Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
RAD17 checkpoint clamp loader component
Synonyms:
9430035O09Rik,  MmRad24

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rad17 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rad17 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lambert Syndrome
Intrahepatic biliary atresia, Cholestasis, Ventricular septal defect, Branchial anomaly, Jaundice ORPHA:1296
X-Linked Mandibulofacial Dysostosis
Pulmonic stenosis, Abnormal mitral valve morphology, Webbed neck, Branchial anomaly ORPHA:1131
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Bicuspid aortic valve, Atrial septal defect, Atrioventricular canal defect, Ventricular septal de... ORPHA:453499
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula ORPHA:50815
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Holoprosencephaly
Abnormal pulmonary valve morphology, Hydrocephalus, Holoprosencephaly, Short neck, Abnormality of... ORPHA:2162
Oligomeganephronia
Branchial cyst, Hypertension, Secundum atrial septal defect ORPHA:2260
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Bor Syndrome
Branchial cyst ORPHA:107
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Bicuspid aortic valve, Atrial septal defect, Ventricular septal defect, Cystic hygroma, Branchial... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Bicuspid aortic valve, Atrial septal defect, Ventricular septal defect, Cystic hygroma, Branchial... ORPHA:352665
Distal 22Q11.2 Microdeletion Syndrome
Atrial septal defect, Branchial fistula, Ventricular septal defect, Aortic regurgitation, Truncus... ORPHA:261330
Distal 22Q11.2 Microduplication Syndrome
Tricuspid valve prolapse, Hydrocephalus, Tricuspid regurgitation, Branchial fistula, Ventricular ... ORPHA:261337
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Treacher-Collins Syndrome
Branchial fistula, Encephalocele ORPHA:861
8Q24.3 Microdeletion Syndrome
Exocrine pancreatic insufficiency, Atrioventricular canal defect, Short neck, Spina bifida occult... ORPHA:508488
Branchiooculofacial Syndrome
Short neck, Low posterior hairline, Branchial anomaly OMIM:113620
Witteveen-Kolk Syndrome
Branchial fistula, Intracranial hemorrhage OMIM:613406
Craniofacial Microsomia
Hydrocephalus, Tetralogy of Fallot, Ventricular septal defect, Branchial anomaly, Occipital encep... OMIM:164210

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rad17

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rad17.

No publications found that use IMPC mice or data for Rad17.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rad17tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Rad17tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Rad17tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rad17tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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