Mrpl22 - mitochondrial ribosomal protein L22 | International Mouse Phenotyping Consortium

Phenotype	System	Allele	Zyg	Sex	Life Stage	P Value
impaired pupillary reflex		Mrpl22^{tm1b(KOMP)Mbp}	HET		postnatal	7.67×10^-08
preweaning lethality, complete penetrance		Mrpl22^{tm1b(KOMP)Mbp}	HOM		n/a	0.00

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	2	No	(2/584)	(2/2)	Section images
Aorta	2	No		(2/2)	N/A
Brain	2	No		(2/2)	Section images
Brainstem	2	No		(2/2)	Section images
Brown adipose tissue	2	No			N/A
Cartilage tissue	2	No		(2/2)	Section images
Cerebellum	2	No		(2/2)	Section images
Cerebral cortex	2	No		(2/2)	Section images
Epididymis	2	No	(18/134)	(1/2)	Section images
Esophagus	2	No	(7/415)	(2/2)	Section images
Eye	2	No		(2/2)	Section images
Heart	2	No		(2/2)	N/A
Hippocampus	2	No		(2/2)	Section images
Hypothalamus	2	No		(2/2)	Section images
Kidney	2	No	(18/584)	(2/2)	Section images
Large intestine	2	No	(10/584)	(2/2)	Section images
Liver	2	No		(2/2)	Section images
Lower urinary tract	2	No			N/A
Lung	2	No		(2/2)	Section images
Lymph node	2	No			N/A
Mammary gland	2	No			N/A
Midbrain	2	No		(2/2)	Section images
Olfactory lobe	2	No		(2/2)	Section images
Ovary	2	No	(1/584)		N/A
Oviduct	2	No		(1/2)	N/A
Pancreas	2	No	(5/584)	(2/2)	Section images
Peripheral nervous system	2	No		(2/2)	Section images
Peyer's patch	2	No			Section images
Pituitary gland	2	No		(2/2)	Section images
Prostate gland	2	No	(12/584)		N/A
Skeletal muscle	2	No		(2/2)	N/A
Skin	2	No		(2/2)	Section images
Small intestine	2	No	(9/584)	(2/2)	Section images
Spinal cord	2	No		(2/2)	N/A
Spleen	2	No	(2/584)	(2/2)	Section images
Stomach	2	No	(12/584)	(2/2)	N/A
Striatum	2	No		(2/2)	Section images
Submandibular gland	2	No	(2/132)		Section images
Testis	2	No	(2/584)	(1/2)	Section images
Thalamus	2	No		(2/2)	Section images
Thymus	2	No			N/A
Thyroid gland	2	No	(15/584)	(2/2)	N/A
Trachea	2	No			N/A
Urinary bladder	2	No		(2/2)	N/A
Uterus	2	No		(1/2)	N/A
Vascular system	2	No		(2/2)	N/A
Vesicular gland	2	No			N/A
White adipose tissue	2	No		(2/2)	N/A

digestive system (6)
Esophagus expression
MA:0000352

endocrine system (1)
Adrenal gland expression
MA:0000116

exocrine system (1)
Submandibular Gland imageOnly
MA:0001589

immune system (2)
Peyers Patch imageOnly
MA:0000137

integumental system (1)
Skin expression
MA:0000151

nervous system (12)
Brain expression
MA:0000168

postnatal mouse (28)
Adrenal gland expression
MA:0000116

reproductive system (2)
Epididymis expression
MA:0000397

respiratory system (2)
Lung expression
MA:0000415

sensory organ (1)
Eye expression
MA:0000261

set of connective tissues (1)
Cartilage tissue expression
MA:0000104

trunk (12)
Adrenal gland expression
MA:0000116

urinary system (1)
Kidney expression
MA:0000368

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	WT Expr	Mutant Expr	Images
Brain	2	(6/485)	(1/2)	N/A
Dorsal root ganglion	2	(1/47)	Image Only	N/A
Ear	2	(1/485)		N/A
Embryo	2	(1/485)	(2/2)	Wholemount images
Eye	2	(1/485)	(2/2)	N/A
Foot	2	(1/485)	(2/2)	N/A
Forebrain	2	(1/485)		N/A
Forelimb	2	(1/485)	(2/2)	N/A
Fronto-nasal process	2	(1/48)	Image Only	N/A
Hand	2	(1/485)	(2/2)	N/A
Head	2	(5/485)	(2/2)	N/A
Heart	2	(1/485)	(2/2)	N/A
Hindbrain	2	(6/485)	(1/2)	N/A
Hindlimb	2	(1/485)	(2/2)	N/A
Liver	2	(1/485)		N/A
Lung	2	(1/485)	Image Only	N/A
Mandibular process	2	(1/485)	(2/2)	N/A
Maxillary process	2	(1/485)	(1/2)	N/A
Midbrain	2	(1/485)		N/A
Nose	2	(1/51)	(1/2)	N/A
Oral cavity	2	(1/485)	Image Only	N/A
Skin	2	(1/485)	Image Only	N/A
Spinal cord	2	(1/50)	(1/2)	N/A
Tail	2	(1/485)	(2/2)	N/A
Tail somite	2	(1/485)		N/A

embryo or Unassigned (4)
Embryo expression
EMAPA:16039 embryo

MGI Allele	Allele Type	Availability
Mrpl22^{tm1a(KOMP)Mbp}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Mrpl22^{tm2a(KOMP)Mbp}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Mrpl22^{tm41846(L1L2_gt2)}		Targeting vectors
Mrpl22^{tm1b(KOMP)Mbp}	Reporter-tagged deletion allele (post-Cre)	Mice

Gene: Mrpl22