Gene: Prkab1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased caudal vertebrae number Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.60×10-06
enlarged spleen Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased mean corpuscular hemoglobin Prkab1em2(IMPC)Mbp HOM Early adult 5.66×10-07
increased red blood cell distribution width Prkab1em2(IMPC)Mbp HOM Early adult 4.23×10-14
enlarged thymus Prkab1em2(IMPC)Mbp HOM Early adult 0.00
decreased mean corpuscular volume Prkab1em2(IMPC)Mbp HOM Early adult 4.56×10-11
decreased total body fat amount Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.46×10-05
decreased leukocyte cell number Prkab1em2(IMPC)Mbp HOM Early adult 5.20×10-06
enlarged heart Prkab1em2(IMPC)Mbp HOM Early adult 0.00
abnormal retinal blood vessel morphology Prkab1tm1b(KOMP)Wtsi HET Early adult 6.59×10-11
decreased circulating iron level Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.68×10-08
cataract Prkab1tm1b(KOMP)Wtsi HET Early adult 4.12×10-05
decreased lean body mass Prkab1tm1b(KOMP)Wtsi HOM Early adult 5.88×10-05
decreased circulating cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.41×10-10
decreased erythrocyte cell number Prkab1tm1b(KOMP)Wtsi HOM Early adult 9.18×10-06
abnormal response to new environment Prkab1tm1a(KOMP)Wtsi HEM Early adult 0.00
enlarged heart Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased heart rate Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.09×10-07
abnormal retinal blood vessel pattern Prkab1tm1a(KOMP)Wtsi HOM Early adult 9.34×10-07
abnormal thymus morphology Prkab1em2(IMPC)Mbp HOM Early adult 0.00
shortened RR interval Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.53×10-07
impaired glucose tolerance Prkab1em1(IMPC)J HOM Early adult 7.03×10-05
decreased circulating magnesium level Prkab1tm1a(KOMP)Wtsi HOM Early adult 4.02×10-05
enlarged testis Prkab1tm1b(KOMP)Wtsi HET Early adult 0.00
abnormal retinal vasculature morphology Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.70×10-13
decreased circulating amylase level Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.06×10-06
decreased hematocrit Prkab1tm1a(KOMP)Wtsi HOM Early adult 6.13×10-06
absent pinna reflex Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.24×10-06
preweaning lethality, incomplete penetrance Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased circulating bilirubin level Prkab1tm1a(KOMP)Wtsi HOM Early adult 2.35×10-08
decreased total retina thickness Prkab1tm1b(KOMP)Wtsi HET Early adult 1.50×10-05
decreased hematocrit Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.90×10-25
abnormal retinal vasculature morphology Prkab1tm1a(KOMP)Wtsi HOM Early adult 3.72×10-06
decreased mean corpuscular volume Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased erythrocyte cell number Prkab1tm1a(KOMP)Wtsi HOM Early adult 9.11×10-05
decreased hemoglobin content Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.96×10-35
abnormal testis morphology Prkab1tm1b(KOMP)Wtsi HET Early adult 0.00
decreased mean corpuscular hemoglobin Prkab1tm1b(KOMP)Wtsi HOM Early adult 2.86×10-41
abnormal heart morphology Prkab1em2(IMPC)Mbp HOM Early adult 0.00
decreased body length Prkab1tm1b(KOMP)Wtsi HOM Early adult 6.93×10-05
anophthalmia Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased hemoglobin content Prkab1tm1a(KOMP)Wtsi HOM Early adult 2.63×10-19
decreased mean corpuscular hemoglobin concentration Prkab1tm1b(KOMP)Wtsi HOM Early adult 8.29×10-16
increased spleen weight Prkab1em1(IMPC)Bay HOM Early adult 1.52×10-05
abnormal spine curvature Prkab1tm1b(KOMP)Wtsi HOM Early adult 6.08×10-07
increased spleen weight Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.27×10-06
abnormal lens morphology Prkab1tm1b(KOMP)Wtsi HET Early adult 2.51×10-07
increased heart weight Prkab1tm1b(KOMP)Wtsi HOM Early adult 9.74×10-05
increased grip strength Prkab1tm1b(KOMP)Wtsi HOM Early adult 7.63×10-05
decreased lymphocyte cell number Prkab1em2(IMPC)Mbp HOM Early adult 6.45×10-06
increased circulating alkaline phosphatase level Prkab1tm1a(KOMP)Wtsi HOM Early adult 1.31×10-05
increased bone mineral density Prkab1tm1b(KOMP)Wtsi HET Early adult 2.15×10-05
kyphosis Prkab1tm1b(KOMP)Wtsi HOM Early adult 6.08×10-07
increased mean platelet volume Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.15×10-05
abnormal spleen morphology Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased mean corpuscular hemoglobin Prkab1tm1a(KOMP)Wtsi HOM Early adult 2.38×10-05
decreased circulating HDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Early adult 8.52×10-11
hypoactivity Prkab1tm1b(KOMP)Wtsi HOM Early adult 1.18×10-08
increased red blood cell distribution width Prkab1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased fluid intake Prkab1tm1b(KOMP)Wtsi HOM Early adult 7.14×10-05
increased circulating bilirubin level Prkab1tm1b(KOMP)Wtsi HOM Early adult 2.20×10-21
decreased total retina thickness Prkab1tm1b(KOMP)Wtsi HOM Early adult 2.28×10-08
increased glycosylated hemoglobin level Prkab1tm1b(KOMP)Wtsi HOM Early adult 5.52×10-10
decreased circulating LDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Early adult 5.60×10-08
abnormal retinal blood vessel morphology Prkab1tm1b(KOMP)Wtsi HOM Early adult 4.70×10-13
impaired glucose tolerance Prkab1tm1b(KOMP)Wtsi HOM Early adult 3.60×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 25 Yes  (2/584)  (20/27)  Wholemount images  Section images
Aorta 25 Yes  (11/27)  Wholemount images  Section images
Blood 8 No N/A
Blood vessel 4 No N/A
Bone 19 Yes  (6/21)  Wholemount images
Bone marrow 8 No N/A
Brain 25 Yes  (22/27)  Wholemount images  Section images
Brainstem 25 No  (17/27)  Wholemount images
Brown adipose tissue 23 No  (2/25)  Section images
Cartilage tissue 25 No  (18/27)  Wholemount images
Cecum 14 Yes  (12/379)  (7/16)  Wholemount images  Section images
Cerebellum 25 No  (20/27)  Wholemount images  Section images
Cerebral cortex 25 No  (18/27)  Wholemount images
Chest bone 12 Yes  (10/14)  Wholemount images
Colon 12 No  (12/127)  (8/14)  Section images
Cranium 10 No N/A
Diaphragm 12 Yes  (8/14)  Wholemount images
Duodenum 10 Yes  (2/127)  (7/12)  Wholemount images  Section images
Epididymis 14 Yes  (18/134)  (2/16)  Wholemount images  Section images
Esophagus 21 Yes  (7/415)  (16/23)  Wholemount images  Section images
Eye 25 Yes  (12/27)  Wholemount images  Section images
Gall bladder 21 Yes  (6/23)  Wholemount images
Gonadal fat pad 10 No N/A
Harderian gland 12 Yes  Wholemount images
Heart 25 Yes  (16/27)  Wholemount images
Hindlimb 12 Yes  (6/14)  Wholemount images
Hippocampus 25 No  (18/27)  Wholemount images
Hypothalamus 25 No  (18/27)  Wholemount images
Ileum 10 Yes  (14/127)  (7/12)  Wholemount images  Section images
Jejunum 10 Yes  (6/127)  (6/12)  Wholemount images
Kidney 25 Yes  (18/584)  (20/27)  Wholemount images  Section images
Large intestine 25 Yes  (10/584)  (14/27)  Wholemount images
Liver 25 Yes  (14/27)  Wholemount images  Section images
Lower urinary tract 25 No  (14/27)  Wholemount images
Lung 25 Yes  (12/27)  Wholemount images  Section images
Lymph node 25 Yes  (2/27)  Wholemount images
Main olfactory bulb 10 Yes  (6/12)  Wholemount images
Mammary gland 25 Yes  (3/27)  Wholemount images
Mesenteric adipose tissue 10 Yes  Wholemount images
Mesenteric lymph node 12 Yes  Wholemount images
Midbrain 12 No  (10/14)  Section images
Esophagus 4 No  (2/4) N/A
Olfactory lobe 25 No  (19/27)  Wholemount images  Section images
Oral epithelium 15 Yes  (6/17)  Wholemount images
Ovary 25 Yes  (1/584)  (8/27)  Wholemount images  Section images
Oviduct 25 Yes  (9/27)  Wholemount images
Pancreas 25 Yes  (5/584)  (12/27)  Wholemount images  Section images
Parathyroid gland 21 Yes  (9/23)  Wholemount images
Parotid gland 12 Yes  Wholemount images
Penis 12 Yes  (4/14)  Wholemount images  Section images
Peripheral nervous system 25 No  (10/27)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 21 No  (1/23) N/A
Pituitary gland 25 Yes  (19/27)  Wholemount images  Section images
Prostate gland 25 Yes  (12/584)  (4/27)  Wholemount images  Section images
Quadriceps 10 Yes  (8/12)  Wholemount images
Sciatic nerve 12 Yes  Wholemount images
Skeletal muscle 21 No  (15/23)  Wholemount images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 25 Yes  (13/27)  Wholemount images  Section images
Small intestine 25 No  (9/584)  (14/27)  Wholemount images
Spinal cord 25 Yes  (24/27)  Wholemount images  Section images
Spleen 25 Yes  (2/584)  (2/27)  Wholemount images
Stomach 25 Yes  (12/584)  (18/27)  Wholemount images  Section images
Stomach pyloric region 12 No N/A
Striatum 25 No  (16/27)  Wholemount images
Sublingual gland 12 Yes  Wholemount images
Submandibular gland 14 Yes  (2/132)  (4/16)  Wholemount images  Section images
Testis 25 Yes  (2/584)  (9/27)  Wholemount images  Section images
Thalamus 10 No  (8/12) N/A
Thymus 25 Yes  (18/27)  Wholemount images  Section images
Thyroid gland 25 Yes  (15/584)  (6/27)  Wholemount images  Section images
Tongue 13 Yes  (5/127)  (11/15)  Wholemount images  Section images
Trachea 25 Yes  (20/27)  Wholemount images  Section images
Trigeminal V nerve 14 Yes  (10/16)  Wholemount images  Section images
Urinary bladder 14 Yes  (12/16)  Wholemount images  Section images
Uterus 25 Yes  (9/27)  Wholemount images  Section images
Vagina 12 Yes  (2/14)  Wholemount images  Section images
Vas deferens 14 No  (15/388)  (1/16)  Section images
Vascular system 21 No  (4/23)  Wholemount images
Vesicular gland 14 Yes  Wholemount images
White adipose tissue 25 No N/A
LacZ Section Images

View all 40 images

View all 26 images

View all 10 images

View all 6 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 16  (6/504)  (15/19) N/A
Central nervous system ganglion 3  (1/70) Image Only N/A
Cranium 3  (1/61) Image Only N/A
Dorsal root ganglion 1  (1/57) Image Only N/A
Ear 16  (1/504)  (4/19) N/A
Embryo 16  (1/505)  (18/19)  Wholemount images
Outer ear 3  (1/66) Image Only N/A
Eye 16  (1/504)  (15/19)  Wholemount images
Foot 16  (1/504)  (7/19) N/A
Forearm 11  (1/297) Image Only N/A
Forebrain 16  (1/504)  (15/19) N/A
Forelimb 16  (1/504)  (7/19) N/A
Fronto-nasal process 1  (1/58) Image Only N/A
Hand 16  (1/503)  (7/19) N/A
Head 16  (5/504)  (15/19)  Wholemount images
Heart 16  (1/504)  (12/19)  Wholemount images
Hindbrain 16  (6/504)  (15/19) N/A
Hindlimb 16  (1/503)  (7/19) N/A
Humerus pre-cartilage condensation 3  (1/61) Image Only N/A
Inner ear 3  (1/61) Image Only N/A
Liver 16  (1/504)  (3/19)  Wholemount images
Lower leg 11  (1/297) Image Only N/A
Lung 16  (1/500)  (3/19) N/A
Mandibular process 16  (1/504)  (4/19) N/A
Maxillary process 16  (1/504)  (4/19) N/A
Midbrain 16  (1/504)  (7/19) N/A
Nose 4  (1/70)  (1/4) N/A
Oral cavity 16  (1/504)  (3/19) N/A
Radius-ulna pre-cartilage condensation 3  (1/61) Image Only N/A
Skeleton 3  (1/70) Image Only N/A
Skin 16  (1/504)  (4/19) N/A
Spinal cord 4  (1/69)  (1/4) N/A
Tail 16  (1/504)  (7/19)  Wholemount images
Tail somite 16  (1/504)  (7/19) N/A
Upper arm 11  (1/297) Image Only N/A
Upper leg 11  (1/297) Image Only N/A
Vibrissa 3  (1/66) Image Only N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
185 Images
X-ray: XRay Images Whole Body Lateral Orientation
144 Images
Sleep Wake: Wake state (bmp file)
25 Images
Electroretinography: Cone waveform (pdf format)
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
54 Images
X-ray: XRay Images Skull Lateral Orientation
50 Images
X-ray: XRay Images Forepaw
39 Images
Eye Morphology: Images Ophthalmoscopy
21 Images
Eye Morphology: Images Slit Lamp
14 Images
Adult LacZ: LacZ Images Wholemount
629 Images
Legacy Phenotype Associated Images

View all 340 images

View all 10 images

View all 6 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Liver - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM Early adult
Sternum - developmental and structural abnormality Prkab1tm1b(KOMP)Wtsi HOM Early adult
Spleen - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM Early adult

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MGI Allele Allele Type Produced
Prkab1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Prkab1em2(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue
Prkab1em1(IMPC)Bay Exon Deletion Mice, Tissue
Prkab1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Prkab1tm301228(L1L2_Bact_P) Targeting vectors
Prkab1tm37294(L1L2_Bact_P) Targeting vectors
Prkab1em1(IMPC)J Exon Deletion Mice