Ap4e1 | adaptor-related protein complex AP-4, epsilon 1
Physiological systems
24 / 24 physiological systems tested
17 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological Skeleton Mortality/aging
7 No significant impact
Gene metrics:74Significant phenotypes
3Associated diseases
Expression examined in:158Adult tissues
59Embryo tissues
decreased total body fat amount | 10 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 7.88x10-14 | ||
abnormal lens morphology | 4 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 4.28x10-7 | ||
increased red blood cell distribution width | 1 supporting dataset | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 7.1x10-5 | ||
small testis | 2 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased anxiety-related response | 1 supporting dataset | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.48x10-7 | ||
decreased mean corpuscular volume | 1 supporting dataset | Ap4e1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.4x10-21 | ||
abnormal sleep behavior | 8 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 5.81x10-9 | ||
decreased grip strength | 3 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.68x10-7 | ||
hyperactivity | 28 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.19x10-14 | ||
abnormal testis morphology | 2 supporting datasets | Ap4e1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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External links
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Ap4e1em1(IMPC)Bay | Exon Deletion | | mouse |
Ap4e1em1(IMPC)J | Indel | | mouse |
Ap4e1em2(IMPC)Mbp | Indel | | mouse |
Ap4e1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Ap4e1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Ap4e1tm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
Ap4e1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
Ap4e1tm35132(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |