Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
embryonic lethality prior to organogenesis | Cdk9tm1.1(KOMP)Vlcg | HOM | E9.5 | 0.00 | ||
abnormal epididymis morphology | Cdk9tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
embryonic lethality prior to tooth bud stage | Cdk9tm1.1(KOMP)Vlcg | HOM | E12.5 | 0.00 | ||
increased vertical activity | Cdk9tm1.1(KOMP)Vlcg | HET | Early adult | 1.43×10-06 | ||
enlarged heart | Cdk9tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
enlarged epididymis | Cdk9tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Cdk9tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 | ||
abnormal heart morphology | Cdk9tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 50% (1 of 2) |
Aorta | Section images | heterozygote | 100% (2 of 2) |
Blood | Section images | heterozygote | 50% (1 of 2) |
Bone marrow | Section images | heterozygote | 100% (2 of 2) |
Brown adipose tissue | Section images | heterozygote | 100% (2 of 2) |
Cecum | Section images | heterozygote | 100% (2 of 2) |
Cerebellum | Section images | heterozygote | 100% (2 of 2) |
Colon | Section images | heterozygote | 100% (2 of 2) |
Diaphragm | Section images | heterozygote | 50% (1 of 2) |
Epididymis | Section images | heterozygote | 50% (1 of 2) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Eye | Section images | heterozygote | 100% (2 of 2) |
Gonadal fat pad | Section images | heterozygote | 50% (1 of 2) |
Harderian gland | Section images | heterozygote | 100% (2 of 2) |
Ileum | Section images | heterozygote | 100% (2 of 2) |
Jejunum | Section images | heterozygote | 100% (2 of 2) |
Kidney | Section images | heterozygote | 100% (2 of 2) |
Liver | Section images | heterozygote | 100% (2 of 2) |
Lung | Section images | heterozygote | 100% (2 of 2) |
Mesenteric adipose tissue | Section images | heterozygote | 100% (2 of 2) |
Mesenteric lymph node | Section images | heterozygote | 100% (2 of 2) |
Midbrain | Section images | heterozygote | 100% (2 of 2) |
Olfactory lobe | Section images | heterozygote | 100% (2 of 2) |
Ovary | Section images | heterozygote | 50% (1 of 2) |
Oviduct | Section images | heterozygote | 50% (1 of 2) |
Pancreas | Section images | heterozygote | 100% (2 of 2) |
Parathyroid gland | Section images | heterozygote | 100% (2 of 2) |
Parotid gland | Section images | heterozygote | 100% (2 of 2) |
Penis | Section images | heterozygote | 50% (1 of 2) |
Pituitary gland | Section images | heterozygote | 50% (1 of 2) |
Prostate gland | Section images | heterozygote | 50% (1 of 2) |
Quadriceps | Section images | heterozygote | 100% (2 of 2) |
Sciatic nerve | Section images | heterozygote | 50% (1 of 2) |
Skin | Section images | heterozygote | 100% (2 of 2) |
Spinal cord | Section images | heterozygote | 100% (2 of 2) |
Spleen | Section images | heterozygote | 100% (2 of 2) |
Stomach | Section images | heterozygote | 100% (2 of 2) |
Sublingual gland | Section images | heterozygote | 100% (2 of 2) |
Submandibular gland | Section images | heterozygote | 100% (2 of 2) |
Testis | Section images | heterozygote | 50% (1 of 2) |
Thymus | Section images | heterozygote | 100% (2 of 2) |
Thyroid gland | Section images | heterozygote | 100% (2 of 2) |
Tongue | Section images | heterozygote | 100% (2 of 2) |
Trachea | Section images | heterozygote | 100% (2 of 2) |
Trigeminal V nerve | Section images | heterozygote | 50% (1 of 2) |
Urinary bladder | Section images | heterozygote | 100% (2 of 2) |
Uterus | Section images | heterozygote | 50% (1 of 2) |
Vas deferens | Section images | heterozygote | 50% (1 of 2) |
Vesicular gland | Section images | heterozygote | 50% (1 of 2) |
Brain | N/A | heterozygote | 100% (2 of 2) |
Brainstem | N/A | heterozygote | Not available |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Duodenum | N/A | heterozygote | Not available |
Gall bladder | N/A | heterozygote | Not available |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 100% (2 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 100% (2 of 2) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Vagina | N/A | heterozygote | Not available |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
Brain | N/A | heterozygote | 28.57% (2 of 7) |
Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
Ear | N/A | heterozygote | 28.57% (2 of 7) |
Embryo | N/A | heterozygote | 28.57% (2 of 7) |
Eye | N/A | heterozygote | 28.57% (2 of 7) |
Footplate | N/A | heterozygote | 28.57% (2 of 7) |
Forebrain | N/A | heterozygote | 28.57% (2 of 7) |
Forelimb | N/A | heterozygote | 28.57% (2 of 7) |
Gut | N/A | heterozygote | 100% (2 of 2) |
Handplate | N/A | heterozygote | 28.57% (2 of 7) |
Head | N/A | heterozygote | 28.57% (2 of 7) |
Heart | N/A | heterozygote | 28.57% (2 of 7) |
Hindbrain | N/A | heterozygote | 28.57% (2 of 7) |
Hindlimb | N/A | heterozygote | 28.57% (2 of 7) |
Liver | N/A | heterozygote | 28.57% (2 of 7) |
Lung | N/A | heterozygote | 28.57% (2 of 7) |
Mandibular process | N/A | heterozygote | 28.57% (2 of 7) |
Maxillary process | N/A | heterozygote | 28.57% (2 of 7) |
Midbrain | N/A | heterozygote | 28.57% (2 of 7) |
Nose | N/A | heterozygote | 100% (2 of 2) |
Oral cavity | N/A | heterozygote | 28.57% (2 of 7) |
Chorioallantoic placenta | N/A | heterozygote | 100% (7 of 7) |
Skeleton | N/A | heterozygote | 100% (2 of 2) |
Skin | N/A | heterozygote | 28.57% (2 of 7) |
Spinal cord | N/A | heterozygote | 100% (2 of 2) |
Tail somite | N/A | heterozygote | 28.57% (2 of 7) |
Tail | N/A | heterozygote | 28.57% (2 of 7) |
Trachea | N/A | heterozygote | 100% (2 of 2) |
Urinary system | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.79% (4 of 507) |
aorta | 0.0% |
blood | 0.0% |
bone marrow | 0.0% |
brain | 0.58% (3 of 513) |
brainstem | 0.39% (2 of 519) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.2% (1 of 496) |
cecum | 4.92% (16 of 325) |
cerebellum | 0.59% (3 of 506) |
cerebral cortex | 0.4% (2 of 494) |
chest bone | Unavailable |
colon | 16.52% (19 of 115) |
diaphragm | 0.0% |
duodenum | 2.59% (3 of 116) |
epididymis | 12.6% (16 of 127) |
esophagus | 1.45% (5 of 345) |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | 0.0% |
heart | 0.4% (2 of 496) |
hindlimb | 0.0% |
hippocampus | 0.41% (2 of 491) |
hypothalamus | 0.4% (2 of 496) |
ileum | 15.93% (18 of 113) |
jejunum | 9.02% (11 of 122) |
kidney | 4.26% (21 of 493) |
large intestine | 5.11% (26 of 509) |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.2% (1 of 502) |
lymph node | 0.2% (1 of 503) |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | 0.38% (1 of 264) |
midbrain | 0.0% |
olfactory lobe | 0.2% (1 of 502) |
ovary | 0.21% (1 of 487) |
oviduct | 0.0% |
pancreas | 0.83% (4 of 483) |
parathyroid gland | 0.21% (1 of 486) |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.2% (1 of 507) |
peyers patch | 0.0% |
pituitary gland | 0.2% (1 of 491) |
prostate gland | 2.06% (10 of 486) |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.21% (1 of 486) |
small intestine | 4.78% (24 of 502) |
spinal cord | 0.39% (2 of 512) |
spleen | 0.6% (3 of 500) |
stomach | 3.05% (15 of 491) |
stomach pyloric region | 0.0% |
striatum | 0.41% (2 of 493) |
sublingual gland | 0.0% |
submandibular gland | 1.69% (2 of 118) |
testis | 1.23% (6 of 489) |
thymus | 0.21% (1 of 476) |
thyroid gland | 2.63% (13 of 495) |
tongue | 3.54% (4 of 113) |
trachea | 0.6% (3 of 497) |
trigeminal v nerve | 0.0% |
urinary bladder | 0.0% |
uterus | 0.2% (1 of 498) |
vagina | 0.0% |
vas deferens | 5.45% (18 of 330) |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | 1.72% (1 of 58) |
brain | 1.3% (6 of 463) |
central nervous system ganglion | 1.43% (1 of 70) |
ear | 0.21% (1 of 470) |
embryo | 0.44% (2 of 455) |
eye | 0.0% |
footplate | 0.22% (1 of 460) |
forebrain | 0.22% (1 of 452) |
forelimb | 0.22% (1 of 455) |
gut | 2.08% (1 of 48) |
handplate | 0.22% (1 of 447) |
head | 0.67% (3 of 450) |
heart | 0.22% (1 of 465) |
hindbrain | 1.35% (6 of 446) |
hindlimb | 0.22% (1 of 462) |
liver | 0.22% (1 of 460) |
lung | 0.22% (1 of 464) |
mandibular process | 0.22% (1 of 455) |
maxillary process | 0.0% |
midbrain | 0.22% (1 of 455) |
nose | 1.47% (1 of 68) |
oral cavity | 0.22% (1 of 453) |
placenta | 17.07% (7 of 41) |
skeleton | 1.35% (1 of 74) |
skin | 0.22% (1 of 450) |
spinal cord | 1.54% (1 of 65) |
tail | 0.22% (1 of 452) |
tail somite group | 0.22% (1 of 455) |
trachea | 1.92% (1 of 52) |
urinary system | 1.96% (1 of 51) |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cdk9 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk9.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
The Role of CDKs and CDKIs in Murine Development. | International journal of molecular sciences (July 2020) | Cdk9tm1.1(KOMP)Vlcg | PMC7432401 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Cdk9tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Cdk9tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Cdk9tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Cdk9tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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