Aspm | abnormal spindle microtubule assembly
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system
13 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased total body fat amount | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 7.78x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 6.1x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 3.16x10-6 | ||
| increased circulating glycerol level | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 4.11x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 1.53x10-6 | ||
| increased circulating cholesterol level | 1 supporting dataset | Aspmtm1a(KOMP)Wtsi | homozygote | Early adult | 2.03x10-5 |
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Human diseases caused by Aspm mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aspm.
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| Aspmtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Aspmtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |