Gene: Ap4e1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating phosphate level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.83×10-05
increased body length Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.01×10-06
increased fasting circulating glucose level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.76×10-06
decreased vertical activity Ap4e1em2(IMPC)Mbp HOM Early adult 5.38×10-11
decreased blood urea nitrogen level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.57×10-05
abnormal sleep behavior Ap4e1em1(IMPC)J HET Early adult 5.54×10-21
abnormal retinal inner nuclear layer morphology Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 2.17×10-06
increased erythrocyte cell number Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 5.32×10-05
decreased mean corpuscular hemoglobin Ap4e1tm1a(KOMP)Wtsi HOM Early adult 4.31×10-09
abnormal heart left ventricle morphology Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 3.28×10-05
decreased circulating alanine transaminase level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 8.83×10-15
decreased circulating calcium level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.84×10-06
abnormal inspiratory capacity Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 8.85×10-08
abnormal bone structure Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 2.48×10-08
decreased respiratory quotient Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.97×10-07
abnormal testis morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal behavior Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 9.21×10-05
increased heart weight Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.72×10-05
decreased circulating bilirubin level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.72×10-05
decreased exploration in new environment Ap4e1em1(IMPC)J HOM   Early adult 8.30×10-06
decreased heart rate variability Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.63×10-05
enlarged spleen Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.27×10-20
decreased circulating insulin level Ap4e1em2(IMPC)Mbp HOM Early adult 7.06×10-06
hypoactivity Ap4e1em2(IMPC)Mbp HOM   Early adult 8.41×10-05
unresponsive to tactile stimuli Ap4e1em1(IMPC)Bay HOM E18.5 0.00
increased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.32×10-11
increased lung compliance Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.26×10-06
cardiovascular system phenotype Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.26×10-05
decreased circulating serum albumin level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.49×10-10
decreased circulating triglyceride level Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.15×10-06
abnormal vertebrae morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.59×10-05
decreased circulating insulin level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.53×10-13
limb grasping Ap4e1em1(IMPC)J HOM Early adult 5.21×10-05
abnormal coat appearance Ap4e1em1(IMPC)Bay HET Early adult 3.30×10-05
hypoactivity Ap4e1tm1a(KOMP)Wtsi HOM   Early adult 9.85×10-05
abnormal heart morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased bone mineral density Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.11×10-05
enlarged lymph nodes Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal behavior Ap4e1em1(IMPC)J HET Early adult 1.21×10-07
limb grasping Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.09×10-06
decreased lung tissue damping Ap4e1tm1b(KOMP)Wtsi HOM Early adult 8.06×10-05
decreased circulating alkaline phosphatase level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.63×10-06
increased kidney weight Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased lung elastance Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 3.90×10-05
hyperactivity Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.19×10-14
abnormal sleep behavior Ap4e1em1(IMPC)J HOM Early adult 1.48×10-07
abnormal vertebral arch morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.67×10-05
decreased circulating glucose level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.11×10-20
abnormal femur morphology Ap4e1tm1a(KOMP)Wtsi HOM Early adult 3.31×10-05
preweaning lethality, incomplete penetrance Ap4e1em1(IMPC)Bay HOM   Early adult 0.00
abnormal sleep behavior Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.73×10-13
decreased total body fat amount Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.86×10-20
abnormal sinus arrhythmia Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.69×10-07
decreased vertical activity Ap4e1em1(IMPC)J HOM Early adult 3.52×10-07
abnormal behavior Ap4e1tm1a(KOMP)Wtsi HOM   Early adult 5.78×10-05
increased hematocrit Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.88×10-05
decreased grip strength Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 6.12×10-09
hypoactivity Ap4e1em1(IMPC)J HET Early adult 1.61×10-05
decreased circulating total protein level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 5.69×10-08
unresponsive to tactile stimuli Ap4e1em1(IMPC)Bay HET E18.5 0.00
decreased cardiac stroke volume Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.96×10-09
increased circulating alkaline phosphatase level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 5.27×10-05
decreased total retina thickness Ap4e1tm1b(KOMP)Wtsi HOM Early adult 5.93×10-09
decreased mean corpuscular volume Ap4e1tm1a(KOMP)Wtsi HOM Early adult 7.41×10-06
decreased circulating LDL cholesterol level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.88×10-06
prolonged RR interval Ap4e1em2(IMPC)Mbp HOM Early adult 1.55×10-05
increased bone mineral density Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.15×10-05
impaired glucose tolerance Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 4.40×10-05
increased cardiac muscle contractility Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.10×10-05
decreased heart rate Ap4e1em2(IMPC)Mbp HOM Early adult 4.30×10-05
abnormal spleen morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased exploration in new environment Ap4e1tm1b(KOMP)Wtsi HOM Early adult 7.21×10-06
decreased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.10×10-05
increased startle reflex Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.09×10-09
decreased heart rate Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.36×10-06
preweaning lethality, incomplete penetrance Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased total body fat amount Ap4e1em1(IMPC)J HOM Early adult 1.95×10-05
increased lean body mass Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.00×10-05
abnormal kidney morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating aspartate transaminase level Ap4e1tm1a(KOMP)Wtsi HOM Early adult 2.04×10-07
decreased thigmotaxis Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.76×10-05
increased thigmotaxis Ap4e1em1(IMPC)J HET Early adult 1.21×10-07
small testis Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased prepulse inhibition Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 2.34×10-07
abnormal coat appearance Ap4e1em1(IMPC)Bay HOM Early adult 3.08×10-05
abnormal lens morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 7.70×10-18
decreased circulating amylase level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 8.05×10-06
enlarged heart Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating chloride level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.03×10-06
decreased cardiac output Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.32×10-11
increased hemoglobin content Ap4e1tm1b(KOMP)Wtsi HOM   Early adult 1.96×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 23 Yes  (4/584)  (15/25)  Wholemount images  Section images
Aorta 23 Yes  (1/584)  (12/25)  Wholemount images  Section images
Blood 7 No N/A
Blood vessel 4 No N/A
Bone 18 Yes  (3/20)  Wholemount images  Section images
Bone marrow 9 No  (2/9)  Section images
Brain 23 Yes  (4/584)  (24/25)  Wholemount images  Section images
Brainstem 23 No  (2/584)  (18/25)  Wholemount images  Section images
Brown adipose tissue 21 Yes  (2/23)  Wholemount images  Section images
Cartilage tissue 23 No  (1/584)  (20/25)  Wholemount images  Section images
Cecum 13 Yes  (11/370)  (7/15)  Wholemount images  Section images
Cerebellum 23 No  (3/584)  (19/25)  Wholemount images  Section images
Cerebral cortex 23 No  (2/584)  (18/25)  Wholemount images  Section images
Chest bone 11 Yes  (8/13)  Wholemount images  Section images
Colon 11 No  (11/126)  (6/13)  Section images
Cranium 10 No  (2/12)  Section images
Diaphragm 11 Yes  (6/13)  Wholemount images  Section images
Duodenum 9 Yes  (1/126)  (6/11)  Wholemount images  Section images
Epididymis 13 Yes  (17/133)  (1/15)  Wholemount images  Section images
Esophagus 19 Yes  (7/408)  (13/21)  Wholemount images  Section images
Eye 23 Yes  (5/25)  Wholemount images  Section images
Gall bladder 19 Yes  (7/21)  Wholemount images  Section images
Gonadal fat pad 9 Yes  Wholemount images
Harderian gland 11 Yes  Wholemount images  Section images
Heart 23 Yes  (2/584)  (14/25)  Wholemount images  Section images
Hindlimb 11 Yes  (8/13)  Wholemount images  Section images
Hippocampus 23 Yes  (3/584)  (18/25)  Wholemount images  Section images
Hypothalamus 23 No  (2/584)  (18/25)  Wholemount images  Section images
Ileum 9 Yes  (13/126)  (6/11)  Wholemount images  Section images
Jejunum 9 Yes  (5/126)  (7/11)  Wholemount images  Section images
Kidney 23 Yes  (21/584)  (24/25)  Wholemount images  Section images
Large intestine 23 Yes  (10/584)  (13/25)  Wholemount images  Section images
Liver 23 Yes  (11/25)  Wholemount images  Section images
Lower urinary tract 23 No  (1/584)  (13/25)  Wholemount images  Section images
Lung 23 Yes  (2/584)  (14/25)  Wholemount images  Section images
Lymph node 23 Yes  (1/584)  (6/25)  Wholemount images  Section images
Main olfactory bulb 10 Yes  (6/12)  Wholemount images
Mammary gland 23 Yes  Wholemount images  Section images
Mesenteric adipose tissue 9 Yes  (2/11)  Wholemount images
Mesenteric lymph node 11 Yes  Wholemount images
Midbrain 11 No  (9/13)  Section images
Esophagus 4 No  (2/4) N/A
Olfactory lobe 23 No  (2/584)  (19/25)  Wholemount images  Section images
Oral epithelium 14 No  (3/16)  Wholemount images  Section images
Ovary 23 Yes  (1/584)  (9/25)  Wholemount images  Section images
Oviduct 23 Yes  (9/25)  Wholemount images  Section images
Pancreas 23 Yes  (5/584)  (10/25)  Wholemount images  Section images
Parathyroid gland 19 Yes  (1/562)  (13/21)  Wholemount images  Section images
Parotid gland 11 Yes  Wholemount images
Penis 11 Yes  (4/13)  Wholemount images  Section images
Peripheral nervous system 23 No  (2/584)  (8/25)  Wholemount images  Section images
Peyer's patch 4 No  (1/176) N/A
Peyer's patch 19 No  (2/21)  Section images
Pituitary gland 23 Yes  (1/584)  (22/25)  Wholemount images  Section images
Prostate gland 23 Yes  (12/584)  (4/25)  Wholemount images  Section images
Quadriceps 9 Yes  (8/11)  Wholemount images  Section images
Sciatic nerve 11 Yes  Wholemount images
Skeletal muscle 19 No  (18/21)  Wholemount images  Section images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 23 Yes  (1/584)  (21/25)  Wholemount images  Section images
Small intestine 23 No  (9/584)  (12/25)  Wholemount images  Section images
Spinal cord 23 Yes  (3/584)  (22/25)  Wholemount images  Section images
Spleen 23 Yes  (3/584)  (6/25)  Wholemount images  Section images
Stomach 23 Yes  (12/584)  (15/25)  Wholemount images  Section images
Stomach pyloric region 11 No N/A
Striatum 23 No  (3/584)  (18/25)  Wholemount images  Section images
Sublingual gland 11 Yes  Wholemount images
Submandibular gland 13 Yes  (2/131)  (2/15)  Wholemount images  Section images
Testis 23 Yes  (6/584)  (11/25)  Wholemount images  Section images
Thalamus 10 No  (8/12)  Section images
Thymus 23 Yes  (1/584)  (4/25)  Wholemount images  Section images
Thyroid gland 23 Yes  (16/584)  (6/25)  Wholemount images  Section images
Tongue 11 Yes  (5/126)  (9/13)  Wholemount images  Section images
Trachea 23 Yes  (3/584)  (18/25)  Wholemount images  Section images
Trigeminal V nerve 13 Yes  (9/15)  Wholemount images  Section images
Urinary bladder 14 Yes  (10/16)  Wholemount images  Section images
Uterus 23 Yes  (9/25)  Wholemount images  Section images
Vagina 11 Yes  (1/13)  Wholemount images  Section images
Vas deferens 13 No  (14/381)  (1/15)  Wholemount images
Vascular system 19 No  (4/21)  Wholemount images  Section images
Vesicular gland 13 Yes  (1/15)  Wholemount images
White adipose tissue 23 Yes  (2/25)  Wholemount images  Section images
LacZ Section Images

View all 32 images

View all 21 images

View all 6 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 12  (6/507)  (1/14) N/A
Central nervous system ganglion 2  (1/72) Image Only N/A
Cranium 2  (1/63) Image Only N/A
Dorsal root ganglion 1  (1/59) Image Only N/A
Ear 12  (1/507)  (2/14) N/A
Embryo 12  (1/508)  (10/14)  Wholemount images
External ear 2  (1/73) Image Only N/A
Eye 12  (1/507)  (8/14)  Wholemount images
Footplate 12  (1/507)  (2/14) N/A
Forearm 8  (1/304) Image Only N/A
Forebrain 12  (1/507)  (1/14) N/A
Forelimb 12  (1/507)  (2/14) N/A
Fronto-nasal process 1  (1/60) Image Only N/A
Handplate 12  (1/507)  (2/14) N/A
Head 12  (5/507)  (2/14)  Wholemount images
Heart 12  (1/507)  (1/14)  Wholemount images
Hindbrain 12  (6/507)  (1/14) N/A
Hindlimb 12  (1/507)  (2/14) N/A
Humerus pre-cartilage condensation 2  (1/63) Image Only N/A
Inner ear 2  (1/63) Image Only N/A
Liver 12  (1/502)  (1/14)  Wholemount images
Lower leg 8  (1/304) Image Only N/A
Lung 12  (1/502) N/A
Mandibular process 12  (1/507)  (2/14) N/A
Maxillary process 12  (1/507)  (2/14) N/A
Midbrain 12  (1/507)  (1/14) N/A
Nose 3  (1/77)  (1/3) N/A
Oral cavity 12  (1/502)  (1/14) N/A
Placenta 2  (7/42)  (2/2) N/A
Radius-ulna pre cartilage condensation 2  (1/63) Image Only N/A
Skeleton 2  (1/77) Image Only N/A
Skin 12  (1/507)  (2/14)  Wholemount images
Spinal cord 3  (1/71)  (1/3) N/A
Tail 12  (1/507)  (2/14)  Wholemount images
Tail somite group 12  (1/507)  (1/14) N/A
Upper arm 8  (1/304) Image Only N/A
Upper leg 8  (1/304) Image Only N/A
Vibrissa 2  (1/73) Image Only N/A

 Associated Images

X-ray: XRay Images Hind Leg and Hip
10 Images
Adult LacZ: LacZ Images Wholemount
521 Images
Adult LacZ: LacZ Images Section
207 Images
Embryo LacZ: LacZ images wholemount
133 Images
X-ray: XRay Images Whole Body Lateral Orientation
117 Images
X-ray: XRay Images Forepaw
69 Images
X-ray: XRay Images Whole Body Dorso Ventral
118 Images
X-ray: XRay Images Hind Leg and Hip
30 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
Eye Morphology: Images Slit Lamp
6 Images
X-ray: XRay Images Skull Lateral Orientation
78 Images
Histopathology
11 Images
Sleep Wake: Wake state (bmp file)
35 Images
X-ray: XRay Images Whole Body Lateral Orientation
15 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
90 Images
Gross Pathology and Tissue Collection
7 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
Eye Morphology: Images Ophthalmoscopy
6 Images
X-ray: XRay Images Whole Body Dorso Ventral
30 Images
X-ray: XRay Images Forepaw
15 Images
Combined SHIRPA and Dysmorphology
1 Images
Immunophenotyping: Panel A FCS file(s)
11 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
20 Images
Immunophenotyping: Panel B FCS file(s)
12 Images
Electroretinography 2: Rod and cone PDF
5 Images
Legacy Phenotype Associated Images

View all 198 images

View all 12 images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Bone marrow - hypoplasia Ap4e1tm1a(KOMP)Wtsi HOM Early adult
Sternum - MPATH pathological process term hyperplasia Ap4e1tm1b(KOMP)Wtsi HOM Early adult
Brain - process of degenerative change Ap4e1tm1a(KOMP)Wtsi HOM Early adult
Eye - MPATH pathological process term hypoplasia Ap4e1tm1b(KOMP)Wtsi HOM Early adult
Eye - MPATH pathological process term hyperplasia Ap4e1tm1b(KOMP)Wtsi HOM Early adult
Sternum - MPATH pathological process term fibro-osseous lesion Ap4e1tm1b(KOMP)Wtsi HOM Early adult
Bone marrow - depletion Ap4e1tm1a(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ap4e1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Ap4e1em1(IMPC)Bay Exon Deletion Mice, Tissue
Ap4e1em1(IMPC)J Indel Mice
Ap4e1tm35132(L1L2_Bact_P) Targeting vectors
Ap4e1em2(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue
Ap4e1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Ap4e1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells