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Genes Phenotypes Help, News, Blog

Gene: Strn MGI:1333757

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
striatin, calmodulin binding protein
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Strn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Strn by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hyperaldosteronism, Familial, Type Iv
Hyperaldosteronism, Hypertension OMIM:617027
Hyperaldosteronism, Familial, Type Ii
Hyperaldosteronism, Hypertension OMIM:605635
Hyperaldosteronism, Familial, Type I
Adrenal hyperplasia, Hyperaldosteronism, Hypertension, Adrenogenital syndrome, Decreased circulat... OMIM:103900
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hyperaldosteronism, Increased circulating renin level, Hypotension OMIM:620125
Familial Hyperaldosteronism Type Ii
Adrenal hyperplasia, Abnormal circulating renin, Hypertension, Intracranial hemorrhage, Glucocort... ORPHA:404
Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete
Adrenal insufficiency, Hyperaldosteronism, Adrenocorticotropic hormone excess OMIM:613743
Paragangliomas 6
Paraganglioma, Hypertension, Elevated circulating catecholamine level OMIM:618464
Hypokalemic Tubulopathy And Deafness
Hyperaldosteronism, Increased circulating renin level OMIM:619406
Familial Hyperaldosteronism Type I
Adrenal hyperplasia, Abnormal circulating renin, Hypertension, Intracranial hemorrhage, Secretory... ORPHA:403
Adrenocortical Carcinoma
Increased circulating androstenedione concentration, Hyperaldosteronism, Elevated serum 11-deoxyc... ORPHA:1501
Hyperaldosteronism, Familial, Type Iii
Adrenal hyperplasia, Hyperaldosteronism, Hypertension, Decreased circulating renin level OMIM:613677
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hyperaldosteronism, Increased circulating renin level, Hypotension, Hyperactive renin-angiotensin... OMIM:177735
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hyperaldosteronism, Hyperactive renin-angiotensin system, Hypotension, Pseudohypoaldosteronism OMIM:264350
Familial Hyperaldosteronism Type Iii
Adrenal hyperplasia, Abnormal circulating renin, Hypertension, Intracranial hemorrhage, Glucocort... ORPHA:251274
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Abnormal T-wave, Increased circulating cortisol level, Palpitations, Hypertension, Intracranial h... ORPHA:231625
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Pigmented Nodular Adrenocortical Disease, Primary, 3
Adrenal hyperplasia, Increased circulating cortisol level OMIM:614190
Coronary Artery Disease, Autosomal Dominant, 1
Myocardial infarction, Diabetes mellitus, Hypertension, Hypercholesterolemia OMIM:608320
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Adrenal hyperplasia, Pulmonary arterial hypertension, Hyperaldosteronism, Abnormal circulating re... ORPHA:369929
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:605115
Pseudohypoaldosteronism, Type Ib3, Autosomal Recessive
Hyperaldosteronism, Increased circulating renin level OMIM:620126
Ectopic Aldosterone-Producing Tumor
Adrenocortical adenoma, Hypertension, Glucocortocoid-insensitive primary hyperaldosteronism, Epis... ORPHA:231632
Primary Unilateral Adrenal Hyperplasia
Adrenal hyperplasia, Palpitations, Hypertension, Glucocortocoid-insensitive primary hyperaldoster... ORPHA:231580
Periodic Fever, Menstrual Cycle-Dependent
Increased circulating cortisol level OMIM:614674
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Hyperaldosteronism, Abnormal response to corticotropin releasing hormone stimulation test, Increa... ORPHA:189427
Andersen-Tawil Syndrome
Prolonged QTc interval, Polymorphic and polytopic ventricular extrasystoles, Abnormal T-wave, Hyp... ORPHA:37553
Primary Aldosteronism, Seizures, And Neurologic Abnormalities
Pulmonary arterial hypertension, Hypertension, Second degree atrioventricular block, Primary hype... OMIM:615474
Glucocorticoid Resistance, Generalized
Increased circulating androstenedione concentration, Increased circulating ACTH level, Increased ... OMIM:615962
Generalized Pseudohypoaldosteronism Type 1
Hypovolemic shock, Increased circulating renin level, Abnormal circulating aldosterone, Arrhythmi... ORPHA:171876
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased circulating cortisol level, Hypertension, Decreased circulating ACTH level, Macronodula... OMIM:615954
Glucocorticoid Deficiency 5
Abnormal response to ACTH stimulation test, Decreased circulating cortisol level OMIM:617825
Late-Onset Familial Hypoaldosteronism
Increased circulating renin level, Hypotension, Decreased circulating aldosterone level, Abnormal... ORPHA:556037
Bartter Syndrome, Type 3
Hyperaldosteronism, Hyperactive renin-angiotensin system, Increased circulating renin level, Hypo... OMIM:607364
Pseudohypoaldosteronism, Type Iia
Hypertension, Pseudohypoaldosteronism OMIM:145260
Early-Onset Familial Hypoaldosteronism
Increased circulating renin level, Hypotension, Decreased circulating aldosterone level, Abnormal... ORPHA:556030
East Syndrome
Hyperaldosteronism, Increased circulating renin level ORPHA:199343
Multiple Endocrine Neoplasia, Type Iia
Thyroid C cell hyperplasia, Elevated calcitonin, Hyperparathyroidism, Increased circulating corti... OMIM:171400
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Hyperaldosteronism, Hypertension, Increased circulating renin level OMIM:612780
Pigmented Nodular Adrenocortical Disease, Primary, 4
Adrenal hyperplasia, Diabetes mellitus, Increased circulating cortisol level, Hypertension, Prima... OMIM:615830
Pigmented Nodular Adrenocortical Disease, Primary, 1
Decreased circulating dehydroepiandrosterone concentration, Increased serum testosterone level, I... OMIM:610489
Atrial Fibrillation, Familial, 14
ST segment elevation, Hypertension, Paroxysmal atrial fibrillation, Prolonged PR interval OMIM:615378
Diarrhea 1, Secretory Chloride, Congenital
Hyperaldosteronism, Hyperactive renin-angiotensin system, Increased circulating renin level OMIM:214700
Pigmented Nodular Adrenocortical Disease, Primary, 2
Pancreatitis, Increased circulating cortisol level, Hypertension, Primary hypercortisolism, Decre... OMIM:610475
Liddle Syndrome 2
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:618114
Liddle Syndrome 3
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:618126
Acth-Independent Macronodular Adrenal Hyperplasia
Adrenal hyperplasia, Increased circulating cortisol level, Hypertension, Primary hypercortisolism... OMIM:219080
Gitelman Syndrome
Raynaud phenomenon, Delayed puberty, Abnormal T-wave, Maternal diabetes, Graves disease, Hashimot... ORPHA:358
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Hyperaldosteronism, Congestive heart failure, Dilated cardiomyopathy, Sudden cardiac death ORPHA:73224
Glucocorticoid Deficiency 2
Increased circulating ACTH level, Decreased circulating cortisol level OMIM:607398
Autoimmune Polyendocrinopathy Type 1
Adrenal hyperplasia, Hypoparathyroidism, Decreased circulating aldosterone level, Increased circu... ORPHA:3453
Bronchial Neuroendocrine Tumor
Elevated circulating growth hormone concentration, Increased circulating ACTH level, Hypotension,... ORPHA:97287
Pseudohypoaldosteronism, Type Iib
Hypertension, Pseudohypoaldosteronism OMIM:614491
Pseudohypoaldosteronism, Type Iid
Hypertension, Pseudohypoaldosteronism OMIM:614495
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Elevated circulating growth hormone concentration, Multiple pancreatic beta-cell adenomas, Increa... ORPHA:79644
Corticosteroid-Binding Globulin Deficiency
Decreased circulating cortisol level, Hypertension, Hypotension OMIM:611489
Liddle Syndrome 1
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:177200
Mccune-Albright Syndrome
Elevated circulating growth hormone concentration, Increased circulating prolactin concentration,... OMIM:174800
Thymic Neuroendocrine Tumor
Pituitary prolactin cell adenoma, Increased circulating ACTH level, Increased circulating prolact... ORPHA:97289
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:613090
Secondary Intestinal Lymphangiectasia
Secondary hyperaldosteronism, Intestinal bleeding, Right ventricular failure, Hypocholesterolemia... ORPHA:90363
Bangstad Syndrome
Primary gonadal insufficiency, Increased circulating cortisol level, Abnormality of the parathyro... ORPHA:1227
Bartter Syndrome Type 4
Hyperactive renin-angiotensin system, Hyperaldosteronism, Hypertension, Increased circulating ren... ORPHA:89938
Nelson Syndrome
Increased circulating prolactin concentration, Pituitary corticotropic cell adenoma, Increased ci... ORPHA:199244
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Increased circulating androstenedione concentration, Increased serum testosterone level, Decrease... OMIM:202010
Bartter Syndrome, Type 1, Antenatal
Hyperaldosteronism, Increased circulating renin level, Hyperparathyroidism, Low-to-normal blood p... OMIM:601678
Pituitary Apoplexy
Hypopituitarism, Elevated circulating growth hormone concentration, Hypotension, Increased circul... ORPHA:95613
Pseudohypoaldosteronism, Type Iie
Hypertension, Pseudohypoaldosteronism OMIM:614496
Oculocerebrorenal Syndrome Of Lowe
Delayed puberty, Hyperaldosteronism, Hyperparathyroidism, Diabetes insipidus, Abnormal calcium-ph... ORPHA:534
Generalized Glucocorticoid Resistance Syndrome
Adrenal hyperplasia, Increased circulating ACTH level, Increased circulating cortisol level, Decr... ORPHA:786
Leprechaunism
Hyperaldosteronism, Increased circulating renin level, Central hypothyroidism, Hyperinsulinemia, ... ORPHA:508
Multiple Endocrine Neoplasia Type 4
Thymoma, Parathyroid carcinoma, Adrenocortical adenoma, Hyperparathyroidism, Increased circulatin... ORPHA:276152
Bartter Syndrome, Type 2, Antenatal
Low-to-normal blood pressure, Hyperactive renin-angiotensin system, Increased circulating renin l... OMIM:241200
Obsolete: Primary Pigmented Nodular Adrenocortical Disease
Adrenal hyperplasia, Diabetes mellitus, Increased circulating cortisol level, Hypertension, Decre... ORPHA:189439
Multiple Endocrine Neoplasia, Type I
Pituitary prolactin cell adenoma, Elevated circulating growth hormone concentration, Adrenocortic... OMIM:131100
Zollinger-Ellison Syndrome
Pituitary prolactin cell adenoma, Elevated circulating growth hormone concentration, Hematochezia... ORPHA:913
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:602522
Dietary Iron Overload Disease
Diabetes mellitus, Increased circulating cortisol level, Abnormal thyroid morphology, Abnormality... ORPHA:139507
Multiple Endocrine Neoplasia Type 1
Thymoma, Parathyroid carcinoma, Increased circulating cortisol level, Insulinoma, Increased serum... ORPHA:652
Somatostatinoma
Elevated circulating growth hormone concentration, Abnormality of the thyroid gland, Adrenocortic... ORPHA:97283
Ppoma
Elevated circulating growth hormone concentration, Abnormality of the thyroid gland, Adrenocortic... ORPHA:97278
Neuroendocrine Neoplasm Of Appendix
Hypotension, Palpitations, Primary hypercortisolism, Increased serum serotonin, Tricuspid stenosi... ORPHA:100079
Mccune-Albright Syndrome
Goiter, Abnormal endocrine physiology, Elevated circulating growth hormone concentration, Increas... ORPHA:562
Grfoma
Elevated circulating growth hormone concentration, Abnormality of the thyroid gland, Adrenocortic... ORPHA:97261
Vipoma
Elevated circulating growth hormone concentration, Hematochezia, Abnormality of the thyroid gland... ORPHA:97282
Glucagonoma
Elevated circulating growth hormone concentration, Abnormality of the thyroid gland, Adrenocortic... ORPHA:97280
Fibrous Dysplasia Of Bone
Hyperpituitarism, Elevated circulating growth hormone concentration, Diabetes mellitus, Increased... ORPHA:249
Cushing Disease
Adrenal hyperplasia, Increased circulating ACTH level, Diabetes mellitus, Increased circulating c... ORPHA:96253
Cushing Syndrome Due To Ectopic Acth Secretion
Adrenal hyperplasia, Increased circulating ACTH level, Pancreatic endocrine tumor, Small intestin... ORPHA:99889
Carney Complex
Elevated circulating growth hormone concentration, Increased circulating prolactin concentration,... ORPHA:1359
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Decreased circulating dehydroepiandrosterone concentration, Increased circulating ACTH level, Ele... OMIM:201750

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Strn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Strn.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Frontiers in cell and developmental biology (July 2020) Strntm1a(KOMP)Wtsi PMC7381154
Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension (Dallas, Tex. : 1979) (July 2015) Strntm1a(KOMP)Wtsi PMC4537321
Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension (Dallas, Tex. : 1979) (November 2014) Strntm1a(KOMP)Wtsi PMC4617687

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MGI Allele Allele Type Produced
Strntm43076(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Strntm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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