Pdcd6ip | programmed cell death 6 interacting protein

GeneMGI:1333753Synonyms: Alix, AIP1

Physiological systems

23 / 24 physiological systems tested

14 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological

9 No significant impact

1 Not tested

Gene metrics:33Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged lymph nodes1 supporting datasetPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
abnormal stomach morphology1 supporting datasetPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
abnormal spleen morphology1 supporting datasetPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
increased blood urea nitrogen level1 supporting datasetPdcd6ipem1(IMPC)HmguhomozygoteLate adult5.35x10-6 
decreased brain size2 supporting datasetsPdcd6ipem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal brain morphology2 supporting datasetsPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
microphthalmia1 supporting datasetPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
small kidney2 supporting datasetsPdcd6ipem1(IMPC)MbphomozygoteLate adultN/A * 
small testis1 supporting datasetPdcd6ipem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal brain morphology2 supporting datasetsPdcd6ipem1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pdcd6ipem1(IMPC)HmguIndelmouse
Pdcd6ipem1(IMPC)MbpExon Deletionmouse
Pdcd6iptm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Pdcd6iptm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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