Gene: Ap4e1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.54×10-11
increased circulating alkaline phosphatase level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.47×10-06
decreased cardiac output Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.18×10-07
increased bone mineral content Ap4e1em1(IMPC)J HOM Early adult 8.36×10-07
decreased grip strength Ap4e1tm1b(KOMP)Wtsi HOM Early adult 8.95×10-06
decreased mean corpuscular hemoglobin Ap4e1tm1a(KOMP)Wtsi HOM Early adult 1.13×10-12
abnormal bone structure Ap4e1tm1b(KOMP)Wtsi HOM Early adult 5.24×10-05
increased erythrocyte cell number Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.79×10-05
increased hematocrit Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.67×10-05
abnormal behavior Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.35×10-13
abnormal retinal inner nuclear layer morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.95×10-05
increased fluid intake Ap4e1tm1b(KOMP)Wtsi HOM Early adult 5.65×10-08
decreased cardiac stroke volume Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.48×10-07
abnormal inspiratory capacity Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.71×10-08
increased heart weight Ap4e1em2(IMPC)Mbp HOM Early adult 7.94×10-05
decreased vertical activity Ap4e1em2(IMPC)Mbp HOM Early adult 2.90×10-06
decreased lung tissue damping Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.93×10-06
abnormal behavior Ap4e1tm1a(KOMP)Wtsi HOM Early adult 6.86×10-05
abnormal heart left ventricle morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 7.70×10-05
abnormal testis morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal sleep behavior Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.26×10-11
hypoactivity Ap4e1em1(IMPC)J HOM Early adult 1.10×10-05
decreased heart weight Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.25×10-05
increased hemoglobin content Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.86×10-06
increased prepulse inhibition Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.02×10-08
abnormal lens morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.52×10-09
decreased circulating glucose level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.21×10-06
decreased circulating chloride level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 7.90×10-06
abnormal kidney morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal vertebral arch morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 8.47×10-06
enlarged heart Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal vertebrae morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.82×10-05
hyperactivity Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.23×10-16
increased kidney weight Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.64×10-05
decreased total body fat amount Ap4e1em1(IMPC)J HOM Early adult 6.12×10-09
short tibia Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.60×10-05
long tibia Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.60×10-05
abnormal seminal vesicle morphology Ap4e1em2(IMPC)Mbp HOM Early adult 0.00
increased lean body mass Ap4e1em1(IMPC)J HOM Early adult 4.49×10-07
limb grasping Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.35×10-06
increased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.58×10-08
abnormal behavioral response to light Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.73×10-06
preweaning lethality, incomplete penetrance Ap4e1em1(IMPC)Bay HOM Early adult 0.00
increased lean body mass Ap4e1tm1a(KOMP)Wtsi HOM Early adult 1.25×10-08
decreased vertical activity Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.13×10-05
increased mean corpuscular volume Ap4e1tm1b(KOMP)Wtsi HOM Early adult 3.63×10-07
decreased lung elastance Ap4e1tm1b(KOMP)Wtsi HOM Early adult 8.50×10-07
abnormal sleep behavior Ap4e1em1(IMPC)J HOM Early adult 2.61×10-06
small testis Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
enlarged lymph nodes Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating insulin level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.46×10-06
increased lung compliance Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.30×10-07
decreased total retina thickness Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.03×10-09
lordosis Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.00×10-07
decreased respiratory quotient Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.28×10-07
abnormal sleep behavior Ap4e1em1(IMPC)J HET Early adult 6.38×10-07
increased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.15×10-09
increased bone mineral density Ap4e1tm1a(KOMP)Wtsi HOM Early adult 6.27×10-06
kyphosis Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.04×10-15
decreased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.80×10-05
abnormal spleen morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased heart weight Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.54×10-05
abnormal heart morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased heart rate Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.58×10-06
impaired glucose tolerance Ap4e1tm1b(KOMP)Wtsi HOM Early adult 4.40×10-07
increased or absent threshold for auditory brainstem response Ap4e1tm1b(KOMP)Wtsi HOM Early adult 5.30×10-06
abnormal vitreous body morphology Ap4e1tm1b(KOMP)Wtsi HOM Early adult 6.51×10-05
enlarged spleen Ap4e1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased body weight Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.45×10-06
decreased hemoglobin content Ap4e1tm1a(KOMP)Wtsi HOM Early adult 1.24×10-05
increased startle reflex Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.25×10-08
limb grasping Ap4e1em1(IMPC)J HOM Early adult 5.58×10-05
increased cardiac muscle contractility Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.54×10-06
decreased circulating triglyceride level Ap4e1tm1b(KOMP)Wtsi HOM Early adult 1.33×10-05
abnormal coat appearance Ap4e1em1(IMPC)Bay HET Early adult 3.50×10-05
decreased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.22×10-05
abnormal spine curvature Ap4e1tm1b(KOMP)Wtsi HOM Early adult 2.04×10-15

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 21 Yes  (2/584)  (15/23)  Wholemount images
Aorta 21 Yes  (10/23)  Wholemount images
Blood 5 No N/A
Blood vessel 4 No N/A
Bone 14 Yes  (3/16)  Wholemount images
Bone marrow 7 No  (2/7) N/A
Brain 21 Yes  (22/23)  Wholemount images  Section images
Brainstem 21 No  (16/23)  Wholemount images
Brown adipose tissue 19 Yes  (2/21)  Wholemount images
Cartilage tissue 21 No  (18/23)  Wholemount images
Cecum 11 Yes  (12/379)  (8/13)  Wholemount images
Cerebellum 21 No  (19/23)  Wholemount images  Section images
Cerebral cortex 21 No  (16/23)  Wholemount images
Chest bone 9 Yes  (8/11)  Wholemount images
Colon 9 No  (12/127)  (8/11) N/A
Cranium 6 No N/A
Diaphragm 9 Yes  (6/11)  Wholemount images
Duodenum 7 Yes  (2/127)  (7/9)  Wholemount images
Epididymis 11 Yes  (18/134)  (2/13)  Wholemount images
Esophagus 17 Yes  (7/415)  (12/19)  Wholemount images
Eye 21 Yes  (5/23)  Wholemount images  Section images
Gall bladder 17 Yes  (6/19)  Wholemount images
Gonadal fat pad 7 Yes  Wholemount images
Harderian gland 9 Yes  Wholemount images
Heart 21 Yes  (12/23)  Wholemount images
Hindlimb 9 Yes  (6/11)  Wholemount images
Hippocampus 21 Yes  (16/23)  Wholemount images
Hypothalamus 21 No  (16/23)  Wholemount images
Ileum 7 Yes  (14/127)  (8/9)  Wholemount images
Jejunum 7 Yes  (6/127)  (7/9)  Wholemount images
Kidney 21 Yes  (18/584)  (23/23)  Wholemount images  Section images
Large intestine 21 Yes  (10/584)  (12/23)  Wholemount images
Liver 21 Yes  (10/23)  Wholemount images  Section images
Lower urinary tract 21 No  (11/23)  Wholemount images
Lung 21 Yes  (14/23)  Wholemount images
Lymph node 21 Yes  (6/23)  Wholemount images
Main olfactory bulb 6 Yes  (6/8)  Wholemount images
Mammary gland 21 Yes  Wholemount images
Mesenteric adipose tissue 7 Yes  (2/9)  Wholemount images
Mesenteric lymph node 9 Yes  Wholemount images
Midbrain 9 No  (11/11)  Wholemount images  Section images
Esophagus 4 No  (2/4) N/A
Olfactory lobe 21 No  (19/23)  Wholemount images  Section images
Oral epithelium 10 No  (2/12)  Wholemount images
Ovary 21 Yes  (1/584)  (9/23)  Wholemount images  Section images
Oviduct 21 Yes  (9/23)  Wholemount images  Section images
Pancreas 21 Yes  (5/584)  (10/23)  Wholemount images
Parathyroid gland 17 Yes  (11/19)  Wholemount images
Parotid gland 9 Yes  Wholemount images
Penis 9 Yes  (3/11)  Wholemount images
Peripheral nervous system 21 No  (8/23)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 17 No  (2/19) N/A
Pituitary gland 21 Yes  (21/23)  Wholemount images  Section images
Prostate gland 21 Yes  (12/584)  (3/23)  Wholemount images
Quadriceps 7 Yes  (6/9)  Wholemount images
Sciatic nerve 9 Yes  Wholemount images
Skeletal muscle 17 No  (16/19)  Wholemount images  Section images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 21 Yes  (18/23)  Wholemount images  Section images
Small intestine 21 No  (9/584)  (12/23)  Wholemount images
Spinal cord 21 Yes  (23/23)  Wholemount images  Section images
Spleen 21 Yes  (2/584)  (6/23)  Wholemount images
Stomach 21 Yes  (12/584)  (15/23)  Wholemount images
Stomach pyloric region 9 No N/A
Striatum 21 No  (16/23)  Wholemount images
Sublingual gland 9 Yes  Wholemount images
Submandibular gland 11 Yes  (2/132)  (2/13)  Wholemount images
Testis 21 Yes  (2/584)  (11/23)  Wholemount images
Thalamus 6 No  (8/8) N/A
Thymus 21 Yes  (4/23)  Wholemount images
Thyroid gland 21 Yes  (15/584)  (7/23)  Wholemount images
Tongue 9 Yes  (5/127)  (6/11)  Wholemount images
Trachea 21 Yes  (18/23)  Wholemount images
Trigeminal V nerve 11 Yes  (9/13)  Wholemount images  Section images
Urinary bladder 12 Yes  (10/14)  Wholemount images  Section images
Uterus 21 Yes  (9/23)  Wholemount images  Section images
Vagina 9 Yes  Wholemount images
Vas deferens 11 No  (15/388)  (2/13)  Wholemount images
Vascular system 17 No  (4/19)  Wholemount images
Vesicular gland 11 Yes  (1/13)  Wholemount images
White adipose tissue 21 Yes  (2/23)  Wholemount images
LacZ Section Images

View all 32 images

View all 21 images

View all 6 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 10  (6/504)  (1/11) N/A
Central nervous system ganglion 2  (1/70) Image Only N/A
Cranium 2  (1/61) Image Only N/A
Dorsal root ganglion 1  (1/57) Image Only N/A
Ear 10  (1/504)  (2/11) N/A
Embryo 10  (1/505)  (10/11)  Wholemount images
Outer ear 2  (1/66) Image Only N/A
Eye 10  (1/504)  (8/11)  Wholemount images
Foot 10  (1/504)  (2/11) N/A
Forearm 8  (1/297) Image Only N/A
Forebrain 10  (1/504)  (1/11) N/A
Forelimb 10  (1/504)  (2/11) N/A
Fronto-nasal process 1  (1/58) Image Only N/A
Hand 10  (1/503)  (2/11) N/A
Head 10  (5/504)  (2/11)  Wholemount images
Heart 10  (1/504)  (1/11)  Wholemount images
Hindbrain 10  (6/504)  (1/11) N/A
Hindlimb 10  (1/503)  (2/11) N/A
Humerus pre-cartilage condensation 2  (1/61) Image Only N/A
Inner ear 2  (1/61) Image Only N/A
Liver 10  (1/504)  (1/11)  Wholemount images
Lower leg 8  (1/297) Image Only N/A
Lung 10  (1/500) N/A
Mandibular process 10  (1/504)  (2/11) N/A
Maxillary process 10  (1/504)  (2/11) N/A
Midbrain 10  (1/504)  (1/11) N/A
Nose 3  (1/70)  (1/3) N/A
Oral cavity 10  (1/504)  (1/11) N/A
2  (7/37)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/61) Image Only N/A
Skeleton 2  (1/70) Image Only N/A
Skin 10  (1/504)  (2/11)  Wholemount images
Spinal cord 3  (1/69)  (1/3) N/A
Tail 10  (1/504)  (2/11)  Wholemount images
Tail somite 10  (1/504)  (1/11) N/A
Upper arm 8  (1/297) Image Only N/A
Upper leg 8  (1/297) Image Only N/A
Vibrissa 2  (1/66) Image Only N/A

 Associated Images

Brain Histopathology: Hippocampal section
3 Images
Brain Histopathology: Cerebellar Section
3 Images
Brain Histopathology: Striatal Section
3 Images
X-ray: XRay Images Whole Body Dorso Ventral
120 Images
Sleep Wake: Wake state (bmp file)
29 Images
Electroretinography 2: Rod and cone PDF
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
53 Images
X-ray: XRay Images Forepaw
33 Images
X-ray: XRay Images Skull Lateral Orientation
43 Images
X-ray: XRay Images Whole Body Lateral Orientation
98 Images
Legacy Phenotype Associated Images

View all 198 images

View all 12 images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Sternum - displacement and deformity Ap4e1tm1b(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ap4e1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ap4e1em1(IMPC)J Indel Mice
Ap4e1tm35132(L1L2_Bact_P) Targeting vectors
Ap4e1em2(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue
Ap4e1em1(IMPC)Bay Exon Deletion Mice, Tissue
Ap4e1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Ap4e1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice