Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
striatin, calmodulin binding protein
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Strn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Strn by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hyperaldosteronism, Familial, Type Iv
Hypertension, Elevated aldosterone:renin ratio, Hyperaldosteronism OMIM:617027
Hyperaldosteronism, Familial, Type Ii
Hypertension, Hyperaldosteronism OMIM:605635
Hyperaldosteronism, Familial, Type I
Decreased circulating renin level, Hypertension, Adrenal hyperplasia, Adrenogenital syndrome, Hyp... OMIM:103900
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Increased circulating renin level, Hypotension, Hyperaldosteronism OMIM:620125
Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete
Hyperaldosteronism, Adrenocorticotropic hormone excess, Adrenal insufficiency OMIM:613743
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Hypertension, Paraganglioma OMIM:618464
Adrenocortical Carcinoma
Increased circulating androstenedione concentration, Elevated serum 11-deoxycortisol, Adrenocorti... ORPHA:1501
Familial Hyperaldosteronism Type Ii
Abnormal circulating renin, Hypertension, Glucocortocoid-insensitive primary hyperaldosteronism, ... ORPHA:404
Familial Hyperaldosteronism Type I
Dexamethasone-suppressible primary hyperaldosteronism, Abnormal circulating renin, Hypertension, ... ORPHA:403
Hyperaldosteronism, Familial, Type Iii
Adrenal hyperplasia, Decreased circulating renin level, Hypertension, Hyperaldosteronism OMIM:613677
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hyperactive renin-angiotensin system, Hypotension, Pseudohypoaldosteronism, Increased circulating... OMIM:177735
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hyperactive renin-angiotensin system, Hypotension, Hyperaldosteronism, Pseudohypoaldosteronism OMIM:264350
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Decreased circulating renin level, Hypertension, Neoplasm of the adrenal gland, Glucocortocoid-in... ORPHA:231625
Hypokalemic Tubulopathy And Deafness
Increased circulating renin level, Hyperaldosteronism OMIM:619406
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Pigmented Nodular Adrenocortical Disease, Primary, 3
Adrenal hyperplasia, Increased circulating cortisol level OMIM:614190
Coronary Artery Disease, Autosomal Dominant, 1
Diabetes mellitus, Hypertension, Hypercholesterolemia, Myocardial infarction OMIM:608320
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Familial Hyperaldosteronism Type Iii
Prolonged QT interval, Abnormal circulating renin, Hypertension, Glucocortocoid-insensitive prima... ORPHA:251274
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Decreased circulating renin level, Hypertension, Decreased circulating aldosterone level OMIM:605115
Pseudohypoaldosteronism, Type Ib3, Autosomal Recessive
Increased circulating renin level, Hyperaldosteronism OMIM:620126
Primary Unilateral Adrenal Hyperplasia
Decreased circulating renin level, Hypertension, Glucocortocoid-insensitive primary hyperaldoster... ORPHA:231580
Periodic Fever, Menstrual Cycle-Dependent
Increased circulating cortisol level OMIM:614674
Ectopic Aldosterone-Producing Tumor
Decreased circulating renin level, Hypertension, Epistaxis, Glucocortocoid-insensitive primary hy... ORPHA:231632
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Hypertension, Abnormal circulating renin, Pulmonary arterial hypertension, Adrenal hyperplasia, E... ORPHA:369929
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Decreased circulating ACTH concentration, Macronodular adrenal hyperplasia, Hypertension, Hyperli... ORPHA:189427
Andersen-Tawil Syndrome
Torsade de pointes, Polymorphic ventricular tachycardia, Prolonged QT interval, Prominent U wave,... ORPHA:37553
Glucocorticoid Resistance, Generalized
Increased circulating androstenedione concentration, Increased serum testosterone level, Hyperten... OMIM:615962
Primary Aldosteronism, Seizures, And Neurologic Abnormalities
Decreased circulating renin level, Hypertension, Pulmonary arterial hypertension, Primary hyperal... OMIM:615474
Supravalvular Aortic Stenosis
Angina pectoris, Hypertension, Systolic heart murmur, Arrhythmia, Syncope, Supravalvular aortic s... ORPHA:3193
Generalized Pseudohypoaldosteronism Type 1
Hypovolemic shock, Glucocortocoid-insensitive primary hyperaldosteronism, Increased circulating r... ORPHA:171876
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency
Adrenal hyperplasia, Hypertension, Adrenogenital syndrome, Elevated circulating 21-deoxycortisol ... OMIM:201910
Late-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Orthostatic hypotension, Abnormal circulating corticosterone lev... ORPHA:556037
Glucocorticoid Deficiency 5
Decreased circulating cortisol level, Abnormal response to ACTH stimulation test OMIM:617825
Acth-Independent Macronodular Adrenal Hyperplasia 2
Decreased circulating ACTH concentration, Macronodular adrenal hyperplasia, Hypertension, Increas... OMIM:615954
Early-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Orthostatic hypotension, Abnormal circulating corticosterone lev... ORPHA:556030
Bartter Syndrome, Type 3
Increased circulating renin level, Hypotension, Hyperaldosteronism, Hyperactive renin-angiotensin... OMIM:607364
Pseudohypoaldosteronism, Type Iia
Hypertension, Pseudohypoaldosteronism OMIM:145260
Pigmented Nodular Adrenocortical Disease, Primary, 2
Pancreatitis, Decreased circulating ACTH concentration, Pigmented micronodular adrenocortical dis... OMIM:610475
Glucocorticoid Deficiency 3
Increased circulating ACTH level, Abnormal circulating renin, Decreased circulating cortisol leve... OMIM:609197
Pigmented Nodular Adrenocortical Disease, Primary, 1
Increased serum testosterone level, Decreased circulating ACTH concentration, Pigmented micronodu... OMIM:610489
East Syndrome
Increased circulating renin level, Hyperaldosteronism ORPHA:199343
Multiple Endocrine Neoplasia, Type Iia
Pheochromocytoma, Thyroid C cell hyperplasia, Hypertension, Elevated circulating calcitonin conce... OMIM:171400
Pigmented Nodular Adrenocortical Disease, Primary, 4
Hypertension, Adrenal hyperplasia, Diabetes mellitus, Primary hypercortisolism, Increased circula... OMIM:615830
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Increased circulating renin level, Hypertension, Hyperaldosteronism OMIM:612780
Atrial Fibrillation, Familial, 14
Paroxysmal atrial fibrillation, ST segment elevation, Hypertension, Prolonged PR interval OMIM:615378
Diarrhea 1, Secretory Chloride, Congenital
Increased circulating renin level, Hyperaldosteronism, Hyperactive renin-angiotensin system OMIM:214700
Acth-Independent Macronodular Adrenal Hyperplasia
Decreased circulating ACTH concentration, Macronodular adrenal hyperplasia, Hypertension, Adrenal... OMIM:219080
Liddle Syndrome 2
Decreased circulating renin level, Hypertension, Decreased circulating aldosterone level OMIM:618114
Liddle Syndrome 3
Decreased circulating renin level, Hypertension, Decreased circulating aldosterone level OMIM:618126
Bronchial Neuroendocrine Tumor
Hypotension, Tricuspid regurgitation, Pulmonary carcinoid tumor, Facial telangiectasia, Right ven... ORPHA:97287
Gitelman Syndrome
Delayed puberty, Prolonged QT interval, Maternal diabetes, Diabetic ketoacidosis, Prominent U wav... ORPHA:358
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Congestive heart failure, Dilated cardiomyopathy, Sudden cardiac death, Hyperaldosteronism ORPHA:73224
Autoimmune Polyendocrinopathy Type 1
Abnormal circulating calcium-phosphate regulating hormone concentration, Hypoparathyroidism, Adre... ORPHA:3453
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Diffuse pancreatic islet hyperplasia, Abnormal response to glucagon stimulation test, Focal pancr... ORPHA:79644
Pseudohypoaldosteronism, Type Iib
Hypertension, Pseudohypoaldosteronism OMIM:614491
Pseudohypoaldosteronism, Type Iid
Hypertension, Pseudohypoaldosteronism OMIM:614495
Thymic Neuroendocrine Tumor
Neoplasm of the endocrine system, Pancreatic islet cell adenoma, Neoplasm of the thymus, Primary ... ORPHA:97289
Liddle Syndrome 1
Decreased circulating renin level, Hypertension, Decreased circulating aldosterone level OMIM:177200
Mccune-Albright Syndrome
Precocious puberty, Pituitary adenoma, Hyperthyroidism, Elevated circulating growth hormone conce... OMIM:174800
Congenital Isolated Acth Deficiency
Adrenal hypoplasia, Decreased circulating cortisol level, Hypotension, Adrenocorticotropin defici... ORPHA:199296
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:613090
Corticosteroid-Binding Globulin Deficiency
Hypertension, Decreased circulating cortisol level, Hypotension OMIM:611489
Secondary Intestinal Lymphangiectasia
Right ventricular failure, Secondary hyperaldosteronism, Intestinal bleeding, Hypocholesterolemia... ORPHA:90363
Bangstad Syndrome
Hyperinsulinemia, Hypothyroidism, Primary gonadal insufficiency, Abnormality of the parathyroid g... ORPHA:1227
Nelson Syndrome
Anterior hypopituitarism, Diabetes insipidus, Secondary hypercortisolism, Adrenocorticotropic hor... ORPHA:199244
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Increased circulating androstenedione concentration, Precocious puberty in males, Elevated serum ... OMIM:202010
Bartter Syndrome, Type 1, Antenatal
Hyperactive renin-angiotensin system, Low-to-normal blood pressure, Increased circulating renin l... OMIM:601678
Pseudohypoaldosteronism, Type Iie
Hypertension, Pseudohypoaldosteronism OMIM:614496
Oculocerebrorenal Syndrome Of Lowe
Delayed puberty, Abnormal circulating calcium-phosphate regulating hormone concentration, Diabete... ORPHA:534
Pituitary Apoplexy
Central diabetes insipidus, Decreased response to growth hormone stimulation test, Reduced circul... ORPHA:95613
Generalized Glucocorticoid Resistance Syndrome
Abnormal circulating testosterone concentration, Hypertension, Increased urinary cortisol level, ... ORPHA:786
Leprechaunism
Hyperinsulinemia, Hypertrophic cardiomyopathy, Increased circulating renin level, Central hypothy... ORPHA:508
Tako-Tsubo Cardiomyopathy
Prolonged QT interval, Bradycardia, Palpitations, Low-output congestive heart failure, Mildly red... ORPHA:66529
Bartter Syndrome, Type 2, Antenatal
Increased circulating renin level, Hyperactive renin-angiotensin system, Hyperaldosteronism, Low-... OMIM:241200
Multiple Endocrine Neoplasia Type 4
Abnormality of the endocrine system, Pituitary growth hormone cell adenoma, Pituitary corticotrop... ORPHA:276152
Multiple Endocrine Neoplasia, Type I
Glucagonoma, Adrenocortical adenoma, Pancreatic islet cell adenoma, Pituitary prolactin cell aden... OMIM:131100
Bartter Syndrome Type 4
Increased circulating renin level, Hyperaldosteronism, Hyperactive renin-angiotensin system ORPHA:89938
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperaldosteronism OMIM:602522
Zollinger-Ellison Syndrome
Gastrointestinal hemorrhage, Glucagonoma, Neuroendocrine neoplasm, Elevated circulating parathyro... ORPHA:913
Dietary Iron Overload Disease
Abnormal adrenal morphology, Congestive heart failure, Abnormal thyroid morphology, Diabetes mell... ORPHA:139507
Multiple Endocrine Neoplasia Type 1
Hematemesis, Adrenocortical abnormality, Pheochromocytoma, Hypertension, Pituitary growth hormone... ORPHA:652
Neuroendocrine Neoplasm Of Appendix
Adrenocorticotropic hormone excess, Tricuspid stenosis, Hypotension, Heart murmur, Palpitations, ... ORPHA:100079
Somatostatinoma
Gastrointestinal hemorrhage, Steatorrhea, Increased circulating gonadotropin level, Adrenocortica... ORPHA:97283
Mccune-Albright Syndrome
Pancreatitis, Increased serum testosterone level, Precocious puberty, Hyperthyroidism, Elevated c... ORPHA:562
Ppoma
Gastrointestinal hemorrhage, Increased circulating gonadotropin level, Adrenocortical adenoma, Pr... ORPHA:97278
Grfoma
Gastrointestinal hemorrhage, Increased circulating gonadotropin level, Adrenocortical adenoma, Ph... ORPHA:97261
Vipoma
Increased circulating gonadotropin level, Adrenocortical adenoma, Primary hyperparathyroidism, El... ORPHA:97282
Glucagonoma
Gastrointestinal hemorrhage, Steatorrhea, Increased circulating gonadotropin level, Adrenocortica... ORPHA:97280
Fibrous Dysplasia Of Bone
Thyroid carcinoma, Precocious puberty in females, Abnormality of the endocrine system, Hyperpitui... ORPHA:249
Cushing Disease
Hypertension, Increased urinary cortisol level, Capillary fragility, Adrenal hyperplasia, Pituita... ORPHA:96253
Cushing Syndrome Due To Ectopic Acth Secretion
Neuroendocrine neoplasm, Pancreatic endocrine tumor, Pheochromocytoma, Hypertension, Increased ur... ORPHA:99889
Carney Complex
Congestive heart failure, Thyroid carcinoma, Increased circulating insulin-like growth factor 1 c... ORPHA:1359
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Decreased circulating androstenedione concentration, Elevated serum 11-deoxycortisol, Decreased c... OMIM:201750

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Strn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Strn.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Frontiers in cell and developmental biology (July 2020) Strntm1a(KOMP)Wtsi PMC7381154
Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension (Dallas, Tex. : 1979) (July 2015) Strntm1a(KOMP)Wtsi PMC4537321
Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension (Dallas, Tex. : 1979) (November 2014) Strntm1a(KOMP)Wtsi PMC4617687

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MGI Allele Allele Type Produced
Strntm43076(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Strntm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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