Gene: Orc1

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Name
origin recognition complex, subunit 1
MGI ID
MGI:1328337
Synonyms
MmORC1 Orc1l
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Orc1tm1a(KOMP)Wtsi HOM Early adult 0.00
prenatal lethality prior to heart atrial septation Orc1tm1a(KOMP)Wtsi HOM E15.5 0.00
increased bone mineral content Orc1tm1a(KOMP)Wtsi HET Early adult 5.13×10-06
preweaning lethality, complete penetrance Orc1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased body length Orc1tm1a(KOMP)Wtsi HET Early adult 5.99×10-05
increased grip strength Orc1tm1a(KOMP)Wtsi HET Early adult 2.28×10-05
increased lean body mass Orc1tm1a(KOMP)Wtsi HET Early adult 4.43×10-07
decreased total body fat amount Orc1tm1a(KOMP)Wtsi HET Early adult 1.30×10-06
increased bone mineral density Orc1tm1a(KOMP)Wtsi HET Early adult 4.14×10-05
abnormal bone structure Orc1tm1a(KOMP)Wtsi HET Early adult 4.65×10-05
embryonic lethality prior to organogenesis Orc1tm1a(KOMP)Wtsi HOM E9.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (1/2) N/A
Testis 2 No  (2/584) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/504) N/A
Dorsal root ganglion 1  (1/57) N/A
Ear 1  (1/504) N/A
Embryo 1  (1/505) N/A
Eye 1  (1/504) N/A
Foot 1  (1/504) N/A
Forebrain 1  (1/504) N/A
Forelimb 1  (1/504) N/A
Fronto-nasal process 1  (1/58) N/A
Hand 1  (1/503) N/A
Head 1  (5/504) N/A
Heart 1  (1/504) N/A
Hindbrain 1  (6/504) N/A
Hindlimb 1  (1/503) N/A
Liver 1  (1/504) N/A
Lung 1  (1/500) N/A
Mandibular process 1  (1/504) N/A
Maxillary process 1  (1/504) N/A
Midbrain 1  (1/504) N/A
Nose 1  (1/70) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/504) N/A
Spinal cord 1  (1/69) N/A
Tail 1  (1/504) N/A
Tail somite 1  (1/504) N/A

 Associated Images

X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
13 Images
Combined SHIRPA and Dysmorphology
3 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Electroretinography 2: Rod and cone PDF
4 Images
Eye Morphology: Images Ophthalmoscopy
6 Images
DSS Histology
8 Images
Anti-nuclear antibody assay
6 Images
Legacy Phenotype Associated Images

View all 90 images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Orc1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Orc1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Orc1tm295368(L1L2_Bact_P) Targeting vectors
Orc1tm36556(L1L2_gt1) Targeting vectors

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