×10-07
limb grasping Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.90×10-06
impaired glucose tolerance Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.40×10-07
abnormal lens morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.52×10-09
decreased respiratory quotient Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.28×10-07
abnormal behavior Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.35×10-13
decreased total retina thickness Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.03×10-09
increased prepulse inhibition Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.02×10-08
lordosis Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.00×10-07
enlarged heart Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
increased lean body mass Ap4e1em1(IMPC)J HOM postnatal 5.47×10-07
abnormal sleep behavior Ap4e1em1(IMPC)J HET postnatal 6.39×10-07
increased cardiac muscle contractility Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.51×10-06
abnormal spine curvature Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.04×10-15
decreased grip strength Ap4e1tm1b(KOMP)Wtsi HOM postnatal 8.18×10-06
abnormal heart left ventricle morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 7.67×10-05
abnormal retinal inner nuclear layer morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.95×10-05
increased heart weight Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.64×10-06
abnormal bone structure Ap4e1tm1b(KOMP)Wtsi HOM postnatal 5.65×10-05
increased erythrocyte cell number Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.05×10-05
decreased mean corpuscular hemoglobin Ap4e1tm1a(KOMP)Wtsi HOM postnatal 5.39×10-12
abnormal vitreous body morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.51×10-05
abnormal behavior Ap4e1tm1a(KOMP)Wtsi HOM postnatal 1.21×10-05
decreased circulating LDL cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.87×10-05
increased startle reflex Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.96×10-10
decreased total body fat amount Ap4e1tm1b(KOMP)Wtsi HOM postnatal 6.67×10-11
abnormal sleep behavior Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.27×10-11
abnormal coat appearance Ap4e1em1(IMPC)Bay HET postnatal 4.55×10-05
increased fluid intake Ap4e1tm1b(KOMP)Wtsi HOM postnatal 5.65×10-08
decreased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.22×10-05
decreased circulating insulin level Ap4e1em2(IMPC)Mbp HOM postnatal 3.75×10-05
decreased circulating insulin level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 8.22×10-06
increased lean body mass Ap4e1tm1a(KOMP)Wtsi HOM postnatal 4.48×10-05
increased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.18×10-09
abnormal behavioral response to light Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.01×10-06
enlarged spleen Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased heart rate Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.00×10-05
decreased circulating HDL cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.40×10-05
kyphosis Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.04×10-15
decreased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.80×10-05
abnormal heart morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased heart weight Ap4e1tm1b(KOMP)Wtsi HOM postnatal 5.35×10-05
abnormal spleen morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
hyperactivity Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.23×10-16
enlarged lymph nodes Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased circulating triglyceride level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.33×10-05
increased or absent threshold for auditory brainstem response Ap4e1tm1b(KOMP)Wtsi HOM postnatal 7.60×10-06
limb grasping Ap4e1em1(IMPC)J HOM postnatal 6.76×10-05
decreased cardiac stroke volume Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.36×10-07
increased bone mineral content Ap4e1em1(IMPC)J HOM postnatal 9.28×10-07
abnormal sensory capabilities/reflexes/nociception Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.13×10-06
decreased vertical activity Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.36×10-05
abnormal seminal vesicle morphology Ap4e1em2(IMPC)Mbp HOM postnatal 0.00
increased circulating alkaline phosphatase level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.47×10-06
decreased total body fat amount Ap4e1em1(IMPC)J HOM postnatal 7.17×10-09
abnormal kidney morphology Ap4e1tm1b(KOMP)Wtsi HOM postnatal 0.00
preweaning lethality, incomplete penetrance Ap4e1em1(IMPC)Bay HOM n/a 0.00
decreased vertical activity Ap4e1em2(IMPC)Mbp HOM postnatal 2.35×10-08
increased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.21×10-08
increased coping response Ap4e1tm1b(KOMP)Wtsi HOM postnatal 3.68×10-05
abnormal femur morphology Ap4e1tm1a(KOMP)Wtsi HOM postnatal 8.12×10-05
increased kidney weight Ap4e1tm1b(KOMP)Wtsi HOM postnatal 2.68×10-05
long tibia Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.60×10-05
abnormal sleep behavior Ap4e1em1(IMPC)J HOM postnatal 2.60×10-06
decreased circulating glucose level Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.07×10-05
short tibia Ap4e1tm1b(KOMP)Wtsi HOM postnatal 1.60×10-05
hypoactivity Ap4e1em1(IMPC)J HOM postnatal 1.33×10-05
decreased cardiac output Ap4e1tm1b(KOMP)Wtsi HOM postnatal 4.16×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 21 Yes  (2/584)  (15/23)  Wholemount images
Aorta 21 Yes  (10/23)  Wholemount images
Blood 5 No N/A
Blood vessel 4 No N/A
Bone 14 Yes  (3/16)  Wholemount images
Bone marrow 7 No  (2/7) N/A
Brain 21 Yes  (22/23)  Wholemount images  Section images
Brainstem 21 No  (16/23)  Wholemount images
Brown adipose tissue 19 Yes  (2/21)  Wholemount images
Cartilage tissue 21 No  (18/23)  Wholemount images
Cecum 11 Yes  (12/383)  (8/13)  Wholemount images
Cerebellum 21 No  (19/23)  Wholemount images  Section images
Cerebral cortex 21 No  (16/23)  Wholemount images
Chest bone 9 Yes  (8/11)  Wholemount images
Colon 9 No  (12/127)  (8/11) N/A
Cranium 6 No N/A
Diaphragm 9 Yes  (6/11)  Wholemount images
Duodenum 7 Yes  (2/127)  (7/9)  Wholemount images
Epididymis 11 Yes  (18/134)  (2/13)  Wholemount images
Esophagus 17 Yes  (7/415)  (12/19)  Wholemount images
Eye 21 Yes  (5/23)  Wholemount images  Section images
Gall bladder 17 Yes  (6/19)  Wholemount images
Gonadal fat pad 7 Yes  Wholemount images
Harderian gland 9 Yes  Wholemount images
Heart 21 Yes  (12/23)  Wholemount images
Hindlimb 9 Yes  (6/11)  Wholemount images
Hippocampus 21 Yes  (16/23)  Wholemount images
Hypothalamus 21 No  (16/23)  Wholemount images
Ileum 7 Yes  (14/127)  (8/9)  Wholemount images
Jejunum 7 Yes  (6/127)  (7/9)  Wholemount images
Kidney 21 Yes  (18/584)  (23/23)  Wholemount images
Large intestine 21 Yes  (10/584)  (12/23)  Wholemount images
Liver 21 Yes  (10/23)  Wholemount images  Section images
Lower urinary tract 21 No  (11/23)  Wholemount images
Lung 21 Yes  (14/23)  Wholemount images
Lymph node 21 Yes  (6/23)  Wholemount images
Main olfactory bulb 6 Yes  (6/8)  Wholemount images
Mammary gland 21 Yes  Wholemount images
Mesenteric adipose tissue 7 Yes  (2/9)  Wholemount images
Mesenteric lymph node 9 Yes  Wholemount images
Midbrain 9 No  (11/11) N/A
Esophagus 4 No  (2/4) N/A
Olfactory lobe 21 No  (19/23)  Wholemount images
Oral epithelium 10 No  (2/12)  Wholemount images
Ovary 21 Yes  (1/584)  (9/23)  Wholemount images
Oviduct 21 Yes  (9/23)  Wholemount images
Pancreas 21 Yes  (5/584)  (10/23)  Wholemount images
Parathyroid gland 17 Yes  (11/19)  Wholemount images
Parotid gland 9 Yes  Wholemount images
Penis 9 Yes  (3/11)  Wholemount images
Peripheral nervous system 21 No  (8/23)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 17 No  (2/19) N/A
Pituitary gland 21 Yes  (21/23)  Wholemount images
Prostate gland 21 Yes  (12/584)  (3/23)  Wholemount images
Quadriceps 7 Yes  (6/9)  Wholemount images
Sciatic nerve 9 Yes  Wholemount images
Skeletal muscle 17 No  (16/19)  Wholemount images  Section images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 21 Yes  (18/23)  Wholemount images  Section images
Small intestine 21 No  (9/584)  (12/23)  Wholemount images
Spinal cord 21 Yes  (23/23)  Wholemount images  Section images
Spleen 21 Yes  (2/584)  (6/23)  Wholemount images
Stomach 21 Yes  (12/584)  (15/23)  Wholemount images
Stomach pyloric region 9 No N/A
Striatum 21 No  (16/23)  Wholemount images
Sublingual gland 9 Yes  Wholemount images
Submandibular gland 11 Yes  (2/132)  (2/13)  Wholemount images
Testis 21 Yes  (2/584)  (11/23)  Wholemount images
Thalamus 6 No  (8/8) N/A
Thymus 21 Yes  (4/23)  Wholemount images
Thyroid gland 21 Yes  (15/584)  (7/23)  Wholemount images
Tongue 9 Yes  (5/127)  (6/11)  Wholemount images
Trachea 21 Yes  (18/23)  Wholemount images
Trigeminal V nerve 11 Yes  (9/13)  Wholemount images
Urinary bladder 12 Yes  (10/14)  Wholemount images  Section images
Uterus 21 Yes  (9/23)  Wholemount images
Vagina 9 Yes  Wholemount images
Vas deferens 11 No  (15/388)  (2/13)  Wholemount images
Vascular system 17 No  (4/19)  Wholemount images
Vesicular gland 11 Yes  (1/13)  Wholemount images
White adipose tissue 21 Yes  (2/23)  Wholemount images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 8  (6/485)  (1/9) N/A
Dorsal root ganglion 1  (1/47) Image Only N/A
Ear 8  (1/485)  (2/9) N/A
Embryo 8  (1/485)  (8/9)  Wholemount images
Eye 8  (1/485)  (8/9)  Wholemount images
Foot 8  (1/485)  (2/9) N/A
Forearm 6  (1/282) N/A
Forebrain 8  (1/485)  (1/9) N/A
Forelimb 8  (1/485)  (2/9) N/A
Fronto-nasal process 1  (1/48) Image Only N/A
Hand 8  (1/485)  (2/9) N/A
Head 8  (5/485)  (2/9)  Wholemount images
Heart 8  (1/485)  (1/9)  Wholemount images
Hindbrain 8  (6/485)  (1/9) N/A
Hindlimb 8  (1/485)  (2/9) N/A
Liver 8  (1/485)  (1/9)  Wholemount images
Lower leg 6  (1/282) N/A
Lung 8  (1/485) N/A
Mandibular process 8  (1/485)  (2/9) N/A
Maxillary process 8  (1/485)  (2/9) N/A
Midbrain 8  (1/485)  (1/9) N/A
Nose 1  (1/51)  (1/1) N/A
Oral cavity 8  (1/485)  (1/9) N/A
Skin 8  (1/485)  (2/9)  Wholemount images
Spinal cord 1  (1/50)  (1/1) N/A
Tail 8  (1/485)  (2/9)  Wholemount images
Tail somite 8  (1/485)  (1/9) N/A
Upper arm 6  (1/282) N/A
Upper leg 6  (1/282) N/A

 Associated Images

Brain Histopathology: Hippocampal section
3 Images
Brain Histopathology: Cerebellar Section
3 Images
Brain Histopathology: Striatal Section
3 Images
Sleep Wake: Wake state (bmp file)
29 Images
X-ray: XRay Images Forepaw
33 Images
X-ray: XRay Images Lateral Orientation
122 Images
X-ray: XRay Images Dorso Ventral
144 Images
DSS Histology
8 Images
Embryo LacZ: LacZ images wholemount
111 Images
Adult LacZ: LacZ Images Wholemount
521 Images

 Disease Models

Please visit the desktop version to see this section

 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Sternum - displacement and deformity Ap4e1tm1b(KOMP)Wtsi HOM postnatal
Bone marrow - hypoplasia Ap4e1tm1a(KOMP)Wtsi HOM postnatal
Brain - process of degenerative change Ap4e1tm1a(KOMP)Wtsi HOM postnatal
Bone marrow - depletion Ap4e1tm1a(KOMP)Wtsi HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Ap4e1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ap4e1em1(IMPC)J Indel Mice
Ap4e1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Ap4e1em1(IMPC)Bay Exon Deletion Mice, Tissue
Ap4e1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Ap4e1tm35132(L1L2_Bact_P) Targeting vectors
Ap4e1em2(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue