Gene: Prkab1

Name
protein kinase, AMP-activated, beta 1 non-catalytic subunit
MGI ID
MGI:1336167
Synonyms
1300015D22Rik
Viability
Homozygous - Viable Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal spleen morphology Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased circulating iron level Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.64×10-08
increased circulating bilirubin level Prkab1tm1a(KOMP)Wtsi HOM postnatal 2.36×10-08
abnormal retinal blood vessel morphology Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.22×10-12
enlarged heart Prkab1em2(IMPC)Mbp HOM postnatal 0.00
hypoactivity Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.95×10-08
decreased circulating amylase level Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.06×10-06
decreased lean body mass Prkab1tm1b(KOMP)Wtsi HOM postnatal 5.88×10-05
decreased lymphocyte cell number Prkab1em2(IMPC)Mbp HOM postnatal 5.48×10-06
increased fluid intake Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.13×10-05
decreased caudal vertebrae number Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.20×10-06
enlarged thymus Prkab1em2(IMPC)Mbp HOM postnatal 0.00
preweaning lethality, incomplete penetrance Prkab1tm1b(KOMP)Wtsi HOM n/a 0.00
decreased mean corpuscular volume Prkab1tm1a(KOMP)Wtsi HOM postnatal 8.32×10-05
decreased hemoglobin content Prkab1tm1a(KOMP)Wtsi HOM postnatal 1.93×10-12
increased memory-marker gamma-delta T cell number Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
increased memory-marker CD4-negative NK T cell number Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased hematocrit Prkab1tm1a(KOMP)Wtsi HOM postnatal 8.86×10-06
shortened RR interval Prkab1tm1b(KOMP)Wtsi HOM postnatal 5.71×10-05
abnormal thymus morphology Prkab1em2(IMPC)Mbp HOM postnatal 0.00
enlarged heart Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
increased bone mineral density Prkab1tm1b(KOMP)Wtsi HET postnatal 2.48×10-05
increased red blood cell distribution width Prkab1em2(IMPC)Mbp HOM postnatal 2.16×10-13
decreased circulating cholesterol level Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.81×10-10
increased spleen weight Prkab1em1(IMPC)Bay HOM postnatal 1.43×10-05
abnormal heart morphology Prkab1em2(IMPC)Mbp HOM postnatal 0.00
decreased body length Prkab1tm1b(KOMP)Wtsi HOM postnatal 6.93×10-05
anophthalmia Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal spine curvature Prkab1tm1b(KOMP)Wtsi HOM postnatal 6.08×10-07
decreased mean corpuscular hemoglobin concentration Prkab1tm1b(KOMP)Wtsi HOM postnatal 8.29×10-16
abnormal retinal blood vessel pattern Prkab1tm1a(KOMP)Wtsi HOM postnatal 2.00×10-05
decreased total retina thickness Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.28×10-08
increased mean platelet volume Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.15×10-05
abnormal retinal vasculature morphology Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.22×10-12
decreased hemoglobin content Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.24×10-12
decreased mean corpuscular hemoglobin Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.60×10-40
decreased mean corpuscular volume Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
increased grip strength Prkab1tm1b(KOMP)Wtsi HOM postnatal 5.23×10-05
decreased erythrocyte cell number Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.03×10-05
decreased total body fat amount Prkab1tm1b(KOMP)Wtsi HOM postnatal 4.46×10-05
increased circulating bilirubin level Prkab1tm1b(KOMP)Wtsi HOM postnatal 4.60×10-21
decreased mean corpuscular volume Prkab1em2(IMPC)Mbp HOM postnatal 3.06×10-09
increased spleen weight Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.13×10-06
decreased mean corpuscular hemoglobin Prkab1em2(IMPC)Mbp HOM postnatal 6.07×10-07
decreased hematocrit Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.79×10-13
decreased leukocyte cell number Prkab1em2(IMPC)Mbp HOM postnatal 4.18×10-06
enlarged spleen Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal retinal vasculature morphology Prkab1tm1a(KOMP)Wtsi HOM postnatal 2.00×10-05
impaired glucose tolerance Prkab1tm1b(KOMP)Wtsi HOM postnatal 2.55×10-06
decreased circulating LDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM postnatal 5.59×10-08
abnormal behavior Prkab1tm1b(KOMP)Wtsi HOM postnatal 7.68×10-05
kyphosis Prkab1tm1b(KOMP)Wtsi HOM postnatal 6.08×10-07
increased glycosylated hemoglobin level Prkab1tm1b(KOMP)Wtsi HOM postnatal 5.52×10-10
increased red blood cell distribution width Prkab1tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased circulating HDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM postnatal 1.38×10-10

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 19 Yes  (2/584)  (18/21)  Wholemount images
Aorta 19 Yes  (10/21)  Wholemount images
Blood 2 No N/A
Blood vessel 4 No N/A
Bone 13 Yes  (4/15)  Wholemount images
Bone marrow 2 No N/A
Brain 19 Yes  (18/21)  Wholemount images  Section images
Brainstem 19 No  (15/21)  Wholemount images
Brown adipose tissue 17 No  (2/19) N/A
Cartilage tissue 19 No  (18/21)  Wholemount images
Cecum 8 Yes  (12/383)  (7/10)  Wholemount images
Cerebellum 19 No  (18/21)  Wholemount images  Section images
Cerebral cortex 19 No  (16/21)  Wholemount images
Chest bone 6 Yes  (6/8)  Wholemount images
Colon 6 No  (12/127)  (8/8) N/A
Cranium 4 No N/A
Diaphragm 6 Yes  (6/8)  Wholemount images
Duodenum 6 Yes  (2/127)  (7/8)  Wholemount images
Epididymis 8 Yes  (18/134)  (2/10)  Wholemount images
Esophagus 15 Yes  (7/415)  (14/17)  Wholemount images
Eye 19 Yes  (10/21)  Wholemount images  Section images
Gall bladder 15 Yes  (4/17)  Wholemount images
Gonadal fat pad 6 No N/A
Harderian gland 6 Yes  Wholemount images
Heart 19 Yes  (14/21)  Wholemount images
Hindlimb 6 Yes  (6/8)  Wholemount images
Hippocampus 19 No  (16/21)  Wholemount images
Hypothalamus 19 No  (16/21)  Wholemount images
Ileum 6 Yes  (14/127)  (7/8)  Wholemount images
Jejunum 6 Yes  (6/127)  (6/8)  Wholemount images
Kidney 19 Yes  (18/584)  (18/21)  Wholemount images
Large intestine 19 Yes  (10/584)  (14/21)  Wholemount images
Liver 19 Yes  (13/21)  Wholemount images  Section images
Lower urinary tract 19 No  (12/21)  Wholemount images
Lung 19 Yes  (11/21)  Wholemount images
Lymph node 19 Yes  (2/21)  Wholemount images
Main olfactory bulb 4 Yes  (6/6)  Wholemount images
Mammary gland 19 Yes  (3/21)  Wholemount images
Mesenteric adipose tissue 6 Yes  Wholemount images
Mesenteric lymph node 6 Yes  Wholemount images
Midbrain 8 No  (10/10) N/A
Esophagus 4 No  (2/4) N/A
Olfactory lobe 19 No  (17/21)  Wholemount images  Section images
Oral epithelium 9 Yes  (6/11)  Wholemount images
Ovary 19 Yes  (1/584)  (8/21)  Wholemount images
Oviduct 19 Yes  (8/21)  Wholemount images
Pancreas 19 Yes  (5/584)  (11/21)  Wholemount images
Parathyroid gland 15 Yes  (7/17)  Wholemount images
Parotid gland 6 Yes  Wholemount images
Penis 6 Yes  (4/8)  Wholemount images
Peripheral nervous system 19 No  (10/21)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 15 No  (1/17) N/A
Pituitary gland 19 Yes  (15/21)  Wholemount images
Prostate gland 19 Yes  (12/584)  (4/21)  Wholemount images
Quadriceps 6 Yes  (6/8)  Wholemount images
Sciatic nerve 6 Yes  Wholemount images
Skeletal muscle 15 No  (13/17)  Wholemount images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 19 Yes  (13/21)  Wholemount images
Small intestine 19 No  (9/584)  (14/21)  Wholemount images
Spinal cord 19 Yes  (20/21)  Wholemount images  Section images
Spleen 19 Yes  (2/584)  (2/21)  Wholemount images
Stomach 19 Yes  (12/584)  (17/21)  Wholemount images
Stomach pyloric region 6 No N/A
Striatum 19 No  (14/21)  Wholemount images
Sublingual gland 6 Yes  Wholemount images
Submandibular gland 8 Yes  (2/132)  (3/10)  Wholemount images
Testis 19 Yes  (2/584)  (9/21)  Wholemount images
Thalamus 6 No  (8/8) N/A
Thymus 19 Yes  (16/21)  Wholemount images
Thyroid gland 19 Yes  (15/584)  (6/21)  Wholemount images
Tongue 7 Yes  (5/127)  (9/9)  Wholemount images  Section images
Trachea 19 Yes  (18/21)  Wholemount images
Trigeminal V nerve 8 Yes  (10/10)  Wholemount images
Urinary bladder 8 Yes  (10/10)  Wholemount images
Uterus 19 Yes  (8/21)  Wholemount images
Vagina 6 Yes  (1/8)  Wholemount images
Vas deferens 8 No  (15/388)  (1/10) N/A
Vascular system 15 No  (4/17)  Wholemount images
Vesicular gland 8 Yes  Wholemount images
White adipose tissue 19 No N/A
LacZ Section Images

View all 6 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 13  (6/485)  (15/16) N/A
Dorsal root ganglion 1  (1/47) Image Only N/A
Ear 13  (1/485)  (4/16) N/A
Embryo 13  (1/485)  (15/16)  Wholemount images
Eye 13  (1/485)  (15/16)  Wholemount images
Foot 13  (1/485)  (7/16) N/A
Forearm 8  (1/282) N/A
Forebrain 13  (1/485)  (15/16) N/A
Forelimb 13  (1/485)  (7/16) N/A
Fronto-nasal process 1  (1/48) Image Only N/A
Hand 13  (1/485)  (7/16) N/A
Head 13  (5/485)  (15/16)  Wholemount images
Heart 13  (1/485)  (12/16)  Wholemount images
Hindbrain 13  (6/485)  (15/16) N/A
Hindlimb 13  (1/485)  (7/16) N/A
Liver 13  (1/485)  (3/16)  Wholemount images
Lower leg 8  (1/282) N/A
Lung 13  (1/485)  (3/16) N/A
Mandibular process 13  (1/485)  (4/16) N/A
Maxillary process 13  (1/485)  (4/16) N/A
Midbrain 13  (1/485)  (7/16) N/A
Nose 1  (1/51)  (1/1) N/A
Oral cavity 13  (1/485)  (3/16) N/A
Skin 13  (1/485)  (4/16) N/A
Spinal cord 1  (1/50)  (1/1) N/A
Tail 13  (1/485)  (7/16)  Wholemount images
Tail somite 13  (1/485)  (7/16) N/A
Upper arm 8  (1/282) N/A
Upper leg 8  (1/282) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
54 Images
X-ray: XRay Images Lateral Orientation
143 Images
X-ray: XRay Images Forepaw
39 Images
X-ray: XRay Images Dorso Ventral
183 Images
Sleep Wake: Wake state (bmp file)
25 Images
X-ray: XRay Images Skull Lateral Orientation
50 Images
Electroretinography: Rod waveform (pdf format)
4 Images
Electroretinography: Cone waveform (pdf format)
4 Images
Embryo LacZ: LacZ images wholemount
102 Images
Adult LacZ: LacZ Images Wholemount
621 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Sternum - developmental and structural abnormality Prkab1tm1b(KOMP)Wtsi HOM postnatal
Liver - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM postnatal
Spleen - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Prkab1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Prkab1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Prkab1em1(IMPC)Bay Exon Deletion Mice, Tissue
Prkab1em2(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue
Prkab1em1(IMPC)J Exon Deletion Mice
Prkab1tm301228(L1L2_Bact_P) Targeting vectors
Prkab1tm37294(L1L2_Bact_P) Targeting vectors