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Gene: Strn MGI:1333757

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
striatin, calmodulin binding protein
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Strn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Strn by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hyperaldosteronism, Familial, Type Iv
Hyperaldosteronism, Elevated aldosterone:renin ratio, Hypertension OMIM:617027
Hyperaldosteronism, Familial, Type Ii
Hyperaldosteronism, Hypertension OMIM:605635
Hyperaldosteronism, Familial, Type I
Hyperaldosteronism, Adrenal hyperplasia, Decreased circulating renin level, Adrenogenital syndrom... OMIM:103900
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hyperaldosteronism, Hypotension, Increased circulating renin level OMIM:620125
Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete
Hyperaldosteronism, Adrenal insufficiency, Adrenocorticotropic hormone excess OMIM:613743
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Hypertension, Paraganglioma OMIM:618464
Familial Hyperaldosteronism Type Ii
Epistaxis, Secretory adrenocortical adenoma, Adrenal hyperplasia, Abnormal circulating renin, Int... ORPHA:404
Adrenocortical Carcinoma
Increased circulating cortisol level, Increased urinary cortisol level, Hyperaldosteronism, Incre... ORPHA:1501
Familial Hyperaldosteronism Type I
Epistaxis, Secretory adrenocortical adenoma, Dexamethasone-suppressible primary hyperaldosteronis... ORPHA:403
Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Hypertension, Adrenal hyperplasia, Decreased circulating renin level OMIM:613677
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension, Hyperaldosteronism, Pseudohypoaldosteronism, Hyperactive renin-angiotensin system, I... OMIM:177735
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hyperaldosteronism, Hypotension, Hyperactive renin-angiotensin system, Pseudohypoaldosteronism OMIM:264350
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Epistaxis, Increased circulating cortisol level, Abnormal T-wave, Palpitations, Decreased circula... ORPHA:231625
Hypokalemic Tubulopathy And Deafness
Hyperaldosteronism, Increased circulating renin level OMIM:619406
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Familial Hyperaldosteronism Type Iii
Epistaxis, Adrenal hyperplasia, Abnormal circulating renin, Prolonged QT interval, Intracranial h... ORPHA:251274
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Coronary Artery Disease, Autosomal Dominant, 1
Hypertension, Hypercholesterolemia, Myocardial infarction, Diabetes mellitus OMIM:608320
Pseudohypoaldosteronism, Type Ib3, Autosomal Recessive
Hyperaldosteronism, Increased circulating renin level OMIM:620126
Primary Unilateral Adrenal Hyperplasia
Epistaxis, Palpitations, Adrenal hyperplasia, Decreased circulating renin level, Hypertension, Gl... ORPHA:231580
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:605115
Ectopic Aldosterone-Producing Tumor
Hypertension, Epistaxis, Decreased circulating renin level, Glucocortocoid-insensitive primary hy... ORPHA:231632
Pigmented Nodular Adrenocortical Disease, Primary, 3
Increased circulating cortisol level, Adrenal hyperplasia OMIM:614190
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Epistaxis, Second degree atrioventricular block, Hyperaldosteronism, Adrenal hyperplasia, Abnorma... ORPHA:369929
Periodic Fever, Menstrual Cycle-Dependent
Increased circulating cortisol level OMIM:614674
Andersen-Tawil Syndrome
Dilated cardiomyopathy, Prominent U wave, Polymorphic and polytopic ventricular extrasystoles, Ab... ORPHA:37553
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Pituitary adenoma, Increased circulating cortisol level, Neuroendocrine neoplasm, Increased urina... ORPHA:189427
Primary Aldosteronism, Seizures, And Neurologic Abnormalities
Second degree atrioventricular block, Decreased circulating renin level, Pulmonary arterial hyper... OMIM:615474
Supravalvular Aortic Stenosis
Supravalvular aortic stenosis, Angina pectoris, Arrhythmia, Syncope, Hypertension, Systolic heart... ORPHA:3193
Glucocorticoid Resistance, Generalized
Increased circulating cortisol level, Increased circulating ACTH level, Increased circulating and... OMIM:615962
Generalized Pseudohypoaldosteronism Type 1
Hypovolemic shock, Abnormal circulating aldosterone, Glucocortocoid-insensitive primary hyperaldo... ORPHA:171876
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency
Elevated circulating 21-deoxycortisol concentration, Adrenogenital syndrome, Hypertension, Adrena... OMIM:201910
Late-Onset Familial Hypoaldosteronism
Hypotension, Decreased circulating aldosterone level, Elevated serum 11-deoxycortisol, Orthostati... ORPHA:556037
Bartter Syndrome, Type 3
Hyperaldosteronism, Hypotension, Hyperactive renin-angiotensin system, Increased circulating reni... OMIM:607364
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased circulating cortisol level, Increased urinary cortisol level, Decreased circulating ACT... OMIM:615954
Pseudohypoaldosteronism, Type Iia
Hypertension, Pseudohypoaldosteronism OMIM:145260
East Syndrome
Hyperaldosteronism, Increased circulating renin level ORPHA:199343
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Hyperaldosteronism, Hypertension, Increased circulating renin level OMIM:612780
Atrial Fibrillation, Familial, 14
Paroxysmal atrial fibrillation, Prolonged PR interval, ST segment elevation, Hypertension OMIM:615378
Diarrhea 1, Secretory Chloride, Congenital
Hyperaldosteronism, Hyperactive renin-angiotensin system, Increased circulating renin level OMIM:214700
Early-Onset Familial Hypoaldosteronism
Hypotension, Decreased circulating aldosterone level, Elevated serum 11-deoxycortisol, Orthostati... ORPHA:556030
Pigmented Nodular Adrenocortical Disease, Primary, 1
Decreased circulating dehydroepiandrosterone concentration, Increased circulating cortisol level,... OMIM:610489
Pigmented Nodular Adrenocortical Disease, Primary, 2
Increased circulating cortisol level, Pigmented micronodular adrenocortical disease, Decreased ci... OMIM:610475
Gitelman Syndrome
Type I diabetes mellitus, Graves disease, Prominent U wave, Abnormal T-wave, Palpitations, Type I... ORPHA:358
Liddle Syndrome 2
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:618114
Liddle Syndrome 3
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:618126
Multiple Endocrine Neoplasia, Type Iia
Thyroid C cell hyperplasia, Hyperparathyroidism, Increased circulating cortisol level, Pheochromo... OMIM:171400
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased circulating cortisol level, Primary hypercortisolism, Adrenal hyperplasia, Hypertension... OMIM:615830
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Hyperaldosteronism, Dilated cardiomyopathy, Sudden cardiac death, Congestive heart failure ORPHA:73224
Acth-Independent Macronodular Adrenal Hyperplasia
Increased circulating cortisol level, Decreased circulating ACTH concentration, Macronodular adre... OMIM:219080
Bronchial Neuroendocrine Tumor
Increased serum serotonin, Hypotension, Cardiogenic shock, Right ventricular failure, Increased c... ORPHA:97287
Pseudohypoaldosteronism, Type Iib
Hypertension, Pseudohypoaldosteronism OMIM:614491
Pseudohypoaldosteronism, Type Iid
Hypertension, Pseudohypoaldosteronism OMIM:614495
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Diffuse pancreatic islet hyperplasia, Increased circulating cortisol level, Focal pancreatic isle... ORPHA:79644
Liddle Syndrome 1
Decreased circulating aldosterone level, Hypertension, Decreased circulating renin level OMIM:177200
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:613090
Autoimmune Polyendocrinopathy Type 1
Abnormal circulating calcium-phosphate regulating hormone concentration, Increased circulating co... ORPHA:3453
Secondary Intestinal Lymphangiectasia
Intestinal bleeding, Right ventricular failure, Secondary hyperaldosteronism, Hypocholesterolemia... ORPHA:90363
Thymic Neuroendocrine Tumor
Pituitary adenoma, Increased circulating cortisol level, Pituitary prolactin cell adenoma, Increa... ORPHA:97289
Bartter Syndrome, Type 1, Antenatal
Hyperparathyroidism, Hyperaldosteronism, Low-to-normal blood pressure, Hyperactive renin-angioten... OMIM:601678
Mccune-Albright Syndrome
Precocious puberty, Hyperparathyroidism, Pituitary adenoma, Increased circulating cortisol level,... OMIM:174800
Oculocerebrorenal Syndrome Of Lowe
Hyperparathyroidism, Abnormal circulating calcium-phosphate regulating hormone concentration, Hyp... ORPHA:534
Bangstad Syndrome
Type I diabetes mellitus, Increased circulating cortisol level, Abnormality of the parathyroid gl... ORPHA:1227
Pseudohypoaldosteronism, Type Iie
Hypertension, Pseudohypoaldosteronism OMIM:614496
Leprechaunism
Central hypothyroidism, Hyperaldosteronism, Hypertrophic cardiomyopathy, Hyperinsulinemia, Increa... ORPHA:508
Tako-Tsubo Cardiomyopathy
Atrial fibrillation, Hypotension, Cardiogenic shock, Prolonged QTc interval, Palpitations, Mitral... ORPHA:66529
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Precocious puberty in males, Congenital adrenal hyperplasia, Increased circulating androstenedion... OMIM:202010
Bartter Syndrome, Type 2, Antenatal
Hyperaldosteronism, Low-to-normal blood pressure, Hyperactive renin-angiotensin system, Increased... OMIM:241200
Nelson Syndrome
Increased circulating cortisol level, Increased circulating prolactin concentration, Pituitary ca... ORPHA:199244
Bartter Syndrome Type 4
Hyperaldosteronism, Hyperactive renin-angiotensin system, Increased circulating renin level ORPHA:89938
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:602522
Pituitary Apoplexy
Hypotension, Pituitary adenoma, Increased circulating cortisol level, Increased circulating prola... ORPHA:95613
Generalized Glucocorticoid Resistance Syndrome
Precocious puberty, Abnormal circulating testosterone concentration, Increased circulating cortis... ORPHA:786
Multiple Endocrine Neoplasia Type 4
Increased circulating cortisol level, Pituitary prolactin cell adenoma, Increased urinary cortiso... ORPHA:276152
Multiple Endocrine Neoplasia, Type I
Thyroid adenoma, Pituitary adenoma, Increased circulating cortisol level, Pituitary prolactin cel... OMIM:131100
Zollinger-Ellison Syndrome
Hyperparathyroidism, Thyroid adenoma, Gastrointestinal hemorrhage, Pituitary adenoma, Increased c... ORPHA:913
Dietary Iron Overload Disease
Abnormal thyroid morphology, Increased circulating cortisol level, Congestive heart failure, Abno... ORPHA:139507
Multiple Endocrine Neoplasia Type 1
Increased serum serotonin, Increased circulating cortisol level, Pituitary prolactin cell adenoma... ORPHA:652
Neuroendocrine Neoplasm Of Appendix
Increased serum serotonin, Hypotension, Primary hypercortisolism, Palpitations, Adrenocorticotrop... ORPHA:100079
Somatostatinoma
Gastrointestinal hemorrhage, Pituitary adenoma, Increased circulating cortisol level, Increased c... ORPHA:97283
Mccune-Albright Syndrome
Precocious puberty, Increased circulating cortisol level, Increased circulating prolactin concent... ORPHA:562
Ppoma
Gastrointestinal hemorrhage, Intestinal carcinoid, Pituitary adenoma, Increased circulating corti... ORPHA:97278
Grfoma
Gastrointestinal hemorrhage, Intestinal carcinoid, Pituitary adenoma, Increased circulating corti... ORPHA:97261
Vipoma
Follicular thyroid carcinoma, Pituitary adenoma, Increased circulating cortisol level, Increased ... ORPHA:97282
Glucagonoma
Gastrointestinal hemorrhage, Pituitary adenoma, Increased circulating cortisol level, Increased c... ORPHA:97280
Cushing Disease
Increased circulating cortisol level, Increased urinary cortisol level, Increased circulating ACT... ORPHA:96253
Fibrous Dysplasia Of Bone
Precocious puberty in females, Increased circulating cortisol level, Thyroid carcinoma, Hyperpitu... ORPHA:249
Cushing Syndrome Due To Ectopic Acth Secretion
Pulmonary carcinoid tumor, Neuroendocrine neoplasm, Increased circulating cortisol level, Increas... ORPHA:99889
Carney Complex
Euthyroid multinodular goiter, Precocious puberty, Follicular thyroid carcinoma, Increased circul... ORPHA:1359
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Elevated circulating 17-hydroxyprogesterone concentration, Decreased circulating dehydroepiandros... OMIM:201750

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Strn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Strn.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Frontiers in cell and developmental biology (July 2020) Strntm1a(KOMP)Wtsi PMC7381154
Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension (Dallas, Tex. : 1979) (July 2015) Strntm1a(KOMP)Wtsi PMC4537321
Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension (Dallas, Tex. : 1979) (November 2014) Strntm1a(KOMP)Wtsi PMC4617687

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MGI Allele Allele Type Produced
Strntm43076(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Strntm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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